Q9LMN1 (PI5KA_ARATH) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Phosphatidylinositol 4-phosphate 5-kinase 10
Short name=AtPIP5K10
EC=2.7.1.68

Alternative name(s):
1-phosphatidylinositol 4-phosphate kinase 10
Diphosphoinositide kinase 10
PtdIns(4)P-5-kinase 10

Gene names

Name:	PIP5K10
Ordered Locus Names:	At1g01460
ORF Names:	F22L4.2

Organism

Arabidopsis thaliana (Mouse-ear cress) [Reference proteome]

Taxonomic identifier

3702 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Viridiplantae › Streptophyta › Streptophytina › Embryophyta › Tracheophyta › Euphyllophyta › Spermatophyta › Magnoliophyta › eudicotyledons › core eudicotyledons › rosids › malvids › Brassicales › Brassicaceae › Camelineae › Arabidopsis

Protein attributes

Sequence length	427 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Catalytic activity	ATP + 1-phosphatidyl-1D-myo-inositol 4-phosphate = ADP + 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate.
Sequence similarities	Contains 1 PIPK domain.
Sequence caution	The sequence AAF81306.1 differs from that shown. Reason: Erroneous gene model prediction.

Ontologies

Keywords
Ligand	ATP-binding Nucleotide-binding
Molecular function	Kinase Transferase
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	phosphatidylinositol phosphorylation Inferred from electronic annotation. Source: GOC
Molecular_function	1-phosphatidylinositol-4-phosphate 5-kinase activity Inferred from electronic annotation. Source: EC ATP binding Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 427	427	Phosphatidylinositol 4-phosphate 5-kinase 10		PRO_0000185482
Regions
	Domain	1 – 419	419	PIPK
	Region	379 – 400	22	Activation loop By similarity
	Compositional bias	244 – 329	86	Ser-rich

Sequences

	Sequence		Length	Mass (Da)
	Q9LMN1 [UniParc]. Last modified October 25, 2005. Version 2. Checksum: 87EDC9019FAFC28F	FASTA	427	48,549
	10 20 30 40 50 60 MFTREITAKD VKATEKNRIR YSSKHIKHLP PGTITEFEWK DYCPLGFRLI QELEDINHDE 70 80 90 100 110 120 YMKSICNDET LRKLSTSKVG NMFLLSKDDR FLIKILRKSE IKVILEMLPG YFRHIHKYRS 130 140 150 160 170 180 TLLSKNYGAH SVKPIGGVKT YFVVMSNILQ SDVFMNKVYD LKGSSQGRTN KKIKVRDKTI 190 200 210 220 230 240 LKDIDLDFCF YVDSLARHRL IKQTKLDCEL LEDEGIMDYS LMLGLQVKGS CHGSIDELIP 250 260 270 280 290 300 VYDSFTSRGS VDSNSSKFMK TASNSPDRSS STMYSCTPSR NSVDSENSVN IQSVASISPS 310 320 330 340 350 360 PAQTNASDSP YESLVSKTNL TNIFQNSSST NFGMKIPGRA RRVGRGESGS VVGKQSREGG 370 380 390 400 410 420 EEWYDVILYL GIIDIFQDYG VRKRLEHCYK SIQHSSKTIS AVHPKMYSSR FQDFVSQIFL PDEDPSH

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Sequence analysis of a 40-kb Arabidopsis thaliana genomic region located at the top of chromosome 1." Terryn N., Gielen J., De Keyser A., Van Den Daele H., Ardiles W., Neyt P., De Clercq R., Coppieters J., Dehais P., Villarroel R., Rouze P., van Montagu M. Gene 215:11-17(1998) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[2]	"Sequence and analysis of chromosome 1 of the plant Arabidopsis thaliana." Theologis A., Ecker J.R., Palm C.J., Federspiel N.A., Kaul S., White O., Alonso J., Altafi H., Araujo R., Bowman C.L., Brooks S.Y., Buehler E., Chan A., Chao Q., Chen H., Cheuk R.F., Chin C.W., Chung M.K. , Conn L., Conway A.B., Conway A.R., Creasy T.H., Dewar K., Dunn P., Etgu P., Feldblyum T.V., Feng J.-D., Fong B., Fujii C.Y., Gill J.E., Goldsmith A.D., Haas B., Hansen N.F., Hughes B., Huizar L., Hunter J.L., Jenkins J., Johnson-Hopson C., Khan S., Khaykin E., Kim C.J., Koo H.L., Kremenetskaia I., Kurtz D.B., Kwan A., Lam B., Langin-Hooper S., Lee A., Lee J.M., Lenz C.A., Li J.H., Li Y.-P., Lin X., Liu S.X., Liu Z.A., Luros J.S., Maiti R., Marziali A., Militscher J., Miranda M., Nguyen M., Nierman W.C., Osborne B.I., Pai G., Peterson J., Pham P.K., Rizzo M., Rooney T., Rowley D., Sakano H., Salzberg S.L., Schwartz J.R., Shinn P., Southwick A.M., Sun H., Tallon L.J., Tambunga G., Toriumi M.J., Town C.D., Utterback T., Van Aken S., Vaysberg M., Vysotskaia V.S., Walker M., Wu D., Yu G., Fraser C.M., Venter J.C., Davis R.W. Nature 408:816-820(2000) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: cv. Columbia.
[3]	The Arabidopsis Information Resource (TAIR) Submitted (APR-2011) to the EMBL/GenBank/DDBJ databases Cited for: GENOME REANNOTATION. Strain: cv. Columbia.
[4]	Underwood B.A., Xiao Y.-L., Moskal W.A. Jr., Monaghan E.L., Wang W., Redman J.C., Wu H.C., Utterback T., Town C.D. Submitted (MAY-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Strain: cv. Columbia.
[5]	"Inositol phospholipid metabolism in Arabidopsis. Characterized and putative isoforms of inositol phospholipid kinase and phosphoinositide-specific phospholipase C." Mueller-Roeber B., Pical C. Plant Physiol. 130:22-46(2002) [PubMed] [Europe PMC] [Abstract] Cited for: GENE FAMILY, NOMENCLATURE.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	Y12776 Genomic DNA. Translation: CAA73312.1. AC061957 Genomic DNA. Translation: AAF81306.1. Sequence problems. CP002684 Genomic DNA. Translation: AEE27290.1. DQ056443 mRNA. Translation: AAY78600.1.
IPI	IPI00533996.
PIR	C86145.
RefSeq	NP_171653.2. NM_100028.2.
UniGene	At.49838.
3D structure databases
ProteinModelPortal	Q9LMN1.
SMR	Q9LMN1. Positions 10-226.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblPlants	AT1G01460.1; AT1G01460.1; AT1G01460.
GeneID	839469.
KEGG	ath:AT1G01460.
Organism-specific databases
TAIR	At1g01460.
Phylogenomic databases
eggNOG	COG5253.
HOGENOM	HOG000193875.
InParanoid	Q9LMN1.
KO	K00889.
OMA	CELLEDE.
PhylomeDB	Q9LMN1.
ProtClustDB	CLSN2685476.
Enzyme and pathway databases
BRENDA	2.7.1.68. 399.
Gene expression databases
ArrayExpress	Q9LMN1.
Genevestigator	Q9LMN1.
GermOnline	AT1G01460. Arabidopsis thaliana.
Family and domain databases
InterPro	IPR023610. PInositol-4-P-5-kinase. IPR002498. PInositol-4-P-5-kinase_core. IPR016034. PInositol-4P-5-kinase_core_sub. [Graphical view]
PANTHER	PTHR23086. PTHR23086. 1 hit.
Pfam	PF01504. PIP5K. 1 hit. [Graphical view]
SMART	SM00330. PIPKc. 1 hit. [Graphical view]
PROSITE	PS51455. PIPK. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

PI5KA_ARATH

Accession

Primary (citable) accession number: Q9LMN1
Secondary accession number(s): O23705

Entry history

Integrated into UniProtKB/Swiss-Prot:	October 25, 2005
Last sequence update:	October 25, 2005
Last modified:	May 1, 2013
This is version 75 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Plant Protein Annotation Program