Reviewed, UniProtKB/Swiss-Prot Q9LK88 (NQR_ARATH)

Names and origin

Protein names

Recommended name:
    NADPH:quinone oxidoreductase
    EC=1.6.5.2

Gene names

Name:	NQR
Ordered Locus Names:	At3g27890
ORF Names:	K16N12.13

Organism

Arabidopsis thaliana (Mouse-ear cress) [Complete proteome]

Taxonomic identifier

3702 [NCBI]

Taxonomic lineage

Eukaryota › Viridiplantae › Streptophyta › Embryophyta › Tracheophyta › Spermatophyta › Magnoliophyta › eudicotyledons › core eudicotyledons › rosids › eurosids II › Brassicales › Brassicaceae › Arabidopsis

Protein attributes

Sequence length	196 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at protein level.

General annotation (Comments)

Function	The enzyme apparently serves as a quinone reductase in connection with conjugation reactions of hydroquinones involved in detoxification pathways.
Catalytic activity	NAD(P)H + a quinone = NAD(P)+ + a hydroquinone. Ref.1
Cofactor	FMN. Ref.1
Subunit structure	Homotetramer. Ref.1
Sequence similarities	Belongs to the ssuE family.

Ontologies

Keywords
Ligand	FMN Flavoprotein NAD NADP
Molecular function	Oxidoreductase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	defense response to bacterium Inferred from expression pattern. Source: TAIR oxidation reduction Inferred from electronic annotation. Source: UniProtKB-KW response to salt stress Inferred from expression pattern. Source: TAIR
Cellular component	chloroplast stroma Inferred from direct assay. Source: TAIR plasma membrane Inferred from direct assay. Source: TAIR
Molecular function	NAD(P)H dehydrogenase (quinone) activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 196	196	NADPH:quinone oxidoreductase		PRO_0000160601
Experimental info
	Sequence conflict	178	1	R → K in AAD37373. Ref.1

Sequences

	Sequence		Length	Mass (Da)
	Q9LK88-1 [UniParc]. Last modified October 1, 2000. Version 1. Checksum: FE74952BC1CB2C18	FASTA	196	21,556
	10 20 30 40 50 60 MEAVTAIKPL IRVAALSGSL RKTSFHTGLL RAAIDLTKES VPGLQIEYID ISPLPLINTD 70 80 90 100 110 120 LEVNGTYPPV VEAFRQKILE ADSILFASPE YNFSVSAPLK NALDWASRPP NVWADKPAAI 130 140 150 160 170 180 ISTGGGFGGG RSQYHLRQIG VFLDLHFINK PEFTLNAFQP PQKFDAEGNL VDEVTKERLK 190 QVLLSLQAFT LRLQGK

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Cloning and heterologous expression of NAD(P)H:quinone reductase of Arabidopsis thaliana, a functional homologue of animal DT-diaphorase." Sparla F., Tedeschi G., Pupillo P., Trost P. FEBS Lett. 463:382-386(1999) [PubMed: 10606758] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA], CATALYTIC ACTIVITY, COFACTOR, SUBUNIT.
[2]	"Structural analysis of Arabidopsis thaliana chromosome 3. II. Sequence features of the 4,251,695 bp regions covered by 90 P1, TAC and BAC clones." Kaneko T., Katoh T., Sato S., Nakamura Y., Asamizu E., Tabata S. DNA Res. 7:217-221(2000) [PubMed: 10907853] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: cv. Columbia.

Cross-references

Sequence databases
EMBLGenBankDDBJ	AF145234 mRNA. Translation: AAD37373.1. AP000371 Genomic DNA. Translation: BAB02535.1.
IPI	IPI00522027.
RefSeq	NP_189427.1.
UniGene	At.5735
3D structure databases
ModBase	Search...
Proteomic databases
PRIDE	Q9LK88.
Genome annotation databases
GeneID	822411.
GenomeReviews	Gene locus AT3G27890 in contig BA000014_GR.
KEGG	ath:AT3G27890.
NMPDR	fig|3702.1.peg.15079.
Organism-specific databases
TAIR	At3g27890.
Phylogenomic databases
OMA	Q9LK88. EVVDQST.
Enzyme and pathway databases
BRENDA	1.6.5.2. 302.
Gene expression databases
GermOnline	AT3G27890. Arabidopsis thaliana.
Family and domain databases
InterPro	IPR005025. FMN_red. [Graphical view]
Pfam	PF03358. FMN_red. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

NQR_ARATH

Accession

Primary (citable) accession number: Q9LK88
Secondary accession number(s): Q9XFI5

Entry history

Integrated into UniProtKB/Swiss-Prot:	January 24, 2006
Last sequence update:	October 1, 2000
Last modified:	June 16, 2009
This is version 39 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

PPAP (Plant Proteome Annotation Project)