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Protein

Probable protein phosphatase 2C 9

Gene

At1g22280

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Involved in the regulation of phytochrome signaling. May regulate phytochrome-interacting factor 3 (PIF3) through the dephosphorylation of phytochrome.1 Publication

Catalytic activityi

[a protein]-serine/threonine phosphate + H2O = [a protein]-serine/threonine + phosphate.

Cofactori

Mg2+By similarity, Mn2+By similarityNote: Binds 2 magnesium or manganese ions per subunit.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi70Manganese 1By similarity1
Metal bindingi70Manganese 2By similarity1
Metal bindingi71Manganese 1; via carbonyl oxygenBy similarity1
Metal bindingi232Manganese 2By similarity1
Metal bindingi271Manganese 2By similarity1

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Protein phosphatase

Keywords - Ligandi

Magnesium, Manganese, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Probable protein phosphatase 2C 9 (EC:3.1.3.16)
Short name:
AtPP2C09
Alternative name(s):
Phytochrome-associated protein phosphatase 2C
Short name:
PAPP2C
Gene namesi
Ordered Locus Names:At1g22280
ORF Names:T16E15.10
OrganismiArabidopsis thaliana (Mouse-ear cress)
Taxonomic identifieri3702 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
Proteomesi
  • UP000006548 Componenti: Chromosome 1

Organism-specific databases

TAIRiAT1G22280.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Disruption phenotypei

Abnormal hypocotyl elongation under continuous red light.1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003679401 – 281Probable protein phosphatase 2C 9Add BLAST281

Proteomic databases

PaxDbiQ9LME4.
PRIDEiQ9LME4.

PTM databases

iPTMnetiQ9LME4.
SwissPalmiQ9LME4.

Expressioni

Gene expression databases

ExpressionAtlasiQ9LME4. baseline and differential.
GenevisibleiQ9LME4. AT.

Interactioni

Subunit structurei

Interacts with phytochromes (via N-terminus).1 Publication

Protein-protein interaction databases

BioGridi24074. 3 interactors.
IntActiQ9LME4. 2 interactors.
STRINGi3702.AT1G22280.3.

Structurei

3D structure databases

ProteinModelPortaliQ9LME4.
SMRiQ9LME4.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini33 – 280PPM-type phosphatasePROSITE-ProRule annotationAdd BLAST248

Sequence similaritiesi

Belongs to the PP2C family.Curated
Contains 1 PPM-type phosphatase domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiKOG0698. Eukaryota.
COG0631. LUCA.
HOGENOMiHOG000233896.
InParanoidiQ9LME4.
PhylomeDBiQ9LME4.

Family and domain databases

Gene3Di3.60.40.10. 1 hit.
InterProiIPR015655. PP2C.
IPR001932. PPM-type_phosphatase_dom.
[Graphical view]
PANTHERiPTHR13832. PTHR13832. 1 hit.
PfamiPF00481. PP2C. 1 hit.
[Graphical view]
SMARTiSM00331. PP2C_SIG. 1 hit.
SM00332. PP2Cc. 1 hit.
[Graphical view]
SUPFAMiSSF81606. SSF81606. 1 hit.
PROSITEiPS51746. PPM_2. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q9LME4-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MGKFCCFTSA SEVVGGQSSS RSGKGRSDEG MIKYGFSLVK GKANHPMEDY
60 70 80 90 100
HVANFINIQD HELGLFAIYD GHMGDSVPAY LQKRLFSNIL KEGEFWVDPR
110 120 130 140 150
RSIAKAYEKT DQAILSNSSD LGRGGSTAVT AILINGRKLW IANVGDSRAV
160 170 180 190 200
LSHGGAITQM STDHEPRTER SSIEDRGGFV SNLPGDVPRV NGQLAVSRAF
210 220 230 240 250
GDKGLKTHLS SEPDIKEATV DSQTDVLLLA SDGIWKVMTN EEAMEIARRV
260 270 280
KDPQKAAKEL TAEALRRESK DDISCVVVRF R
Length:281
Mass (Da):30,722
Last modified:October 1, 2000 - v1
Checksum:i2EE90E4F8FB56768
GO
Isoform 2 (identifier: Q9LME4-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     186-199: DVPRVNGQLAVSRA → KELILSIECLMKIE
     200-281: Missing.

Note: No experimental confirmation available.
Show »
Length:199
Mass (Da):21,732
Checksum:i502ABB9152C7E9B2
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti111 – 112DQ → E in AAM61437 (Ref. 5) Curated2

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_036759186 – 199DVPRV…AVSRA → KELILSIECLMKIE in isoform 2. 1 PublicationAdd BLAST14
Alternative sequenceiVSP_036760200 – 281Missing in isoform 2. 1 PublicationAdd BLAST82

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC068562 Genomic DNA. Translation: AAF87263.1.
CP002684 Genomic DNA. Translation: AEE30220.1.
CP002684 Genomic DNA. Translation: AEE30221.1.
AY080735 mRNA. Translation: AAL86005.1.
AY133737 mRNA. Translation: AAM91671.1.
BX813947 mRNA. No translation available.
AY084874 mRNA. Translation: AAM61437.1.
PIRiF86355.
RefSeqiNP_564165.1. NM_102079.5. [Q9LME4-1]
NP_973883.1. NM_202154.2. [Q9LME4-2]
UniGeneiAt.41611.

Genome annotation databases

EnsemblPlantsiAT1G22280.1; AT1G22280.1; AT1G22280. [Q9LME4-1]
GeneIDi838835.
GrameneiAT1G22280.1; AT1G22280.1; AT1G22280.
KEGGiath:AT1G22280.

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC068562 Genomic DNA. Translation: AAF87263.1.
CP002684 Genomic DNA. Translation: AEE30220.1.
CP002684 Genomic DNA. Translation: AEE30221.1.
AY080735 mRNA. Translation: AAL86005.1.
AY133737 mRNA. Translation: AAM91671.1.
BX813947 mRNA. No translation available.
AY084874 mRNA. Translation: AAM61437.1.
PIRiF86355.
RefSeqiNP_564165.1. NM_102079.5. [Q9LME4-1]
NP_973883.1. NM_202154.2. [Q9LME4-2]
UniGeneiAt.41611.

3D structure databases

ProteinModelPortaliQ9LME4.
SMRiQ9LME4.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi24074. 3 interactors.
IntActiQ9LME4. 2 interactors.
STRINGi3702.AT1G22280.3.

PTM databases

iPTMnetiQ9LME4.
SwissPalmiQ9LME4.

Proteomic databases

PaxDbiQ9LME4.
PRIDEiQ9LME4.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblPlantsiAT1G22280.1; AT1G22280.1; AT1G22280. [Q9LME4-1]
GeneIDi838835.
GrameneiAT1G22280.1; AT1G22280.1; AT1G22280.
KEGGiath:AT1G22280.

Organism-specific databases

TAIRiAT1G22280.

Phylogenomic databases

eggNOGiKOG0698. Eukaryota.
COG0631. LUCA.
HOGENOMiHOG000233896.
InParanoidiQ9LME4.
PhylomeDBiQ9LME4.

Miscellaneous databases

PROiQ9LME4.

Gene expression databases

ExpressionAtlasiQ9LME4. baseline and differential.
GenevisibleiQ9LME4. AT.

Family and domain databases

Gene3Di3.60.40.10. 1 hit.
InterProiIPR015655. PP2C.
IPR001932. PPM-type_phosphatase_dom.
[Graphical view]
PANTHERiPTHR13832. PTHR13832. 1 hit.
PfamiPF00481. PP2C. 1 hit.
[Graphical view]
SMARTiSM00331. PP2C_SIG. 1 hit.
SM00332. PP2Cc. 1 hit.
[Graphical view]
SUPFAMiSSF81606. SSF81606. 1 hit.
PROSITEiPS51746. PPM_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiP2C09_ARATH
AccessioniPrimary (citable) accession number: Q9LME4
Secondary accession number(s): Q3ED74, Q8LFF8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 14, 2009
Last sequence update: October 1, 2000
Last modified: November 30, 2016
This is version 109 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Arabidopsis thaliana
    Arabidopsis thaliana: entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.