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Protein

Laccase-1

Gene

LAC1

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Lignin degradation and detoxification of lignin-derived products.By similarity

Catalytic activityi

4 benzenediol + O2 = 4 benzosemiquinone + 2 H2O.

Cofactori

Cu cationBy similarityNote: Binds 4 Cu cations per monomer.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi84Copper 1; type 2By similarity1
Metal bindingi86Copper 2; type 3By similarity1
Metal bindingi129Copper 2; type 3By similarity1
Metal bindingi131Copper 3; type 3By similarity1
Metal bindingi482Copper 4; type 1By similarity1
Metal bindingi485Copper 1; type 2By similarity1
Metal bindingi487Copper 3; type 3By similarity1
Metal bindingi544Copper 3; type 3By similarity1
Metal bindingi545Copper 4; type 1By similarity1
Metal bindingi546Copper 2; type 3By similarity1
Metal bindingi550Copper 4; type 1By similarity1

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Lignin degradation

Keywords - Ligandi

Copper, Metal-binding

Enzyme and pathway databases

BioCyciARA:AT1G18140-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Laccase-1 (EC:1.10.3.2)
Alternative name(s):
Benzenediol:oxygen oxidoreductase 1
Diphenol oxidase 1
Urishiol oxidase 1
Gene namesi
Name:LAC1
Ordered Locus Names:At1g18140
ORF Names:T10F20.14, T10O22.11
OrganismiArabidopsis thaliana (Mouse-ear cress)
Taxonomic identifieri3702 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
Proteomesi
  • UP000006548 Componenti: Chromosome 1

Organism-specific databases

TAIRiAT1G18140.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Apoplast, Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 25Sequence analysisAdd BLAST25
ChainiPRO_000028362926 – 581Laccase-1Add BLAST556

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi80N-linked (GlcNAc...)Sequence analysis1
Glycosylationi241N-linked (GlcNAc...)Sequence analysis1
Glycosylationi300N-linked (GlcNAc...)Sequence analysis1
Glycosylationi386N-linked (GlcNAc...)Sequence analysis1
Glycosylationi403N-linked (GlcNAc...)Sequence analysis1

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiQ9LMS3.

Expressioni

Tissue specificityi

Expressed in roots, stems and flowers.1 Publication

Gene expression databases

GenevisibleiQ9LMS3. AT.

Interactioni

Protein-protein interaction databases

STRINGi3702.AT1G18140.1.

Structurei

3D structure databases

ProteinModelPortaliQ9LMS3.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini34 – 150Plastocyanin-like 1Add BLAST117
Domaini161 – 312Plastocyanin-like 2Add BLAST152
Domaini429 – 565Plastocyanin-like 3Add BLAST137

Sequence similaritiesi

Belongs to the multicopper oxidase family.Curated
Contains 3 plastocyanin-like domains.Curated

Keywords - Domaini

Repeat, Signal

Phylogenomic databases

eggNOGiKOG1263. Eukaryota.
COG2132. LUCA.
HOGENOMiHOG000241916.
InParanoidiQ9LMS3.
KOiK05909.
OMAiWAAIRIN.
OrthoDBiEOG0936081C.
PhylomeDBiQ9LMS3.

Family and domain databases

Gene3Di2.60.40.420. 3 hits.
InterProiIPR001117. Cu-oxidase.
IPR011706. Cu-oxidase_2.
IPR011707. Cu-oxidase_3.
IPR033138. Cu_oxidase_CS.
IPR002355. Cu_oxidase_Cu_BS.
IPR008972. Cupredoxin.
IPR017761. Laccase.
[Graphical view]
PfamiPF00394. Cu-oxidase. 1 hit.
PF07731. Cu-oxidase_2. 1 hit.
PF07732. Cu-oxidase_3. 1 hit.
[Graphical view]
SUPFAMiSSF49503. SSF49503. 3 hits.
TIGRFAMsiTIGR03389. laccase. 1 hit.
PROSITEiPS00079. MULTICOPPER_OXIDASE1. 1 hit.
PS00080. MULTICOPPER_OXIDASE2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9LMS3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MENLGFLIIS TFLLLFTTLL PYSSASTTRR FHFNVEWKKV TRLCHTKQLL
60 70 80 90 100
TVNGQYPGPT VAVHEGDIVE IKVTNRIAHN TTIHWHGLRQ YRTGWADGPA
110 120 130 140 150
YITQCPIRSK QSYTYRFKVE DQRGTLLWHA HHSWQRASVY GAFIIYPRQP
160 170 180 190 200
YPFSGSHIQS EIPIILGEWW NDDVDNVEKA MMKTGAGAKV SDAYTLNGLP
210 220 230 240 250
GPLYPCSTKD TFTATVDAGK TYILRIINAA LNNELFVAVA NHTLTVVEVD
260 270 280 290 300
AVYTKPVHTK AIMIAPGQTT TLLLRADQLS GGEFLIAATP YVTSVFPFNN
310 320 330 340 350
STTVGFIRYT GKTKPENSVN TRRRRRLTAM STVVALPNML DTKFATKFSD
360 370 380 390 400
SIKSLGSAKY PCKVPTKIDK RVITTISLNL QDCPLNQTCD GYAGKRFFAS
410 420 430 440 450
MNNISFVRPP ISILESYYKK QSKGVFSLDF PEKPPNRFDF TGVDPVSENM
460 470 480 490 500
NTEFGTKLFE VEFGSRLEIV FQGTSFLNIE NHPLHVHGHN FFVVGRGFGN
510 520 530 540 550
FDPEKDPKRY NLVDPPERNT FAVPTGGWAA IRINADNPGV WFIHCHLEQH
560 570 580
TSWGLAMGFI VKDGPLPSQT LLPPPHDLPQ C
Length:581
Mass (Da):65,229
Last modified:October 1, 2000 - v1
Checksum:iEE2071A7673C28AD
GO

Sequence cautioni

The sequence AAF78389 differs from that shown. Reason: Erroneous gene model prediction.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC034107 Genomic DNA. Translation: AAF97830.1.
AC069551 Genomic DNA. Translation: AAF78389.1. Sequence problems.
CP002684 Genomic DNA. Translation: AEE29678.1.
AK227320 mRNA. Translation: BAE99334.1.
PIRiE86316.
RefSeqiNP_173252.2. NM_101674.4.
UniGeneiAt.41805.

Genome annotation databases

EnsemblPlantsiAT1G18140.1; AT1G18140.1; AT1G18140.
GeneIDi838393.
GrameneiAT1G18140.1; AT1G18140.1; AT1G18140.
KEGGiath:AT1G18140.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC034107 Genomic DNA. Translation: AAF97830.1.
AC069551 Genomic DNA. Translation: AAF78389.1. Sequence problems.
CP002684 Genomic DNA. Translation: AEE29678.1.
AK227320 mRNA. Translation: BAE99334.1.
PIRiE86316.
RefSeqiNP_173252.2. NM_101674.4.
UniGeneiAt.41805.

3D structure databases

ProteinModelPortaliQ9LMS3.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi3702.AT1G18140.1.

Proteomic databases

PaxDbiQ9LMS3.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblPlantsiAT1G18140.1; AT1G18140.1; AT1G18140.
GeneIDi838393.
GrameneiAT1G18140.1; AT1G18140.1; AT1G18140.
KEGGiath:AT1G18140.

Organism-specific databases

TAIRiAT1G18140.

Phylogenomic databases

eggNOGiKOG1263. Eukaryota.
COG2132. LUCA.
HOGENOMiHOG000241916.
InParanoidiQ9LMS3.
KOiK05909.
OMAiWAAIRIN.
OrthoDBiEOG0936081C.
PhylomeDBiQ9LMS3.

Enzyme and pathway databases

BioCyciARA:AT1G18140-MONOMER.

Miscellaneous databases

PROiQ9LMS3.

Gene expression databases

GenevisibleiQ9LMS3. AT.

Family and domain databases

Gene3Di2.60.40.420. 3 hits.
InterProiIPR001117. Cu-oxidase.
IPR011706. Cu-oxidase_2.
IPR011707. Cu-oxidase_3.
IPR033138. Cu_oxidase_CS.
IPR002355. Cu_oxidase_Cu_BS.
IPR008972. Cupredoxin.
IPR017761. Laccase.
[Graphical view]
PfamiPF00394. Cu-oxidase. 1 hit.
PF07731. Cu-oxidase_2. 1 hit.
PF07732. Cu-oxidase_3. 1 hit.
[Graphical view]
SUPFAMiSSF49503. SSF49503. 3 hits.
TIGRFAMsiTIGR03389. laccase. 1 hit.
PROSITEiPS00079. MULTICOPPER_OXIDASE1. 1 hit.
PS00080. MULTICOPPER_OXIDASE2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiLAC1_ARATH
AccessioniPrimary (citable) accession number: Q9LMS3
Secondary accession number(s): Q9LM34
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 3, 2007
Last sequence update: October 1, 2000
Last modified: November 30, 2016
This is version 107 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Arabidopsis thaliana
    Arabidopsis thaliana: entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.