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Protein

ABC transporter C family member 7

Gene

ABCC7

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Pump for glutathione S-conjugates.HMP:

Catalytic activityi

ATP + H2O + xenobiotic(In) = ADP + phosphate + xenobiotic(Out).

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi659 – 666ATP 1IEP:8
Nucleotide bindingi1275 – 1282ATP 2IEP:8

GO - Molecular functioni

GO - Biological processi

  • response to other organism Source: TAIR
  • transmembrane transport Source: GO_Central

Keywordsi

Molecular functionHydrolase
Biological processTransport
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciARA:AT3G13100-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
ABC transporter C family member 7 (EC:3.6.3.44)
Short name:
ABC transporter ABCC.7
Short name:
AtABCC7
Alternative name(s):
ATP-energized glutathione S-conjugate pump 7
Glutathione S-conjugate-transporting ATPase 7
Multidrug resistance-associated protein 7
Gene namesi
Name:ABCC7
Synonyms:MRP7
Ordered Locus Names:At3g13100
ORF Names:MJG19.5
OrganismiArabidopsis thaliana (Mouse-ear cress)
Taxonomic identifieri3702 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
Proteomesi
  • UP000006548 Componenti: Chromosome 3

Organism-specific databases

AraportiAT3G13100.
TAIRilocus:2090049. AT3G13100.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Chloroplast Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertion Graphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei21 – 41HelicalIEP:Add BLAST21
Transmembranei70 – 90HelicalIEP:Add BLAST21
Transmembranei102 – 122HelicalIEP:Add BLAST21
Transmembranei140 – 160HelicalIEP:Add BLAST21
Transmembranei165 – 185HelicalIEP:Add BLAST21
Transmembranei309 – 329HelicalIEP:Add BLAST21
Transmembranei343 – 360HelicalIEP:Add BLAST18
Transmembranei423 – 443HelicalIEP:Add BLAST21
Transmembranei448 – 468HelicalIEP:Add BLAST21
Transmembranei535 – 555HelicalIEP:Add BLAST21
Transmembranei915 – 935HelicalIEP:Add BLAST21
Transmembranei959 – 979HelicalIEP:Add BLAST21
Transmembranei1038 – 1055HelicalIEP:Add BLAST18
Transmembranei1059 – 1081HelicalIEP:Add BLAST23
Transmembranei1153 – 1173HelicalIEP:Add BLAST21
Transmembranei1177 – 1197HelicalIEP:Add BLAST21

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002260781 – 1493ABC transporter C family member 7Add BLAST1493

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei888PhosphoserineND:1

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiQ9LK62.
PRIDEiQ9LK62.

PTM databases

iPTMnetiQ9LK62.

Expressioni

Tissue specificityi

Ubiquitous.1 Publication

Inductioni

By salicylic acid (SA).1 Publication

Gene expression databases

ExpressionAtlasiQ9LK62. baseline and differential.
GenevisibleiQ9LK62. AT.

Interactioni

Protein-protein interaction databases

STRINGi3702.AT3G13100.1.

Structurei

3D structure databases

ProteinModelPortaliQ9LK62.
SMRiQ9LK62.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini309 – 590ABC transmembrane type-1 1IEP:Add BLAST282
Domaini624 – 847ABC transporter 1IEP:Add BLAST224
Domaini922 – 1204ABC transmembrane type-1 2IEP:Add BLAST283
Domaini1241 – 1475ABC transporter 2IEP:Add BLAST235

Sequence similaritiesi

Keywords - Domaini

Repeat, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG0054. Eukaryota.
COG1132. LUCA.
InParanoidiQ9LK62.
OMAiFLCYSCL.
OrthoDBiEOG0936009E.
PhylomeDBiQ9LK62.

Family and domain databases

Gene3Di1.20.1560.10. 2 hits.
InterProiView protein in InterPro
IPR003593. AAA+_ATPase.
IPR011527. ABC1_TM_dom.
IPR036640. ABC1_TM_sf.
IPR003439. ABC_transporter-like.
IPR017871. ABC_transporter_CS.
IPR027417. P-loop_NTPase.
PfamiView protein in Pfam
PF00664. ABC_membrane. 2 hits.
PF00005. ABC_tran. 2 hits.
SMARTiView protein in SMART
SM00382. AAA. 2 hits.
SUPFAMiSSF52540. SSF52540. 2 hits.
SSF90123. SSF90123. 2 hits.
PROSITEiView protein in PROSITE
PS50929. ABC_TM1F. 2 hits.
PS00211. ABC_TRANSPORTER_1. 1 hit.
PS50893. ABC_TRANSPORTER_2. 2 hits.

Sequencei

Sequence statusi: Complete.

Q9LK62-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKQSYAMDNP IVFFLLESNY FPMFSIFFNL LLLLVMFGSC VYKKRLGWEN
60 70 80 90 100
SDAFTNERFK DMSLTYNKLV VICCETLSAL NSVLLLLSCF NLHKNGWDRS
110 120 130 140 150
ELMILLDLLF TALSWGAISF YIRSQFTYSH DQKFPILLRV WWVLYFMFSC
160 170 180 190 200
YRLLVDIALY KKQELVSVHL LLSDVLAVSV GLFLCYSCLQ KQGQGERINL
210 220 230 240 250
LLEEPLLNGA ESSAATSVQL DKAEDDEVVT PFSNAGFLSH VSFSWMSPLI
260 270 280 290 300
VLGNEKIIDS EDVPQVDNSD RAEKLFWIFR SKLEWDDGER RITTYKLIKA
310 320 330 340 350
LFFSVWRDIL LSTLFAFVYT VSCYVAPYLM DTFVQYLNGQ RQYSNQGVVL
360 370 380 390 400
VTTFFVAKLV ECQARRNWYF RLQKAGIGMR SVLVSMIYEK GLTLPCYSKQ
410 420 430 440 450
GHTSGEIINL MTVDAERISA FSWYMHDPWI LVLQISLALL ILYRSLGLGS
460 470 480 490 500
IAAFAATFLV MLGNIPLAKL EEKFQGNLME SKDNRMKKTS EALLNMRILK
510 520 530 540 550
LQGWEMKFLH KILDLRGIEA GWLKKFVYNS AAISSVLWAA PSFVSATAFG
560 570 580 590 600
ACMLLKIPLE SGKIIAALAT FRILQTPIYK LPDTISMIVQ TKVSLDRIAT
610 620 630 640 650
FLCLDDLQQD GMERLPSGSS KMDVEVSNGA FSWDDSSPIP TLKDIRFKIP
660 670 680 690 700
HGMNIAICGT VGSGKSSLLS SILGEVPKIS GNLKVCGRKA YIAQSPWIQS
710 720 730 740 750
GKVEENILFG KPMQREWYQR VLEACSLNKD LEVFPFRDQT VIGERGINLS
760 770 780 790 800
GGQKQRIQIA RALYQDADIY LFDDPFSAVD AHTGSHLFKE VLLGLLRNKT
810 820 830 840 850
VIYVTHQLEF LPEADLILVM KDGRITQAGK YNEILESGTD FMELVGAHTD
860 870 880 890 900
ALAAVDSYEK GSASAQSTTS KESKVSNDEE KQEEDLPSPK GQLVQEEERE
910 920 930 940 950
KGKVGFTVYQ KYMKLAYGGA LVPIILVVQI LFQVLNIGSN YWMAWVTPVS
960 970 980 990 1000
KDVKPLVSGS TLILVYVFLA TASSFCILVR AMLSAMTGFK IATELFNQMH
1010 1020 1030 1040 1050
FRIFRASMSF FDATPIGRIL NRASTDQSAV DLRLPSQFSN LAIAAVNILG
1060 1070 1080 1090 1100
IIGVMGQVAW QVLIVFIPVI AACTWYRQYY ISAARELARL SGISRSPLVQ
1110 1120 1130 1140 1150
HFSETLSGIT TIRSFDQEPR FRTDIMRLND CYSRLRFHAI SAMEWLCFRL
1160 1170 1180 1190 1200
DLLSTVAFAL SLVILVSVPE GVINPSFAGL AVTYALNLNS LQATLIWTLC
1210 1220 1230 1240 1250
DLENKMISVE RMLQYIDIPS EPSLVIESTR PEKSWPCRGE ITICNLQVRY
1260 1270 1280 1290 1300
GPHLPMVLRG LTCTFRGGLK TGIVGRTGCG KSTLIQTLFR IVEPAAGEIR
1310 1320 1330 1340 1350
IDGINILTIG LHDLRSRLSI IPQEPTMFEG TVRSNLDPLE EYADDQIWEA
1360 1370 1380 1390 1400
LDKCQLGDEI RKKELKLDSP VSENGQNWSV GQRQLVCLGR VLLKRSKVLI
1410 1420 1430 1440 1450
LDEATASVDT ATDTLIQETL RQHFSGCTVI TIAHRISSVI DSDMVLLLDQ
1460 1470 1480 1490
GLIEEHDSPA RLLEDKSSSF SKLVAEYTAS SDSRFKRSSM KTN
Length:1,493
Mass (Da):167,805
Last modified:October 1, 2000 - v1
Checksum:iF8A781A6A26FF64C
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti32L → V in CAD45086 (PubMed:12430019).IKR:1
Sequence conflicti507K → N in CAD45086 (PubMed:12430019).IKR:1
Sequence conflicti950S → A in CAD45086 (PubMed:12430019).IKR:1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ507129 mRNA. Translation: CAD45086.1.
AP000375 Genomic DNA. Translation: BAB01401.1.
CP002686 Genomic DNA. Translation: AEE75296.1.
RefSeqiNP_187917.3. NM_112149.4.
UniGeneiAt.39492.

Genome annotation databases

EnsemblPlantsiAT3G13100.1; AT3G13100.1; AT3G13100.
GeneIDi820498.
GrameneiAT3G13100.1; AT3G13100.1; AT3G13100.
KEGGiath:AT3G13100.

Similar proteinsi

Entry informationi

Entry nameiAB7C_ARATH
AccessioniPrimary (citable) accession number: Q9LK62
Secondary accession number(s): Q8LGU0
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 7, 2006
Last sequence update: October 1, 2000
Last modified: October 25, 2017
This is version 122 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Arabidopsis thaliana
    Arabidopsis thaliana: entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families