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Protein

Phosphatidylinositol 4-phosphate 5-kinase 10

Gene

PIP5K10

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Catalytic activityi

ATP + 1-phosphatidyl-1D-myo-inositol 4-phosphate = ADP + 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate.

GO - Molecular functioni

Keywordsi

Molecular functionKinase, Transferase
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciARA:AT1G01460-MONOMER
BRENDAi2.7.1.68 399
ReactomeiR-ATH-1660499 Synthesis of PIPs at the plasma membrane
R-ATH-6811558 PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling
R-ATH-8856828 Clathrin-mediated endocytosis

Names & Taxonomyi

Protein namesi
Recommended name:
Phosphatidylinositol 4-phosphate 5-kinase 10 (EC:2.7.1.68)
Short name:
AtPIP5K10
Alternative name(s):
1-phosphatidylinositol 4-phosphate kinase 10
Diphosphoinositide kinase 10
PtdIns(4)P-5-kinase 10
Gene namesi
Name:PIP5K10
Ordered Locus Names:At1g01460
ORF Names:F22L4.2
OrganismiArabidopsis thaliana (Mouse-ear cress)
Taxonomic identifieri3702 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
Proteomesi
  • UP000006548 Componenti: Chromosome 1

Organism-specific databases

AraportiAT1G01460
TAIRilocus:2025336 AT1G01460

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001854821 – 427Phosphatidylinositol 4-phosphate 5-kinase 10Add BLAST427

Proteomic databases

PaxDbiQ9LMN1

Expressioni

Gene expression databases

ExpressionAtlasiQ9LMN1 baseline and differential
GenevisibleiQ9LMN1 AT

Interactioni

Protein-protein interaction databases

STRINGi3702.AT1G01460.1

Structurei

3D structure databases

ProteinModelPortaliQ9LMN1
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini1 – 419PIPKPROSITE-ProRule annotationAdd BLAST419

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni379 – 400Activation loopBy similarityAdd BLAST22

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi244 – 329Ser-richAdd BLAST86

Phylogenomic databases

eggNOGiKOG0229 Eukaryota
COG5253 LUCA
HOGENOMiHOG000193875
InParanoidiQ9LMN1
KOiK00889
OMAiECENDGL
OrthoDBiEOG09360D7O
PhylomeDBiQ9LMN1

Family and domain databases

Gene3Di3.30.800.10, 1 hit
3.30.810.10, 2 hits
InterProiView protein in InterPro
IPR023610 PInositol-4-P-5-kinase
IPR027483 PInositol-4-P-5-kinase_C
IPR002498 PInositol-4-P-5-kinase_core
IPR027484 PInositol-4-P-5-kinase_N
PANTHERiPTHR23086 PTHR23086, 1 hit
PfamiView protein in Pfam
PF01504 PIP5K, 1 hit
SMARTiView protein in SMART
SM00330 PIPKc, 1 hit
PROSITEiView protein in PROSITE
PS51455 PIPK, 1 hit

Sequencei

Sequence statusi: Complete.

Q9LMN1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MFTREITAKD VKATEKNRIR YSSKHIKHLP PGTITEFEWK DYCPLGFRLI
60 70 80 90 100
QELEDINHDE YMKSICNDET LRKLSTSKVG NMFLLSKDDR FLIKILRKSE
110 120 130 140 150
IKVILEMLPG YFRHIHKYRS TLLSKNYGAH SVKPIGGVKT YFVVMSNILQ
160 170 180 190 200
SDVFMNKVYD LKGSSQGRTN KKIKVRDKTI LKDIDLDFCF YVDSLARHRL
210 220 230 240 250
IKQTKLDCEL LEDEGIMDYS LMLGLQVKGS CHGSIDELIP VYDSFTSRGS
260 270 280 290 300
VDSNSSKFMK TASNSPDRSS STMYSCTPSR NSVDSENSVN IQSVASISPS
310 320 330 340 350
PAQTNASDSP YESLVSKTNL TNIFQNSSST NFGMKIPGRA RRVGRGESGS
360 370 380 390 400
VVGKQSREGG EEWYDVILYL GIIDIFQDYG VRKRLEHCYK SIQHSSKTIS
410 420
AVHPKMYSSR FQDFVSQIFL PDEDPSH
Length:427
Mass (Da):48,549
Last modified:October 25, 2005 - v2
Checksum:i87EDC9019FAFC28F
GO

Sequence cautioni

The sequence AAF81306 differs from that shown. Reason: Erroneous gene model prediction.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Y12776 Genomic DNA Translation: CAA73312.1
AC061957 Genomic DNA Translation: AAF81306.1 Sequence problems.
CP002684 Genomic DNA Translation: AEE27290.1
DQ056443 mRNA Translation: AAY78600.1
PIRiC86145
RefSeqiNP_171653.2, NM_100028.3
UniGeneiAt.49838

Genome annotation databases

EnsemblPlantsiAT1G01460.1; AT1G01460.1; AT1G01460
GeneIDi839469
GrameneiAT1G01460.1; AT1G01460.1; AT1G01460
KEGGiath:AT1G01460

Similar proteinsi

Entry informationi

Entry nameiPI5KA_ARATH
AccessioniPrimary (citable) accession number: Q9LMN1
Secondary accession number(s): O23705
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 25, 2005
Last sequence update: October 25, 2005
Last modified: April 25, 2018
This is version 109 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health