Q9LK88 (NQR_ARATH) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
NADPH:quinone oxidoreductase
EC=1.6.5.2

Gene names

Name:	NQR
Ordered Locus Names:	At3g27890
ORF Names:	K16N12.13

Organism

Arabidopsis thaliana (Mouse-ear cress)

Taxonomic identifier

3702 [NCBI]

Taxonomic lineage

Eukaryota › Viridiplantae › Streptophyta › Embryophyta › Tracheophyta › Spermatophyta › Magnoliophyta › eudicotyledons › core eudicotyledons › rosids › malvids › Brassicales › Brassicaceae › Camelineae › Arabidopsis

Protein attributes

Sequence length	196 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	The enzyme apparently serves as a quinone reductase in connection with conjugation reactions of hydroquinones involved in detoxification pathways.
Catalytic activity	NAD(P)H + a quinone = NAD(P)+ + a hydroquinone. Ref.1
Cofactor	FMN. Ref.1
Subunit structure	Homotetramer. Ref.1
Sequence similarities	Belongs to the ssuE family.

Ontologies

Keywords
Ligand	FMN Flavoprotein NAD NADP
Molecular function	Oxidoreductase
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological process	defense response to bacterium Inferred from expression pattern. Source: TAIR response to salt stress Inferred from expression pattern. Source: TAIR
Cellular component	chloroplast stroma Inferred from direct assay. Source: TAIR cytosol Inferred from direct assay. Source: TAIR plasma membrane Inferred from direct assay. Source: TAIR
Molecular function	NAD(P)H dehydrogenase (quinone) activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 196	196	NADPH:quinone oxidoreductase		PRO_0000160601
Experimental info
	Sequence conflict	178	1	R → K in AAD37373. Ref.1

Sequences

	Sequence		Length	Mass (Da)
	Q9LK88 [UniParc]. Last modified October 1, 2000. Version 1. Checksum: FE74952BC1CB2C18	FASTA	196	21,556
	10 20 30 40 50 60 MEAVTAIKPL IRVAALSGSL RKTSFHTGLL RAAIDLTKES VPGLQIEYID ISPLPLINTD 70 80 90 100 110 120 LEVNGTYPPV VEAFRQKILE ADSILFASPE YNFSVSAPLK NALDWASRPP NVWADKPAAI 130 140 150 160 170 180 ISTGGGFGGG RSQYHLRQIG VFLDLHFINK PEFTLNAFQP PQKFDAEGNL VDEVTKERLK 190 QVLLSLQAFT LRLQGK

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Cloning and heterologous expression of NAD(P)H:quinone reductase of Arabidopsis thaliana, a functional homologue of animal DT-diaphorase." Sparla F., Tedeschi G., Pupillo P., Trost P. FEBS Lett. 463:382-386(1999) [PubMed: 10606758] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA], CATALYTIC ACTIVITY, COFACTOR, SUBUNIT.
[2]	"Structural analysis of Arabidopsis thaliana chromosome 3. II. Sequence features of the 4,251,695 bp regions covered by 90 P1, TAC and BAC clones." Kaneko T., Katoh T., Sato S., Nakamura Y., Asamizu E., Tabata S. DNA Res. 7:217-221(2000) [PubMed: 10907853] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: cv. Columbia.
[3]	The Arabidopsis Information Resource (TAIR) Submitted (APR-2011) to the EMBL/GenBank/DDBJ databases Cited for: GENOME REANNOTATION. Strain: cv. Columbia.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AF145234 mRNA. Translation: AAD37373.1. AP000371 Genomic DNA. Translation: BAB02535.1. CP002686 Genomic DNA. Translation: AEE77376.1.
IPI	IPI00522027.
RefSeq	NP_189427.1. NM_113705.3.
UniGene	At.5735.
3D structure databases
ProteinModelPortal	Q9LK88.
SMR	Q9LK88. Positions 11-186.
ModBase	Search...
Proteomic databases
PRIDE	Q9LK88.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblPlants	AT3G27890.1; AT3G27890.1; AT3G27890.
GeneID	822411.
GenomeReviews	Gene locus AT3G27890 in contig BA000014_GR.
KEGG	ath:AT3G27890.
NMPDR	fig|3702.1.peg.15079.
Organism-specific databases
TAIR	At3g27890.
Phylogenomic databases
GeneTree	EPGT00050000018665.
HOGENOM	HBG697130.
InParanoid	Q9LK88.
OMA	ASPEYNF.
PhylomeDB	Q9LK88.
ProtClustDB	CLSN2685191.
Gene expression databases
Genevestigator	Q9LK88.
GermOnline	AT3G27890. Arabidopsis thaliana.
Family and domain databases
InterPro	IPR005025. FMN_red. [Graphical view]
Pfam	PF03358. FMN_red. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

NQR_ARATH

Accession

Primary (citable) accession number: Q9LK88
Secondary accession number(s): Q9XFI5

Entry history

Integrated into UniProtKB/Swiss-Prot:	January 24, 2006
Last sequence update:	October 1, 2000
Last modified:	September 21, 2011
This is version 55 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Plant Protein Annotation Program