Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Mitogen-activated protein kinase 11

Gene

MPK11

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Catalytic activityi

ATP + a protein = ADP + a phosphoprotein.

Enzyme regulationi

Activated by threonine and tyrosine phosphorylation.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei69ATPPROSITE-ProRule annotation1
Active sitei166Proton acceptorPROSITE-ProRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi46 – 54ATPPROSITE-ProRule annotation9

GO - Molecular functioni

  • ATP binding Source: UniProtKB-KW
  • MAP kinase activity Source: TAIR

GO - Biological processi

  • regulation of gene expression Source: GO_Central
  • response to abscisic acid Source: TAIR

Keywordsi

Molecular functionKinase, Serine/threonine-protein kinase, Transferase
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

ReactomeiR-ATH-198753 ERK/MAPK targets
R-ATH-198765 Signalling to ERK5
R-ATH-202670 ERKs are inactivated
R-ATH-2559582 Senescence-Associated Secretory Phenotype (SASP)
R-ATH-881907 Gastrin-CREB signalling pathway via PKC and MAPK

Names & Taxonomyi

Protein namesi
Recommended name:
Mitogen-activated protein kinase 11 (EC:2.7.11.24)
Short name:
AtMPK11
Short name:
MAP kinase 11
Gene namesi
Name:MPK11
Ordered Locus Names:At1g01560
ORF Names:F22L4.10
OrganismiArabidopsis thaliana (Mouse-ear cress)
Taxonomic identifieri3702 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
Proteomesi
  • UP000006548 Componenti: Chromosome 1

Organism-specific databases

AraportiAT1G01560
TAIRilocus:2025341 AT1G01560

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Chloroplast Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertion Graphics by Christian Stolte; Source: COMPARTMENTS

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002458111 – 369Mitogen-activated protein kinase 11Add BLAST369

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei198PhosphothreonineBy similarity1
Modified residuei200PhosphotyrosineBy similarity1
Modified residuei203PhosphothreonineBy similarity1

Post-translational modificationi

Dually phosphorylated on Thr-198 and Tyr-200, which activates the enzyme.By similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiQ9LMM5
PRIDEiQ9LMM5

PTM databases

iPTMnetiQ9LMM5

Expressioni

Gene expression databases

ExpressionAtlasiQ9LMM5 baseline and differential
GenevisibleiQ9LMM5 AT

Interactioni

Subunit structurei

Interacts with MKK1, MKK2 and MKK6.2 Publications

Binary interactionsi

Show more details

Protein-protein interaction databases

BioGridi24758, 1 interactor
IntActiQ9LMM5, 3 interactors
STRINGi3702.AT1G01560.2

Structurei

3D structure databases

ProteinModelPortaliQ9LMM5
SMRiQ9LMM5
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini40 – 326Protein kinasePROSITE-ProRule annotationAdd BLAST287

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi198 – 200TXY3

Domaini

The TXY motif contains the threonine and tyrosine residues whose phosphorylation activates the MAP kinases.

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG0660 Eukaryota
ENOG410XNY0 LUCA
HOGENOMiHOG000233024
InParanoidiQ9LMM5
KOiK04464
OMAiRVQEPQM
OrthoDBiEOG09360BXQ
PhylomeDBiQ9LMM5

Family and domain databases

InterProiView protein in InterPro
IPR011009 Kinase-like_dom_sf
IPR003527 MAP_kinase_CS
IPR000719 Prot_kinase_dom
IPR017441 Protein_kinase_ATP_BS
IPR008271 Ser/Thr_kinase_AS
PfamiView protein in Pfam
PF00069 Pkinase, 1 hit
SMARTiView protein in SMART
SM00220 S_TKc, 1 hit
SUPFAMiSSF56112 SSF56112, 1 hit
PROSITEiView protein in PROSITE
PS01351 MAPK, 1 hit
PS00107 PROTEIN_KINASE_ATP, 1 hit
PS50011 PROTEIN_KINASE_DOM, 1 hit
PS00108 PROTEIN_KINASE_ST, 1 hit

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q9LMM5-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MSIEKPFFGD DSNRGVSING GRYVQYNVYG NLFEVSKKYV PPLRPIGRGA
60 70 80 90 100
SGIVCAAWNS ETGEEVAIKK IGNAFGNIID AKRTLREIKL LKHMDHDNVI
110 120 130 140 150
AIIDIIRPPQ PDNFNDVHIV YELMDTDLHH IIRSNQPLTD DHSRFFLYQL
160 170 180 190 200
LRGLKYVHSA NVLHRDLKPS NLLLNANCDL KIGDFGLART KSETDFMTEY
210 220 230 240 250
VVTRWYRAPE LLLNCSEYTA AIDIWSVGCI LGEIMTREPL FPGRDYVQQL
260 270 280 290 300
RLITELIGSP DDSSLGFLRS DNARRYVRQL PQYPRQNFAA RFPNMSVNAV
310 320 330 340 350
DLLQKMLVFD PNRRITVDEA LCHPYLAPLH EYNEEPVCVR PFHFDFEQPS
360
LTEENIKELI YRESVKFNP
Length:369
Mass (Da):42,475
Last modified:October 1, 2000 - v1
Checksum:i446673DB42C3DAA6
GO
Isoform 2 (identifier: Q9LMM5-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     256-275: LIGSPDDSSLGFLRSDNARR → VNFSLFHLTILFRFNLKKEH
     276-369: Missing.

Note: May be due to introns retention. No experimental confirmation available.
Show »
Length:275
Mass (Da):31,596
Checksum:iB8C8A7A9DCF110C8
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti13N → D in BX815051 (PubMed:14993207).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_035539256 – 275LIGSP…DNARR → VNFSLFHLTILFRFNLKKEH in isoform 2. 1 PublicationAdd BLAST20
Alternative sequenceiVSP_035540276 – 369Missing in isoform 2. 1 PublicationAdd BLAST94

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC061957 Genomic DNA Translation: AAF81314.1
CP002684 Genomic DNA Translation: AEE27305.1
CP002684 Genomic DNA Translation: AEE27306.1
CP002684 Genomic DNA Translation: ANM59779.1
BX815051 mRNA No translation available.
PIRiC86146
RefSeqiNP_001117210.1, NM_001123738.2 [Q9LMM5-1]
NP_001322113.1, NM_001331282.1 [Q9LMM5-2]
NP_563631.2, NM_100038.4 [Q9LMM5-2]
UniGeneiAt.49840

Genome annotation databases

EnsemblPlantsiAT1G01560.1; AT1G01560.1; AT1G01560 [Q9LMM5-2]
AT1G01560.2; AT1G01560.2; AT1G01560 [Q9LMM5-1]
AT1G01560.4; AT1G01560.4; AT1G01560 [Q9LMM5-2]
GeneIDi839523
GrameneiAT1G01560.1; AT1G01560.1; AT1G01560 [Q9LMM5-2]
AT1G01560.2; AT1G01560.2; AT1G01560 [Q9LMM5-1]
AT1G01560.4; AT1G01560.4; AT1G01560 [Q9LMM5-2]
KEGGiath:AT1G01560

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Entry informationi

Entry nameiMPK11_ARATH
AccessioniPrimary (citable) accession number: Q9LMM5
Secondary accession number(s): B3H762
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 11, 2006
Last sequence update: October 1, 2000
Last modified: May 23, 2018
This is version 137 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health