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Protein

Receptor-like protein kinase HAIKU2

Gene

IKU2

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Modulates the seed size by negatively regulating the cellularization of syncytial endosperm.2 Publications

Catalytic activityi

ATP + a protein = ADP + a phosphoprotein.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei699ATPPROSITE-ProRule annotation1
Active sitei814Proton acceptorPROSITE-ProRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi677 – 685ATPPROSITE-ProRule annotation9

GO - Molecular functioni

GO - Biological processi

  • endosperm development Source: TAIR

Keywordsi

Molecular functionKinase, Receptor, Serine/threonine-protein kinase, Transferase
LigandATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Receptor-like protein kinase HAIKU2 (EC:2.7.11.1)
Gene namesi
Name:IKU2
Ordered Locus Names:At3g19700
ORF Names:MMB12.19
OrganismiArabidopsis thaliana (Mouse-ear cress)
Taxonomic identifieri3702 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
Proteomesi
  • UP000006548 Componenti: Chromosome 3

Organism-specific databases

AraportiAT3G19700.
TAIRilocus:2091206. AT3G19700.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini20 – 616ExtracellularSequence analysisAdd BLAST597
Transmembranei617 – 637HelicalSequence analysisAdd BLAST21
Topological domaini638 – 991CytoplasmicSequence analysisAdd BLAST354

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi953R → K in iku2-3; reduced seed size and earlier endosperm cellularization. 1 Publication1

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 19Sequence analysisAdd BLAST19
ChainiPRO_000024027820 – 991Receptor-like protein kinase HAIKU2Add BLAST972

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi22N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi109N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi135N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi155N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi195N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi206N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi267N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi278N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi397N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi427N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi495N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi538N-linked (GlcNAc...) asparagineSequence analysis1
Modified residuei762PhosphotyrosineBy similarity1
Modified residuei801PhosphotyrosineBy similarity1
Modified residuei859PhosphotyrosineBy similarity1
Modified residuei866PhosphotyrosineBy similarity1
Modified residuei867PhosphothreonineBy similarity1

Keywords - PTMi

Glycoprotein, Phosphoprotein

Proteomic databases

PaxDbiQ9LJM4.
PRIDEiQ9LJM4.

Expressioni

Tissue specificityi

Expressed in the endosperm of fertilized ovules.1 Publication

Gene expression databases

GenevisibleiQ9LJM4. AT.

Interactioni

Protein-protein interaction databases

STRINGi3702.AT3G19700.1.

Structurei

3D structure databases

ProteinModelPortaliQ9LJM4.
SMRiQ9LJM4.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati66 – 90LRR 1Add BLAST25
Repeati99 – 123LRR 2Add BLAST25
Repeati125 – 148LRR 3Add BLAST24
Repeati150 – 170LRR 4Add BLAST21
Repeati171 – 196LRR 5Add BLAST26
Repeati197 – 220LRR 6Add BLAST24
Repeati221 – 244LRR 7Add BLAST24
Repeati246 – 267LRR 8Add BLAST22
Repeati269 – 291LRR 9Add BLAST23
Repeati292 – 314LRR 10Add BLAST23
Repeati315 – 339LRR 11Add BLAST25
Repeati341 – 363LRR 12Add BLAST23
Repeati365 – 387LRR 13Add BLAST23
Repeati388 – 411LRR 14Add BLAST24
Repeati413 – 435LRR 15Add BLAST23
Repeati436 – 459LRR 16Add BLAST24
Repeati461 – 482LRR 17Add BLAST22
Repeati483 – 508LRR 18Add BLAST26
Repeati510 – 531LRR 19Add BLAST22
Repeati532 – 554LRR 20Add BLAST23
Repeati555 – 578LRR 21Add BLAST24
Domaini671 – 970Protein kinasePROSITE-ProRule annotationAdd BLAST300

Sequence similaritiesi

Belongs to the protein kinase superfamily. Ser/Thr protein kinase family.PROSITE-ProRule annotation

Keywords - Domaini

Leucine-rich repeat, Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410JTJJ. Eukaryota.
COG4886. LUCA.
HOGENOMiHOG000116551.
InParanoidiQ9LJM4.
OMAiPFDSICD.
OrthoDBiEOG0936042K.
PhylomeDBiQ9LJM4.

Family and domain databases

Gene3Di3.80.10.10. 5 hits.
InterProiView protein in InterPro
IPR011009. Kinase-like_dom.
IPR032675. L_dom-like.
IPR001611. Leu-rich_rpt.
IPR003591. Leu-rich_rpt_typical-subtyp.
IPR013210. LRR_N_plant-typ.
IPR000719. Prot_kinase_dom.
IPR001245. Ser-Thr/Tyr_kinase_cat_dom.
IPR008271. Ser/Thr_kinase_AS.
PfamiView protein in Pfam
PF13855. LRR_8. 2 hits.
PF08263. LRRNT_2. 1 hit.
PF07714. Pkinase_Tyr. 1 hit.
SMARTiView protein in SMART
SM00369. LRR_TYP. 6 hits.
SM00220. S_TKc. 1 hit.
SUPFAMiSSF52058. SSF52058. 3 hits.
SSF56112. SSF56112. 1 hit.
PROSITEiView protein in PROSITE
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9LJM4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLRLLFIVRL LFLMPLASSR SNHSEEVENL LKLKSTFGET KSDDVFKTWT
60 70 80 90 100
HRNSACEFAG IVCNSDGNVV EINLGSRSLI NRDDDGRFTD LPFDSICDLK
110 120 130 140 150
LLEKLVLGNN SLRGQIGTNL GKCNRLRYLD LGINNFSGEF PAIDSLQLLE
160 170 180 190 200
FLSLNASGIS GIFPWSSLKD LKRLSFLSVG DNRFGSHPFP REILNLTALQ
210 220 230 240 250
WVYLSNSSIT GKIPEGIKNL VRLQNLELSD NQISGEIPKE IVQLKNLRQL
260 270 280 290 300
EIYSNDLTGK LPLGFRNLTN LRNFDASNNS LEGDLSELRF LKNLVSLGMF
310 320 330 340 350
ENRLTGEIPK EFGDFKSLAA LSLYRNQLTG KLPRRLGSWT AFKYIDVSEN
360 370 380 390 400
FLEGQIPPYM CKKGVMTHLL MLQNRFTGQF PESYAKCKTL IRLRVSNNSL
410 420 430 440 450
SGMIPSGIWG LPNLQFLDLA SNYFEGNLTG DIGNAKSLGS LDLSNNRFSG
460 470 480 490 500
SLPFQISGAN SLVSVNLRMN KFSGIVPESF GKLKELSSLI LDQNNLSGAI
510 520 530 540 550
PKSLGLCTSL VDLNFAGNSL SEEIPESLGS LKLLNSLNLS GNKLSGMIPV
560 570 580 590 600
GLSALKLSLL DLSNNQLTGS VPESLVSGSF EGNSGLCSSK IRYLRPCPLG
610 620 630 640 650
KPHSQGKRKH LSKVDMCFIV AAILALFFLF SYVIFKIRRD KLNKTVQKKN
660 670 680 690 700
DWQVSSFRLL NFNEMEIIDE IKSENIIGRG GQGNVYKVSL RSGETLAVKH
710 720 730 740 750
IWCPESSHES FRSSTAMLSD GNNRSNNGEF EAEVATLSNI KHINVVKLFC
760 770 780 790 800
SITCEDSKLL VYEYMPNGSL WEQLHERRGE QEIGWRVRQA LALGAAKGLE
810 820 830 840 850
YLHHGLDRPV IHRDVKSSNI LLDEEWRPRI ADFGLAKIIQ ADSVQRDFSA
860 870 880 890 900
PLVKGTLGYI APEYAYTTKV NEKSDVYSFG VVLMELVTGK KPLETDFGEN
910 920 930 940 950
NDIVMWVWSV SKETNREMMM KLIDTSIEDE YKEDALKVLT IALLCTDKSP
960 970 980 990
QARPFMKSVV SMLEKIEPSY NKNSGEASYG ESANDEITKV V
Length:991
Mass (Da):110,475
Last modified:October 1, 2000 - v1
Checksum:iDDA49AF2F2CFE8D6
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AP000417 Genomic DNA. Translation: BAB02557.1.
CP002686 Genomic DNA. Translation: AEE76277.1.
PIRiT52400.
RefSeqiNP_188604.1. NM_112860.1.
UniGeneiAt.22630.
At.25237.
At.53392.

Genome annotation databases

EnsemblPlantsiAT3G19700.1; AT3G19700.1; AT3G19700.
GeneIDi821507.
GrameneiAT3G19700.1; AT3G19700.1; AT3G19700.
KEGGiath:AT3G19700.

Similar proteinsi

Entry informationi

Entry nameiIKU2_ARATH
AccessioniPrimary (citable) accession number: Q9LJM4
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 13, 2006
Last sequence update: October 1, 2000
Last modified: June 7, 2017
This is version 125 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Arabidopsis thaliana
    Arabidopsis thaliana: entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families