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Protein

Cytochrome c1 1, heme protein, mitochondrial

Gene

CYC11

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

This is the heme-containing component of the cytochrome b-c1 complex, which accepts electrons from Rieske protein and transfers electrons to cytochrome c in the mitochondrial respiratory chain.By similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei103 – 1031Heme (covalent)PROSITE-ProRule annotation
Binding sitei106 – 1061Heme (covalent)PROSITE-ProRule annotation
Metal bindingi107 – 1071Iron (heme axial ligand)PROSITE-ProRule annotation
Metal bindingi226 – 2261Iron (heme axial ligand)PROSITE-ProRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Electron transport, Respiratory chain, Transport

Keywords - Ligandi

Heme, Iron, Metal-binding

Enzyme and pathway databases

BioCyciARA:AT3G27240-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Cytochrome c1 1, heme protein, mitochondrial
Alternative name(s):
Complex III subunit 4-1
Complex III subunit IV-1
Cytochrome b-c1 complex subunit 4-1
Ubiquinol-cytochrome-c reductase complex cytochrome c1 subunit 1
Short name:
Cytochrome c-1 1
Gene namesi
Name:CYC11
Ordered Locus Names:At3g27240
ORF Names:K17E12.6
OrganismiArabidopsis thaliana (Mouse-ear cress)
Taxonomic identifieri3702 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
Proteomesi
  • UP000006548 Componenti: Chromosome 3

Organism-specific databases

TAIRiAT3G27240.

Subcellular locationi

  • Mitochondrion inner membrane 1 Publication; Single-pass membrane protein 1 Publication; Intermembrane side 1 Publication

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei268 – 28821Helical; Note=Anchors to the membraneSequence analysisAdd
BLAST

GO - Cellular componenti

  • membrane Source: TAIR
  • mitochondrial respiratory chain complex III Source: TAIR
  • mitochondrion Source: TAIR
  • plasma membrane Source: TAIR
  • vacuolar membrane Source: TAIR
  • vacuole Source: TAIR
Complete GO annotation...

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transit peptidei1 – 6464MitochondrionSequence analysisAdd
BLAST
Chaini65 – 307243Cytochrome c1 1, heme protein, mitochondrialPRO_0000428672Add
BLAST

Post-translational modificationi

Binds 1 heme group per subunit.By similarity

Proteomic databases

PaxDbiQ9LK29.
PRIDEiQ9LK29.

Expressioni

Gene expression databases

GenevisibleiQ9LK29. AT.

Interactioni

Subunit structurei

The main subunits of complex b-c1 are: cytochrome b, cytochrome c1 and the Rieske protein. Associated to the mitochondrial respiratory chain complex III.1 Publication

Protein-protein interaction databases

IntActiQ9LK29. 3 interactions.
STRINGi3702.AT3G27240.1.

Structurei

3D structure databases

ProteinModelPortaliQ9LK29.
SMRiQ9LK29. Positions 71-301.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini90 – 246157Cytochrome cPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Belongs to the cytochrome c family.Curated
Contains 1 cytochrome c domain.PROSITE-ProRule annotation

Keywords - Domaini

Transit peptide, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3052. Eukaryota.
COG2857. LUCA.
HOGENOMiHOG000003867.
InParanoidiQ9LK29.
KOiK00413.
OMAiFPSEQIA.
PhylomeDBiQ9LK29.

Family and domain databases

Gene3Di1.10.760.10. 1 hit.
InterProiIPR009056. Cyt_c-like_dom.
IPR002326. Cyt_c1.
IPR021157. Cyt_c1_TM_anchor_C.
[Graphical view]
PANTHERiPTHR10266. PTHR10266. 1 hit.
PfamiPF02167. Cytochrom_C1. 1 hit.
[Graphical view]
PRINTSiPR00603. CYTOCHROMEC1.
SUPFAMiSSF46626. SSF46626. 1 hit.
SSF81496. SSF81496. 1 hit.
PROSITEiPS51007. CYTC. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9LK29-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVGGGVIQQI LRRKLHSQSL ATPVLSWFSS KKAHEDAGSS GVRALALLGA
60 70 80 90 100
GVTGLLSFST VASADEAEHG LESPEYPWPH DGILSSYDHA SIRRGHQVYQ
110 120 130 140 150
QVCASCHSMS LISYRDLVGV AYTEEEAKAM AAEIEVVDGP NDEGEMFTRP
160 170 180 190 200
GKLSDRFPQP YANESAARFA NGGAYPPDLS LITKARHNGP NYVFALLTGY
210 220 230 240 250
RDPPAGISIR EGLHYNPYFP GGAIAMPKML NDEAVEYEDG VPATEAQMGK
260 270 280 290 300
DIVSFLAWAA EPEMEERKLM GFKWIFLLSL ALLQAAYYRR LKWSVLKSRK

LVLDVVN
Length:307
Mass (Da):33,650
Last modified:October 1, 2000 - v1
Checksum:iD041537B37D84C03
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti53 – 531T → S in AAM65645 (Ref. 4) Curated
Sequence conflicti123 – 1231T → A in AAL51110 (PubMed:14593172).Curated
Sequence conflicti123 – 1231T → A in AAL06905 (PubMed:14593172).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AP000381 Genomic DNA. Translation: BAB02119.1.
CP002686 Genomic DNA. Translation: AEE77282.1.
AF458338 mRNA. Translation: AAL51110.1.
AY054246 mRNA. Translation: AAL06905.1.
AY088099 mRNA. Translation: AAM65645.1.
RefSeqiNP_189360.1. NM_113638.2.
UniGeneiAt.25451.

Genome annotation databases

EnsemblPlantsiAT3G27240.1; AT3G27240.1; AT3G27240.
GeneIDi822343.
GrameneiAT3G27240.1; AT3G27240.1; AT3G27240.
KEGGiath:AT3G27240.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AP000381 Genomic DNA. Translation: BAB02119.1.
CP002686 Genomic DNA. Translation: AEE77282.1.
AF458338 mRNA. Translation: AAL51110.1.
AY054246 mRNA. Translation: AAL06905.1.
AY088099 mRNA. Translation: AAM65645.1.
RefSeqiNP_189360.1. NM_113638.2.
UniGeneiAt.25451.

3D structure databases

ProteinModelPortaliQ9LK29.
SMRiQ9LK29. Positions 71-301.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ9LK29. 3 interactions.
STRINGi3702.AT3G27240.1.

Proteomic databases

PaxDbiQ9LK29.
PRIDEiQ9LK29.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblPlantsiAT3G27240.1; AT3G27240.1; AT3G27240.
GeneIDi822343.
GrameneiAT3G27240.1; AT3G27240.1; AT3G27240.
KEGGiath:AT3G27240.

Organism-specific databases

TAIRiAT3G27240.

Phylogenomic databases

eggNOGiKOG3052. Eukaryota.
COG2857. LUCA.
HOGENOMiHOG000003867.
InParanoidiQ9LK29.
KOiK00413.
OMAiFPSEQIA.
PhylomeDBiQ9LK29.

Enzyme and pathway databases

BioCyciARA:AT3G27240-MONOMER.

Miscellaneous databases

PROiQ9LK29.

Gene expression databases

GenevisibleiQ9LK29. AT.

Family and domain databases

Gene3Di1.10.760.10. 1 hit.
InterProiIPR009056. Cyt_c-like_dom.
IPR002326. Cyt_c1.
IPR021157. Cyt_c1_TM_anchor_C.
[Graphical view]
PANTHERiPTHR10266. PTHR10266. 1 hit.
PfamiPF02167. Cytochrom_C1. 1 hit.
[Graphical view]
PRINTSiPR00603. CYTOCHROMEC1.
SUPFAMiSSF46626. SSF46626. 1 hit.
SSF81496. SSF81496. 1 hit.
PROSITEiPS51007. CYTC. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Structural analysis of Arabidopsis thaliana chromosome 3. II. Sequence features of the 4,251,695 bp regions covered by 90 P1, TAC and BAC clones."
    Kaneko T., Katoh T., Sato S., Nakamura Y., Asamizu E., Tabata S.
    DNA Res. 7:217-221(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: cv. Columbia.
  2. The Arabidopsis Information Resource (TAIR)
    Submitted (APR-2011) to the EMBL/GenBank/DDBJ databases
    Cited for: GENOME REANNOTATION.
    Strain: cv. Columbia.
  3. "Empirical analysis of transcriptional activity in the Arabidopsis genome."
    Yamada K., Lim J., Dale J.M., Chen H., Shinn P., Palm C.J., Southwick A.M., Wu H.C., Kim C.J., Nguyen M., Pham P.K., Cheuk R.F., Karlin-Newmann G., Liu S.X., Lam B., Sakano H., Wu T., Yu G.
    , Miranda M., Quach H.L., Tripp M., Chang C.H., Lee J.M., Toriumi M.J., Chan M.M., Tang C.C., Onodera C.S., Deng J.M., Akiyama K., Ansari Y., Arakawa T., Banh J., Banno F., Bowser L., Brooks S.Y., Carninci P., Chao Q., Choy N., Enju A., Goldsmith A.D., Gurjal M., Hansen N.F., Hayashizaki Y., Johnson-Hopson C., Hsuan V.W., Iida K., Karnes M., Khan S., Koesema E., Ishida J., Jiang P.X., Jones T., Kawai J., Kamiya A., Meyers C., Nakajima M., Narusaka M., Seki M., Sakurai T., Satou M., Tamse R., Vaysberg M., Wallender E.K., Wong C., Yamamura Y., Yuan S., Shinozaki K., Davis R.W., Theologis A., Ecker J.R.
    Science 302:842-846(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: cv. Columbia.
  4. "Full-length cDNA from Arabidopsis thaliana."
    Brover V.V., Troukhan M.E., Alexandrov N.A., Lu Y.-P., Flavell R.B., Feldmann K.A.
    Submitted (MAR-2002) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  5. "New insights into the respiratory chain of plant mitochondria. Supercomplexes and a unique composition of complex II."
    Eubel H., Jansch L., Braun H.P.
    Plant Physiol. 133:274-286(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: REVIEW.
  6. "Resolving and identifying protein components of plant mitochondrial respiratory complexes using three dimensions of gel electrophoresis."
    Meyer E.H., Taylor N.L., Millar A.H.
    J. Proteome Res. 7:786-794(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: SUBCELLULAR LOCATION, SUBUNIT, IDENTIFICATION BY MASS SPECTROMETRY, REVIEW, NOMENCLATURE.

Entry informationi

Entry nameiCYC1A_ARATH
AccessioniPrimary (citable) accession number: Q9LK29
Secondary accession number(s): Q8LA08, Q940N2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 16, 2014
Last sequence update: October 1, 2000
Last modified: February 17, 2016
This is version 91 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Arabidopsis thaliana
    Arabidopsis thaliana: entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.