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Q9LKP7 (CHSY_DIAMO) Reviewed, UniProtKB/Swiss-Prot

Last modified February 19, 2014. Version 55. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Chalcone synthase

EC=2.3.1.74
Alternative name(s):
Naringenin-chalcone synthase
Gene names
Name:CHS
OrganismDianthus monspessulanus
Taxonomic identifier129769 [NCBI]
Taxonomic lineageEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaeCaryophyllalesCaryophyllaceaeDianthus

Protein attributes

Sequence length391 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

The primary product of this enzyme is 4,2',4',6'-tetrahydroxychalcone (also termed naringenin-chalcone or chalcone) which can under specific conditions spontaneously isomerize into naringenin.

Catalytic activity

3 malonyl-CoA + 4-coumaroyl-CoA = 4 CoA + naringenin chalcone + 3 CO2.

Pathway

Secondary metabolite biosynthesis; flavonoid biosynthesis.

Sequence similarities

Belongs to the chalcone/stilbene synthases family.

Ontologies

Keywords
   Biological processFlavonoid biosynthesis
   Molecular functionAcyltransferase
Transferase
Gene Ontology (GO)
   Biological_processflavonoid biosynthetic process

Inferred from electronic annotation. Source: UniProtKB-UniPathway

   Molecular_functionnaringenin-chalcone synthase activity

Inferred from electronic annotation. Source: UniProtKB-EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 391391Chalcone synthase
PRO_0000215974

Sites

Active site1641 By similarity

Sequences

Sequence LengthMass (Da)Tools
Q9LKP7 [UniParc].

Last modified October 1, 2000. Version 1.
Checksum: 7C132D24E66C6C5D

FASTA39142,766
        10         20         30         40         50         60 
MASIEEIRQA QRADGPATIL AIGTATPPNA IYQADYPDYY FRVTKSEHMT ELKEKFRRMC 

        70         80         90        100        110        120 
DKSMIKKRYM YLTEEILKEN PNLCEYMGSS LDTRQDMVVS EVPRLGKEAA VKAIKEWGQP 

       130        140        150        160        170        180 
KSKITHVIMC TTSGVDMPGA DYQLTKLLGL RPSVRRFMLY QQGCFAGGTV LRLAKDLAEN 

       190        200        210        220        230        240 
NKGARVLVVC SEITAICFRG PTEAALDSMV GQALFGDGAG ALIVGSDPDL SIERPLFQMA 

       250        260        270        280        290        300 
WAGQTLLPDS EGAIDGHLRE VGLTFHLLKD VPGIISKNIT NALEEAFSPI GVSDWNNLFW 

       310        320        330        340        350        360 
IAHPGGPAIL DQVEAKLGLK EEKLAATRNV LSDFGNMSSA CVLFILDEMR KKSLRDGATT 

       370        380        390 
TGEGLDWGVL FGFGPGLTVE TVVLHSVPLN C 

« Hide

References

[1]"Molecular cloning of chalcone synthase cDNA from Dianthus monspessulanus."
Yagishita Y., Ohya T., Kaminishi A., Nomura K., Kita N.
Submitted (MAY-2000) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [MRNA].

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AF267173 mRNA. Translation: AAF81743.1.

3D structure databases

ProteinModelPortalQ9LKP7.
SMRQ9LKP7. Positions 3-389.
ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Enzyme and pathway databases

UniPathwayUPA00154.

Family and domain databases

Gene3D3.40.47.10. 2 hits.
InterProIPR012328. Chalcone/stilbene_synth_C.
IPR018088. Chalcone/stilbene_synthase_AS.
IPR001099. Chalcone/stilbene_synthase_N.
IPR011141. Polyketide_synthase_type-III.
IPR016039. Thiolase-like.
IPR016038. Thiolase-like_subgr.
[Graphical view]
PfamPF02797. Chal_sti_synt_C. 1 hit.
PF00195. Chal_sti_synt_N. 1 hit.
[Graphical view]
PIRSFPIRSF000451. PKS_III. 1 hit.
SUPFAMSSF53901. SSF53901. 2 hits.
PROSITEPS00441. CHALCONE_SYNTH. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameCHSY_DIAMO
AccessionPrimary (citable) accession number: Q9LKP7
Entry history
Integrated into UniProtKB/Swiss-Prot: December 8, 2000
Last sequence update: October 1, 2000
Last modified: February 19, 2014
This is version 55 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways