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Q9LMT1

- P2C08_ARATH

UniProt

Q9LMT1 - P2C08_ARATH

Protein

Probable protein phosphatase 2C 8

Gene

At1g18030

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed - Annotation score: 2 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 74 (01 Oct 2014)
      Sequence version 2 (14 Apr 2009)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    [a protein]-serine/threonine phosphate + H2O = [a protein]-serine/threonine + phosphate.

    Cofactori

    Binds 2 magnesium or manganese ions per subunit.By similarity

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Metal bindingi114 – 1141Manganese 1By similarity
    Metal bindingi114 – 1141Manganese 2By similarity
    Metal bindingi115 – 1151Manganese 1; via carbonyl oxygenBy similarity
    Metal bindingi295 – 2951Manganese 2By similarity
    Metal bindingi339 – 3391Manganese 2By similarity

    GO - Molecular functioni

    1. metal ion binding Source: UniProtKB-KW
    2. phosphoprotein phosphatase activity Source: UniProtKB-KW

    Keywords - Molecular functioni

    Hydrolase, Protein phosphatase

    Keywords - Ligandi

    Magnesium, Manganese, Metal-binding

    Enzyme and pathway databases

    BioCyciARA:AT1G18030-MONOMER.
    ARA:GQT-968-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Probable protein phosphatase 2C 8 (EC:3.1.3.16)
    Short name:
    AtPP2C08
    Gene namesi
    Ordered Locus Names:At1g18030
    ORF Names:T10F20.4
    OrganismiArabidopsis thaliana (Mouse-ear cress)
    Taxonomic identifieri3702 [NCBI]
    Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
    ProteomesiUP000006548: Chromosome 1

    Organism-specific databases

    TAIRiAT1G18030.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 351351Probable protein phosphatase 2C 8PRO_0000367939Add
    BLAST

    Proteomic databases

    PaxDbiQ9LMT1.
    PRIDEiQ9LMT1.

    Expressioni

    Gene expression databases

    GenevestigatoriQ9LMT1.

    Interactioni

    Protein-protein interaction databases

    BioGridi23622. 1 interaction.
    IntActiQ9LMT1. 1 interaction.
    MINTiMINT-8390724.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9LMT1.
    SMRiQ9LMT1. Positions 82-349.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini73 – 341269PP2C-likeAdd
    BLAST

    Sequence similaritiesi

    Belongs to the PP2C family.Curated
    Contains 1 PP2C-like domain.Curated

    Phylogenomic databases

    eggNOGiCOG0631.
    HOGENOMiHOG000233896.
    InParanoidiQ147S0.
    KOiK17500.
    OMAiTAVCVWV.
    PhylomeDBiQ9LMT1.

    Family and domain databases

    Gene3Di3.60.40.10. 1 hit.
    InterProiIPR001932. PP2C-like_dom.
    IPR015655. Protein_Pase_2C.
    [Graphical view]
    PANTHERiPTHR13832. PTHR13832. 1 hit.
    PfamiPF00481. PP2C. 1 hit.
    [Graphical view]
    SMARTiSM00331. PP2C_SIG. 1 hit.
    SM00332. PP2Cc. 1 hit.
    [Graphical view]
    SUPFAMiSSF81606. SSF81606. 1 hit.

    Sequences (2)i

    Sequence statusi: Complete.

    This entry describes 2 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q9LMT1-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MLEKESDLTA MEKPNNKHAA DSFSSEDLVS PVKKAKKSEE VSGGGEAVAA    50
    VGNREAEEDK PSFVSEEKKE FLVEADVAED KGARHTMEDV WVVLPDASLD 100
    FPGTLRCAHF AIYDGHGGRL AAEFAKKHLH LNVLSAGLPR ELLDVKVAKK 150
    AILEGFRKTD ELLLQKSVSG GWQDGATAVC VWILDQKVFV ANIGDAKAVL 200
    ARSSTTNELG NHTEAGNPLK AIVLTREHKA IYPQERSRIQ KSGGVISSNG 250
    RLQGRLEVSR AFGDRHFKKF GVSATPDIHA FELTERENFM ILGCDGLWEV 300
    FGPSDAVGFV QKLLKEGLHV STVSRRLVKE AVKERRCKDN CTAIVIVFKR 350
    V 351
    Length:351
    Mass (Da):38,486
    Last modified:April 14, 2009 - v2
    Checksum:i0A6808FD713CCB7E
    GO
    Isoform 2 (identifier: Q9LMT1-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         301-305: FGPSD → SVWTK
         306-351: Missing.

    Note: Derived from EST data. May be due to a competing donor splice site. No experimental confirmation available.

    Show »
    Length:305
    Mass (Da):33,377
    Checksum:i94E635FEEE8FA112
    GO

    Sequence cautioni

    The sequence AAF97840.1 differs from that shown. Reason: Erroneous initiation.

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti56 – 561A → V in AAL16282. (PubMed:14593172)Curated

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei301 – 3055FGPSD → SVWTK in isoform 2. CuratedVSP_036757
    Alternative sequencei306 – 35146Missing in isoform 2. CuratedVSP_036758Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AC034107 Genomic DNA. Translation: AAF97840.1. Different initiation.
    CP002684 Genomic DNA. Translation: AEE29665.1.
    CP002684 Genomic DNA. Translation: AEE29666.1.
    AF428352 mRNA. Translation: AAL16282.1.
    BT026023 mRNA. Translation: ABG48379.1.
    PIRiG86315.
    RefSeqiNP_001077557.1. NM_001084088.1. [Q9LMT1-2]
    NP_564045.1. NM_101665.2. [Q9LMT1-1]
    UniGeneiAt.14957.
    At.26247.
    At.26787.
    At.73166.

    Genome annotation databases

    EnsemblPlantsiAT1G18030.1; AT1G18030.1; AT1G18030. [Q9LMT1-1]
    GeneIDi838383.
    KEGGiath:AT1G18030.

    Keywords - Coding sequence diversityi

    Alternative splicing

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AC034107 Genomic DNA. Translation: AAF97840.1 . Different initiation.
    CP002684 Genomic DNA. Translation: AEE29665.1 .
    CP002684 Genomic DNA. Translation: AEE29666.1 .
    AF428352 mRNA. Translation: AAL16282.1 .
    BT026023 mRNA. Translation: ABG48379.1 .
    PIRi G86315.
    RefSeqi NP_001077557.1. NM_001084088.1. [Q9LMT1-2 ]
    NP_564045.1. NM_101665.2. [Q9LMT1-1 ]
    UniGenei At.14957.
    At.26247.
    At.26787.
    At.73166.

    3D structure databases

    ProteinModelPortali Q9LMT1.
    SMRi Q9LMT1. Positions 82-349.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 23622. 1 interaction.
    IntActi Q9LMT1. 1 interaction.
    MINTi MINT-8390724.

    Proteomic databases

    PaxDbi Q9LMT1.
    PRIDEi Q9LMT1.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblPlantsi AT1G18030.1 ; AT1G18030.1 ; AT1G18030 . [Q9LMT1-1 ]
    GeneIDi 838383.
    KEGGi ath:AT1G18030.

    Organism-specific databases

    TAIRi AT1G18030.

    Phylogenomic databases

    eggNOGi COG0631.
    HOGENOMi HOG000233896.
    InParanoidi Q147S0.
    KOi K17500.
    OMAi TAVCVWV.
    PhylomeDBi Q9LMT1.

    Enzyme and pathway databases

    BioCyci ARA:AT1G18030-MONOMER.
    ARA:GQT-968-MONOMER.

    Miscellaneous databases

    PROi Q9LMT1.

    Gene expression databases

    Genevestigatori Q9LMT1.

    Family and domain databases

    Gene3Di 3.60.40.10. 1 hit.
    InterProi IPR001932. PP2C-like_dom.
    IPR015655. Protein_Pase_2C.
    [Graphical view ]
    PANTHERi PTHR13832. PTHR13832. 1 hit.
    Pfami PF00481. PP2C. 1 hit.
    [Graphical view ]
    SMARTi SM00331. PP2C_SIG. 1 hit.
    SM00332. PP2Cc. 1 hit.
    [Graphical view ]
    SUPFAMi SSF81606. SSF81606. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "Sequence and analysis of chromosome 1 of the plant Arabidopsis thaliana."
      Theologis A., Ecker J.R., Palm C.J., Federspiel N.A., Kaul S., White O., Alonso J., Altafi H., Araujo R., Bowman C.L., Brooks S.Y., Buehler E., Chan A., Chao Q., Chen H., Cheuk R.F., Chin C.W., Chung M.K.
      , Conn L., Conway A.B., Conway A.R., Creasy T.H., Dewar K., Dunn P., Etgu P., Feldblyum T.V., Feng J.-D., Fong B., Fujii C.Y., Gill J.E., Goldsmith A.D., Haas B., Hansen N.F., Hughes B., Huizar L., Hunter J.L., Jenkins J., Johnson-Hopson C., Khan S., Khaykin E., Kim C.J., Koo H.L., Kremenetskaia I., Kurtz D.B., Kwan A., Lam B., Langin-Hooper S., Lee A., Lee J.M., Lenz C.A., Li J.H., Li Y.-P., Lin X., Liu S.X., Liu Z.A., Luros J.S., Maiti R., Marziali A., Militscher J., Miranda M., Nguyen M., Nierman W.C., Osborne B.I., Pai G., Peterson J., Pham P.K., Rizzo M., Rooney T., Rowley D., Sakano H., Salzberg S.L., Schwartz J.R., Shinn P., Southwick A.M., Sun H., Tallon L.J., Tambunga G., Toriumi M.J., Town C.D., Utterback T., Van Aken S., Vaysberg M., Vysotskaia V.S., Walker M., Wu D., Yu G., Fraser C.M., Venter J.C., Davis R.W.
      Nature 408:816-820(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: cv. Columbia.
    2. The Arabidopsis Information Resource (TAIR)
      Submitted (APR-2011) to the EMBL/GenBank/DDBJ databases
      Cited for: GENOME REANNOTATION.
      Strain: cv. Columbia.
    3. "Empirical analysis of transcriptional activity in the Arabidopsis genome."
      Yamada K., Lim J., Dale J.M., Chen H., Shinn P., Palm C.J., Southwick A.M., Wu H.C., Kim C.J., Nguyen M., Pham P.K., Cheuk R.F., Karlin-Newmann G., Liu S.X., Lam B., Sakano H., Wu T., Yu G.
      , Miranda M., Quach H.L., Tripp M., Chang C.H., Lee J.M., Toriumi M.J., Chan M.M., Tang C.C., Onodera C.S., Deng J.M., Akiyama K., Ansari Y., Arakawa T., Banh J., Banno F., Bowser L., Brooks S.Y., Carninci P., Chao Q., Choy N., Enju A., Goldsmith A.D., Gurjal M., Hansen N.F., Hayashizaki Y., Johnson-Hopson C., Hsuan V.W., Iida K., Karnes M., Khan S., Koesema E., Ishida J., Jiang P.X., Jones T., Kawai J., Kamiya A., Meyers C., Nakajima M., Narusaka M., Seki M., Sakurai T., Satou M., Tamse R., Vaysberg M., Wallender E.K., Wong C., Yamamura Y., Yuan S., Shinozaki K., Davis R.W., Theologis A., Ecker J.R.
      Science 302:842-846(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
      Strain: cv. Columbia.
    4. "Arabidopsis ORF clone."
      Quinitio C., Chen H., Kim C.J., Shinn P., Ecker J.R.
      Submitted (JUL-2006) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
      Strain: cv. Columbia.
    5. "Genome-wide and expression analysis of protein phosphatase 2C in rice and Arabidopsis."
      Xue T., Wang D., Zhang S., Ehlting J., Ni F., Jacab S., Zheng C., Zhong Y.
      BMC Genomics 9:550-550(2008) [PubMed] [Europe PMC] [Abstract]
      Cited for: GENE FAMILY, NOMENCLATURE.

    Entry informationi

    Entry nameiP2C08_ARATH
    AccessioniPrimary (citable) accession number: Q9LMT1
    Secondary accession number(s): A8MRQ0, Q147S0, Q944K0
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: April 14, 2009
    Last sequence update: April 14, 2009
    Last modified: October 1, 2014
    This is version 74 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programPlant Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Arabidopsis thaliana
      Arabidopsis thaliana: entries and gene names
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3