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Q9LMS3

- LAC1_ARATH

UniProt

Q9LMS3 - LAC1_ARATH

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Protein

Laccase-1

Gene

LAC1

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli

Functioni

Lignin degradation and detoxification of lignin-derived products.By similarity

Catalytic activityi

4 benzenediol + O2 = 4 benzosemiquinone + 2 H2O.

Cofactori

Binds 4 copper ions per monomer.By similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi84 – 841Copper 1; type 2By similarity
Metal bindingi86 – 861Copper 2; type 3By similarity
Metal bindingi129 – 1291Copper 2; type 3By similarity
Metal bindingi131 – 1311Copper 3; type 3By similarity
Metal bindingi482 – 4821Copper 4; type 1By similarity
Metal bindingi485 – 4851Copper 1; type 2By similarity
Metal bindingi487 – 4871Copper 3; type 3By similarity
Metal bindingi544 – 5441Copper 3; type 3By similarity
Metal bindingi545 – 5451Copper 4; type 1By similarity
Metal bindingi546 – 5461Copper 2; type 3By similarity
Metal bindingi550 – 5501Copper 4; type 1By similarity

GO - Molecular functioni

  1. copper ion binding Source: InterPro
  2. hydroquinone:oxygen oxidoreductase activity Source: UniProtKB-EC

GO - Biological processi

  1. lignin catabolic process Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Lignin degradation

Keywords - Ligandi

Copper, Metal-binding

Enzyme and pathway databases

BioCyciARA:AT1G18140-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Laccase-1 (EC:1.10.3.2)
Alternative name(s):
Benzenediol:oxygen oxidoreductase 1
Diphenol oxidase 1
Urishiol oxidase 1
Gene namesi
Name:LAC1
Ordered Locus Names:At1g18140
ORF Names:T10F20.14, T10O22.11
OrganismiArabidopsis thaliana (Mouse-ear cress)
Taxonomic identifieri3702 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
ProteomesiUP000006548: Chromosome 1

Organism-specific databases

TAIRiAT1G18140.

Subcellular locationi

GO - Cellular componenti

  1. apoplast Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Apoplast, Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2525Sequence AnalysisAdd
BLAST
Chaini26 – 581556Laccase-1PRO_0000283629Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi80 – 801N-linked (GlcNAc...)Sequence Analysis
Glycosylationi241 – 2411N-linked (GlcNAc...)Sequence Analysis
Glycosylationi300 – 3001N-linked (GlcNAc...)Sequence Analysis
Glycosylationi386 – 3861N-linked (GlcNAc...)Sequence Analysis
Glycosylationi403 – 4031N-linked (GlcNAc...)Sequence Analysis

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiQ9LMS3.
PRIDEiQ9LMS3.

Expressioni

Tissue specificityi

Expressed in roots, stems and flowers.1 Publication

Gene expression databases

GenevestigatoriQ9LMS3.

Structurei

3D structure databases

ProteinModelPortaliQ9LMS3.
SMRiQ9LMS3. Positions 46-560.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini34 – 150117Plastocyanin-like 1Add
BLAST
Domaini161 – 312152Plastocyanin-like 2Add
BLAST
Domaini429 – 565137Plastocyanin-like 3Add
BLAST

Sequence similaritiesi

Belongs to the multicopper oxidase family.Curated
Contains 3 plastocyanin-like domains.Curated

Keywords - Domaini

Repeat, Signal

Phylogenomic databases

eggNOGiCOG2132.
HOGENOMiHOG000241916.
InParanoidiQ9LMS3.
OMAiKRFFASM.
PhylomeDBiQ9LMS3.

Family and domain databases

Gene3Di2.60.40.420. 3 hits.
InterProiIPR001117. Cu-oxidase.
IPR011706. Cu-oxidase_2.
IPR011707. Cu-oxidase_3.
IPR002355. Cu_oxidase_Cu_BS.
IPR008972. Cupredoxin.
IPR017761. Laccase.
[Graphical view]
PfamiPF00394. Cu-oxidase. 1 hit.
PF07731. Cu-oxidase_2. 1 hit.
PF07732. Cu-oxidase_3. 1 hit.
[Graphical view]
SUPFAMiSSF49503. SSF49503. 3 hits.
TIGRFAMsiTIGR03389. laccase. 1 hit.
PROSITEiPS00079. MULTICOPPER_OXIDASE1. 1 hit.
PS00080. MULTICOPPER_OXIDASE2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9LMS3-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MENLGFLIIS TFLLLFTTLL PYSSASTTRR FHFNVEWKKV TRLCHTKQLL
60 70 80 90 100
TVNGQYPGPT VAVHEGDIVE IKVTNRIAHN TTIHWHGLRQ YRTGWADGPA
110 120 130 140 150
YITQCPIRSK QSYTYRFKVE DQRGTLLWHA HHSWQRASVY GAFIIYPRQP
160 170 180 190 200
YPFSGSHIQS EIPIILGEWW NDDVDNVEKA MMKTGAGAKV SDAYTLNGLP
210 220 230 240 250
GPLYPCSTKD TFTATVDAGK TYILRIINAA LNNELFVAVA NHTLTVVEVD
260 270 280 290 300
AVYTKPVHTK AIMIAPGQTT TLLLRADQLS GGEFLIAATP YVTSVFPFNN
310 320 330 340 350
STTVGFIRYT GKTKPENSVN TRRRRRLTAM STVVALPNML DTKFATKFSD
360 370 380 390 400
SIKSLGSAKY PCKVPTKIDK RVITTISLNL QDCPLNQTCD GYAGKRFFAS
410 420 430 440 450
MNNISFVRPP ISILESYYKK QSKGVFSLDF PEKPPNRFDF TGVDPVSENM
460 470 480 490 500
NTEFGTKLFE VEFGSRLEIV FQGTSFLNIE NHPLHVHGHN FFVVGRGFGN
510 520 530 540 550
FDPEKDPKRY NLVDPPERNT FAVPTGGWAA IRINADNPGV WFIHCHLEQH
560 570 580
TSWGLAMGFI VKDGPLPSQT LLPPPHDLPQ C
Length:581
Mass (Da):65,229
Last modified:October 1, 2000 - v1
Checksum:iEE2071A7673C28AD
GO

Sequence cautioni

The sequence AAF78389.1 differs from that shown. Reason: Erroneous gene model prediction.

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AC034107 Genomic DNA. Translation: AAF97830.1.
AC069551 Genomic DNA. Translation: AAF78389.1. Sequence problems.
CP002684 Genomic DNA. Translation: AEE29678.1.
AK227320 mRNA. Translation: BAE99334.1.
PIRiE86316.
RefSeqiNP_173252.2. NM_101674.3.
UniGeneiAt.41805.

Genome annotation databases

EnsemblPlantsiAT1G18140.1; AT1G18140.1; AT1G18140.
GeneIDi838393.
KEGGiath:AT1G18140.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AC034107 Genomic DNA. Translation: AAF97830.1 .
AC069551 Genomic DNA. Translation: AAF78389.1 . Sequence problems.
CP002684 Genomic DNA. Translation: AEE29678.1 .
AK227320 mRNA. Translation: BAE99334.1 .
PIRi E86316.
RefSeqi NP_173252.2. NM_101674.3.
UniGenei At.41805.

3D structure databases

ProteinModelPortali Q9LMS3.
SMRi Q9LMS3. Positions 46-560.
ModBasei Search...
MobiDBi Search...

Proteomic databases

PaxDbi Q9LMS3.
PRIDEi Q9LMS3.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblPlantsi AT1G18140.1 ; AT1G18140.1 ; AT1G18140 .
GeneIDi 838393.
KEGGi ath:AT1G18140.

Organism-specific databases

TAIRi AT1G18140.

Phylogenomic databases

eggNOGi COG2132.
HOGENOMi HOG000241916.
InParanoidi Q9LMS3.
OMAi KRFFASM.
PhylomeDBi Q9LMS3.

Enzyme and pathway databases

BioCyci ARA:AT1G18140-MONOMER.

Gene expression databases

Genevestigatori Q9LMS3.

Family and domain databases

Gene3Di 2.60.40.420. 3 hits.
InterProi IPR001117. Cu-oxidase.
IPR011706. Cu-oxidase_2.
IPR011707. Cu-oxidase_3.
IPR002355. Cu_oxidase_Cu_BS.
IPR008972. Cupredoxin.
IPR017761. Laccase.
[Graphical view ]
Pfami PF00394. Cu-oxidase. 1 hit.
PF07731. Cu-oxidase_2. 1 hit.
PF07732. Cu-oxidase_3. 1 hit.
[Graphical view ]
SUPFAMi SSF49503. SSF49503. 3 hits.
TIGRFAMsi TIGR03389. laccase. 1 hit.
PROSITEi PS00079. MULTICOPPER_OXIDASE1. 1 hit.
PS00080. MULTICOPPER_OXIDASE2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Sequence and analysis of chromosome 1 of the plant Arabidopsis thaliana."
    Theologis A., Ecker J.R., Palm C.J., Federspiel N.A., Kaul S., White O., Alonso J., Altafi H., Araujo R., Bowman C.L., Brooks S.Y., Buehler E., Chan A., Chao Q., Chen H., Cheuk R.F., Chin C.W., Chung M.K.
    , Conn L., Conway A.B., Conway A.R., Creasy T.H., Dewar K., Dunn P., Etgu P., Feldblyum T.V., Feng J.-D., Fong B., Fujii C.Y., Gill J.E., Goldsmith A.D., Haas B., Hansen N.F., Hughes B., Huizar L., Hunter J.L., Jenkins J., Johnson-Hopson C., Khan S., Khaykin E., Kim C.J., Koo H.L., Kremenetskaia I., Kurtz D.B., Kwan A., Lam B., Langin-Hooper S., Lee A., Lee J.M., Lenz C.A., Li J.H., Li Y.-P., Lin X., Liu S.X., Liu Z.A., Luros J.S., Maiti R., Marziali A., Militscher J., Miranda M., Nguyen M., Nierman W.C., Osborne B.I., Pai G., Peterson J., Pham P.K., Rizzo M., Rooney T., Rowley D., Sakano H., Salzberg S.L., Schwartz J.R., Shinn P., Southwick A.M., Sun H., Tallon L.J., Tambunga G., Toriumi M.J., Town C.D., Utterback T., Van Aken S., Vaysberg M., Vysotskaia V.S., Walker M., Wu D., Yu G., Fraser C.M., Venter J.C., Davis R.W.
    Nature 408:816-820(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: cv. Columbia.
  2. The Arabidopsis Information Resource (TAIR)
    Submitted (APR-2011) to the EMBL/GenBank/DDBJ databases
    Cited for: GENOME REANNOTATION.
    Strain: cv. Columbia.
  3. "Large-scale analysis of RIKEN Arabidopsis full-length (RAFL) cDNAs."
    Totoki Y., Seki M., Ishida J., Nakajima M., Enju A., Kamiya A., Narusaka M., Shin-i T., Nakagawa M., Sakamoto N., Oishi K., Kohara Y., Kobayashi M., Toyoda A., Sakaki Y., Sakurai T., Iida K., Akiyama K.
    , Satou M., Toyoda T., Konagaya A., Carninci P., Kawai J., Hayashizaki Y., Shinozaki K.
    Submitted (JUL-2006) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: cv. Columbia.
  4. "Mutant identification and characterization of the laccase gene family in Arabidopsis."
    Cai X., Davis E.J., Ballif J., Liang M., Bushman E., Haroldsen V., Torabinejad J., Wu Y.
    J. Exp. Bot. 57:2563-2569(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: TISSUE SPECIFICITY.

Entry informationi

Entry nameiLAC1_ARATH
AccessioniPrimary (citable) accession number: Q9LMS3
Secondary accession number(s): Q9LM34
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 3, 2007
Last sequence update: October 1, 2000
Last modified: October 29, 2014
This is version 94 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Arabidopsis thaliana
    Arabidopsis thaliana: entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3