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Q9LMT1

- P2C08_ARATH

UniProt

Q9LMT1 - P2C08_ARATH

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Protein

Probable protein phosphatase 2C 8

Gene

At1g18030

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed - Annotation score: 2 out of 5- Experimental evidence at transcript leveli

Functioni

Catalytic activityi

[a protein]-serine/threonine phosphate + H2O = [a protein]-serine/threonine + phosphate.

Cofactori

Binds 2 magnesium or manganese ions per subunit.By similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi114 – 1141Manganese 1By similarity
Metal bindingi114 – 1141Manganese 2By similarity
Metal bindingi115 – 1151Manganese 1; via carbonyl oxygenBy similarity
Metal bindingi295 – 2951Manganese 2By similarity
Metal bindingi339 – 3391Manganese 2By similarity

GO - Molecular functioni

  1. metal ion binding Source: UniProtKB-KW
  2. phosphoprotein phosphatase activity Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Protein phosphatase

Keywords - Ligandi

Magnesium, Manganese, Metal-binding

Enzyme and pathway databases

BioCyciARA:AT1G18030-MONOMER.
ARA:GQT-968-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Probable protein phosphatase 2C 8 (EC:3.1.3.16)
Short name:
AtPP2C08
Gene namesi
Ordered Locus Names:At1g18030
ORF Names:T10F20.4
OrganismiArabidopsis thaliana (Mouse-ear cress)
Taxonomic identifieri3702 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
ProteomesiUP000006548: Chromosome 1

Organism-specific databases

TAIRiAT1G18030.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 351351Probable protein phosphatase 2C 8PRO_0000367939Add
BLAST

Proteomic databases

PaxDbiQ9LMT1.
PRIDEiQ9LMT1.

Expressioni

Gene expression databases

GenevestigatoriQ9LMT1.

Interactioni

Protein-protein interaction databases

BioGridi23622. 1 interaction.
IntActiQ9LMT1. 1 interaction.
MINTiMINT-8390724.

Structurei

3D structure databases

ProteinModelPortaliQ9LMT1.
SMRiQ9LMT1. Positions 82-349.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini73 – 341269PP2C-likeAdd
BLAST

Sequence similaritiesi

Belongs to the PP2C family.Curated
Contains 1 PP2C-like domain.Curated

Phylogenomic databases

eggNOGiCOG0631.
HOGENOMiHOG000233896.
InParanoidiQ9LMT1.
KOiK17500.
OMAiTAVCVWV.
PhylomeDBiQ9LMT1.

Family and domain databases

Gene3Di3.60.40.10. 1 hit.
InterProiIPR001932. PP2C-like_dom.
IPR015655. Protein_Pase_2C.
[Graphical view]
PANTHERiPTHR13832. PTHR13832. 1 hit.
PfamiPF00481. PP2C. 1 hit.
[Graphical view]
SMARTiSM00331. PP2C_SIG. 1 hit.
SM00332. PP2Cc. 1 hit.
[Graphical view]
SUPFAMiSSF81606. SSF81606. 1 hit.

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: Q9LMT1-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MLEKESDLTA MEKPNNKHAA DSFSSEDLVS PVKKAKKSEE VSGGGEAVAA
60 70 80 90 100
VGNREAEEDK PSFVSEEKKE FLVEADVAED KGARHTMEDV WVVLPDASLD
110 120 130 140 150
FPGTLRCAHF AIYDGHGGRL AAEFAKKHLH LNVLSAGLPR ELLDVKVAKK
160 170 180 190 200
AILEGFRKTD ELLLQKSVSG GWQDGATAVC VWILDQKVFV ANIGDAKAVL
210 220 230 240 250
ARSSTTNELG NHTEAGNPLK AIVLTREHKA IYPQERSRIQ KSGGVISSNG
260 270 280 290 300
RLQGRLEVSR AFGDRHFKKF GVSATPDIHA FELTERENFM ILGCDGLWEV
310 320 330 340 350
FGPSDAVGFV QKLLKEGLHV STVSRRLVKE AVKERRCKDN CTAIVIVFKR

V
Length:351
Mass (Da):38,486
Last modified:April 14, 2009 - v2
Checksum:i0A6808FD713CCB7E
GO
Isoform 2 (identifier: Q9LMT1-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     301-305: FGPSD → SVWTK
     306-351: Missing.

Note: Derived from EST data. May be due to a competing donor splice site. No experimental confirmation available.

Show »
Length:305
Mass (Da):33,377
Checksum:i94E635FEEE8FA112
GO

Sequence cautioni

The sequence AAF97840.1 differs from that shown. Reason: Erroneous initiation.

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti56 – 561A → V in AAL16282. (PubMed:14593172)Curated

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei301 – 3055FGPSD → SVWTK in isoform 2. CuratedVSP_036757
Alternative sequencei306 – 35146Missing in isoform 2. CuratedVSP_036758Add
BLAST

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AC034107 Genomic DNA. Translation: AAF97840.1. Different initiation.
CP002684 Genomic DNA. Translation: AEE29665.1.
CP002684 Genomic DNA. Translation: AEE29666.1.
AF428352 mRNA. Translation: AAL16282.1.
BT026023 mRNA. Translation: ABG48379.1.
PIRiG86315.
RefSeqiNP_001077557.1. NM_001084088.1. [Q9LMT1-2]
NP_564045.1. NM_101665.2. [Q9LMT1-1]
UniGeneiAt.14957.
At.26247.
At.26787.
At.73166.

Genome annotation databases

EnsemblPlantsiAT1G18030.1; AT1G18030.1; AT1G18030. [Q9LMT1-1]
GeneIDi838383.
KEGGiath:AT1G18030.

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AC034107 Genomic DNA. Translation: AAF97840.1 . Different initiation.
CP002684 Genomic DNA. Translation: AEE29665.1 .
CP002684 Genomic DNA. Translation: AEE29666.1 .
AF428352 mRNA. Translation: AAL16282.1 .
BT026023 mRNA. Translation: ABG48379.1 .
PIRi G86315.
RefSeqi NP_001077557.1. NM_001084088.1. [Q9LMT1-2 ]
NP_564045.1. NM_101665.2. [Q9LMT1-1 ]
UniGenei At.14957.
At.26247.
At.26787.
At.73166.

3D structure databases

ProteinModelPortali Q9LMT1.
SMRi Q9LMT1. Positions 82-349.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 23622. 1 interaction.
IntActi Q9LMT1. 1 interaction.
MINTi MINT-8390724.

Proteomic databases

PaxDbi Q9LMT1.
PRIDEi Q9LMT1.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblPlantsi AT1G18030.1 ; AT1G18030.1 ; AT1G18030 . [Q9LMT1-1 ]
GeneIDi 838383.
KEGGi ath:AT1G18030.

Organism-specific databases

TAIRi AT1G18030.

Phylogenomic databases

eggNOGi COG0631.
HOGENOMi HOG000233896.
InParanoidi Q9LMT1.
KOi K17500.
OMAi TAVCVWV.
PhylomeDBi Q9LMT1.

Enzyme and pathway databases

BioCyci ARA:AT1G18030-MONOMER.
ARA:GQT-968-MONOMER.

Miscellaneous databases

PROi Q9LMT1.

Gene expression databases

Genevestigatori Q9LMT1.

Family and domain databases

Gene3Di 3.60.40.10. 1 hit.
InterProi IPR001932. PP2C-like_dom.
IPR015655. Protein_Pase_2C.
[Graphical view ]
PANTHERi PTHR13832. PTHR13832. 1 hit.
Pfami PF00481. PP2C. 1 hit.
[Graphical view ]
SMARTi SM00331. PP2C_SIG. 1 hit.
SM00332. PP2Cc. 1 hit.
[Graphical view ]
SUPFAMi SSF81606. SSF81606. 1 hit.
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Sequence and analysis of chromosome 1 of the plant Arabidopsis thaliana."
    Theologis A., Ecker J.R., Palm C.J., Federspiel N.A., Kaul S., White O., Alonso J., Altafi H., Araujo R., Bowman C.L., Brooks S.Y., Buehler E., Chan A., Chao Q., Chen H., Cheuk R.F., Chin C.W., Chung M.K.
    , Conn L., Conway A.B., Conway A.R., Creasy T.H., Dewar K., Dunn P., Etgu P., Feldblyum T.V., Feng J.-D., Fong B., Fujii C.Y., Gill J.E., Goldsmith A.D., Haas B., Hansen N.F., Hughes B., Huizar L., Hunter J.L., Jenkins J., Johnson-Hopson C., Khan S., Khaykin E., Kim C.J., Koo H.L., Kremenetskaia I., Kurtz D.B., Kwan A., Lam B., Langin-Hooper S., Lee A., Lee J.M., Lenz C.A., Li J.H., Li Y.-P., Lin X., Liu S.X., Liu Z.A., Luros J.S., Maiti R., Marziali A., Militscher J., Miranda M., Nguyen M., Nierman W.C., Osborne B.I., Pai G., Peterson J., Pham P.K., Rizzo M., Rooney T., Rowley D., Sakano H., Salzberg S.L., Schwartz J.R., Shinn P., Southwick A.M., Sun H., Tallon L.J., Tambunga G., Toriumi M.J., Town C.D., Utterback T., Van Aken S., Vaysberg M., Vysotskaia V.S., Walker M., Wu D., Yu G., Fraser C.M., Venter J.C., Davis R.W.
    Nature 408:816-820(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: cv. Columbia.
  2. The Arabidopsis Information Resource (TAIR)
    Submitted (APR-2011) to the EMBL/GenBank/DDBJ databases
    Cited for: GENOME REANNOTATION.
    Strain: cv. Columbia.
  3. "Empirical analysis of transcriptional activity in the Arabidopsis genome."
    Yamada K., Lim J., Dale J.M., Chen H., Shinn P., Palm C.J., Southwick A.M., Wu H.C., Kim C.J., Nguyen M., Pham P.K., Cheuk R.F., Karlin-Newmann G., Liu S.X., Lam B., Sakano H., Wu T., Yu G.
    , Miranda M., Quach H.L., Tripp M., Chang C.H., Lee J.M., Toriumi M.J., Chan M.M., Tang C.C., Onodera C.S., Deng J.M., Akiyama K., Ansari Y., Arakawa T., Banh J., Banno F., Bowser L., Brooks S.Y., Carninci P., Chao Q., Choy N., Enju A., Goldsmith A.D., Gurjal M., Hansen N.F., Hayashizaki Y., Johnson-Hopson C., Hsuan V.W., Iida K., Karnes M., Khan S., Koesema E., Ishida J., Jiang P.X., Jones T., Kawai J., Kamiya A., Meyers C., Nakajima M., Narusaka M., Seki M., Sakurai T., Satou M., Tamse R., Vaysberg M., Wallender E.K., Wong C., Yamamura Y., Yuan S., Shinozaki K., Davis R.W., Theologis A., Ecker J.R.
    Science 302:842-846(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Strain: cv. Columbia.
  4. "Arabidopsis ORF clone."
    Quinitio C., Chen H., Kim C.J., Shinn P., Ecker J.R.
    Submitted (JUL-2006) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Strain: cv. Columbia.
  5. "Genome-wide and expression analysis of protein phosphatase 2C in rice and Arabidopsis."
    Xue T., Wang D., Zhang S., Ehlting J., Ni F., Jacab S., Zheng C., Zhong Y.
    BMC Genomics 9:550-550(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: GENE FAMILY, NOMENCLATURE.

Entry informationi

Entry nameiP2C08_ARATH
AccessioniPrimary (citable) accession number: Q9LMT1
Secondary accession number(s): A8MRQ0, Q147S0, Q944K0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 14, 2009
Last sequence update: April 14, 2009
Last modified: October 29, 2014
This is version 75 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Arabidopsis thaliana
    Arabidopsis thaliana: entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3