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Q9LJH5

- GLO4_ARATH

UniProt

Q9LJH5 - GLO4_ARATH

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Protein
Peroxisomal (S)-2-hydroxy-acid oxidase GLO4
Gene
GLO4, At3g14130, MAG2.2
Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed - Annotation score: 4 out of 5 - Experimental evidence at transcript leveli

Functioni

Catalytic activityi

(S)-2-hydroxy acid + O2 = 2-oxo acid + H2O2.

Cofactori

FMN By similarity.

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei107 – 1071FMN By similarity
Binding sitei128 – 1281FMN By similarity
Binding sitei130 – 1301Substrate By similarity
Binding sitei156 – 1561FMN By similarity
Binding sitei165 – 1651Substrate By similarity
Binding sitei228 – 2281FMN By similarity
Active sitei252 – 2521Proton acceptor By similarity
Binding sitei255 – 2551Substrate Reviewed prediction

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi283 – 30725FMN By similarity
Add
BLAST

GO - Molecular functioni

  1. FMN binding Source: InterPro
  2. long-chain-(S)-2-hydroxy-long-chain-acid oxidase activity Source: UniProtKB-EC
  3. medium-chain-(S)-2-hydroxy-acid oxidase activity Source: UniProtKB-EC
  4. very-long-chain-(S)-2-hydroxy-acid oxidase activity Source: UniProtKB-EC

GO - Biological processi

  1. defense response to bacterium Source: TAIR
  2. hydrogen peroxide biosynthetic process Source: TAIR
  3. oxidative photosynthetic carbon pathway Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Glycolate pathway, Photorespiration

Keywords - Ligandi

Flavoprotein, FMN

Enzyme and pathway databases

BioCyciARA:AT3G14130-MONOMER.
UniPathwayiUPA00951; UER00912.

Names & Taxonomyi

Protein namesi
Recommended name:
Peroxisomal (S)-2-hydroxy-acid oxidase GLO4 (EC:1.1.3.15)
Alternative name(s):
Glycolate oxidase 4
Short name:
AtGLO4
Short name:
GOX 4
Short chain alpha-hydroxy acid oxidase GLO4
Gene namesi
Name:GLO4
Ordered Locus Names:At3g14130
ORF Names:MAG2.2
OrganismiArabidopsis thaliana (Mouse-ear cress)
Taxonomic identifieri3702 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
ProteomesiUP000006548: Chromosome 3

Organism-specific databases

TAIRiAT3G14130.

Subcellular locationi

Peroxisome By similarity

GO - Cellular componenti

  1. peroxisome Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Peroxisome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 363363Peroxisomal (S)-2-hydroxy-acid oxidase GLO4
PRO_0000403407Add
BLAST

Proteomic databases

PaxDbiQ9LJH5.
PRIDEiQ9LJH5.

Expressioni

Gene expression databases

GenevestigatoriQ9LJH5.

Interactioni

Subunit structurei

Homotetramer or homooctamer By similarity.

Protein-protein interaction databases

STRINGi3702.AT3G14130.1-P.

Structurei

3D structure databases

ProteinModelPortaliQ9LJH5.
SMRiQ9LJH5. Positions 3-355.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini1 – 357357FMN hydroxy acid dehydrogenase
Add
BLAST

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi361 – 3633Microbody targeting signal Reviewed prediction

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG1304.
HOGENOMiHOG000217463.
InParanoidiQ9LJH5.
KOiK11517.
OMAiESCWVIV.
PhylomeDBiQ9LJH5.

Family and domain databases

Gene3Di3.20.20.70. 1 hit.
InterProiIPR013785. Aldolase_TIM.
IPR012133. Alpha-hydoxy_acid_DH_FMN.
IPR000262. FMN-dep_DH.
IPR008259. FMN_hydac_DH_AS.
[Graphical view]
PfamiPF01070. FMN_dh. 1 hit.
[Graphical view]
PIRSFiPIRSF000138. Al-hdrx_acd_dh. 1 hit.
PROSITEiPS00557. FMN_HYDROXY_ACID_DH_1. 1 hit.
PS51349. FMN_HYDROXY_ACID_DH_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9LJH5-1 [UniParc]FASTAAdd to Basket

« Hide

MDQIVNVDEF QELAKQALPK MYYDFYNGGA EDQHTLNENV QAFRRIMFRP    50
RVLVDVSNID MSTSMLGYPI SAPIMIAPTA MHKLAHPKGE IATAKAAAAC 100
NTIMIVSFMS TCTIEEVASS CNAVRFLQIY VYKRRDVTAQ IVKRAEKAGF 150
KAIVLTVDVP RLGRREADIK NKMISPQLKN FEGLVSTEVR PNEGSGVEAF 200
ASSAFDASLS WKDIEWLRSI TKLPILVKGL LTREDALKAV EAGVDGIVVS 250
NHGARQLDYS PATITVLEEV VHAVKGRIPV LLDGGVRRGT DVFKALALGA 300
QAVLIGRPIV YGLAAKGEDG VKKVIDMLKN EFEITMALSG CPTIDDVTRN 350
HVRTENERIK SML 363
Length:363
Mass (Da):39,878
Last modified:October 1, 2000 - v1
Checksum:i19A62CDD8F9E1088
GO

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti65 – 651M → I in AAM61594. 1 Publication
Sequence conflicti107 – 1071S → P in AAM61594. 1 Publication
Sequence conflicti273 – 2731A → V in AAM61594. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AP000600 Genomic DNA. Translation: BAB02977.1.
CP002686 Genomic DNA. Translation: AEE75475.1.
BT002739 mRNA. Translation: AAO22568.1.
AY085037 mRNA. Translation: AAM61594.1.
RefSeqiNP_188029.1. NM_112269.3.
UniGeneiAt.39288.
At.42696.

Genome annotation databases

EnsemblPlantsiAT3G14130.1; AT3G14130.1; AT3G14130.
GeneIDi820630.
KEGGiath:AT3G14130.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AP000600 Genomic DNA. Translation: BAB02977.1 .
CP002686 Genomic DNA. Translation: AEE75475.1 .
BT002739 mRNA. Translation: AAO22568.1 .
AY085037 mRNA. Translation: AAM61594.1 .
RefSeqi NP_188029.1. NM_112269.3.
UniGenei At.39288.
At.42696.

3D structure databases

ProteinModelPortali Q9LJH5.
SMRi Q9LJH5. Positions 3-355.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 3702.AT3G14130.1-P.

Proteomic databases

PaxDbi Q9LJH5.
PRIDEi Q9LJH5.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblPlantsi AT3G14130.1 ; AT3G14130.1 ; AT3G14130 .
GeneIDi 820630.
KEGGi ath:AT3G14130.

Organism-specific databases

TAIRi AT3G14130.

Phylogenomic databases

eggNOGi COG1304.
HOGENOMi HOG000217463.
InParanoidi Q9LJH5.
KOi K11517.
OMAi ESCWVIV.
PhylomeDBi Q9LJH5.

Enzyme and pathway databases

UniPathwayi UPA00951 ; UER00912 .
BioCyci ARA:AT3G14130-MONOMER.

Miscellaneous databases

PROi Q9LJH5.

Gene expression databases

Genevestigatori Q9LJH5.

Family and domain databases

Gene3Di 3.20.20.70. 1 hit.
InterProi IPR013785. Aldolase_TIM.
IPR012133. Alpha-hydoxy_acid_DH_FMN.
IPR000262. FMN-dep_DH.
IPR008259. FMN_hydac_DH_AS.
[Graphical view ]
Pfami PF01070. FMN_dh. 1 hit.
[Graphical view ]
PIRSFi PIRSF000138. Al-hdrx_acd_dh. 1 hit.
PROSITEi PS00557. FMN_HYDROXY_ACID_DH_1. 1 hit.
PS51349. FMN_HYDROXY_ACID_DH_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Structural analysis of Arabidopsis thaliana chromosome 3. II. Sequence features of the 4,251,695 bp regions covered by 90 P1, TAC and BAC clones."
    Kaneko T., Katoh T., Sato S., Nakamura Y., Asamizu E., Tabata S.
    DNA Res. 7:217-221(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: cv. Columbia.
  2. The Arabidopsis Information Resource (TAIR)
    Submitted (APR-2011) to the EMBL/GenBank/DDBJ databases
    Cited for: GENOME REANNOTATION.
    Strain: cv. Columbia.
  3. "Empirical analysis of transcriptional activity in the Arabidopsis genome."
    Yamada K., Lim J., Dale J.M., Chen H., Shinn P., Palm C.J., Southwick A.M., Wu H.C., Kim C.J., Nguyen M., Pham P.K., Cheuk R.F., Karlin-Newmann G., Liu S.X., Lam B., Sakano H., Wu T., Yu G.
    , Miranda M., Quach H.L., Tripp M., Chang C.H., Lee J.M., Toriumi M.J., Chan M.M., Tang C.C., Onodera C.S., Deng J.M., Akiyama K., Ansari Y., Arakawa T., Banh J., Banno F., Bowser L., Brooks S.Y., Carninci P., Chao Q., Choy N., Enju A., Goldsmith A.D., Gurjal M., Hansen N.F., Hayashizaki Y., Johnson-Hopson C., Hsuan V.W., Iida K., Karnes M., Khan S., Koesema E., Ishida J., Jiang P.X., Jones T., Kawai J., Kamiya A., Meyers C., Nakajima M., Narusaka M., Seki M., Sakurai T., Satou M., Tamse R., Vaysberg M., Wallender E.K., Wong C., Yamamura Y., Yuan S., Shinozaki K., Davis R.W., Theologis A., Ecker J.R.
    Science 302:842-846(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: cv. Columbia.
  4. "Full-length cDNA from Arabidopsis thaliana."
    Brover V.V., Troukhan M.E., Alexandrov N.A., Lu Y.-P., Flavell R.B., Feldmann K.A.
    Submitted (MAR-2002) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  5. "Inducible antisense suppression of glycolate oxidase reveals its strong regulation over photosynthesis in rice."
    Xu H.-W., Zhang J., Zeng J., Jiang L., Liu E., Peng C., He Z.-H., Peng X.-X.
    J. Exp. Bot. 60:1799-1809(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: GENE FAMILY, NOMENCLATURE.

Entry informationi

Entry nameiGLO4_ARATH
AccessioniPrimary (citable) accession number: Q9LJH5
Secondary accession number(s): Q8LF60
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 11, 2011
Last sequence update: October 1, 2000
Last modified: May 14, 2014
This is version 95 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Arabidopsis thaliana
    Arabidopsis thaliana: entries and gene names
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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