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Protein

Probable protein phosphatase 2C 8

Gene

At1g18030

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Catalytic activityi

[a protein]-serine/threonine phosphate + H2O = [a protein]-serine/threonine + phosphate.

Cofactori

Mg2+By similarity, Mn2+By similarityNote: Binds 2 magnesium or manganese ions per subunit.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi114Manganese 1By similarity1
Metal bindingi114Manganese 2By similarity1
Metal bindingi115Manganese 1; via carbonyl oxygenBy similarity1
Metal bindingi295Manganese 2By similarity1
Metal bindingi339Manganese 2By similarity1

GO - Molecular functioni

Keywordsi

Molecular functionHydrolase, Protein phosphatase
LigandMagnesium, Manganese, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Probable protein phosphatase 2C 8 (EC:3.1.3.16)
Short name:
AtPP2C08
Gene namesi
Ordered Locus Names:At1g18030
ORF Names:T10F20.4
OrganismiArabidopsis thaliana (Mouse-ear cress)
Taxonomic identifieri3702 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
Proteomesi
  • UP000006548 Componenti: Chromosome 1

Organism-specific databases

AraportiAT1G18030
TAIRilocus:2194035 AT1G18030

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003679391 – 351Probable protein phosphatase 2C 8Add BLAST351

Proteomic databases

PaxDbiQ9LMT1
PRIDEiQ9LMT1

Expressioni

Gene expression databases

ExpressionAtlasiQ9LMT1 baseline and differential
GenevisibleiQ9LMT1 AT

Interactioni

Protein-protein interaction databases

BioGridi23622, 1 interactor
IntActiQ9LMT1, 1 interactor
MINTiQ9LMT1
STRINGi3702.AT1G18030.1

Structurei

3D structure databases

ProteinModelPortaliQ9LMT1
SMRiQ9LMT1
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini74 – 348PPM-type phosphatasePROSITE-ProRule annotationAdd BLAST275

Sequence similaritiesi

Belongs to the PP2C family.Curated

Phylogenomic databases

eggNOGiKOG0698 Eukaryota
COG0631 LUCA
HOGENOMiHOG000233896
InParanoidiQ9LMT1
KOiK17500
OMAiPDIKRCQ
OrthoDBiEOG09360BEB
PhylomeDBiQ9LMT1

Family and domain databases

CDDicd00143 PP2Cc, 1 hit
Gene3Di3.60.40.10, 1 hit
InterProiView protein in InterPro
IPR015655 PP2C
IPR036457 PPM-type_dom_sf
IPR001932 PPM-type_phosphatase_dom
PANTHERiPTHR13832 PTHR13832, 1 hit
PfamiView protein in Pfam
PF00481 PP2C, 1 hit
SMARTiView protein in SMART
SM00332 PP2Cc, 1 hit
SUPFAMiSSF81606 SSF81606, 1 hit
PROSITEiView protein in PROSITE
PS51746 PPM_2, 1 hit

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q9LMT1-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MLEKESDLTA MEKPNNKHAA DSFSSEDLVS PVKKAKKSEE VSGGGEAVAA
60 70 80 90 100
VGNREAEEDK PSFVSEEKKE FLVEADVAED KGARHTMEDV WVVLPDASLD
110 120 130 140 150
FPGTLRCAHF AIYDGHGGRL AAEFAKKHLH LNVLSAGLPR ELLDVKVAKK
160 170 180 190 200
AILEGFRKTD ELLLQKSVSG GWQDGATAVC VWILDQKVFV ANIGDAKAVL
210 220 230 240 250
ARSSTTNELG NHTEAGNPLK AIVLTREHKA IYPQERSRIQ KSGGVISSNG
260 270 280 290 300
RLQGRLEVSR AFGDRHFKKF GVSATPDIHA FELTERENFM ILGCDGLWEV
310 320 330 340 350
FGPSDAVGFV QKLLKEGLHV STVSRRLVKE AVKERRCKDN CTAIVIVFKR

V
Length:351
Mass (Da):38,486
Last modified:April 14, 2009 - v2
Checksum:i0A6808FD713CCB7E
GO
Isoform 2 (identifier: Q9LMT1-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     301-305: FGPSD → SVWTK
     306-351: Missing.

Note: Derived from EST data. May be due to a competing donor splice site. No experimental confirmation available.
Show »
Length:305
Mass (Da):33,377
Checksum:i94E635FEEE8FA112
GO

Sequence cautioni

The sequence AAF97840 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti56A → V in AAL16282 (PubMed:14593172).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_036757301 – 305FGPSD → SVWTK in isoform 2. Curated5
Alternative sequenceiVSP_036758306 – 351Missing in isoform 2. CuratedAdd BLAST46

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC034107 Genomic DNA Translation: AAF97840.1 Different initiation.
CP002684 Genomic DNA Translation: AEE29665.1
CP002684 Genomic DNA Translation: AEE29666.1
AF428352 mRNA Translation: AAL16282.1
BT026023 mRNA Translation: ABG48379.1
PIRiG86315
RefSeqiNP_001077557.1, NM_001084088.2 [Q9LMT1-2]
NP_564045.1, NM_101665.3 [Q9LMT1-1]
UniGeneiAt.14957
At.26247
At.26787
At.73166

Genome annotation databases

EnsemblPlantsiAT1G18030.1; AT1G18030.1; AT1G18030 [Q9LMT1-1]
AT1G18030.2; AT1G18030.2; AT1G18030 [Q9LMT1-2]
GeneIDi838383
GrameneiAT1G18030.1; AT1G18030.1; AT1G18030 [Q9LMT1-1]
AT1G18030.2; AT1G18030.2; AT1G18030 [Q9LMT1-2]
KEGGiath:AT1G18030

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Entry informationi

Entry nameiP2C08_ARATH
AccessioniPrimary (citable) accession number: Q9LMT1
Secondary accession number(s): A8MRQ0, Q147S0, Q944K0
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 14, 2009
Last sequence update: April 14, 2009
Last modified: May 23, 2018
This is version 98 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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