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Protein

ABC transporter B family member 19

Gene

ABCB19

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Auxin efflux transporter that acts as a negative regulator of light signaling to promote hypocotyl elongation. Mediates the accumulation of chlorophyll and anthocyanin, as well as the expression of genes in response to light. Participates in auxin efflux and thus regulates the polar auxin basipetal transport (from auxin-producing leaves to auxin-sensitive tissues, and from root tips to root elongating zone). Involved in divers auxin-mediated responses including gravitropism, phototropism and lateral root formation.3 Publications

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi400 – 407ATP 1PROSITE-ProRule annotation8
Nucleotide bindingi1045 – 1052ATP 2PROSITE-ProRule annotation8

GO - Molecular functioni

GO - Biological processi

  • acropetal auxin transport Source: TAIR
  • anthocyanin accumulation in tissues in response to UV light Source: TAIR
  • auxin-activated signaling pathway Source: UniProtKB-KW
  • auxin polar transport Source: TAIR
  • auxin transport Source: TAIR
  • basipetal auxin transport Source: TAIR
  • formation of plant organ boundary Source: TAIR
  • lateral root development Source: TAIR
  • photomorphogenesis Source: TAIR
  • positive gravitropism Source: TAIR
  • regulation of cell size Source: TAIR
  • response to auxin Source: TAIR
  • response to blue light Source: TAIR
  • response to far red light Source: TAIR
  • response to red or far red light Source: TAIR
  • root development Source: TAIR
  • stamen development Source: TAIR
Complete GO annotation...

Keywords - Biological processi

Auxin signaling pathway, Transport

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciARA:AT3G28860-MONOMER.

Protein family/group databases

TCDBi3.A.1.201.6. the atp-binding cassette (abc) superfamily.

Names & Taxonomyi

Protein namesi
Recommended name:
ABC transporter B family member 19
Short name:
ABC transporter ABCB.19
Short name:
AtABCB19
Alternative name(s):
Multidrug resistance protein 11
P-glycoprotein 19
Gene namesi
Name:ABCB19
Synonyms:MDR1, MDR11, PGP19
Ordered Locus Names:At3g28860
ORF Names:MLD15.2
OrganismiArabidopsis thaliana (Mouse-ear cress)
Taxonomic identifieri3702 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
Proteomesi
  • UP000006548 Componenti: Chromosome 3

Organism-specific databases

TAIRiAT3G28860.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei42 – 62HelicalPROSITE-ProRule annotationAdd BLAST21
Transmembranei88 – 108HelicalPROSITE-ProRule annotationAdd BLAST21
Transmembranei163 – 183HelicalPROSITE-ProRule annotationAdd BLAST21
Transmembranei187 – 207HelicalPROSITE-ProRule annotationAdd BLAST21
Transmembranei274 – 294HelicalPROSITE-ProRule annotationAdd BLAST21
Transmembranei308 – 328HelicalPROSITE-ProRule annotationAdd BLAST21
Transmembranei688 – 708HelicalPROSITE-ProRule annotationAdd BLAST21
Transmembranei732 – 752HelicalPROSITE-ProRule annotationAdd BLAST21
Transmembranei822 – 842HelicalPROSITE-ProRule annotationAdd BLAST21
Transmembranei914 – 934HelicalPROSITE-ProRule annotationAdd BLAST21
Transmembranei949 – 969HelicalPROSITE-ProRule annotationAdd BLAST21

GO - Cellular componenti

  • integral component of membrane Source: GO_Central
  • plasma membrane Source: TAIR
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002279221 – 1252ABC transporter B family member 19Add BLAST1252

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi5N-linked (GlcNAc...)Sequence analysis1
Glycosylationi641N-linked (GlcNAc...)Sequence analysis1
Glycosylationi758N-linked (GlcNAc...)Sequence analysis1
Glycosylationi785N-linked (GlcNAc...)Sequence analysis1
Glycosylationi814N-linked (GlcNAc...)Sequence analysis1

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiQ9LJX0.

PTM databases

iPTMnetiQ9LJX0.

Expressioni

Tissue specificityi

Ubiquitous, mostly in shoot meristems.1 Publication

Developmental stagei

In seedlings, confined to hypocotyls in darkness, but expressed in all tissues except in hypocotyls in light. In flowers, present in all organs except petals.1 Publication

Inductioni

By auxin (IAA). Induced by red light, but repressed by far-red light.2 Publications

Gene expression databases

GenevisibleiQ9LJX0. AT.

Interactioni

Subunit structurei

Interacts with 1-naphthylphthalamic acid (NPA), and FKBP42/TWD1.3 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
PIN1Q9C6B87EBI-371791,EBI-1541799

Protein-protein interaction databases

BioGridi7848. 3 interactors.
IntActiQ9LJX0. 3 interactors.
MINTiMINT-1701415.
STRINGi3702.AT3G28860.1.

Structurei

3D structure databases

ProteinModelPortaliQ9LJX0.
SMRiQ9LJX0.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini41 – 330ABC transmembrane type-1 1PROSITE-ProRule annotationAdd BLAST290
Domaini365 – 601ABC transporter 1PROSITE-ProRule annotationAdd BLAST237
Domaini687 – 975ABC transmembrane type-1 2PROSITE-ProRule annotationAdd BLAST289
Domaini1010 – 1246ABC transporter 2PROSITE-ProRule annotationAdd BLAST237

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni965 – 1252Interaction with FKBP42/TWD1Add BLAST288

Sequence similaritiesi

Contains 2 ABC transmembrane type-1 domains.PROSITE-ProRule annotation
Contains 2 ABC transporter domains.PROSITE-ProRule annotation

Keywords - Domaini

Repeat, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG0055. Eukaryota.
COG1132. LUCA.
InParanoidiQ9LJX0.
KOiK05658.
OMAiDIATHRI.
OrthoDBiEOG093600JM.
PhylomeDBiQ9LJX0.

Family and domain databases

Gene3Di3.40.50.300. 2 hits.
InterProiIPR003593. AAA+_ATPase.
IPR011527. ABC1_TM_dom.
IPR003439. ABC_transporter-like.
IPR017871. ABC_transporter_CS.
IPR027417. P-loop_NTPase.
[Graphical view]
PfamiPF00664. ABC_membrane. 2 hits.
PF00005. ABC_tran. 2 hits.
[Graphical view]
SMARTiSM00382. AAA. 2 hits.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 2 hits.
SSF90123. SSF90123. 2 hits.
PROSITEiPS50929. ABC_TM1F. 2 hits.
PS00211. ABC_TRANSPORTER_1. 2 hits.
PS50893. ABC_TRANSPORTER_2. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9LJX0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSETNTTDAK TVPAEAEKKK EQSLPFFKLF SFADKFDYLL MFVGSLGAIV
60 70 80 90 100
HGSSMPVFFL LFGQMVNGFG KNQMDLHQMV HEVSRYSLYF VYLGLVVCFS
110 120 130 140 150
SYAEIACWMY SGERQVAALR KKYLEAVLKQ DVGFFDTDAR TGDIVFSVST
160 170 180 190 200
DTLLVQDAIS EKVGNFIHYL STFLAGLVVG FVSAWKLALL SVAVIPGIAF
210 220 230 240 250
AGGLYAYTLT GITSKSRESY ANAGVIAEQA IAQVRTVYSY VGESKALNAY
260 270 280 290 300
SDAIQYTLKL GYKAGMAKGL GLGCTYGIAC MSWALVFWYA GVFIRNGQTD
310 320 330 340 350
GGKAFTAIFS AIVGGMSLGQ SFSNLGAFSK GKAAGYKLME IINQRPTIIQ
360 370 380 390 400
DPLDGKCLDQ VHGNIEFKDV TFSYPSRPDV MIFRNFNIFF PSGKTVAVVG
410 420 430 440 450
GSGSGKSTVV SLIERFYDPN SGQILLDGVE IKTLQLKFLR EQIGLVNQEP
460 470 480 490 500
ALFATTILEN ILYGKPDATM VEVEAAASAA NAHSFITLLP KGYDTQVGER
510 520 530 540 550
GVQLSGGQKQ RIAIARAMLK DPKILLLDEA TSALDASSES IVQEALDRVM
560 570 580 590 600
VGRTTVVVAH RLCTIRNVDS IAVIQQGQVV ETGTHEELIA KSGAYASLIR
610 620 630 640 650
FQEMVGTRDF SNPSTRRTRS TRLSHSLSTK SLSLRSGSLR NLSYSYSTGA
660 670 680 690 700
DGRIEMISNA ETDRKTRAPE NYFYRLLKLN SPEWPYSIMG AVGSILSGFI
710 720 730 740 750
GPTFAIVMSN MIEVFYYTDY DSMERKTKEY VFIYIGAGLY AVGAYLIQHY
760 770 780 790 800
FFSIMGENLT TRVRRMMLSA ILRNEVGWFD EDEHNSSLIA ARLATDAADV
810 820 830 840 850
KSAIAERISV ILQNMTSLLT SFIVAFIVEW RVSLLILGTF PLLVLANFAQ
860 870 880 890 900
QLSLKGFAGD TAKAHAKTSM IAGEGVSNIR TVAAFNAQSK ILSLFCHELR
910 920 930 940 950
VPQKRSLYRS QTSGFLFGLS QLALYGSEAL ILWYGAHLVS KGVSTFSKVI
960 970 980 990 1000
KVFVVLVITA NSVAETVSLA PEIIRGGEAV GSVFSVLDRQ TRIDPDDADA
1010 1020 1030 1040 1050
DPVETIRGDI EFRHVDFAYP SRPDVMVFRD FNLRIRAGHS QALVGASGSG
1060 1070 1080 1090 1100
KSSVIAMIER FYDPLAGKVM IDGKDIRRLN LKSLRLKIGL VQQEPALFAA
1110 1120 1130 1140 1150
TIFDNIAYGK DGATESEVID AARAANAHGF ISGLPEGYKT PVGERGVQLS
1160 1170 1180 1190 1200
GGQKQRIAIA RAVLKNPTVL LLDEATSALD AESECVLQEA LERLMRGRTT
1210 1220 1230 1240 1250
VVVAHRLSTI RGVDCIGVIQ DGRIVEQGSH SELVSRPEGA YSRLLQLQTH

RI
Length:1,252
Mass (Da):136,788
Last modified:October 1, 2000 - v1
Checksum:i6EB8D5229FBFC7F3
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti1064P → L in AAN28720 (PubMed:11701880).Curated1
Sequence conflicti1222G → E in BAC41846 (PubMed:11910074).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF540384 mRNA. Translation: AAN28720.2.
AP000386 Genomic DNA. Translation: BAB02129.1.
CP002686 Genomic DNA. Translation: AEE77498.1.
AK117168 mRNA. Translation: BAC41846.1.
RefSeqiNP_189528.1. NM_113807.3.
UniGeneiAt.24939.

Genome annotation databases

EnsemblPlantsiAT3G28860.1; AT3G28860.1; AT3G28860.
GeneIDi822519.
GrameneiAT3G28860.1; AT3G28860.1; AT3G28860.
KEGGiath:AT3G28860.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF540384 mRNA. Translation: AAN28720.2.
AP000386 Genomic DNA. Translation: BAB02129.1.
CP002686 Genomic DNA. Translation: AEE77498.1.
AK117168 mRNA. Translation: BAC41846.1.
RefSeqiNP_189528.1. NM_113807.3.
UniGeneiAt.24939.

3D structure databases

ProteinModelPortaliQ9LJX0.
SMRiQ9LJX0.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi7848. 3 interactors.
IntActiQ9LJX0. 3 interactors.
MINTiMINT-1701415.
STRINGi3702.AT3G28860.1.

Protein family/group databases

TCDBi3.A.1.201.6. the atp-binding cassette (abc) superfamily.

PTM databases

iPTMnetiQ9LJX0.

Proteomic databases

PaxDbiQ9LJX0.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblPlantsiAT3G28860.1; AT3G28860.1; AT3G28860.
GeneIDi822519.
GrameneiAT3G28860.1; AT3G28860.1; AT3G28860.
KEGGiath:AT3G28860.

Organism-specific databases

TAIRiAT3G28860.

Phylogenomic databases

eggNOGiKOG0055. Eukaryota.
COG1132. LUCA.
InParanoidiQ9LJX0.
KOiK05658.
OMAiDIATHRI.
OrthoDBiEOG093600JM.
PhylomeDBiQ9LJX0.

Enzyme and pathway databases

BioCyciARA:AT3G28860-MONOMER.

Miscellaneous databases

PROiQ9LJX0.

Gene expression databases

GenevisibleiQ9LJX0. AT.

Family and domain databases

Gene3Di3.40.50.300. 2 hits.
InterProiIPR003593. AAA+_ATPase.
IPR011527. ABC1_TM_dom.
IPR003439. ABC_transporter-like.
IPR017871. ABC_transporter_CS.
IPR027417. P-loop_NTPase.
[Graphical view]
PfamiPF00664. ABC_membrane. 2 hits.
PF00005. ABC_tran. 2 hits.
[Graphical view]
SMARTiSM00382. AAA. 2 hits.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 2 hits.
SSF90123. SSF90123. 2 hits.
PROSITEiPS50929. ABC_TM1F. 2 hits.
PS00211. ABC_TRANSPORTER_1. 2 hits.
PS50893. ABC_TRANSPORTER_2. 2 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiAB19B_ARATH
AccessioniPrimary (citable) accession number: Q9LJX0
Secondary accession number(s): Q8GZ77, Q8H6F5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 21, 2006
Last sequence update: October 1, 2000
Last modified: November 30, 2016
This is version 120 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Arabidopsis thaliana
    Arabidopsis thaliana: entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.