Q9LLT1 (MPAJ1_JUNVI) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names	Recommended name: Major pollen allergen Jun v 1 Alternative name(s): Allergen=Jun v 1
Organism	Juniperus virginiana (Eastern red cedar)
Taxonomic identifier	39584 [NCBI]
Taxonomic lineage	cellular organisms › Eukaryota › Viridiplantae › Streptophyta › Streptophytina › Embryophyta › Tracheophyta › Euphyllophyta › Spermatophyta › Coniferophyta › Coniferopsida › Coniferales › Cupressaceae › Juniperus

Protein attributes

Sequence length	367 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at protein level

General annotation (Comments)

Allergenic properties	Causes an allergic reaction in human. Binds to IgE of patients who are allergic to J.ashei. Ref.1
Sequence similarities	Belongs to the polysaccharide lyase 1 family. Amb a subfamily.

Ontologies

Keywords
Coding sequence diversity	Polymorphism
Disease	Allergen
Domain	Signal
PTM	Disulfide bond Glycoprotein
Technical term	Direct protein sequencing
Gene Ontology (GO)
None. [Check GOA]

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Signal peptide	1 – 21	21	Ref.1
	Chain	22 – 367	346	Major pollen allergen Jun v 1 Ref.1		PRO_0000024909
Amino acid modifications
	Glycosylation	148	1	N-linked (GlcNAc...) Potential
	Glycosylation	178	1	N-linked (GlcNAc...) Potential
	Disulfide bond	28 ↔ 45		By similarity
	Disulfide bond	128 ↔ 147		By similarity
	Disulfide bond	306 ↔ 312		By similarity
Natural variations
	Natural variant	209	1	S → F. Ref.1

Sequences

	Sequence		Length	Mass (Da)
	Q9LLT1 [UniParc]. Last modified October 1, 2000. Version 1. Checksum: DCBD1981A74E4711	FASTA	367	39,709
	10 20 30 40 50 60 MASPCLIAFL VFLCAIVSCC SDNPIDSCWR GDSNWGQNRM KLADCAVGFG SSTMGGKGGD 70 80 90 100 110 120 FYTVTSADDN PVNPTPGTLR YGATREKTLW IIFSQNMNIK LKMPLYVAGH KTIDGRGADV 130 140 150 160 170 180 HLGNGGPCLF MRKVSHVILH GLHIHGCNTS VLGDVLVSES IGVVPVHAQD GDAITMRNVT 190 200 210 220 230 240 NAWIDHNSLS DCSDGLIDVT LGSTGITISN NHFFNHHKVM LLGHDDTYDD DKSMKVTVAF 250 260 270 280 290 300 NQFGPNAGQR MPRARYGLVH VANNNYDPWN IYAIGGSSNP TILSEGNSFT APNENYKKEV 310 320 330 340 350 360 TKRIGCESTS ACANWVWRST RDAFSNGAYF VSSGKIEETN IYNSNEAFKV ENGNAAPQLT KNAGVVA

References

[1]

"Identification of mutations in the genes for the pollen allergens of eastern red cedar (Juniperus virginiana)." Midoro-Horiuti T., Goldblum R.M., Brooks E.G. Clin. Exp. Allergy 31:771-778(2001) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA], PROTEIN SEQUENCE OF 22-26, VARIANT PHE-209, ALLERGEN. Tissue: Pollen.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AF151427 mRNA. Translation: AAF80164.1. AF151429 mRNA. Translation: AAF80166.1.
3D structure databases
ProteinModelPortal	Q9LLT1.
SMR	Q9LLT1. Positions 22-366.
ModBase	Search...
Protein family/group databases
Allergome	3342. Jun v 1.0101. 3343. Jun v 1.0102. 431. Jun v 1.
CAZy	PL1. Polysaccharide Lyase Family 1.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Family and domain databases
Gene3D	2.160.20.10. 1 hit.
InterPro	IPR002022. Amb_allergen_dom. IPR018082. AmbAllergen. IPR012334. Pectin_lyas_fold. IPR011050. Pectin_lyase_fold/virulence. [Graphical view]
Pfam	PF00544. Pec_lyase_C. 1 hit. [Graphical view]
PRINTS	PR00807. AMBALLERGEN.
SMART	SM00656. Amb_all. 1 hit. [Graphical view]
SUPFAM	SSF51126. Pectin_lyas_like. 1 hit.
ProtoNet	Search...

Entry information

Entry name

MPAJ1_JUNVI

Accession

Primary (citable) accession number: Q9LLT1
Secondary accession number(s): P81825, Q9LLT2

Entry history

Integrated into UniProtKB/Swiss-Prot:	August 16, 2004
Last sequence update:	October 1, 2000
Last modified:	April 3, 2013
This is version 40 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Plant Protein Annotation Program