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Protein

Probable protein phosphatase 2C 8

Gene

At1g18030

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

Catalytic activityi

[a protein]-serine/threonine phosphate + H2O = [a protein]-serine/threonine + phosphate.

Cofactori

Mg2+By similarity, Mn2+By similarityNote: Binds 2 magnesium or manganese ions per subunit.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi114Manganese 1By similarity1
Metal bindingi114Manganese 2By similarity1
Metal bindingi115Manganese 1; via carbonyl oxygenBy similarity1
Metal bindingi295Manganese 2By similarity1
Metal bindingi339Manganese 2By similarity1

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Protein phosphatase

Keywords - Ligandi

Magnesium, Manganese, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Probable protein phosphatase 2C 8 (EC:3.1.3.16)
Short name:
AtPP2C08
Gene namesi
Ordered Locus Names:At1g18030
ORF Names:T10F20.4
OrganismiArabidopsis thaliana (Mouse-ear cress)
Taxonomic identifieri3702 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
Proteomesi
  • UP000006548 Componenti: Chromosome 1

Organism-specific databases

TAIRiAT1G18030.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003679391 – 351Probable protein phosphatase 2C 8Add BLAST351

Proteomic databases

PaxDbiQ9LMT1.

Expressioni

Gene expression databases

GenevisibleiQ9LMT1. AT.

Interactioni

Protein-protein interaction databases

BioGridi23622. 1 interactor.
IntActiQ9LMT1. 1 interactor.
MINTiMINT-8390724.
STRINGi3702.AT1G18030.1.

Structurei

3D structure databases

ProteinModelPortaliQ9LMT1.
SMRiQ9LMT1.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini74 – 348PPM-type phosphatasePROSITE-ProRule annotationAdd BLAST275

Sequence similaritiesi

Belongs to the PP2C family.Curated
Contains 1 PPM-type phosphatase domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiKOG0698. Eukaryota.
COG0631. LUCA.
HOGENOMiHOG000233896.
InParanoidiQ9LMT1.
KOiK17500.
OMAiAIVIVFK.
OrthoDBiEOG09360BEB.
PhylomeDBiQ9LMT1.

Family and domain databases

Gene3Di3.60.40.10. 1 hit.
InterProiIPR015655. PP2C.
IPR001932. PPM-type_phosphatase_dom.
[Graphical view]
PANTHERiPTHR13832. PTHR13832. 1 hit.
PfamiPF00481. PP2C. 1 hit.
[Graphical view]
SMARTiSM00332. PP2Cc. 1 hit.
[Graphical view]
SUPFAMiSSF81606. SSF81606. 1 hit.
PROSITEiPS51746. PPM_2. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q9LMT1-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MLEKESDLTA MEKPNNKHAA DSFSSEDLVS PVKKAKKSEE VSGGGEAVAA
60 70 80 90 100
VGNREAEEDK PSFVSEEKKE FLVEADVAED KGARHTMEDV WVVLPDASLD
110 120 130 140 150
FPGTLRCAHF AIYDGHGGRL AAEFAKKHLH LNVLSAGLPR ELLDVKVAKK
160 170 180 190 200
AILEGFRKTD ELLLQKSVSG GWQDGATAVC VWILDQKVFV ANIGDAKAVL
210 220 230 240 250
ARSSTTNELG NHTEAGNPLK AIVLTREHKA IYPQERSRIQ KSGGVISSNG
260 270 280 290 300
RLQGRLEVSR AFGDRHFKKF GVSATPDIHA FELTERENFM ILGCDGLWEV
310 320 330 340 350
FGPSDAVGFV QKLLKEGLHV STVSRRLVKE AVKERRCKDN CTAIVIVFKR

V
Length:351
Mass (Da):38,486
Last modified:April 14, 2009 - v2
Checksum:i0A6808FD713CCB7E
GO
Isoform 2 (identifier: Q9LMT1-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     301-305: FGPSD → SVWTK
     306-351: Missing.

Note: Derived from EST data. May be due to a competing donor splice site. No experimental confirmation available.
Show »
Length:305
Mass (Da):33,377
Checksum:i94E635FEEE8FA112
GO

Sequence cautioni

The sequence AAF97840 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti56A → V in AAL16282 (PubMed:14593172).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_036757301 – 305FGPSD → SVWTK in isoform 2. Curated5
Alternative sequenceiVSP_036758306 – 351Missing in isoform 2. CuratedAdd BLAST46

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC034107 Genomic DNA. Translation: AAF97840.1. Different initiation.
CP002684 Genomic DNA. Translation: AEE29665.1.
CP002684 Genomic DNA. Translation: AEE29666.1.
AF428352 mRNA. Translation: AAL16282.1.
BT026023 mRNA. Translation: ABG48379.1.
PIRiG86315.
RefSeqiNP_001077557.1. NM_001084088.2. [Q9LMT1-2]
NP_564045.1. NM_101665.3. [Q9LMT1-1]
UniGeneiAt.14957.
At.26247.
At.26787.
At.73166.

Genome annotation databases

EnsemblPlantsiAT1G18030.1; AT1G18030.1; AT1G18030. [Q9LMT1-1]
GeneIDi838383.
GrameneiAT1G18030.1; AT1G18030.1; AT1G18030.
KEGGiath:AT1G18030.

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC034107 Genomic DNA. Translation: AAF97840.1. Different initiation.
CP002684 Genomic DNA. Translation: AEE29665.1.
CP002684 Genomic DNA. Translation: AEE29666.1.
AF428352 mRNA. Translation: AAL16282.1.
BT026023 mRNA. Translation: ABG48379.1.
PIRiG86315.
RefSeqiNP_001077557.1. NM_001084088.2. [Q9LMT1-2]
NP_564045.1. NM_101665.3. [Q9LMT1-1]
UniGeneiAt.14957.
At.26247.
At.26787.
At.73166.

3D structure databases

ProteinModelPortaliQ9LMT1.
SMRiQ9LMT1.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi23622. 1 interactor.
IntActiQ9LMT1. 1 interactor.
MINTiMINT-8390724.
STRINGi3702.AT1G18030.1.

Proteomic databases

PaxDbiQ9LMT1.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblPlantsiAT1G18030.1; AT1G18030.1; AT1G18030. [Q9LMT1-1]
GeneIDi838383.
GrameneiAT1G18030.1; AT1G18030.1; AT1G18030.
KEGGiath:AT1G18030.

Organism-specific databases

TAIRiAT1G18030.

Phylogenomic databases

eggNOGiKOG0698. Eukaryota.
COG0631. LUCA.
HOGENOMiHOG000233896.
InParanoidiQ9LMT1.
KOiK17500.
OMAiAIVIVFK.
OrthoDBiEOG09360BEB.
PhylomeDBiQ9LMT1.

Miscellaneous databases

PROiQ9LMT1.

Gene expression databases

GenevisibleiQ9LMT1. AT.

Family and domain databases

Gene3Di3.60.40.10. 1 hit.
InterProiIPR015655. PP2C.
IPR001932. PPM-type_phosphatase_dom.
[Graphical view]
PANTHERiPTHR13832. PTHR13832. 1 hit.
PfamiPF00481. PP2C. 1 hit.
[Graphical view]
SMARTiSM00332. PP2Cc. 1 hit.
[Graphical view]
SUPFAMiSSF81606. SSF81606. 1 hit.
PROSITEiPS51746. PPM_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiP2C08_ARATH
AccessioniPrimary (citable) accession number: Q9LMT1
Secondary accession number(s): A8MRQ0, Q147S0, Q944K0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 14, 2009
Last sequence update: April 14, 2009
Last modified: November 30, 2016
This is version 88 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Arabidopsis thaliana
    Arabidopsis thaliana: entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.