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Protein

Laccase-1

Gene

LAC1

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Lignin degradation and detoxification of lignin-derived products.By similarity

Catalytic activityi

4 benzenediol + O2 = 4 benzosemiquinone + 2 H2O.

Cofactori

Cu cationBy similarityNote: Binds 4 Cu cations per monomer.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi84Copper 1; type 2By similarity1
Metal bindingi86Copper 2; type 3By similarity1
Metal bindingi129Copper 2; type 3By similarity1
Metal bindingi131Copper 3; type 3By similarity1
Metal bindingi482Copper 4; type 1By similarity1
Metal bindingi485Copper 1; type 2By similarity1
Metal bindingi487Copper 3; type 3By similarity1
Metal bindingi544Copper 3; type 3By similarity1
Metal bindingi545Copper 4; type 1By similarity1
Metal bindingi546Copper 2; type 3By similarity1
Metal bindingi550Copper 4; type 1By similarity1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionOxidoreductase
Biological processLignin degradation
LigandCopper, Metal-binding

Enzyme and pathway databases

BioCyciARA:AT1G18140-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
Laccase-1 (EC:1.10.3.2)
Alternative name(s):
Benzenediol:oxygen oxidoreductase 1
Diphenol oxidase 1
Urishiol oxidase 1
Gene namesi
Name:LAC1
Ordered Locus Names:At1g18140
ORF Names:T10F20.14, T10O22.11
OrganismiArabidopsis thaliana (Mouse-ear cress)
Taxonomic identifieri3702 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
Proteomesi
  • UP000006548 Componenti: Chromosome 1

Organism-specific databases

AraportiAT1G18140
TAIRilocus:2194110 AT1G18140

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Chloroplast Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertion Graphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Apoplast, Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 25Sequence analysisAdd BLAST25
ChainiPRO_000028362926 – 581Laccase-1Add BLAST556

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi80N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi241N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi300N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi386N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi403N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiQ9LMS3
PRIDEiQ9LMS3

Expressioni

Tissue specificityi

Expressed in roots, stems and flowers.1 Publication

Gene expression databases

ExpressionAtlasiQ9LMS3 baseline and differential
GenevisibleiQ9LMS3 AT

Interactioni

Protein-protein interaction databases

STRINGi3702.AT1G18140.1

Structurei

3D structure databases

ProteinModelPortaliQ9LMS3
SMRiQ9LMS3
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini34 – 150Plastocyanin-like 1Add BLAST117
Domaini161 – 312Plastocyanin-like 2Add BLAST152
Domaini429 – 565Plastocyanin-like 3Add BLAST137

Sequence similaritiesi

Belongs to the multicopper oxidase family.Curated

Keywords - Domaini

Repeat, Signal

Phylogenomic databases

eggNOGiKOG1263 Eukaryota
COG2132 LUCA
HOGENOMiHOG000241916
InParanoidiQ9LMS3
KOiK05909
OMAiDEHEFYV
OrthoDBiEOG0936081C
PhylomeDBiQ9LMS3

Family and domain databases

CDDicd13849 CuRO_1_LCC_plant, 1 hit
cd13875 CuRO_2_LCC_plant, 1 hit
cd13897 CuRO_3_LCC_plant, 1 hit
Gene3Di2.60.40.420, 3 hits
InterProiView protein in InterPro
IPR001117 Cu-oxidase
IPR011706 Cu-oxidase_2
IPR011707 Cu-oxidase_3
IPR033138 Cu_oxidase_CS
IPR002355 Cu_oxidase_Cu_BS
IPR008972 Cupredoxin
IPR034288 CuRO_1_LCC
IPR034285 CuRO_2_LCC
IPR034289 CuRO_3_LCC
IPR017761 Laccase
PfamiView protein in Pfam
PF00394 Cu-oxidase, 1 hit
PF07731 Cu-oxidase_2, 1 hit
PF07732 Cu-oxidase_3, 1 hit
SUPFAMiSSF49503 SSF49503, 3 hits
TIGRFAMsiTIGR03389 laccase, 1 hit
PROSITEiView protein in PROSITE
PS00079 MULTICOPPER_OXIDASE1, 1 hit
PS00080 MULTICOPPER_OXIDASE2, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9LMS3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MENLGFLIIS TFLLLFTTLL PYSSASTTRR FHFNVEWKKV TRLCHTKQLL
60 70 80 90 100
TVNGQYPGPT VAVHEGDIVE IKVTNRIAHN TTIHWHGLRQ YRTGWADGPA
110 120 130 140 150
YITQCPIRSK QSYTYRFKVE DQRGTLLWHA HHSWQRASVY GAFIIYPRQP
160 170 180 190 200
YPFSGSHIQS EIPIILGEWW NDDVDNVEKA MMKTGAGAKV SDAYTLNGLP
210 220 230 240 250
GPLYPCSTKD TFTATVDAGK TYILRIINAA LNNELFVAVA NHTLTVVEVD
260 270 280 290 300
AVYTKPVHTK AIMIAPGQTT TLLLRADQLS GGEFLIAATP YVTSVFPFNN
310 320 330 340 350
STTVGFIRYT GKTKPENSVN TRRRRRLTAM STVVALPNML DTKFATKFSD
360 370 380 390 400
SIKSLGSAKY PCKVPTKIDK RVITTISLNL QDCPLNQTCD GYAGKRFFAS
410 420 430 440 450
MNNISFVRPP ISILESYYKK QSKGVFSLDF PEKPPNRFDF TGVDPVSENM
460 470 480 490 500
NTEFGTKLFE VEFGSRLEIV FQGTSFLNIE NHPLHVHGHN FFVVGRGFGN
510 520 530 540 550
FDPEKDPKRY NLVDPPERNT FAVPTGGWAA IRINADNPGV WFIHCHLEQH
560 570 580
TSWGLAMGFI VKDGPLPSQT LLPPPHDLPQ C
Length:581
Mass (Da):65,229
Last modified:October 1, 2000 - v1
Checksum:iEE2071A7673C28AD
GO

Sequence cautioni

The sequence AAF78389 differs from that shown. Reason: Erroneous gene model prediction.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC034107 Genomic DNA Translation: AAF97830.1
AC069551 Genomic DNA Translation: AAF78389.1 Sequence problems.
CP002684 Genomic DNA Translation: AEE29678.1
AK227320 mRNA Translation: BAE99334.1
PIRiE86316
RefSeqiNP_173252.2, NM_101674.4
UniGeneiAt.41805

Genome annotation databases

EnsemblPlantsiAT1G18140.1; AT1G18140.1; AT1G18140
GeneIDi838393
GrameneiAT1G18140.1; AT1G18140.1; AT1G18140
KEGGiath:AT1G18140

Similar proteinsi

Entry informationi

Entry nameiLAC1_ARATH
AccessioniPrimary (citable) accession number: Q9LMS3
Secondary accession number(s): Q9LM34
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 3, 2007
Last sequence update: October 1, 2000
Last modified: May 23, 2018
This is version 118 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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