Reviewed,
UniProtKB/Swiss-Prot Q9LKL2 (APRR1_ARATH)
Last modified
July 22, 2008.
Version 58.
History...
Clusters with 100%,
90%,
50% identity |
Documents (3) |
Third-party data |
Customize display | text xml rdf/xml gff fasta |
Names and origin
| Protein names | Recommended name: Two-component response regulator-like APRR1 Alternative name(s): Pseudo-response regulator 1 Timing of CAB expression 1 ABI3-interacting protein 1 | ||||||||
| Gene names |
| ||||||||
| Organism | Arabidopsis thaliana (Mouse-ear cress) [Complete proteome] | ||||||||
| Taxonomic identifier | 3702 [NCBI] | ||||||||
| Taxonomic lineage | Eukaryota › Viridiplantae › Streptophyta › Embryophyta › Tracheophyta › Spermatophyta › Magnoliophyta › eudicotyledons › core eudicotyledons › rosids › eurosids II › Brassicales › Brassicaceae › Arabidopsis |
Protein attributes
| Sequence length | 618 AA. |
| Sequence status | Complete. |
| Sequence processing | The displayed sequence is not processed. |
| Protein existence | Evidence at protein level. |
General annotation (Comments)
| Function | Controls photoperiodic flowering response. Seems to be one of the component of the circadian clock. Expression of several members of the ARR-like family is controlled by circadian rhythm. The particular coordinated sequential expression of APRR9, APRR7, APRR5, APRR3 and APPR1 result to circadian waves that may be at the basis of the endogenous circadian clock. |
| Subunit structure | Interacts with ABI3. Also interacts with ADO1 and ADO2. |
| Subcellular location | |
| Tissue specificity | Expressed in leaves, flowers and siliques. |
| Induction | Expressed with a circadian rhythm showing a broad peak in the late day. Negatively regulated by LHY and CCA1. |
| Sequence similarities | Belongs to the ARR-like family. Contains 1 CCT domain. Contains 1 response regulatory domain. |
| Caution | Lacks the phospho-accepting Asp (here Glu-71), present in the receiver domain, which is one of the conserved features of the two-component response regulators (ARRs) family. |
Ontologies
Keywords | |
|---|---|
| Biological process | Transcription Transcription regulation Two-component regulatory system |
| Cellular component | Nucleus |
| Domain | Coiled coil |
| Technical term | Complete proteome |
Gene Ontology (GO) | |
| Molecular function | protein binding Inferred from physical interaction. Source: IntAct transcription regulator activityTraceable author statement. Source: TAIR |
| Complete GO annotation... | |
Binary interactions
With | Entry | #Exp. | IntAct | Notes |
|---|---|---|---|---|
| ADO1 | Q94BT6 | 4 | EBI-618423,EBI-300691 | |
| ADO2 | Q8W420 | 2 | EBI-618423,EBI-1015688 | |
| APRR3 | Q9LVG4 | 1 | EBI-618423,EBI-1606968 | |
| At2g46970 | O80727 | 3 | EBI-618423,EBI-630752 |
Sequence annotation (Features)
| Feature key | Position(s) | Length | Description | Graphical view | ||||
Molecule processing | ||||||||
|---|---|---|---|---|---|---|---|---|
| Chain | 1 – 618 | 618 | Two-component response regulator-like APRR1 | |||||
Regions | ||||||||
| Domain | 20 – 138 | 119 | Response regulatory | |||||
| Domain | 533 – 575 | 43 | CCT | |||||
| Coiled coil | 588 – 610 | 23 | Potential | |||||
| Compositional bias | 595 – 605 | 11 | Poly-Glu | |||||
Experimental info | ||||||||
| Mutagenesis | 562 | 1 | A → V in toc1-1; causes shortened circadian rhythms in light-grown plants | |||||
| Sequence conflict | 126 | 1 | R → L in CAB75508. Ref.2 | |||||
Sequences
| ||||||||||||||||||
References
| « Hide 'large scale' references | |
| [1] | "Genes encoding pseudo-response regulators: insight into His-to-Asp phosphorelay and circadian rhythm in Arabidopsis thaliana." Makino S., Kiba T., Imamura A., Hanaki N., Nakamura A., Suzuki T., Taniguchi M., Ueguchi C., Sugiyama T., Mizuno T. Plant Cell Physiol. 41:791-803(2000) [PubMed: 10945350] [Abstract] Cited for: NUCLEOTIDE SEQUENCE, CHARACTERIZATION, GENE FAMILY. Strain: cv. Columbia. |
| [2] | "Cloning of the Arabidopsis clock gene TOC1, an autoregulatory response regulator homolog." Strayer C., Oyama T., Schultz T.F., Raman R., Somers D.E., Mas P., Panda S., Kreps J.A., Kay S.A. Science 289:768-771(2000) [PubMed: 10926537] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA], MUTAGENESIS OF ALA-562. Strain: cv. Columbia. |
| [3] | "Interactions of the developmental regulator ABI3 with proteins identified from developing Arabidopsis seeds." Kurup S., Jones H.D., Holdsworth M.J. Plant J. 21:143-155(2000) [PubMed: 10743655] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY, INTERACTION WITH ABI3. Strain: cv. Landsberg erecta. |
| [4] | "Structural analysis of Arabidopsis thaliana chromosome 5. IV. Sequence features of the regions of 1,456,315 bp covered by nineteen physically assigned P1 and TAC clones." Sato S., Kaneko T., Kotani H., Nakamura Y., Asamizu E., Miyajima N., Tabata S. DNA Res. 5:41-54(1998) [PubMed: 9628582] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: cv. Columbia. |
| [5] | "Empirical analysis of transcriptional activity in the Arabidopsis genome." Yamada K., Lim J., Dale J.M., Chen H., Shinn P., Palm C.J., Southwick A.M., Wu H.C., Kim C.J., Nguyen M., Pham P.K., Cheuk R.F., Karlin-Newmann G., Liu S.X., Lam B., Sakano H., Wu T., Yu G. Ecker J.R.Science 302:842-846(2003) [PubMed: 14593172] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Strain: cv. Columbia. |
| [6] | "Circadian waves of expression of the APRR1/TOC1 family of pseudo-response regulators in Arabidopsis thaliana: insight into the plant circadian clock." Matsushika A., Makino S., Kojima M., Mizuno T. Plant Cell Physiol. 41:1002-1012(2000) [PubMed: 11100772] [Abstract] Cited for: FUNCTION. |
| [7] | "Reciprocal regulation between TOC1 and LHY/CCA1 within the Arabidopsis circadian clock." Alabadi D., Oyama T., Yanovsky M.J., Harmon F.G., Mas P., Kay S.A. Science 293:880-883(2001) [PubMed: 11486091] [Abstract] Cited for: INDUCTION. |
| [8] | "Identification of ASK and clock-associated proteins as molecular partners of LKP2 (LOV kelch protein 2) in Arabidopsis." Yasuhara M., Mitsui S., Hirano H., Takanabe R., Tokioka Y., Ihara N., Komatsu A., Seki M., Shinozaki K., Kiyosue T. J. Exp. Bot. 55:2015-2027(2004) [PubMed: 15310821] [Abstract] Cited for: INTERACTION WITH ADO1 AND ADO2. |
Cross-references
Sequence databases | |
|---|---|
| AB041530 mRNA. Translation: BAA94547.1. AF272039 mRNA. Translation: AAF86252.1. AJ251086 mRNA. Translation: CAB75508.1. AB010073 Genomic DNA. Translation: BAB08493.1. AY094393 mRNA. Translation: AAM19772.1. BT005816 mRNA. Translation: AAO64751.1. | |
| PIR | T52075. T52076. |
| RefSeq | NP_200946.1. |
| UniGene | At.21919 |
3D structure databases | |
| ModBase | Search... |
Protein-protein interaction databases | |
| IntAct | Q9LKL2. |
Genome annotation databases | |
| GeneID | 836259. |
| GenomeReviews | Gene locus AT5G61380 in contig BA000015_GR. |
| KEGG | ath:AT5G61380. |
| NMPDR | fig|3702.1.peg.28159. |
Organism-specific databases | |
| GeneFarm | 4313. 437. |
| TAIR | At5g61380. |
Gene expression databases | |
| ArrayExpress | Q9LKL2. |
| GermOnline | AT5G61380. Arabidopsis thaliana. |
Family and domain databases | |
| InterPro | IPR010402. CCT. IPR001789. Sig_transdc_resp-reg_receiver. [Graphical view] |
| Pfam | PF06203. CCT. 1 hit. PF00072. Response_reg. 1 hit. [Graphical view] |
| ProDom | PD000039. Response_reg. 1 hit. [Graphical view] [Entries sharing at least one domain] |
| SMART | SM00448. REC. 1 hit. [Graphical view] |
| PROSITE | PS51017. CCT. 1 hit. PS50110. RESPONSE_REGULATORY. 1 hit. [Graphical view] |
| BLOCKS | Search... |
Other Resources | |
| ProtoNet | Search... |
Entry information
| Entry name | APRR1_ARATH | ||||||||
| Accession | Primary (citable) accession number: Q9LKL2 Secondary accession number(s): Q9M4B7 | ||||||||
| Entry history |
| ||||||||
| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation project | PPAP (Plant Proteome Annotation Project) | ||||||||
Relevant documents
| Arabidopsis thaliana Arabidopsis thaliana: entries and gene names |
| UniProtKB secondary accession numbers Index of UniProtKB secondary accession numbers |
| SIMILARITY comments Index of protein domains and families |

Clusters with


