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Q9LK23

- G6PD5_ARATH

UniProt

Q9LK23 - G6PD5_ARATH

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Protein
Glucose-6-phosphate 1-dehydrogenase, cytoplasmic isoform 1
Gene
ACG9, At3g27300, K17E12.12
Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at transcript leveli

Functioni

Catalyzes the rate-limiting step of the oxidative pentose-phosphate pathway, which represents a route for the dissimilation of carbohydrates besides glycolysis. The main function of this enzyme is to provide reducing power (NADPH) and pentose phosphates for fatty acid and nucleic acid synthesis which are involved in membrane synthesis and cell division.UniRule annotation

Catalytic activityi

D-glucose 6-phosphate + NADP+ = 6-phospho-D-glucono-1,5-lactone + NADPH.UniRule annotation

Enzyme regulationi

Regulated by metabolites.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei73 – 731NADP By similarity
Binding sitei183 – 1831NADP; via carbonyl oxygen By similarity
Binding sitei183 – 1831Substrate By similarity
Binding sitei251 – 2511Substrate By similarity
Binding sitei270 – 2701Substrate By similarity
Active sitei275 – 2751Proton acceptor By similarity
Binding sitei361 – 3611Substrate By similarity
Binding sitei397 – 3971Substrate By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi38 – 458NADP By similarity

GO - Molecular functioni

  1. NADP binding Source: InterPro
  2. glucose-6-phosphate dehydrogenase activity Source: TAIR

GO - Biological processi

  1. glucose metabolic process Source: TAIR
  2. pentose-phosphate shunt, oxidative branch Source: TAIR
  3. response to cadmium ion Source: TAIR
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Carbohydrate metabolism, Glucose metabolism

Keywords - Ligandi

NADP

Enzyme and pathway databases

BioCyciARA:GQT-1236-MONOMER.
ARA:GQT-1237-MONOMER.
UniPathwayiUPA00115; UER00408.

Names & Taxonomyi

Protein namesi
Recommended name:
Glucose-6-phosphate 1-dehydrogenase, cytoplasmic isoform 1 (EC:1.1.1.49)
Alternative name(s):
G6PDH5
Short name:
G6PD5
Gene namesi
Name:ACG9
Ordered Locus Names:At3g27300
ORF Names:K17E12.12
OrganismiArabidopsis thaliana (Mouse-ear cress)
Taxonomic identifieri3702 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
ProteomesiUP000006548: Chromosome 3

Organism-specific databases

TAIRiAT3G27300.

Subcellular locationi

Cytoplasm UniRule annotation

GO - Cellular componenti

  1. chloroplast Source: TAIR
  2. cytosol Source: TAIR
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 516516Glucose-6-phosphate 1-dehydrogenase, cytoplasmic isoform 1UniRule annotation
PRO_0000068097Add
BLAST

Proteomic databases

PaxDbiQ9LK23.
PRIDEiQ9LK23.

Expressioni

Gene expression databases

ArrayExpressiQ9LK23.
GenevestigatoriQ9LK23.

Interactioni

Subunit structurei

Homodimer By similarity.UniRule annotation

Structurei

3D structure databases

ProteinModelPortaliQ9LK23.
SMRiQ9LK23. Positions 24-506.

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni213 – 2175Substrate binding By similarity

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0364.
HOGENOMiHOG000046192.
InParanoidiQ9LK23.
KOiK00036.
OMAiVVVMYVA.
PhylomeDBiQ9LK23.

Family and domain databases

Gene3Di3.40.50.720. 1 hit.
HAMAPiMF_00966. G6PD.
InterProiIPR001282. G6P_DH.
IPR019796. G6P_DH_AS.
IPR022675. G6P_DH_C.
IPR022674. G6P_DH_NAD-bd.
IPR016040. NAD(P)-bd_dom.
[Graphical view]
PANTHERiPTHR23429. PTHR23429. 1 hit.
PfamiPF02781. G6PD_C. 1 hit.
PF00479. G6PD_N. 1 hit.
[Graphical view]
PIRSFiPIRSF000110. G6PD. 1 hit.
PRINTSiPR00079. G6PDHDRGNASE.
TIGRFAMsiTIGR00871. zwf. 1 hit.
PROSITEiPS00069. G6P_DEHYDROGENASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9LK23-1 [UniParc]FASTAAdd to Basket

« Hide

MGSGQWHMEK RSTLKNDSFV KEYNPVTETG SLSIIVLGAS GDLAKKKTFP    50
ALFNLFHQGF LNPDEVHIFG YARSKITDEE LRDKIRGYLV DEKNASKKTE 100
ALSKFLKLIK YVSGPYDSEE GFKRLDKAIL EHEISKKTAE GSSRRLFYLA 150
LPPSVYPPVS KMIKAWCTNK SDLGGWTRIV VEKPFGKDLE SAEQLSSQIG 200
ALFEEPQIYR IDHYLGKELV QNMLVLRFAN RLFLPLWNRD NIANVQIVFR 250
EDFGTEGRGG YFDEYGIIRD IIQNHLLQVL CLVAMEKPIS LKPEHIRDEK 300
VKVLQSVIPI KDEEVVLGQY EGYRDDPTVP NDSNTPTFAT TILRINNERW 350
EGVPFILKAG KAMSSKKADI RIQFKDVPGD IFKCQNQGRN EFVIRLQPSE 400
AMYMKLTVKQ PGLEMQTVQS ELDLSYKQRY QDVSIPEAYE RLILDTIRGD 450
QQHFVRRDEL KAAWEIFTPL LHRIDKGEVK SVPYKQGSRG PAEADQLLKK 500
AGYMQTHGYI WIPPTL 516
Length:516
Mass (Da):59,157
Last modified:October 1, 2000 - v1
Checksum:i407E42590EFC20E2
GO

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti26 – 261V → I in CAB52674. 1 Publication
Sequence conflicti376 – 3761D → G in AAL57688. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AJ010970 mRNA. Translation: CAB52674.1.
AP000381 Genomic DNA. Translation: BAB02125.1.
CP002686 Genomic DNA. Translation: AEE77290.1.
CP002686 Genomic DNA. Translation: AEE77291.1.
CP002686 Genomic DNA. Translation: AEE77292.1.
AY065054 mRNA. Translation: AAL57688.1.
PIRiT52611.
RefSeqiNP_001030780.1. NM_001035703.2.
NP_001078214.1. NM_001084745.1.
NP_189366.1. NM_113644.4.
UniGeneiAt.25212.

Genome annotation databases

EnsemblPlantsiAT3G27300.1; AT3G27300.1; AT3G27300.
AT3G27300.2; AT3G27300.2; AT3G27300.
AT3G27300.3; AT3G27300.3; AT3G27300.
GeneIDi822349.
KEGGiath:AT3G27300.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AJ010970 mRNA. Translation: CAB52674.1 .
AP000381 Genomic DNA. Translation: BAB02125.1 .
CP002686 Genomic DNA. Translation: AEE77290.1 .
CP002686 Genomic DNA. Translation: AEE77291.1 .
CP002686 Genomic DNA. Translation: AEE77292.1 .
AY065054 mRNA. Translation: AAL57688.1 .
PIRi T52611.
RefSeqi NP_001030780.1. NM_001035703.2.
NP_001078214.1. NM_001084745.1.
NP_189366.1. NM_113644.4.
UniGenei At.25212.

3D structure databases

ProteinModelPortali Q9LK23.
SMRi Q9LK23. Positions 24-506.
ModBasei Search...
MobiDBi Search...

Proteomic databases

PaxDbi Q9LK23.
PRIDEi Q9LK23.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblPlantsi AT3G27300.1 ; AT3G27300.1 ; AT3G27300 .
AT3G27300.2 ; AT3G27300.2 ; AT3G27300 .
AT3G27300.3 ; AT3G27300.3 ; AT3G27300 .
GeneIDi 822349.
KEGGi ath:AT3G27300.

Organism-specific databases

TAIRi AT3G27300.

Phylogenomic databases

eggNOGi COG0364.
HOGENOMi HOG000046192.
InParanoidi Q9LK23.
KOi K00036.
OMAi VVVMYVA.
PhylomeDBi Q9LK23.

Enzyme and pathway databases

UniPathwayi UPA00115 ; UER00408 .
BioCyci ARA:GQT-1236-MONOMER.
ARA:GQT-1237-MONOMER.

Gene expression databases

ArrayExpressi Q9LK23.
Genevestigatori Q9LK23.

Family and domain databases

Gene3Di 3.40.50.720. 1 hit.
HAMAPi MF_00966. G6PD.
InterProi IPR001282. G6P_DH.
IPR019796. G6P_DH_AS.
IPR022675. G6P_DH_C.
IPR022674. G6P_DH_NAD-bd.
IPR016040. NAD(P)-bd_dom.
[Graphical view ]
PANTHERi PTHR23429. PTHR23429. 1 hit.
Pfami PF02781. G6PD_C. 1 hit.
PF00479. G6PD_N. 1 hit.
[Graphical view ]
PIRSFi PIRSF000110. G6PD. 1 hit.
PRINTSi PR00079. G6PDHDRGNASE.
TIGRFAMsi TIGR00871. zwf. 1 hit.
PROSITEi PS00069. G6P_DEHYDROGENASE. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Evidence for functional convergence of redox regulation in G6PDH isoforms of cyanobacteria and higher plants."
    Wendt U.K., Hauschild R., Lange C., Pietersma M., Wenderoth I., von Schaewen A.
    Plant Mol. Biol. 40:487-494(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. "Structural analysis of Arabidopsis thaliana chromosome 3. II. Sequence features of the 4,251,695 bp regions covered by 90 P1, TAC and BAC clones."
    Kaneko T., Katoh T., Sato S., Nakamura Y., Asamizu E., Tabata S.
    DNA Res. 7:217-221(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: cv. Columbia.
  3. The Arabidopsis Information Resource (TAIR)
    Submitted (APR-2011) to the EMBL/GenBank/DDBJ databases
    Cited for: GENOME REANNOTATION.
    Strain: cv. Columbia.
  4. "Empirical analysis of transcriptional activity in the Arabidopsis genome."
    Yamada K., Lim J., Dale J.M., Chen H., Shinn P., Palm C.J., Southwick A.M., Wu H.C., Kim C.J., Nguyen M., Pham P.K., Cheuk R.F., Karlin-Newmann G., Liu S.X., Lam B., Sakano H., Wu T., Yu G.
    , Miranda M., Quach H.L., Tripp M., Chang C.H., Lee J.M., Toriumi M.J., Chan M.M., Tang C.C., Onodera C.S., Deng J.M., Akiyama K., Ansari Y., Arakawa T., Banh J., Banno F., Bowser L., Brooks S.Y., Carninci P., Chao Q., Choy N., Enju A., Goldsmith A.D., Gurjal M., Hansen N.F., Hayashizaki Y., Johnson-Hopson C., Hsuan V.W., Iida K., Karnes M., Khan S., Koesema E., Ishida J., Jiang P.X., Jones T., Kawai J., Kamiya A., Meyers C., Nakajima M., Narusaka M., Seki M., Sakurai T., Satou M., Tamse R., Vaysberg M., Wallender E.K., Wong C., Yamamura Y., Yuan S., Shinozaki K., Davis R.W., Theologis A., Ecker J.R.
    Science 302:842-846(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: cv. Columbia.

Entry informationi

Entry nameiG6PD5_ARATH
AccessioniPrimary (citable) accession number: Q9LK23
Secondary accession number(s): Q8VZD0, Q9SUK0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 25, 2002
Last sequence update: October 1, 2000
Last modified: May 14, 2014
This is version 107 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Miscellaneous

There are 6 glucose-6-phosphate 1-dehydrogenase genes in A.thaliana.

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Arabidopsis thaliana
    Arabidopsis thaliana: entries and gene names
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi