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Q9LK62 (AB7C_ARATH) Reviewed, UniProtKB/Swiss-Prot

Last modified November 16, 2011. Version 78. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
ABC transporter C family member 7
Short name=ABC transporter ABCC.7
Short name=AtABCC7
EC=3.6.3.44
Alternative name(s):
ATP-energized glutathione S-conjugate pump 7
Glutathione S-conjugate-transporting ATPase 7
Multidrug resistance-associated protein 7
Gene names
Name:ABCC7
Synonyms:MRP7
Ordered Locus Names:At3g13100
ORF Names:MJG19.5
OrganismArabidopsis thaliana (Mouse-ear cress)
Taxonomic identifier3702 [NCBI]
Taxonomic lineageEukaryota › Viridiplantae › Streptophyta › Embryophyta › Tracheophyta › Spermatophyta › Magnoliophyta › eudicotyledons › core eudicotyledons › rosids › malvids › Brassicales › Brassicaceae › Camelineae › Arabidopsis

Protein attributes

Sequence length1493 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Pump for glutathione S-conjugates By similarity.

Catalytic activity

ATP + H2O + xenobiotic(In) = ADP + phosphate + xenobiotic(Out).

Subcellular location

Membrane; Multi-pass membrane protein Potential.

Tissue specificity

Ubiquitous. Ref.1

Induction

By salicylic acid (SA). Ref.1

Sequence similarities

Belongs to the ABC transporter superfamily. ABCC family. Conjugate transporter (TC 3.A.1.208) subfamily. [View classification]

Contains 2 ABC transmembrane type-1 domains.

Contains 2 ABC transporter domains.

Ontologies

Keywords
   Biological processTransport
   Cellular componentMembrane
   DomainRepeat
Transmembrane
Transmembrane helix
   LigandATP-binding
Nucleotide-binding
   Molecular functionHydrolase
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological processresponse to other organism

Inferred from expression pattern. Source: TAIR

   Cellular componentintegral to membrane

Inferred from electronic annotation. Source: UniProtKB-KW

vacuolar membrane

Inferred from direct assay. Source: TAIR

   Molecular functionATP binding

Inferred from electronic annotation. Source: UniProtKB-KW

xenobiotic-transporting ATPase activity

Inferred from electronic annotation. Source: EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 14931493ABC transporter C family member 7
PRO_0000226078

Regions

Transmembrane21 – 4121Helical; Potential
Transmembrane70 – 9021Helical; Potential
Transmembrane102 – 12221Helical; Potential
Transmembrane140 – 16021Helical; Potential
Transmembrane165 – 18521Helical; Potential
Transmembrane309 – 32921Helical; Potential
Transmembrane343 – 36018Helical; Potential
Transmembrane423 – 44321Helical; Potential
Transmembrane448 – 46821Helical; Potential
Transmembrane535 – 55521Helical; Potential
Transmembrane915 – 93521Helical; Potential
Transmembrane959 – 97921Helical; Potential
Transmembrane1038 – 105518Helical; Potential
Transmembrane1059 – 108123Helical; Potential
Transmembrane1153 – 117321Helical; Potential
Transmembrane1177 – 119721Helical; Potential
Domain309 – 590282ABC transmembrane type-1 1
Domain624 – 847224ABC transporter 1
Domain922 – 1204283ABC transmembrane type-1 2
Domain1241 – 1475235ABC transporter 2
Nucleotide binding659 – 6668ATP 1 Potential
Nucleotide binding1275 – 12828ATP 2 Potential

Experimental info

Sequence conflict321L → V in CAD45086. Ref.1
Sequence conflict5071K → N in CAD45086. Ref.1
Sequence conflict9501S → A in CAD45086. Ref.1

Sequences

Sequence LengthMass (Da)Tools
Q9LK62 [UniParc].

Last modified October 1, 2000. Version 1.
Checksum: F8A781A6A26FF64C

FASTA1,493167,805
        10         20         30         40         50         60 
MKQSYAMDNP IVFFLLESNY FPMFSIFFNL LLLLVMFGSC VYKKRLGWEN SDAFTNERFK 

        70         80         90        100        110        120 
DMSLTYNKLV VICCETLSAL NSVLLLLSCF NLHKNGWDRS ELMILLDLLF TALSWGAISF 

       130        140        150        160        170        180 
YIRSQFTYSH DQKFPILLRV WWVLYFMFSC YRLLVDIALY KKQELVSVHL LLSDVLAVSV 

       190        200        210        220        230        240 
GLFLCYSCLQ KQGQGERINL LLEEPLLNGA ESSAATSVQL DKAEDDEVVT PFSNAGFLSH 

       250        260        270        280        290        300 
VSFSWMSPLI VLGNEKIIDS EDVPQVDNSD RAEKLFWIFR SKLEWDDGER RITTYKLIKA 

       310        320        330        340        350        360 
LFFSVWRDIL LSTLFAFVYT VSCYVAPYLM DTFVQYLNGQ RQYSNQGVVL VTTFFVAKLV 

       370        380        390        400        410        420 
ECQARRNWYF RLQKAGIGMR SVLVSMIYEK GLTLPCYSKQ GHTSGEIINL MTVDAERISA 

       430        440        450        460        470        480 
FSWYMHDPWI LVLQISLALL ILYRSLGLGS IAAFAATFLV MLGNIPLAKL EEKFQGNLME 

       490        500        510        520        530        540 
SKDNRMKKTS EALLNMRILK LQGWEMKFLH KILDLRGIEA GWLKKFVYNS AAISSVLWAA 

       550        560        570        580        590        600 
PSFVSATAFG ACMLLKIPLE SGKIIAALAT FRILQTPIYK LPDTISMIVQ TKVSLDRIAT 

       610        620        630        640        650        660 
FLCLDDLQQD GMERLPSGSS KMDVEVSNGA FSWDDSSPIP TLKDIRFKIP HGMNIAICGT 

       670        680        690        700        710        720 
VGSGKSSLLS SILGEVPKIS GNLKVCGRKA YIAQSPWIQS GKVEENILFG KPMQREWYQR 

       730        740        750        760        770        780 
VLEACSLNKD LEVFPFRDQT VIGERGINLS GGQKQRIQIA RALYQDADIY LFDDPFSAVD 

       790        800        810        820        830        840 
AHTGSHLFKE VLLGLLRNKT VIYVTHQLEF LPEADLILVM KDGRITQAGK YNEILESGTD 

       850        860        870        880        890        900 
FMELVGAHTD ALAAVDSYEK GSASAQSTTS KESKVSNDEE KQEEDLPSPK GQLVQEEERE 

       910        920        930        940        950        960 
KGKVGFTVYQ KYMKLAYGGA LVPIILVVQI LFQVLNIGSN YWMAWVTPVS KDVKPLVSGS 

       970        980        990       1000       1010       1020 
TLILVYVFLA TASSFCILVR AMLSAMTGFK IATELFNQMH FRIFRASMSF FDATPIGRIL 

      1030       1040       1050       1060       1070       1080 
NRASTDQSAV DLRLPSQFSN LAIAAVNILG IIGVMGQVAW QVLIVFIPVI AACTWYRQYY 

      1090       1100       1110       1120       1130       1140 
ISAARELARL SGISRSPLVQ HFSETLSGIT TIRSFDQEPR FRTDIMRLND CYSRLRFHAI 

      1150       1160       1170       1180       1190       1200 
SAMEWLCFRL DLLSTVAFAL SLVILVSVPE GVINPSFAGL AVTYALNLNS LQATLIWTLC 

      1210       1220       1230       1240       1250       1260 
DLENKMISVE RMLQYIDIPS EPSLVIESTR PEKSWPCRGE ITICNLQVRY GPHLPMVLRG 

      1270       1280       1290       1300       1310       1320 
LTCTFRGGLK TGIVGRTGCG KSTLIQTLFR IVEPAAGEIR IDGINILTIG LHDLRSRLSI 

      1330       1340       1350       1360       1370       1380 
IPQEPTMFEG TVRSNLDPLE EYADDQIWEA LDKCQLGDEI RKKELKLDSP VSENGQNWSV 

      1390       1400       1410       1420       1430       1440 
GQRQLVCLGR VLLKRSKVLI LDEATASVDT ATDTLIQETL RQHFSGCTVI TIAHRISSVI 

      1450       1460       1470       1480       1490 
DSDMVLLLDQ GLIEEHDSPA RLLEDKSSSF SKLVAEYTAS SDSRFKRSSM KTN

« Hide

References

« Hide 'large scale' references
[1]"Family business: the multidrug-resistance related protein (MRP) ABC transporter genes in Arabidopsis thaliana."
Kolukisaoglu U.H., Bovet L., Klein M., Eggmann T., Geisler M., Wanke D., Martinoia E., Schulz B.
Planta 216:107-119(2002) [PubMed: 12430019] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY, INDUCTION.
[2]"Structural analysis of Arabidopsis thaliana chromosome 3. II. Sequence features of the 4,251,695 bp regions covered by 90 P1, TAC and BAC clones."
Kaneko T., Katoh T., Sato S., Nakamura Y., Asamizu E., Tabata S.
DNA Res. 7:217-221(2000) [PubMed: 10907853] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: cv. Columbia.
[3]The Arabidopsis Information Resource (TAIR)
Submitted (APR-2011) to the EMBL/GenBank/DDBJ databases
Cited for: GENOME REANNOTATION.
Strain: cv. Columbia.
[4]"The Arabidopsis thaliana ABC protein superfamily, a complete inventory."
Sanchez-Fernandez R., Davies T.G., Coleman J.O., Rea P.A.
J. Biol. Chem. 276:30231-30244(2001) [PubMed: 11346655] [Abstract]
Cited for: GENE FAMILY, NOMENCLATURE.
[5]"Multifunctionality of plant ABC transporters -- more than just detoxifiers."
Martinoia E., Klein M., Geisler M., Bovet L., Forestier C., Kolukisaoglu H.U., Mueller-Roeber B., Schulz B.
Planta 214:345-355(2002) [PubMed: 11855639] [Abstract]
Cited for: GENE FAMILY.
[6]"Plant ABC proteins - a unified nomenclature and updated inventory."
Verrier P.J., Bird D., Burla B., Dassa E., Forestier C., Geisler M., Klein M., Kolukisaoglu H.U., Lee Y., Martinoia E., Murphy A., Rea P.A., Samuels L., Schulz B., Spalding E.J., Yazaki K., Theodoulou F.L.
Trends Plant Sci. 13:151-159(2008) [PubMed: 18299247] [Abstract]
Cited for: GENE FAMILY, NOMENCLATURE.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		AJ507129 mRNA. Translation: CAD45086.1.
AP000375 Genomic DNA. Translation: BAB01401.1.
CP002686 Genomic DNA. Translation: AEE75296.1.
IPIIPI00540125.
RefSeqNP_187917.3. NM_112149.3.
UniGeneAt.39492.

3D structure databases

ProteinModelPortalQ9LK62.
SMRQ9LK62. Positions 297-849, 906-1477.
ModBaseSearch...

Proteomic databases

PRIDEQ9LK62.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblPlantsAT3G13100.1; AT3G13100.1; AT3G13100.
GeneID820498.
GenomeReviewsGene locus AT3G13100 in contig BA000014_GR.
KEGGath:AT3G13100.
NMPDRfig|3702.1.peg.13401.

Organism-specific databases

TAIRAt3g13100.

Phylogenomic databases

eggNOGKOG0054.
GeneTreeEPGT00070000028299.
HOGENOMHBG758042.
InParanoidQ9LK62.
OMAFRIFRAS.
PhylomeDBQ9LK62.
ProtClustDBCLSN2690900.

Gene expression databases

GenevestigatorQ9LK62.
GermOnlineAT3G13100. Arabidopsis thaliana.

Family and domain databases

InterProIPR003439. ABC_transporter-like.
IPR017871. ABC_transporter_CS.
IPR017940. ABC_transporter_type1.
IPR001140. ABC_transptr_TM_dom.
IPR011527. ABC_transptrTM_dom_typ1.
IPR003593. ATPase_AAA+_core.
[Graphical view]
PfamPF00664. ABC_membrane. 2 hits.
PF00005. ABC_tran. 2 hits.
[Graphical view]
SMARTSM00382. AAA. 2 hits.
[Graphical view]
SUPFAMSSF90123. ABC_TM_1. 2 hits.
PROSITEPS50929. ABC_TM1F. 2 hits.
PS00211. ABC_TRANSPORTER_1. 1 hit.
PS50893. ABC_TRANSPORTER_2. 2 hits.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameAB7C_ARATH
AccessionPrimary (citable) accession number: Q9LK62
Secondary accession number(s): Q8LGU0
Entry history
Integrated into UniProtKB/Swiss-Prot: March 7, 2006
Last sequence update: October 1, 2000
Last modified: November 16, 2011
This is version 78 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Relevant documents

Arabidopsis thaliana

Arabidopsis thaliana: entries and gene names

SIMILARITY comments

Index of protein domains and families

to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·Documents