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Protein

Glucose-6-phosphate 1-dehydrogenase

Gene

G6PDHP2

Organism
Nicotiana tabacum (Common tobacco)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalyzes the rate-limiting step of the oxidative pentose-phosphate pathway, which represents a route for the dissimilation of carbohydrates besides glycolysis.UniRule annotation

Catalytic activityi

D-glucose 6-phosphate + NADP+ = 6-phospho-D-glucono-1,5-lactone + NADPH.UniRule annotation

Pathwayi: pentose phosphate pathway

This protein is involved in step 1 of the subpathway that synthesizes D-ribulose 5-phosphate from D-glucose 6-phosphate (oxidative stage).UniRule annotation
Proteins known to be involved in the 3 steps of the subpathway in this organism are:
  1. Glucose-6-phosphate 1-dehydrogenase (LOC107828938), Glucose-6-phosphate 1-dehydrogenase (LOC107822069), Glucose-6-phosphate 1-dehydrogenase, Glucose-6-phosphate 1-dehydrogenase, Glucose-6-phosphate 1-dehydrogenase, Glucose-6-phosphate 1-dehydrogenase, chloroplastic, Glucose-6-phosphate 1-dehydrogenase (LOC107794892), Glucose-6-phosphate 1-dehydrogenase (LOC107805957), Glucose-6-phosphate 1-dehydrogenase (LOC107758909), Glucose-6-phosphate 1-dehydrogenase (LOC107831534), Glucose-6-phosphate 1-dehydrogenase (LOC107805957), Glucose-6-phosphate 1-dehydrogenase (G6PDHP2), Glucose-6-phosphate 1-dehydrogenase (LOC107786177), Glucose-6-phosphate 1-dehydrogenase (LOC107828938)
  2. no protein annotated in this organism
  3. 6-phosphogluconate dehydrogenase, decarboxylating (LOC107777046), 6-phosphogluconate dehydrogenase, decarboxylating (LOC107791333), 6-phosphogluconate dehydrogenase, decarboxylating (LOC107799009), 6-phosphogluconate dehydrogenase, decarboxylating (LOC107789656), 6-phosphogluconate dehydrogenase, decarboxylating (LOC107779182)
This subpathway is part of the pathway pentose phosphate pathway, which is itself part of Carbohydrate degradation.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes D-ribulose 5-phosphate from D-glucose 6-phosphate (oxidative stage), the pathway pentose phosphate pathway and in Carbohydrate degradation.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionOxidoreductaseUniRule annotationImported
Biological processCarbohydrate metabolism, Glucose metabolismUniRule annotation
LigandNADPUniRule annotation

Enzyme and pathway databases

UniPathwayiUPA00115; UER00408.

Names & Taxonomyi

Protein namesi
Recommended name:
Glucose-6-phosphate 1-dehydrogenaseUniRule annotation (EC:1.1.1.49UniRule annotation)
Gene namesi
Name:G6PDHP2Imported
OrganismiNicotiana tabacum (Common tobacco)Imported
Taxonomic identifieri4097 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaeasteridslamiidsSolanalesSolanaceaeNicotianoideaeNicotianeaeNicotiana

Structurei

3D structure databases

ProteinModelPortaliQ9LL88.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini114 – 292G6PD_NInterPro annotationAdd BLAST179
Domaini295 – 589G6PD_CInterPro annotationAdd BLAST295

Sequence similaritiesi

Belongs to the glucose-6-phosphate dehydrogenase family.UniRule annotation

Family and domain databases

HAMAPiMF_00966. G6PD. 1 hit.
InterProiView protein in InterPro
IPR001282. G6P_DH.
IPR019796. G6P_DH_AS.
IPR022675. G6P_DH_C.
IPR022674. G6P_DH_NAD-bd.
IPR016040. NAD(P)-bd_dom.
PANTHERiPTHR23429. PTHR23429. 1 hit.
PfamiView protein in Pfam
PF02781. G6PD_C. 1 hit.
PF00479. G6PD_N. 1 hit.
PRINTSiPR00079. G6PDHDRGNASE.
SUPFAMiSSF51735. SSF51735. 1 hit.
TIGRFAMsiTIGR00871. zwf. 1 hit.
PROSITEiView protein in PROSITE
PS00069. G6P_DEHYDROGENASE. 1 hit.

Sequencei

Sequence statusi: Complete.

Q9LL88-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVTLYSSPST HSSGAVASYS NSSIGLYNYH HNKQIAVSSI LSRKFGSLQI
60 70 80 90 100
NQKPFWNAVR MQDGAVATPP SKIENETPLK KLKNGILPVA PPKEQKDTID
110 120 130 140 150
FDSNKAKSTV SITVVGASGD LAKKKIFPAL FALYYEGCLP EHFTIFGYAR
160 170 180 190 200
SKMTDAELRN MVSKTLTCRI DKRENCGEKM EQFLERCFYH SGQYDSLENF
210 220 230 240 250
AELDKKLKEH EAGRFSNRLF YLSIPPNIFI NAVRCASLSA SSAHGWTRVI
260 270 280 290 300
VEKPFGRDSE SSAALTRSLK QYLNEDQIFR IDHYLGKELV ENLSVLRFSN
310 320 330 340 350
LIFEPLWSRQ YIRNVQFIFS EDFGTEGRGG YFDHYGIIRD IMQNHLLQIL
360 370 380 390 400
ALFAMETPVS LDAEDIRNEK VKVLRSMRPL QLDDVIIGQY KSHTKGDVTY
410 420 430 440 450
PGYTDDKTVP KDSLTPTFAA AALFIDNARW DGVPFLMKAG KALHTRSAEI
460 470 480 490 500
RVQFRHVPGN LYNKNFGSDL DQATNELVIR VQPNEAIYLK INNKVPGLGM
510 520 530 540 550
RLDRSNLNLL YSARYSKEIP DPYERLLLDA IEGERRLFIR SDELDAAWSL
560 570 580 590
FTPVLKELED KKIVPEYYPY GSRGPIGAHY LAARYKVRWG DLV
Length:593
Mass (Da):67,413
Last modified:October 1, 2000 - v1
Checksum:i47E6935C5D78033B
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF231351 Genomic DNA. Translation: AAF87216.1.

Similar proteinsi

Entry informationi

Entry nameiQ9LL88_TOBAC
AccessioniPrimary (citable) accession number: Q9LL88
Entry historyiIntegrated into UniProtKB/TrEMBL: October 1, 2000
Last sequence update: October 1, 2000
Last modified: May 10, 2017
This is version 74 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)