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Protein

Phosphatidylinositol 4-phosphate 5-kinase 10

Gene

PIP5K10

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

Catalytic activityi

ATP + 1-phosphatidyl-1D-myo-inositol 4-phosphate = ADP + 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate.

GO - Molecular functioni

  1. 1-phosphatidylinositol-4-phosphate 5-kinase activity Source: UniProtKB-EC
  2. ATP binding Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Kinase, Transferase

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciARA:AT1G01460-MONOMER.
BRENDAi2.7.1.68. 399.
ReactomeiREACT_345128. Synthesis of PIPs at the plasma membrane.

Names & Taxonomyi

Protein namesi
Recommended name:
Phosphatidylinositol 4-phosphate 5-kinase 10 (EC:2.7.1.68)
Short name:
AtPIP5K10
Alternative name(s):
1-phosphatidylinositol 4-phosphate kinase 10
Diphosphoinositide kinase 10
PtdIns(4)P-5-kinase 10
Gene namesi
Name:PIP5K10
Ordered Locus Names:At1g01460
ORF Names:F22L4.2
OrganismiArabidopsis thaliana (Mouse-ear cress)
Taxonomic identifieri3702 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
ProteomesiUP000006548 Componenti: Chromosome 1

Organism-specific databases

TAIRiAT1G01460.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 427427Phosphatidylinositol 4-phosphate 5-kinase 10PRO_0000185482Add
BLAST

Expressioni

Gene expression databases

ExpressionAtlasiQ9LMN1. differential.
GenevestigatoriQ9LMN1.

Structurei

3D structure databases

ProteinModelPortaliQ9LMN1.
SMRiQ9LMN1. Positions 10-226.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini1 – 419419PIPKPROSITE-ProRule annotationAdd
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni379 – 40022Activation loopBy similarityAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi244 – 32986Ser-richAdd
BLAST

Sequence similaritiesi

Contains 1 PIPK domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiCOG5253.
HOGENOMiHOG000193875.
InParanoidiQ9LMN1.
KOiK00889.
OMAiELEDINH.
PhylomeDBiQ9LMN1.

Family and domain databases

Gene3Di3.30.800.10. 1 hit.
3.30.810.10. 2 hits.
InterProiIPR023610. PInositol-4-P-5-kinase.
IPR027483. PInositol-4-P-5-kinase_C.
IPR002498. PInositol-4-P-5-kinase_core.
IPR027484. PInositol-4-P-5-kinase_N.
IPR016034. PInositol-4P-5-kinase_core_sub.
[Graphical view]
PANTHERiPTHR23086. PTHR23086. 1 hit.
PfamiPF01504. PIP5K. 1 hit.
[Graphical view]
SMARTiSM00330. PIPKc. 1 hit.
[Graphical view]
PROSITEiPS51455. PIPK. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9LMN1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MFTREITAKD VKATEKNRIR YSSKHIKHLP PGTITEFEWK DYCPLGFRLI
60 70 80 90 100
QELEDINHDE YMKSICNDET LRKLSTSKVG NMFLLSKDDR FLIKILRKSE
110 120 130 140 150
IKVILEMLPG YFRHIHKYRS TLLSKNYGAH SVKPIGGVKT YFVVMSNILQ
160 170 180 190 200
SDVFMNKVYD LKGSSQGRTN KKIKVRDKTI LKDIDLDFCF YVDSLARHRL
210 220 230 240 250
IKQTKLDCEL LEDEGIMDYS LMLGLQVKGS CHGSIDELIP VYDSFTSRGS
260 270 280 290 300
VDSNSSKFMK TASNSPDRSS STMYSCTPSR NSVDSENSVN IQSVASISPS
310 320 330 340 350
PAQTNASDSP YESLVSKTNL TNIFQNSSST NFGMKIPGRA RRVGRGESGS
360 370 380 390 400
VVGKQSREGG EEWYDVILYL GIIDIFQDYG VRKRLEHCYK SIQHSSKTIS
410 420
AVHPKMYSSR FQDFVSQIFL PDEDPSH
Length:427
Mass (Da):48,549
Last modified:October 24, 2005 - v2
Checksum:i87EDC9019FAFC28F
GO

Sequence cautioni

The sequence AAF81306.1 differs from that shown. Reason: Erroneous gene model prediction. Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Y12776 Genomic DNA. Translation: CAA73312.1.
AC061957 Genomic DNA. Translation: AAF81306.1. Sequence problems.
CP002684 Genomic DNA. Translation: AEE27290.1.
DQ056443 mRNA. Translation: AAY78600.1.
PIRiC86145.
RefSeqiNP_171653.2. NM_100028.2.
UniGeneiAt.49838.

Genome annotation databases

EnsemblPlantsiAT1G01460.1; AT1G01460.1; AT1G01460.
GeneIDi839469.
KEGGiath:AT1G01460.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Y12776 Genomic DNA. Translation: CAA73312.1.
AC061957 Genomic DNA. Translation: AAF81306.1. Sequence problems.
CP002684 Genomic DNA. Translation: AEE27290.1.
DQ056443 mRNA. Translation: AAY78600.1.
PIRiC86145.
RefSeqiNP_171653.2. NM_100028.2.
UniGeneiAt.49838.

3D structure databases

ProteinModelPortaliQ9LMN1.
SMRiQ9LMN1. Positions 10-226.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblPlantsiAT1G01460.1; AT1G01460.1; AT1G01460.
GeneIDi839469.
KEGGiath:AT1G01460.

Organism-specific databases

TAIRiAT1G01460.

Phylogenomic databases

eggNOGiCOG5253.
HOGENOMiHOG000193875.
InParanoidiQ9LMN1.
KOiK00889.
OMAiELEDINH.
PhylomeDBiQ9LMN1.

Enzyme and pathway databases

BioCyciARA:AT1G01460-MONOMER.
BRENDAi2.7.1.68. 399.
ReactomeiREACT_345128. Synthesis of PIPs at the plasma membrane.

Gene expression databases

ExpressionAtlasiQ9LMN1. differential.
GenevestigatoriQ9LMN1.

Family and domain databases

Gene3Di3.30.800.10. 1 hit.
3.30.810.10. 2 hits.
InterProiIPR023610. PInositol-4-P-5-kinase.
IPR027483. PInositol-4-P-5-kinase_C.
IPR002498. PInositol-4-P-5-kinase_core.
IPR027484. PInositol-4-P-5-kinase_N.
IPR016034. PInositol-4P-5-kinase_core_sub.
[Graphical view]
PANTHERiPTHR23086. PTHR23086. 1 hit.
PfamiPF01504. PIP5K. 1 hit.
[Graphical view]
SMARTiSM00330. PIPKc. 1 hit.
[Graphical view]
PROSITEiPS51455. PIPK. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Sequence analysis of a 40-kb Arabidopsis thaliana genomic region located at the top of chromosome 1."
    Terryn N., Gielen J., De Keyser A., Van Den Daele H., Ardiles W., Neyt P., De Clercq R., Coppieters J., Dehais P., Villarroel R., Rouze P., van Montagu M.
    Gene 215:11-17(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  2. "Sequence and analysis of chromosome 1 of the plant Arabidopsis thaliana."
    Theologis A., Ecker J.R., Palm C.J., Federspiel N.A., Kaul S., White O., Alonso J., Altafi H., Araujo R., Bowman C.L., Brooks S.Y., Buehler E., Chan A., Chao Q., Chen H., Cheuk R.F., Chin C.W., Chung M.K.
    , Conn L., Conway A.B., Conway A.R., Creasy T.H., Dewar K., Dunn P., Etgu P., Feldblyum T.V., Feng J.-D., Fong B., Fujii C.Y., Gill J.E., Goldsmith A.D., Haas B., Hansen N.F., Hughes B., Huizar L., Hunter J.L., Jenkins J., Johnson-Hopson C., Khan S., Khaykin E., Kim C.J., Koo H.L., Kremenetskaia I., Kurtz D.B., Kwan A., Lam B., Langin-Hooper S., Lee A., Lee J.M., Lenz C.A., Li J.H., Li Y.-P., Lin X., Liu S.X., Liu Z.A., Luros J.S., Maiti R., Marziali A., Militscher J., Miranda M., Nguyen M., Nierman W.C., Osborne B.I., Pai G., Peterson J., Pham P.K., Rizzo M., Rooney T., Rowley D., Sakano H., Salzberg S.L., Schwartz J.R., Shinn P., Southwick A.M., Sun H., Tallon L.J., Tambunga G., Toriumi M.J., Town C.D., Utterback T., Van Aken S., Vaysberg M., Vysotskaia V.S., Walker M., Wu D., Yu G., Fraser C.M., Venter J.C., Davis R.W.
    Nature 408:816-820(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: cv. Columbia.
  3. The Arabidopsis Information Resource (TAIR)
    Submitted (MAR-2011) to the EMBL/GenBank/DDBJ databases
    Cited for: GENOME REANNOTATION.
    Strain: cv. Columbia.
  4. Underwood B.A., Xiao Y.-L., Moskal W.A. Jr., Monaghan E.L., Wang W., Redman J.C., Wu H.C., Utterback T., Town C.D.
    Submitted (APR-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: cv. Columbia.
  5. "Inositol phospholipid metabolism in Arabidopsis. Characterized and putative isoforms of inositol phospholipid kinase and phosphoinositide-specific phospholipase C."
    Mueller-Roeber B., Pical C.
    Plant Physiol. 130:22-46(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: GENE FAMILY, NOMENCLATURE.

Entry informationi

Entry nameiPI5KA_ARATH
AccessioniPrimary (citable) accession number: Q9LMN1
Secondary accession number(s): O23705
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 24, 2005
Last sequence update: October 24, 2005
Last modified: March 31, 2015
This is version 89 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Arabidopsis thaliana
    Arabidopsis thaliana: entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.