ID   PI5KA_ARATH             Reviewed;         427 AA.
AC   Q9LMN1; O23705;
DT   25-OCT-2005, integrated into UniProtKB/Swiss-Prot.
DT   25-OCT-2005, sequence version 2.
DT   27-MAR-2024, entry version 135.
DE   RecName: Full=Phosphatidylinositol 4-phosphate 5-kinase 10;
DE            Short=AtPIP5K10;
DE            EC=2.7.1.68;
DE   AltName: Full=1-phosphatidylinositol 4-phosphate kinase 10;
DE   AltName: Full=Diphosphoinositide kinase 10;
DE   AltName: Full=PtdIns(4)P-5-kinase 10;
GN   Name=PIP5K10; OrderedLocusNames=At1g01460; ORFNames=F22L4.2;
OS   Arabidopsis thaliana (Mouse-ear cress).
OC   Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC   Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC   rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX   NCBI_TaxID=3702;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=9666060; DOI=10.1016/s0378-1119(98)00286-8;
RA   Terryn N., Gielen J., De Keyser A., Van Den Daele H., Ardiles W., Neyt P.,
RA   De Clercq R., Coppieters J., Dehais P., Villarroel R., Rouze P.,
RA   van Montagu M.;
RT   "Sequence analysis of a 40-kb Arabidopsis thaliana genomic region located
RT   at the top of chromosome 1.";
RL   Gene 215:11-17(1998).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=cv. Columbia;
RX   PubMed=11130712; DOI=10.1038/35048500;
RA   Theologis A., Ecker J.R., Palm C.J., Federspiel N.A., Kaul S., White O.,
RA   Alonso J., Altafi H., Araujo R., Bowman C.L., Brooks S.Y., Buehler E.,
RA   Chan A., Chao Q., Chen H., Cheuk R.F., Chin C.W., Chung M.K., Conn L.,
RA   Conway A.B., Conway A.R., Creasy T.H., Dewar K., Dunn P., Etgu P.,
RA   Feldblyum T.V., Feng J.-D., Fong B., Fujii C.Y., Gill J.E., Goldsmith A.D.,
RA   Haas B., Hansen N.F., Hughes B., Huizar L., Hunter J.L., Jenkins J.,
RA   Johnson-Hopson C., Khan S., Khaykin E., Kim C.J., Koo H.L.,
RA   Kremenetskaia I., Kurtz D.B., Kwan A., Lam B., Langin-Hooper S., Lee A.,
RA   Lee J.M., Lenz C.A., Li J.H., Li Y.-P., Lin X., Liu S.X., Liu Z.A.,
RA   Luros J.S., Maiti R., Marziali A., Militscher J., Miranda M., Nguyen M.,
RA   Nierman W.C., Osborne B.I., Pai G., Peterson J., Pham P.K., Rizzo M.,
RA   Rooney T., Rowley D., Sakano H., Salzberg S.L., Schwartz J.R., Shinn P.,
RA   Southwick A.M., Sun H., Tallon L.J., Tambunga G., Toriumi M.J., Town C.D.,
RA   Utterback T., Van Aken S., Vaysberg M., Vysotskaia V.S., Walker M., Wu D.,
RA   Yu G., Fraser C.M., Venter J.C., Davis R.W.;
RT   "Sequence and analysis of chromosome 1 of the plant Arabidopsis thaliana.";
RL   Nature 408:816-820(2000).
RN   [3]
RP   GENOME REANNOTATION.
RC   STRAIN=cv. Columbia;
RX   PubMed=27862469; DOI=10.1111/tpj.13415;
RA   Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA   Town C.D.;
RT   "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT   genome.";
RL   Plant J. 89:789-804(2017).
RN   [4]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=cv. Columbia;
RA   Underwood B.A., Xiao Y.-L., Moskal W.A. Jr., Monaghan E.L., Wang W.,
RA   Redman J.C., Wu H.C., Utterback T., Town C.D.;
RL   Submitted (MAY-2005) to the EMBL/GenBank/DDBJ databases.
RN   [5]
RP   GENE FAMILY, AND NOMENCLATURE.
RX   PubMed=12226484; DOI=10.1104/pp.004770;
RA   Mueller-Roeber B., Pical C.;
RT   "Inositol phospholipid metabolism in Arabidopsis. Characterized and
RT   putative isoforms of inositol phospholipid kinase and phosphoinositide-
RT   specific phospholipase C.";
RL   Plant Physiol. 130:22-46(2002).
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol 4-
CC         phosphate) + ATP = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-
CC         inositol-4,5-bisphosphate) + ADP + H(+); Xref=Rhea:RHEA:14425,
CC         ChEBI:CHEBI:15378, ChEBI:CHEBI:30616, ChEBI:CHEBI:58178,
CC         ChEBI:CHEBI:58456, ChEBI:CHEBI:456216; EC=2.7.1.68;
CC   -!- SEQUENCE CAUTION:
CC       Sequence=AAF81306.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
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DR   EMBL; Y12776; CAA73312.1; -; Genomic_DNA.
DR   EMBL; AC061957; AAF81306.1; ALT_SEQ; Genomic_DNA.
DR   EMBL; CP002684; AEE27290.1; -; Genomic_DNA.
DR   EMBL; DQ056443; AAY78600.1; -; mRNA.
DR   PIR; C86145; C86145.
DR   RefSeq; NP_171653.2; NM_100028.3.
DR   AlphaFoldDB; Q9LMN1; -.
DR   SMR; Q9LMN1; -.
DR   STRING; 3702.Q9LMN1; -.
DR   PaxDb; 3702-AT1G01460-1; -.
DR   ProteomicsDB; 234755; -.
DR   EnsemblPlants; AT1G01460.1; AT1G01460.1; AT1G01460.
DR   GeneID; 839469; -.
DR   Gramene; AT1G01460.1; AT1G01460.1; AT1G01460.
DR   KEGG; ath:AT1G01460; -.
DR   Araport; AT1G01460; -.
DR   TAIR; AT1G01460; PIPK11.
DR   eggNOG; KOG0229; Eukaryota.
DR   HOGENOM; CLU_004312_6_3_1; -.
DR   InParanoid; Q9LMN1; -.
DR   OMA; MFTREIT; -.
DR   OrthoDB; 340426at2759; -.
DR   PhylomeDB; Q9LMN1; -.
DR   BioCyc; ARA:AT1G01460-MONOMER; -.
DR   BRENDA; 2.7.1.68; 399.
DR   PRO; PR:Q9LMN1; -.
DR   Proteomes; UP000006548; Chromosome 1.
DR   ExpressionAtlas; Q9LMN1; baseline and differential.
DR   GO; GO:0016308; F:1-phosphatidylinositol-4-phosphate 5-kinase activity; IEA:UniProtKB-EC.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0046488; P:phosphatidylinositol metabolic process; IEA:InterPro.
DR   GO; GO:0016310; P:phosphorylation; IEA:UniProtKB-KW.
DR   Gene3D; 3.30.810.10; 2-Layer Sandwich; 1.
DR   Gene3D; 3.30.800.10; Phosphatidylinositol Phosphate Kinase II Beta; 1.
DR   InterPro; IPR027483; PInositol-4-P-4/5-kinase_C_sf.
DR   InterPro; IPR002498; PInositol-4-P-4/5-kinase_core.
DR   InterPro; IPR027484; PInositol-4-P-5-kinase_N.
DR   InterPro; IPR023610; PInositol-4/5-P-5/4-kinase.
DR   PANTHER; PTHR23086:SF111; PHOSPHATIDYLINOSITOL 4-PHOSPHATE 5-KINASE 10; 1.
DR   PANTHER; PTHR23086; PHOSPHATIDYLINOSITOL-4-PHOSPHATE 5-KINASE; 1.
DR   Pfam; PF01504; PIP5K; 1.
DR   SMART; SM00330; PIPKc; 1.
DR   SUPFAM; SSF56104; SAICAR synthase-like; 1.
DR   PROSITE; PS51455; PIPK; 1.
DR   Genevisible; Q9LMN1; AT.
PE   2: Evidence at transcript level;
KW   ATP-binding; Kinase; Nucleotide-binding; Reference proteome; Transferase.
FT   CHAIN           1..427
FT                   /note="Phosphatidylinositol 4-phosphate 5-kinase 10"
FT                   /id="PRO_0000185482"
FT   DOMAIN          1..419
FT                   /note="PIPK"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00781"
FT   REGION          247..287
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          334..355
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          379..400
FT                   /note="Activation loop"
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   427 AA;  48549 MW;  87EDC9019FAFC28F CRC64;
     MFTREITAKD VKATEKNRIR YSSKHIKHLP PGTITEFEWK DYCPLGFRLI QELEDINHDE
     YMKSICNDET LRKLSTSKVG NMFLLSKDDR FLIKILRKSE IKVILEMLPG YFRHIHKYRS
     TLLSKNYGAH SVKPIGGVKT YFVVMSNILQ SDVFMNKVYD LKGSSQGRTN KKIKVRDKTI
     LKDIDLDFCF YVDSLARHRL IKQTKLDCEL LEDEGIMDYS LMLGLQVKGS CHGSIDELIP
     VYDSFTSRGS VDSNSSKFMK TASNSPDRSS STMYSCTPSR NSVDSENSVN IQSVASISPS
     PAQTNASDSP YESLVSKTNL TNIFQNSSST NFGMKIPGRA RRVGRGESGS VVGKQSREGG
     EEWYDVILYL GIIDIFQDYG VRKRLEHCYK SIQHSSKTIS AVHPKMYSSR FQDFVSQIFL
     PDEDPSH
//