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Q9LMN1

- PI5KA_ARATH

UniProt

Q9LMN1 - PI5KA_ARATH

Protein

Phosphatidylinositol 4-phosphate 5-kinase 10

Gene

PIP5K10

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed - Annotation score: 2 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 86 (01 Oct 2014)
      Sequence version 2 (25 Oct 2005)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    ATP + 1-phosphatidyl-1D-myo-inositol 4-phosphate = ADP + 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate.

    GO - Molecular functioni

    1. 1-phosphatidylinositol-4-phosphate 5-kinase activity Source: UniProtKB-EC
    2. ATP binding Source: UniProtKB-KW

    Keywords - Molecular functioni

    Kinase, Transferase

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Enzyme and pathway databases

    BioCyciARA:AT1G01460-MONOMER.
    BRENDAi2.7.1.68. 399.
    ReactomeiREACT_187642. Synthesis of PIPs at the plasma membrane.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Phosphatidylinositol 4-phosphate 5-kinase 10 (EC:2.7.1.68)
    Short name:
    AtPIP5K10
    Alternative name(s):
    1-phosphatidylinositol 4-phosphate kinase 10
    Diphosphoinositide kinase 10
    PtdIns(4)P-5-kinase 10
    Gene namesi
    Name:PIP5K10
    Ordered Locus Names:At1g01460
    ORF Names:F22L4.2
    OrganismiArabidopsis thaliana (Mouse-ear cress)
    Taxonomic identifieri3702 [NCBI]
    Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
    ProteomesiUP000006548: Chromosome 1

    Organism-specific databases

    TAIRiAT1G01460.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 427427Phosphatidylinositol 4-phosphate 5-kinase 10PRO_0000185482Add
    BLAST

    Expressioni

    Gene expression databases

    GenevestigatoriQ9LMN1.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9LMN1.
    SMRiQ9LMN1. Positions 10-226.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini1 – 419419PIPKPROSITE-ProRule annotationAdd
    BLAST

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni379 – 40022Activation loopBy similarityAdd
    BLAST

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi244 – 32986Ser-richAdd
    BLAST

    Sequence similaritiesi

    Contains 1 PIPK domain.PROSITE-ProRule annotation

    Phylogenomic databases

    eggNOGiCOG5253.
    HOGENOMiHOG000193875.
    InParanoidiQ9LMN1.
    KOiK00889.
    OMAiCELLEDE.
    PhylomeDBiQ9LMN1.

    Family and domain databases

    Gene3Di3.30.800.10. 1 hit.
    3.30.810.10. 2 hits.
    InterProiIPR023610. PInositol-4-P-5-kinase.
    IPR027483. PInositol-4-P-5-kinase_C.
    IPR002498. PInositol-4-P-5-kinase_core.
    IPR027484. PInositol-4-P-5-kinase_N.
    IPR016034. PInositol-4P-5-kinase_core_sub.
    [Graphical view]
    PANTHERiPTHR23086. PTHR23086. 1 hit.
    PfamiPF01504. PIP5K. 1 hit.
    [Graphical view]
    SMARTiSM00330. PIPKc. 1 hit.
    [Graphical view]
    PROSITEiPS51455. PIPK. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q9LMN1-1 [UniParc]FASTAAdd to Basket

    « Hide

    MFTREITAKD VKATEKNRIR YSSKHIKHLP PGTITEFEWK DYCPLGFRLI    50
    QELEDINHDE YMKSICNDET LRKLSTSKVG NMFLLSKDDR FLIKILRKSE 100
    IKVILEMLPG YFRHIHKYRS TLLSKNYGAH SVKPIGGVKT YFVVMSNILQ 150
    SDVFMNKVYD LKGSSQGRTN KKIKVRDKTI LKDIDLDFCF YVDSLARHRL 200
    IKQTKLDCEL LEDEGIMDYS LMLGLQVKGS CHGSIDELIP VYDSFTSRGS 250
    VDSNSSKFMK TASNSPDRSS STMYSCTPSR NSVDSENSVN IQSVASISPS 300
    PAQTNASDSP YESLVSKTNL TNIFQNSSST NFGMKIPGRA RRVGRGESGS 350
    VVGKQSREGG EEWYDVILYL GIIDIFQDYG VRKRLEHCYK SIQHSSKTIS 400
    AVHPKMYSSR FQDFVSQIFL PDEDPSH 427
    Length:427
    Mass (Da):48,549
    Last modified:October 25, 2005 - v2
    Checksum:i87EDC9019FAFC28F
    GO

    Sequence cautioni

    The sequence AAF81306.1 differs from that shown. Reason: Erroneous gene model prediction.

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    Y12776 Genomic DNA. Translation: CAA73312.1.
    AC061957 Genomic DNA. Translation: AAF81306.1. Sequence problems.
    CP002684 Genomic DNA. Translation: AEE27290.1.
    DQ056443 mRNA. Translation: AAY78600.1.
    PIRiC86145.
    RefSeqiNP_171653.2. NM_100028.2.
    UniGeneiAt.49838.

    Genome annotation databases

    EnsemblPlantsiAT1G01460.1; AT1G01460.1; AT1G01460.
    GeneIDi839469.
    KEGGiath:AT1G01460.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    Y12776 Genomic DNA. Translation: CAA73312.1 .
    AC061957 Genomic DNA. Translation: AAF81306.1 . Sequence problems.
    CP002684 Genomic DNA. Translation: AEE27290.1 .
    DQ056443 mRNA. Translation: AAY78600.1 .
    PIRi C86145.
    RefSeqi NP_171653.2. NM_100028.2.
    UniGenei At.49838.

    3D structure databases

    ProteinModelPortali Q9LMN1.
    SMRi Q9LMN1. Positions 10-226.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblPlantsi AT1G01460.1 ; AT1G01460.1 ; AT1G01460 .
    GeneIDi 839469.
    KEGGi ath:AT1G01460.

    Organism-specific databases

    TAIRi AT1G01460.

    Phylogenomic databases

    eggNOGi COG5253.
    HOGENOMi HOG000193875.
    InParanoidi Q9LMN1.
    KOi K00889.
    OMAi CELLEDE.
    PhylomeDBi Q9LMN1.

    Enzyme and pathway databases

    BioCyci ARA:AT1G01460-MONOMER.
    BRENDAi 2.7.1.68. 399.
    Reactomei REACT_187642. Synthesis of PIPs at the plasma membrane.

    Gene expression databases

    Genevestigatori Q9LMN1.

    Family and domain databases

    Gene3Di 3.30.800.10. 1 hit.
    3.30.810.10. 2 hits.
    InterProi IPR023610. PInositol-4-P-5-kinase.
    IPR027483. PInositol-4-P-5-kinase_C.
    IPR002498. PInositol-4-P-5-kinase_core.
    IPR027484. PInositol-4-P-5-kinase_N.
    IPR016034. PInositol-4P-5-kinase_core_sub.
    [Graphical view ]
    PANTHERi PTHR23086. PTHR23086. 1 hit.
    Pfami PF01504. PIP5K. 1 hit.
    [Graphical view ]
    SMARTi SM00330. PIPKc. 1 hit.
    [Graphical view ]
    PROSITEi PS51455. PIPK. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Sequence analysis of a 40-kb Arabidopsis thaliana genomic region located at the top of chromosome 1."
      Terryn N., Gielen J., De Keyser A., Van Den Daele H., Ardiles W., Neyt P., De Clercq R., Coppieters J., Dehais P., Villarroel R., Rouze P., van Montagu M.
      Gene 215:11-17(1998) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    2. "Sequence and analysis of chromosome 1 of the plant Arabidopsis thaliana."
      Theologis A., Ecker J.R., Palm C.J., Federspiel N.A., Kaul S., White O., Alonso J., Altafi H., Araujo R., Bowman C.L., Brooks S.Y., Buehler E., Chan A., Chao Q., Chen H., Cheuk R.F., Chin C.W., Chung M.K.
      , Conn L., Conway A.B., Conway A.R., Creasy T.H., Dewar K., Dunn P., Etgu P., Feldblyum T.V., Feng J.-D., Fong B., Fujii C.Y., Gill J.E., Goldsmith A.D., Haas B., Hansen N.F., Hughes B., Huizar L., Hunter J.L., Jenkins J., Johnson-Hopson C., Khan S., Khaykin E., Kim C.J., Koo H.L., Kremenetskaia I., Kurtz D.B., Kwan A., Lam B., Langin-Hooper S., Lee A., Lee J.M., Lenz C.A., Li J.H., Li Y.-P., Lin X., Liu S.X., Liu Z.A., Luros J.S., Maiti R., Marziali A., Militscher J., Miranda M., Nguyen M., Nierman W.C., Osborne B.I., Pai G., Peterson J., Pham P.K., Rizzo M., Rooney T., Rowley D., Sakano H., Salzberg S.L., Schwartz J.R., Shinn P., Southwick A.M., Sun H., Tallon L.J., Tambunga G., Toriumi M.J., Town C.D., Utterback T., Van Aken S., Vaysberg M., Vysotskaia V.S., Walker M., Wu D., Yu G., Fraser C.M., Venter J.C., Davis R.W.
      Nature 408:816-820(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: cv. Columbia.
    3. The Arabidopsis Information Resource (TAIR)
      Submitted (APR-2011) to the EMBL/GenBank/DDBJ databases
      Cited for: GENOME REANNOTATION.
      Strain: cv. Columbia.
    4. Underwood B.A., Xiao Y.-L., Moskal W.A. Jr., Monaghan E.L., Wang W., Redman J.C., Wu H.C., Utterback T., Town C.D.
      Submitted (MAY-2005) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: cv. Columbia.
    5. "Inositol phospholipid metabolism in Arabidopsis. Characterized and putative isoforms of inositol phospholipid kinase and phosphoinositide-specific phospholipase C."
      Mueller-Roeber B., Pical C.
      Plant Physiol. 130:22-46(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: GENE FAMILY, NOMENCLATURE.

    Entry informationi

    Entry nameiPI5KA_ARATH
    AccessioniPrimary (citable) accession number: Q9LMN1
    Secondary accession number(s): O23705
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 25, 2005
    Last sequence update: October 25, 2005
    Last modified: October 1, 2014
    This is version 86 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programPlant Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Arabidopsis thaliana
      Arabidopsis thaliana: entries and gene names
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3