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Q9LMS3

- LAC1_ARATH

UniProt

Q9LMS3 - LAC1_ARATH

Protein

Laccase-1

Gene

LAC1

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 93 (01 Oct 2014)
      Sequence version 1 (01 Oct 2000)
      Previous versions | rss
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    Functioni

    Lignin degradation and detoxification of lignin-derived products.By similarity

    Catalytic activityi

    4 benzenediol + O2 = 4 benzosemiquinone + 2 H2O.

    Cofactori

    Binds 4 copper ions per monomer.By similarity

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Metal bindingi84 – 841Copper 1; type 2By similarity
    Metal bindingi86 – 861Copper 2; type 3By similarity
    Metal bindingi129 – 1291Copper 2; type 3By similarity
    Metal bindingi131 – 1311Copper 3; type 3By similarity
    Metal bindingi482 – 4821Copper 4; type 1By similarity
    Metal bindingi485 – 4851Copper 1; type 2By similarity
    Metal bindingi487 – 4871Copper 3; type 3By similarity
    Metal bindingi544 – 5441Copper 3; type 3By similarity
    Metal bindingi545 – 5451Copper 4; type 1By similarity
    Metal bindingi546 – 5461Copper 2; type 3By similarity
    Metal bindingi550 – 5501Copper 4; type 1By similarity

    GO - Molecular functioni

    1. copper ion binding Source: InterPro
    2. hydroquinone:oxygen oxidoreductase activity Source: UniProtKB-EC

    GO - Biological processi

    1. lignin catabolic process Source: UniProtKB-KW

    Keywords - Molecular functioni

    Oxidoreductase

    Keywords - Biological processi

    Lignin degradation

    Keywords - Ligandi

    Copper, Metal-binding

    Enzyme and pathway databases

    BioCyciARA:AT1G18140-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Laccase-1 (EC:1.10.3.2)
    Alternative name(s):
    Benzenediol:oxygen oxidoreductase 1
    Diphenol oxidase 1
    Urishiol oxidase 1
    Gene namesi
    Name:LAC1
    Ordered Locus Names:At1g18140
    ORF Names:T10F20.14, T10O22.11
    OrganismiArabidopsis thaliana (Mouse-ear cress)
    Taxonomic identifieri3702 [NCBI]
    Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
    ProteomesiUP000006548: Chromosome 1

    Organism-specific databases

    TAIRiAT1G18140.

    Subcellular locationi

    GO - Cellular componenti

    1. apoplast Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Apoplast, Secreted

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 2525Sequence AnalysisAdd
    BLAST
    Chaini26 – 581556Laccase-1PRO_0000283629Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi80 – 801N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi241 – 2411N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi300 – 3001N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi386 – 3861N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi403 – 4031N-linked (GlcNAc...)Sequence Analysis

    Keywords - PTMi

    Glycoprotein

    Proteomic databases

    PaxDbiQ9LMS3.
    PRIDEiQ9LMS3.

    Expressioni

    Tissue specificityi

    Expressed in roots, stems and flowers.1 Publication

    Gene expression databases

    GenevestigatoriQ9LMS3.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9LMS3.
    SMRiQ9LMS3. Positions 46-560.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini34 – 150117Plastocyanin-like 1Add
    BLAST
    Domaini161 – 312152Plastocyanin-like 2Add
    BLAST
    Domaini429 – 565137Plastocyanin-like 3Add
    BLAST

    Sequence similaritiesi

    Belongs to the multicopper oxidase family.Curated
    Contains 3 plastocyanin-like domains.Curated

    Keywords - Domaini

    Repeat, Signal

    Phylogenomic databases

    eggNOGiCOG2132.
    HOGENOMiHOG000241916.
    InParanoidiQ9LMS3.
    OMAiKRFFASM.
    PhylomeDBiQ9LMS3.

    Family and domain databases

    Gene3Di2.60.40.420. 3 hits.
    InterProiIPR001117. Cu-oxidase.
    IPR011706. Cu-oxidase_2.
    IPR011707. Cu-oxidase_3.
    IPR002355. Cu_oxidase_Cu_BS.
    IPR008972. Cupredoxin.
    IPR017761. Laccase.
    [Graphical view]
    PfamiPF00394. Cu-oxidase. 1 hit.
    PF07731. Cu-oxidase_2. 1 hit.
    PF07732. Cu-oxidase_3. 1 hit.
    [Graphical view]
    SUPFAMiSSF49503. SSF49503. 3 hits.
    TIGRFAMsiTIGR03389. laccase. 1 hit.
    PROSITEiPS00079. MULTICOPPER_OXIDASE1. 1 hit.
    PS00080. MULTICOPPER_OXIDASE2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q9LMS3-1 [UniParc]FASTAAdd to Basket

    « Hide

    MENLGFLIIS TFLLLFTTLL PYSSASTTRR FHFNVEWKKV TRLCHTKQLL    50
    TVNGQYPGPT VAVHEGDIVE IKVTNRIAHN TTIHWHGLRQ YRTGWADGPA 100
    YITQCPIRSK QSYTYRFKVE DQRGTLLWHA HHSWQRASVY GAFIIYPRQP 150
    YPFSGSHIQS EIPIILGEWW NDDVDNVEKA MMKTGAGAKV SDAYTLNGLP 200
    GPLYPCSTKD TFTATVDAGK TYILRIINAA LNNELFVAVA NHTLTVVEVD 250
    AVYTKPVHTK AIMIAPGQTT TLLLRADQLS GGEFLIAATP YVTSVFPFNN 300
    STTVGFIRYT GKTKPENSVN TRRRRRLTAM STVVALPNML DTKFATKFSD 350
    SIKSLGSAKY PCKVPTKIDK RVITTISLNL QDCPLNQTCD GYAGKRFFAS 400
    MNNISFVRPP ISILESYYKK QSKGVFSLDF PEKPPNRFDF TGVDPVSENM 450
    NTEFGTKLFE VEFGSRLEIV FQGTSFLNIE NHPLHVHGHN FFVVGRGFGN 500
    FDPEKDPKRY NLVDPPERNT FAVPTGGWAA IRINADNPGV WFIHCHLEQH 550
    TSWGLAMGFI VKDGPLPSQT LLPPPHDLPQ C 581
    Length:581
    Mass (Da):65,229
    Last modified:October 1, 2000 - v1
    Checksum:iEE2071A7673C28AD
    GO

    Sequence cautioni

    The sequence AAF78389.1 differs from that shown. Reason: Erroneous gene model prediction.

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AC034107 Genomic DNA. Translation: AAF97830.1.
    AC069551 Genomic DNA. Translation: AAF78389.1. Sequence problems.
    CP002684 Genomic DNA. Translation: AEE29678.1.
    AK227320 mRNA. Translation: BAE99334.1.
    PIRiE86316.
    RefSeqiNP_173252.2. NM_101674.3.
    UniGeneiAt.41805.

    Genome annotation databases

    EnsemblPlantsiAT1G18140.1; AT1G18140.1; AT1G18140.
    GeneIDi838393.
    KEGGiath:AT1G18140.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AC034107 Genomic DNA. Translation: AAF97830.1 .
    AC069551 Genomic DNA. Translation: AAF78389.1 . Sequence problems.
    CP002684 Genomic DNA. Translation: AEE29678.1 .
    AK227320 mRNA. Translation: BAE99334.1 .
    PIRi E86316.
    RefSeqi NP_173252.2. NM_101674.3.
    UniGenei At.41805.

    3D structure databases

    ProteinModelPortali Q9LMS3.
    SMRi Q9LMS3. Positions 46-560.
    ModBasei Search...
    MobiDBi Search...

    Proteomic databases

    PaxDbi Q9LMS3.
    PRIDEi Q9LMS3.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblPlantsi AT1G18140.1 ; AT1G18140.1 ; AT1G18140 .
    GeneIDi 838393.
    KEGGi ath:AT1G18140.

    Organism-specific databases

    TAIRi AT1G18140.

    Phylogenomic databases

    eggNOGi COG2132.
    HOGENOMi HOG000241916.
    InParanoidi Q9LMS3.
    OMAi KRFFASM.
    PhylomeDBi Q9LMS3.

    Enzyme and pathway databases

    BioCyci ARA:AT1G18140-MONOMER.

    Gene expression databases

    Genevestigatori Q9LMS3.

    Family and domain databases

    Gene3Di 2.60.40.420. 3 hits.
    InterProi IPR001117. Cu-oxidase.
    IPR011706. Cu-oxidase_2.
    IPR011707. Cu-oxidase_3.
    IPR002355. Cu_oxidase_Cu_BS.
    IPR008972. Cupredoxin.
    IPR017761. Laccase.
    [Graphical view ]
    Pfami PF00394. Cu-oxidase. 1 hit.
    PF07731. Cu-oxidase_2. 1 hit.
    PF07732. Cu-oxidase_3. 1 hit.
    [Graphical view ]
    SUPFAMi SSF49503. SSF49503. 3 hits.
    TIGRFAMsi TIGR03389. laccase. 1 hit.
    PROSITEi PS00079. MULTICOPPER_OXIDASE1. 1 hit.
    PS00080. MULTICOPPER_OXIDASE2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Sequence and analysis of chromosome 1 of the plant Arabidopsis thaliana."
      Theologis A., Ecker J.R., Palm C.J., Federspiel N.A., Kaul S., White O., Alonso J., Altafi H., Araujo R., Bowman C.L., Brooks S.Y., Buehler E., Chan A., Chao Q., Chen H., Cheuk R.F., Chin C.W., Chung M.K.
      , Conn L., Conway A.B., Conway A.R., Creasy T.H., Dewar K., Dunn P., Etgu P., Feldblyum T.V., Feng J.-D., Fong B., Fujii C.Y., Gill J.E., Goldsmith A.D., Haas B., Hansen N.F., Hughes B., Huizar L., Hunter J.L., Jenkins J., Johnson-Hopson C., Khan S., Khaykin E., Kim C.J., Koo H.L., Kremenetskaia I., Kurtz D.B., Kwan A., Lam B., Langin-Hooper S., Lee A., Lee J.M., Lenz C.A., Li J.H., Li Y.-P., Lin X., Liu S.X., Liu Z.A., Luros J.S., Maiti R., Marziali A., Militscher J., Miranda M., Nguyen M., Nierman W.C., Osborne B.I., Pai G., Peterson J., Pham P.K., Rizzo M., Rooney T., Rowley D., Sakano H., Salzberg S.L., Schwartz J.R., Shinn P., Southwick A.M., Sun H., Tallon L.J., Tambunga G., Toriumi M.J., Town C.D., Utterback T., Van Aken S., Vaysberg M., Vysotskaia V.S., Walker M., Wu D., Yu G., Fraser C.M., Venter J.C., Davis R.W.
      Nature 408:816-820(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: cv. Columbia.
    2. The Arabidopsis Information Resource (TAIR)
      Submitted (APR-2011) to the EMBL/GenBank/DDBJ databases
      Cited for: GENOME REANNOTATION.
      Strain: cv. Columbia.
    3. "Large-scale analysis of RIKEN Arabidopsis full-length (RAFL) cDNAs."
      Totoki Y., Seki M., Ishida J., Nakajima M., Enju A., Kamiya A., Narusaka M., Shin-i T., Nakagawa M., Sakamoto N., Oishi K., Kohara Y., Kobayashi M., Toyoda A., Sakaki Y., Sakurai T., Iida K., Akiyama K.
      , Satou M., Toyoda T., Konagaya A., Carninci P., Kawai J., Hayashizaki Y., Shinozaki K.
      Submitted (JUL-2006) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: cv. Columbia.
    4. "Mutant identification and characterization of the laccase gene family in Arabidopsis."
      Cai X., Davis E.J., Ballif J., Liang M., Bushman E., Haroldsen V., Torabinejad J., Wu Y.
      J. Exp. Bot. 57:2563-2569(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: TISSUE SPECIFICITY.

    Entry informationi

    Entry nameiLAC1_ARATH
    AccessioniPrimary (citable) accession number: Q9LMS3
    Secondary accession number(s): Q9LM34
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: April 3, 2007
    Last sequence update: October 1, 2000
    Last modified: October 1, 2014
    This is version 93 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programPlant Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Arabidopsis thaliana
      Arabidopsis thaliana: entries and gene names
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3