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Protein

Probable phospholipid-transporting ATPase 8

Gene

ALA8

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Involved in transport of phospholipids.1 Publication

Catalytic activityi

ATP + H2O + phospholipid(Side 1) = ADP + phosphate + phospholipid(Side 2).1 Publication

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei4244-aspartylphosphate intermediateBy similarity1
Metal bindingi865MagnesiumBy similarity1
Metal bindingi869MagnesiumBy similarity1

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Ligandi

ATP-binding, Magnesium, Metal-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciARA:AT3G27870-MONOMER.
ReactomeiR-ATH-6798695. Neutrophil degranulation.
R-ATH-936837. Ion transport by P-type ATPases.

Names & Taxonomyi

Protein namesi
Recommended name:
Probable phospholipid-transporting ATPase 81 Publication (EC:3.6.3.11 Publication)
Short name:
AtALA81 Publication
Alternative name(s):
Aminophospholipid flippase 81 Publication
Gene namesi
Name:ALA81 Publication
Ordered Locus Names:At3g27870Imported
ORF Names:K16N12.9Imported
OrganismiArabidopsis thaliana (Mouse-ear cress)
Taxonomic identifieri3702 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
Proteomesi
  • UP000006548 Componenti: Chromosome 3

Organism-specific databases

TAIRiAT3G27870.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 71CytoplasmicSequence analysisAdd BLAST71
Transmembranei72 – 93HelicalSequence analysisAdd BLAST22
Topological domaini94 – 97ExtracellularSequence analysis4
Transmembranei98 – 120HelicalSequence analysisAdd BLAST23
Topological domaini121 – 299CytoplasmicSequence analysisAdd BLAST179
Transmembranei300 – 321HelicalSequence analysisAdd BLAST22
Topological domaini322 – 358ExtracellularSequence analysisAdd BLAST37
Transmembranei359 – 376HelicalSequence analysisAdd BLAST18
Topological domaini377 – 920CytoplasmicSequence analysisAdd BLAST544
Transmembranei921 – 940HelicalSequence analysisAdd BLAST20
Topological domaini941 – 954ExtracellularSequence analysisAdd BLAST14
Transmembranei955 – 974HelicalSequence analysisAdd BLAST20
Topological domaini975 – 1004CytoplasmicSequence analysisAdd BLAST30
Transmembranei1005 – 1027HelicalSequence analysisAdd BLAST23
Topological domaini1028 – 1040ExtracellularSequence analysisAdd BLAST13
Transmembranei1041 – 1063HelicalSequence analysisAdd BLAST23
Topological domaini1064 – 1069CytoplasmicSequence analysis6
Transmembranei1070 – 1090HelicalSequence analysisAdd BLAST21
Topological domaini1091 – 1107ExtracellularSequence analysisAdd BLAST17
Transmembranei1108 – 1132HelicalSequence analysisAdd BLAST25
Topological domaini1133 – 1189CytoplasmicSequence analysisAdd BLAST57

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000463921 – 1189Probable phospholipid-transporting ATPase 8Add BLAST1189

Proteomic databases

PaxDbiQ9LK90.
PRIDEiQ9LK90.

PTM databases

iPTMnetiQ9LK90.

Expressioni

Gene expression databases

GenevisibleiQ9LK90. AT.

Interactioni

Protein-protein interaction databases

STRINGi3702.AT3G27870.1.

Structurei

3D structure databases

ProteinModelPortaliQ9LK90.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410ITKD. Eukaryota.
ENOG410XPYK. LUCA.
HOGENOMiHOG000202528.
InParanoidiQ9LK90.
KOiK01530.
OMAiFWDERIV.
OrthoDBiEOG0936012H.
PhylomeDBiQ9LK90.

Family and domain databases

Gene3Di2.70.150.10. 2 hits.
3.40.1110.10. 2 hits.
3.40.50.1000. 2 hits.
InterProiIPR023299. ATPase_P-typ_cyto_domN.
IPR018303. ATPase_P-typ_P_site.
IPR008250. ATPase_P-typ_transduc_dom_A.
IPR023214. HAD-like_dom.
IPR006539. P-type_ATPase_IV.
IPR032631. P-type_ATPase_N.
IPR001757. P_typ_ATPase.
IPR032630. P_typ_ATPase_c.
[Graphical view]
PANTHERiPTHR24092. PTHR24092. 1 hit.
PfamiPF00122. E1-E2_ATPase. 1 hit.
PF16212. PhoLip_ATPase_C. 1 hit.
PF16209. PhoLip_ATPase_N. 1 hit.
[Graphical view]
SUPFAMiSSF56784. SSF56784. 3 hits.
SSF81660. SSF81660. 1 hit.
TIGRFAMsiTIGR01652. ATPase-Plipid. 1 hit.
TIGR01494. ATPase_P-type. 2 hits.
PROSITEiPS00154. ATPASE_E1_E2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9LK90-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAGERRKGMK FSKLYSFKCF KPFSREDHSQ IGSRGYSRVV FCNDPDNPEA
60 70 80 90 100
LQLNYRGNYV STTKYTAANF IPKSLFEQFR RVANIYFLVV AFVSFSPLAP
110 120 130 140 150
YTAPSVLAPL LIVIGATMVK EGVEDLRRRK QDVEANNRKV EVLGKTGTFV
160 170 180 190 200
ETKWKNLRVG DLVKVHKDEY FPADLLLLSS SYEDGICYVE TMNLDGETNL
210 220 230 240 250
KLKHALEITS DEESIKNFRG MIKCEDPNEH LYSFVGTLYF EGKQYPLSPQ
260 270 280 290 300
QILLRDSKLK NTDYVYGVVV FTGHDTKVMQ NATDPPSKRS KIEKKMDQII
310 320 330 340 350
YILFSILIVI AFTGSVFFGI ATRRDMSDNG KLRRWYLRPD HTTVFYDPRR
360 370 380 390 400
AVAAAFFHFL TALMLYGYLI PISLYVSIEV VKVLQSIFIN QDQEMYHEET
410 420 430 440 450
DRPARARTSN LNEELGQVDT ILSDKTGTLT CNSMEFVKCS IAGTAYGRGM
460 470 480 490 500
TEVEVALRKQ KGLMTQEEVG DNESLSIKEQ KAVKGFNFWD ERIVDGQWIN
510 520 530 540 550
QPNAELIQKF FRVLAICHTA IPDVNSDTGE ITYEAESPDE AAFVIASREL
560 570 580 590 600
GFEFFSRSQT SISLHEIDHM TGEKVDRVYE LLHVLEFSSS RKRMSVIVRN
610 620 630 640 650
PENRLLLLSK GADSVMFKRL AKHGRQNERE TKEHIKKYAE AGLRTLVITY
660 670 680 690 700
REIDEDEYIV WEEEFLNAKT LVTEDRDALI DAAADKIEKD LILLGSTAVE
710 720 730 740 750
DKLQKGVPDC IEKLSQAGVK IWVLTGDKTE TAINIGYACS LLREGMKQIL
760 770 780 790 800
VTLDSSDIEA LEKQGDKEAV AKASFQSIKK QLREGMSQTA AVTDNSAKEN
810 820 830 840 850
SEMFGLVIDG KSLTYALDSK LEKEFLELAI RCNSVICCRS SPKQKALVTR
860 870 880 890 900
LVKNGTGRTT LAIGDGANDV GMLQEADIGV GISGAEGMQA VMASDFAIAQ
910 920 930 940 950
FRFLERLLLV HGHWCYRRIT LMICYFFYKN LAFGFTLFWY EAYASFSGKP
960 970 980 990 1000
AYNDWYMSCY NVFFTSLPVI ALGVFDQDVS ARLCLKYPLL YQEGVQNVLF
1010 1020 1030 1040 1050
SWERILGWML NGVISSMIIF FLTINTMATQ AFRKDGQVVD YSVLGVTMYS
1060 1070 1080 1090 1100
SVVWTVNCQM AISINYFTWI QHCFIWGSIG VWYLFLVIYG SLPPTFSTTA
1110 1120 1130 1140 1150
FQVFVETSAP SPIYWLVLFL VVFSALLPYF TYRAFQIKFR PMYHDIIVEQ
1160 1170 1180
RRTERTETAP NAVLGELPVQ VEFTLHHLRA NLSRRDSWN
Length:1,189
Mass (Da):135,309
Last modified:October 1, 2000 - v1
Checksum:iDCF951CF3FC55E83
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AP000371 Genomic DNA. Translation: BAB02533.1.
CP002686 Genomic DNA. Translation: AEE77374.1.
RefSeqiNP_189425.2. NM_113703.3.

Genome annotation databases

EnsemblPlantsiAT3G27870.1; AT3G27870.1; AT3G27870.
GeneIDi822407.
GrameneiAT3G27870.1; AT3G27870.1; AT3G27870.
KEGGiath:AT3G27870.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AP000371 Genomic DNA. Translation: BAB02533.1.
CP002686 Genomic DNA. Translation: AEE77374.1.
RefSeqiNP_189425.2. NM_113703.3.

3D structure databases

ProteinModelPortaliQ9LK90.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi3702.AT3G27870.1.

PTM databases

iPTMnetiQ9LK90.

Proteomic databases

PaxDbiQ9LK90.
PRIDEiQ9LK90.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblPlantsiAT3G27870.1; AT3G27870.1; AT3G27870.
GeneIDi822407.
GrameneiAT3G27870.1; AT3G27870.1; AT3G27870.
KEGGiath:AT3G27870.

Organism-specific databases

TAIRiAT3G27870.

Phylogenomic databases

eggNOGiENOG410ITKD. Eukaryota.
ENOG410XPYK. LUCA.
HOGENOMiHOG000202528.
InParanoidiQ9LK90.
KOiK01530.
OMAiFWDERIV.
OrthoDBiEOG0936012H.
PhylomeDBiQ9LK90.

Enzyme and pathway databases

BioCyciARA:AT3G27870-MONOMER.
ReactomeiR-ATH-6798695. Neutrophil degranulation.
R-ATH-936837. Ion transport by P-type ATPases.

Miscellaneous databases

PROiQ9LK90.

Gene expression databases

GenevisibleiQ9LK90. AT.

Family and domain databases

Gene3Di2.70.150.10. 2 hits.
3.40.1110.10. 2 hits.
3.40.50.1000. 2 hits.
InterProiIPR023299. ATPase_P-typ_cyto_domN.
IPR018303. ATPase_P-typ_P_site.
IPR008250. ATPase_P-typ_transduc_dom_A.
IPR023214. HAD-like_dom.
IPR006539. P-type_ATPase_IV.
IPR032631. P-type_ATPase_N.
IPR001757. P_typ_ATPase.
IPR032630. P_typ_ATPase_c.
[Graphical view]
PANTHERiPTHR24092. PTHR24092. 1 hit.
PfamiPF00122. E1-E2_ATPase. 1 hit.
PF16212. PhoLip_ATPase_C. 1 hit.
PF16209. PhoLip_ATPase_N. 1 hit.
[Graphical view]
SUPFAMiSSF56784. SSF56784. 3 hits.
SSF81660. SSF81660. 1 hit.
TIGRFAMsiTIGR01652. ATPase-Plipid. 1 hit.
TIGR01494. ATPase_P-type. 2 hits.
PROSITEiPS00154. ATPASE_E1_E2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiALA8_ARATH
AccessioniPrimary (citable) accession number: Q9LK90
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 11, 2001
Last sequence update: October 1, 2000
Last modified: November 30, 2016
This is version 128 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Arabidopsis thaliana
    Arabidopsis thaliana: entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.