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Protein

Biotin carboxyl carrier protein of acetyl-CoA carboxylase 2, chloroplastic

Gene

BCCP2

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

This protein is a component of the acetyl coenzyme A carboxylase complex; first, biotin carboxylase catalyzes the carboxylation of the carrier protein and then the transcarboxylase transfers the carboxyl group to form malonyl-CoA.

Pathwayi: fatty acid biosynthesis

This protein is involved in the pathway fatty acid biosynthesis, which is part of Lipid metabolism.
View all proteins of this organism that are known to be involved in the pathway fatty acid biosynthesis and in Lipid metabolism.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Fatty acid biosynthesis, Fatty acid metabolism, Lipid biosynthesis, Lipid metabolism

Keywords - Ligandi

Biotin

Enzyme and pathway databases

BioCyciARA:GQT-2156-MONOMER.
UniPathwayiUPA00094.

Names & Taxonomyi

Protein namesi
Recommended name:
Biotin carboxyl carrier protein of acetyl-CoA carboxylase 2, chloroplastic
Short name:
AtBCCP2
Short name:
BCCP-2
Gene namesi
Name:BCCP2
Ordered Locus Names:At5g15530
ORF Names:T20K14_140
OrganismiArabidopsis thaliana (Mouse-ear cress)
Taxonomic identifieri3702 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
Proteomesi
  • UP000006548 Componenti: Chromosome 5

Organism-specific databases

TAIRiAT5G15530.

Subcellular locationi

GO - Cellular componenti

  • acetyl-CoA carboxylase complex Source: InterPro
  • chloroplast envelope Source: TAIR
  • chloroplast stroma Source: TAIR
Complete GO annotation...

Keywords - Cellular componenti

Chloroplast, Plastid

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transit peptidei1 – 8787ChloroplastSequence analysisAdd
BLAST
Chaini88 – 255168Biotin carboxyl carrier protein of acetyl-CoA carboxylase 2, chloroplasticPRO_0000295893Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei220 – 2201N6-biotinyllysinePROSITE-ProRule annotationBy similarity

Proteomic databases

PaxDbiQ9LLC1.
PRIDEiQ9LLC1.

Expressioni

Tissue specificityi

Primarily expressed in 7 to 10 days after flowering seeds at levels approximately 2-fold less abundant than BCCP1.1 Publication

Gene expression databases

GenevisibleiQ9LLC1. AT.

Interactioni

Subunit structurei

Acetyl-CoA carboxylase is a heterohexamer composed of biotin carboxyl carrier protein, biotin carboxylase and 2 subunits each of ACCase subunit alpha and ACCase plastid-coded subunit beta (accD).

Protein-protein interaction databases

DIPiDIP-58513N.
STRINGi3702.AT5G15530.1.

Structurei

3D structure databases

ProteinModelPortaliQ9LLC1.
SMRiQ9LLC1. Positions 181-253.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini178 – 25477Biotinyl-bindingPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 1 biotinyl-binding domain.PROSITE-ProRule annotationCurated

Keywords - Domaini

Transit peptide

Phylogenomic databases

eggNOGiENOG410IWH6. Eukaryota.
COG0511. LUCA.
HOGENOMiHOG000008876.
InParanoidiQ9LLC1.
KOiK02160.
OMAiTHIAWQR.
PhylomeDBiQ9LLC1.

Family and domain databases

InterProiIPR001249. AcCoA_biotinCC.
IPR001882. Biotin_BS.
IPR000089. Biotin_lipoyl.
IPR011053. Single_hybrid_motif.
[Graphical view]
PfamiPF00364. Biotin_lipoyl. 1 hit.
[Graphical view]
PRINTSiPR01071. ACOABIOTINCC.
SUPFAMiSSF51230. SSF51230. 1 hit.
TIGRFAMsiTIGR00531. BCCP. 1 hit.
PROSITEiPS00188. BIOTIN. 1 hit.
PS50968. BIOTINYL_LIPOYL. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9LLC1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MASLSVPCVK ICALNRRVGS LPGISTQRWQ PQPNGISFPS DVSQNHSAFW
60 70 80 90 100
RLRATTNEVV SNSTPMTNGG YMNGKAKTNV PEPAELSEFM AKVSGLLKLV
110 120 130 140 150
DSKDIVELEL KQLDCEIVIR KKEALQQAVP PAPVYHSMPP VMADFSMPPA
160 170 180 190 200
QPVALPPSPT PTSTPATAKP TSAPSSSHPP LKSPMAGTFY RSPGPGEPPF
210 220 230 240 250
VKVGDKVQKG QIVCIIEAMK LMNEIEAEKS GTIMELLAED GKPVSVDTPL

FVIAP
Length:255
Mass (Da):27,280
Last modified:October 1, 2000 - v1
Checksum:iF868E344EAC89CDA
GO

Sequence cautioni

The sequence CAC01752.1 differs from that shown. Reason: Erroneous gene model prediction. Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF223948 mRNA. Translation: AAF80592.1.
AL391143 Genomic DNA. Translation: CAC01752.1. Sequence problems.
CP002688 Genomic DNA. Translation: AED92173.1.
AY086528 mRNA. Translation: AAM63527.1.
BT028902 mRNA. Translation: ABI49449.1.
PIRiT51531.
RefSeqiNP_568316.1. NM_121557.3.
UniGeneiAt.20538.
At.69216.

Genome annotation databases

EnsemblPlantsiAT5G15530.1; AT5G15530.1; AT5G15530.
GeneIDi831406.
GrameneiAT5G15530.1; AT5G15530.1; AT5G15530.
KEGGiath:AT5G15530.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF223948 mRNA. Translation: AAF80592.1.
AL391143 Genomic DNA. Translation: CAC01752.1. Sequence problems.
CP002688 Genomic DNA. Translation: AED92173.1.
AY086528 mRNA. Translation: AAM63527.1.
BT028902 mRNA. Translation: ABI49449.1.
PIRiT51531.
RefSeqiNP_568316.1. NM_121557.3.
UniGeneiAt.20538.
At.69216.

3D structure databases

ProteinModelPortaliQ9LLC1.
SMRiQ9LLC1. Positions 181-253.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

DIPiDIP-58513N.
STRINGi3702.AT5G15530.1.

Proteomic databases

PaxDbiQ9LLC1.
PRIDEiQ9LLC1.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblPlantsiAT5G15530.1; AT5G15530.1; AT5G15530.
GeneIDi831406.
GrameneiAT5G15530.1; AT5G15530.1; AT5G15530.
KEGGiath:AT5G15530.

Organism-specific databases

TAIRiAT5G15530.

Phylogenomic databases

eggNOGiENOG410IWH6. Eukaryota.
COG0511. LUCA.
HOGENOMiHOG000008876.
InParanoidiQ9LLC1.
KOiK02160.
OMAiTHIAWQR.
PhylomeDBiQ9LLC1.

Enzyme and pathway databases

UniPathwayiUPA00094.
BioCyciARA:GQT-2156-MONOMER.

Miscellaneous databases

PROiQ9LLC1.

Gene expression databases

GenevisibleiQ9LLC1. AT.

Family and domain databases

InterProiIPR001249. AcCoA_biotinCC.
IPR001882. Biotin_BS.
IPR000089. Biotin_lipoyl.
IPR011053. Single_hybrid_motif.
[Graphical view]
PfamiPF00364. Biotin_lipoyl. 1 hit.
[Graphical view]
PRINTSiPR01071. ACOABIOTINCC.
SUPFAMiSSF51230. SSF51230. 1 hit.
TIGRFAMsiTIGR00531. BCCP. 1 hit.
PROSITEiPS00188. BIOTIN. 1 hit.
PS50968. BIOTINYL_LIPOYL. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Brassicaceae express multiple isoforms of biotin carboxyl carrier protein in a tissue-specific manner."
    Thelen J.J., Mekhedov S., Ohlrogge J.B.
    Plant Physiol. 125:2016-2028(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], SUBCELLULAR LOCATION, TISSUE SPECIFICITY.
  2. "Sequence and analysis of chromosome 5 of the plant Arabidopsis thaliana."
    Tabata S., Kaneko T., Nakamura Y., Kotani H., Kato T., Asamizu E., Miyajima N., Sasamoto S., Kimura T., Hosouchi T., Kawashima K., Kohara M., Matsumoto M., Matsuno A., Muraki A., Nakayama S., Nakazaki N., Naruo K.
    , Okumura S., Shinpo S., Takeuchi C., Wada T., Watanabe A., Yamada M., Yasuda M., Sato S., de la Bastide M., Huang E., Spiegel L., Gnoj L., O'Shaughnessy A., Preston R., Habermann K., Murray J., Johnson D., Rohlfing T., Nelson J., Stoneking T., Pepin K., Spieth J., Sekhon M., Armstrong J., Becker M., Belter E., Cordum H., Cordes M., Courtney L., Courtney W., Dante M., Du H., Edwards J., Fryman J., Haakensen B., Lamar E., Latreille P., Leonard S., Meyer R., Mulvaney E., Ozersky P., Riley A., Strowmatt C., Wagner-McPherson C., Wollam A., Yoakum M., Bell M., Dedhia N., Parnell L., Shah R., Rodriguez M., Hoon See L., Vil D., Baker J., Kirchoff K., Toth K., King L., Bahret A., Miller B., Marra M.A., Martienssen R., McCombie W.R., Wilson R.K., Murphy G., Bancroft I., Volckaert G., Wambutt R., Duesterhoeft A., Stiekema W., Pohl T., Entian K.-D., Terryn N., Hartley N., Bent E., Johnson S., Langham S.-A., McCullagh B., Robben J., Grymonprez B., Zimmermann W., Ramsperger U., Wedler H., Balke K., Wedler E., Peters S., van Staveren M., Dirkse W., Mooijman P., Klein Lankhorst R., Weitzenegger T., Bothe G., Rose M., Hauf J., Berneiser S., Hempel S., Feldpausch M., Lamberth S., Villarroel R., Gielen J., Ardiles W., Bents O., Lemcke K., Kolesov G., Mayer K.F.X., Rudd S., Schoof H., Schueller C., Zaccaria P., Mewes H.-W., Bevan M., Fransz P.F.
    Nature 408:823-826(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: cv. Columbia.
  3. The Arabidopsis Information Resource (TAIR)
    Submitted (APR-2011) to the EMBL/GenBank/DDBJ databases
    Cited for: GENOME REANNOTATION.
    Strain: cv. Columbia.
  4. "Full-length cDNA from Arabidopsis thaliana."
    Brover V.V., Troukhan M.E., Alexandrov N.A., Lu Y.-P., Flavell R.B., Feldmann K.A.
    Submitted (MAR-2002) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  5. "Arabidopsis ORF clones."
    Bautista V.R., Kim C.J., Chen H., Quinitio C., Ecker J.R.
    Submitted (SEP-2006) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: cv. Columbia.

Entry informationi

Entry nameiBCCP2_ARATH
AccessioniPrimary (citable) accession number: Q9LLC1
Secondary accession number(s): Q9LF29
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 24, 2007
Last sequence update: October 1, 2000
Last modified: February 17, 2016
This is version 89 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Arabidopsis thaliana
    Arabidopsis thaliana: entries and gene names
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.