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Q9LMM5

- MPK11_ARATH

UniProt

Q9LMM5 - MPK11_ARATH

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Protein

Mitogen-activated protein kinase 11

Gene

MPK11

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli

Functioni

Catalytic activityi

ATP + a protein = ADP + a phosphoprotein.

Enzyme regulationi

Activated by threonine and tyrosine phosphorylation.By similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei69 – 691ATPPROSITE-ProRule annotation
Active sitei166 – 1661Proton acceptorPROSITE-ProRule annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi46 – 549ATPPROSITE-ProRule annotation

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. MAP kinase activity Source: TAIR

GO - Biological processi

  1. response to abscisic acid Source: TAIR
Complete GO annotation...

Keywords - Molecular functioni

Kinase, Serine/threonine-protein kinase, Transferase

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciARA:AT1G01560-MONOMER.
ARA:GQT-2439-MONOMER.
ReactomeiREACT_190855. CREB phosphorylation through the activation of Ras.
REACT_190946. KSRP destabilizes mRNA.
REACT_202229. ERK1 activation.
REACT_208246. ERKs are inactivated.
REACT_209747. ERK2 activation.
REACT_216613. Signalling to ERK5.

Names & Taxonomyi

Protein namesi
Recommended name:
Mitogen-activated protein kinase 11 (EC:2.7.11.24)
Short name:
AtMPK11
Short name:
MAP kinase 11
Gene namesi
Name:MPK11
Ordered Locus Names:At1g01560
ORF Names:F22L4.10
OrganismiArabidopsis thaliana (Mouse-ear cress)
Taxonomic identifieri3702 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
ProteomesiUP000006548: Chromosome 1

Organism-specific databases

TAIRiAT1G01560.

Subcellular locationi

GO - Cellular componenti

  1. cytosol Source: TAIR
Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 369369Mitogen-activated protein kinase 11PRO_0000245811Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei198 – 1981PhosphothreonineBy similarity
Modified residuei200 – 2001PhosphotyrosineBy similarity
Modified residuei203 – 2031PhosphothreonineBy similarity

Post-translational modificationi

Dually phosphorylated on Thr-198 and Tyr-200, which activates the enzyme.By similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiQ9LMM5.
PRIDEiQ9LMM5.

Expressioni

Gene expression databases

GenevestigatoriQ9LMM5.

Interactioni

Subunit structurei

Interacts with MKK1, MKK2 and MKK6.2 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
MKK1Q94A062EBI-2358699,EBI-994464
MKK2Q9S7U92EBI-2358699,EBI-994350

Protein-protein interaction databases

BioGridi24758. 1 interaction.
IntActiQ9LMM5. 3 interactions.
STRINGi3702.AT1G01560.2-P.

Structurei

3D structure databases

ProteinModelPortaliQ9LMM5.
SMRiQ9LMM5. Positions 33-368.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini40 – 326287Protein kinasePROSITE-ProRule annotationAdd
BLAST

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi198 – 2003TXY

Domaini

The TXY motif contains the threonine and tyrosine residues whose phosphorylation activates the MAP kinases.

Sequence similaritiesi

Contains 1 protein kinase domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiCOG0515.
HOGENOMiHOG000233024.
InParanoidiQ9LMM5.
KOiK04371.
OMAiPGRDYVQ.
PhylomeDBiQ9LMM5.

Family and domain databases

InterProiIPR011009. Kinase-like_dom.
IPR003527. MAP_kinase_CS.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR002290. Ser/Thr_dual-sp_kinase.
IPR008271. Ser/Thr_kinase_AS.
[Graphical view]
PfamiPF00069. Pkinase. 1 hit.
[Graphical view]
SMARTiSM00220. S_TKc. 1 hit.
[Graphical view]
SUPFAMiSSF56112. SSF56112. 1 hit.
PROSITEiPS01351. MAPK. 1 hit.
PS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: Q9LMM5-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MSIEKPFFGD DSNRGVSING GRYVQYNVYG NLFEVSKKYV PPLRPIGRGA
60 70 80 90 100
SGIVCAAWNS ETGEEVAIKK IGNAFGNIID AKRTLREIKL LKHMDHDNVI
110 120 130 140 150
AIIDIIRPPQ PDNFNDVHIV YELMDTDLHH IIRSNQPLTD DHSRFFLYQL
160 170 180 190 200
LRGLKYVHSA NVLHRDLKPS NLLLNANCDL KIGDFGLART KSETDFMTEY
210 220 230 240 250
VVTRWYRAPE LLLNCSEYTA AIDIWSVGCI LGEIMTREPL FPGRDYVQQL
260 270 280 290 300
RLITELIGSP DDSSLGFLRS DNARRYVRQL PQYPRQNFAA RFPNMSVNAV
310 320 330 340 350
DLLQKMLVFD PNRRITVDEA LCHPYLAPLH EYNEEPVCVR PFHFDFEQPS
360
LTEENIKELI YRESVKFNP
Length:369
Mass (Da):42,475
Last modified:October 1, 2000 - v1
Checksum:i446673DB42C3DAA6
GO
Isoform 2 (identifier: Q9LMM5-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     256-275: LIGSPDDSSLGFLRSDNARR → VNFSLFHLTILFRFNLKKEH
     276-369: Missing.

Note: May be due to introns retention. No experimental confirmation available.

Show »
Length:275
Mass (Da):31,596
Checksum:iB8C8A7A9DCF110C8
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti13 – 131N → D in BX815051. (PubMed:14993207)Curated

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei256 – 27520LIGSP…DNARR → VNFSLFHLTILFRFNLKKEH in isoform 2. 1 PublicationVSP_035539Add
BLAST
Alternative sequencei276 – 36994Missing in isoform 2. 1 PublicationVSP_035540Add
BLAST

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AC061957 Genomic DNA. Translation: AAF81314.1.
CP002684 Genomic DNA. Translation: AEE27305.1.
CP002684 Genomic DNA. Translation: AEE27306.1.
BX815051 mRNA. No translation available.
PIRiC86146.
RefSeqiNP_001117210.1. NM_001123738.1. [Q9LMM5-1]
NP_563631.2. NM_100038.4. [Q9LMM5-2]
UniGeneiAt.49840.

Genome annotation databases

EnsemblPlantsiAT1G01560.2; AT1G01560.2; AT1G01560. [Q9LMM5-1]
GeneIDi839523.
KEGGiath:AT1G01560.

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AC061957 Genomic DNA. Translation: AAF81314.1 .
CP002684 Genomic DNA. Translation: AEE27305.1 .
CP002684 Genomic DNA. Translation: AEE27306.1 .
BX815051 mRNA. No translation available.
PIRi C86146.
RefSeqi NP_001117210.1. NM_001123738.1. [Q9LMM5-1 ]
NP_563631.2. NM_100038.4. [Q9LMM5-2 ]
UniGenei At.49840.

3D structure databases

ProteinModelPortali Q9LMM5.
SMRi Q9LMM5. Positions 33-368.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 24758. 1 interaction.
IntActi Q9LMM5. 3 interactions.
STRINGi 3702.AT1G01560.2-P.

Proteomic databases

PaxDbi Q9LMM5.
PRIDEi Q9LMM5.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblPlantsi AT1G01560.2 ; AT1G01560.2 ; AT1G01560 . [Q9LMM5-1 ]
GeneIDi 839523.
KEGGi ath:AT1G01560.

Organism-specific databases

GeneFarmi 845. 89.
TAIRi AT1G01560.

Phylogenomic databases

eggNOGi COG0515.
HOGENOMi HOG000233024.
InParanoidi Q9LMM5.
KOi K04371.
OMAi PGRDYVQ.
PhylomeDBi Q9LMM5.

Enzyme and pathway databases

BioCyci ARA:AT1G01560-MONOMER.
ARA:GQT-2439-MONOMER.
Reactomei REACT_190855. CREB phosphorylation through the activation of Ras.
REACT_190946. KSRP destabilizes mRNA.
REACT_202229. ERK1 activation.
REACT_208246. ERKs are inactivated.
REACT_209747. ERK2 activation.
REACT_216613. Signalling to ERK5.

Gene expression databases

Genevestigatori Q9LMM5.

Family and domain databases

InterProi IPR011009. Kinase-like_dom.
IPR003527. MAP_kinase_CS.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR002290. Ser/Thr_dual-sp_kinase.
IPR008271. Ser/Thr_kinase_AS.
[Graphical view ]
Pfami PF00069. Pkinase. 1 hit.
[Graphical view ]
SMARTi SM00220. S_TKc. 1 hit.
[Graphical view ]
SUPFAMi SSF56112. SSF56112. 1 hit.
PROSITEi PS01351. MAPK. 1 hit.
PS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Sequence and analysis of chromosome 1 of the plant Arabidopsis thaliana."
    Theologis A., Ecker J.R., Palm C.J., Federspiel N.A., Kaul S., White O., Alonso J., Altafi H., Araujo R., Bowman C.L., Brooks S.Y., Buehler E., Chan A., Chao Q., Chen H., Cheuk R.F., Chin C.W., Chung M.K.
    , Conn L., Conway A.B., Conway A.R., Creasy T.H., Dewar K., Dunn P., Etgu P., Feldblyum T.V., Feng J.-D., Fong B., Fujii C.Y., Gill J.E., Goldsmith A.D., Haas B., Hansen N.F., Hughes B., Huizar L., Hunter J.L., Jenkins J., Johnson-Hopson C., Khan S., Khaykin E., Kim C.J., Koo H.L., Kremenetskaia I., Kurtz D.B., Kwan A., Lam B., Langin-Hooper S., Lee A., Lee J.M., Lenz C.A., Li J.H., Li Y.-P., Lin X., Liu S.X., Liu Z.A., Luros J.S., Maiti R., Marziali A., Militscher J., Miranda M., Nguyen M., Nierman W.C., Osborne B.I., Pai G., Peterson J., Pham P.K., Rizzo M., Rooney T., Rowley D., Sakano H., Salzberg S.L., Schwartz J.R., Shinn P., Southwick A.M., Sun H., Tallon L.J., Tambunga G., Toriumi M.J., Town C.D., Utterback T., Van Aken S., Vaysberg M., Vysotskaia V.S., Walker M., Wu D., Yu G., Fraser C.M., Venter J.C., Davis R.W.
    Nature 408:816-820(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: cv. Columbia.
  2. The Arabidopsis Information Resource (TAIR)
    Submitted (APR-2011) to the EMBL/GenBank/DDBJ databases
    Cited for: GENOME REANNOTATION.
    Strain: cv. Columbia.
  3. "Whole genome sequence comparisons and 'full-length' cDNA sequences: a combined approach to evaluate and improve Arabidopsis genome annotation."
    Castelli V., Aury J.-M., Jaillon O., Wincker P., Clepet C., Menard M., Cruaud C., Quetier F., Scarpelli C., Schaechter V., Temple G., Caboche M., Weissenbach J., Salanoubat M.
    Genome Res. 14:406-413(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
    Strain: cv. Columbia.
  4. "Mitogen-activated protein kinase cascades in plants: a new nomenclature."
    MAPK group
    Trends Plant Sci. 7:301-308(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: GENE FAMILY, NOMENCLATURE.
  5. Cited for: GENE FAMILY.
  6. "Comprehensive analysis of protein-protein interactions between Arabidopsis MAPKs and MAPK kinases helps define potential MAPK signalling modules."
    Lee J.S., Huh K.W., Bhargava A., Ellis B.E.
    Plant Signal. Behav. 3:1037-1041(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH MKK1; MKK2 AND MKK6.
  7. "AtMPK4 is required for male-specific meiotic cytokinesis in Arabidopsis."
    Zeng Q., Chen J.G., Ellis B.E.
    Plant J. 67:895-906(2011) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH MKK6.

Entry informationi

Entry nameiMPK11_ARATH
AccessioniPrimary (citable) accession number: Q9LMM5
Secondary accession number(s): B3H762
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 11, 2006
Last sequence update: October 1, 2000
Last modified: October 29, 2014
This is version 106 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Arabidopsis thaliana
    Arabidopsis thaliana: entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3