Probable UDP-glucose 6-dehydrogenase 1 - Arabidopsis thaliana (Mouse-ear cress)

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Q9LIA8 (UGDH1_ARATH) Reviewed, UniProtKB/Swiss-Prot

Last modified January 25, 2012. Version 90. History...

Clusters with 100%, 90%, 50% identity |

Documents (3) |

Third-party data

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Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·Documents Customize order

Names and origin

Protein names

Recommended name:
Probable UDP-glucose 6-dehydrogenase 1
Short name=UDP-Glc dehydrogenase 1
Short name=UDP-GlcDH 1
Short name=UDPGDH 1
EC=1.1.1.22

Gene names

Name:	UGD1
Ordered Locus Names:	At3g29360
ORF Names:	MUO10_6, MUO10.18

Organism

Arabidopsis thaliana (Mouse-ear cress)

Taxonomic identifier

3702 [NCBI]

Taxonomic lineage

Eukaryota › Viridiplantae › Streptophyta › Embryophyta › Tracheophyta › Spermatophyta › Magnoliophyta › eudicotyledons › core eudicotyledons › rosids › malvids › Brassicales › Brassicaceae › Camelineae › Arabidopsis

Protein attributes

Sequence length	480 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Provides UDP-glucuronic acid for hemicellulose precursors By similarity.
Catalytic activity	UDP-glucose + 2 NAD⁺ + H₂O = UDP-glucuronate + 2 NADH.
Pathway	Nucleotide-sugar biosynthesis; UDP-alpha-D-glucuronate biosynthesis; UDP-alpha-D-glucuronate from UDP-alpha-D-glucose: step 1/1.
Post-translational modification	Phosphorylation level varies significantly during early response to general elicitors.
Sequence similarities	Belongs to the UDP-glucose/GDP-mannose dehydrogenase family.

Ontologies

Keywords
Ligand	NAD
Molecular function	Oxidoreductase
PTM	Phosphoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Cellular component	cytosol Inferred from direct assay. Source: TAIR nucleus Inferred from direct assay. Source: TAIR
Molecular function	NAD binding Inferred from electronic annotation. Source: InterPro UDP-glucose 6-dehydrogenase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Molecule processing

Chain

1 – 480

480

Probable UDP-glucose 6-dehydrogenase 1

PRO_0000312027

Regions

Nucleotide binding

8 – 13

NAD By similarity

Nucleotide binding

86 – 90

NAD By similarity

Nucleotide binding

127 – 128

NAD By similarity

Nucleotide binding

272 – 275

NAD By similarity

Region

157 – 161

Substrate binding By similarity

Region

216 – 223

Substrate binding By similarity

Region

256 – 269

Substrate binding By similarity

Region

334 – 335

Substrate binding By similarity

Sites

Active site

272

Nucleophile By similarity

Binding site

NAD By similarity

Binding site

NAD By similarity

Binding site

161

NAD By similarity

Binding site

342

NAD By similarity

Binding site

447

Substrate By similarity

Amino acid modifications

Modified residue

393

Phosphoserine Ref.8

Experimental info

Sequence conflict

V → I in AAL11570. Ref.3

Sequence conflict

178

G → R in AAL11570. Ref.3

Sequence conflict

193

N → D in AAM67208. Ref.4

Sequences

Sequence

Length

Mass (Da)

Tools

Q9LIA8 [UniParc].

Last modified October 1, 2000. Version 1.
Checksum: D6281D20442CBADF
Show »

FASTA

480

53,173

        10         20         30         40         50         60 
MVKICCIGAG YVGGPTMAVI ALKCPDVEVA VVDISVPRIN AWNSDTLPIY EPGLDDVVKQ 

        70         80         90        100        110        120 
CRGKNLFFST DVEKHVREAD IVFVSVNTPT KTRGLGAGKA ADLTYWESAA RMIADVSVSD 

       130        140        150        160        170        180 
KIVVEKSTVP VKTAEAIEKI LTHNSKGIKF QILSNPEFLA EGTAIKDLFN PDRVLIGGRE 

       190        200        210        220        230        240 
TPEGFKAVQT LKNVYAHWVP EGQIITTNLW SAELSKLAAN AFLAQRISSV NAMSALCEAT 

       250        260        270        280        290        300 
GADVTQVSYA VGTDSRIGPK FLNSSVGFGG SCFQKDILNL VYICECNGLP EVAEYWKQVI 

       310        320        330        340        350        360 
KINDYQKSRF VNRVVSSMFN SVSNKKIAVL GFAFKKDTGD TRETPAIDVC KGLLEDKARL 

       370        380        390        400        410        420 
SIYDPQVTED QIQRDLSMNK FDWDHPLHLQ PMSPTTVKQV TVTWDAYEAT KDAHGICIMT 

       430        440        450        460        470        480 
EWDEFKNLDF QKIFDNMQKP AFVFDGRNIM NLQKLREIGF IVYSIGKPLD DWLKDMPAVA

« Hide

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Structural analysis of Arabidopsis thaliana chromosome 3. II. Sequence features of the 4,251,695 bp regions covered by 90 P1, TAC and BAC clones." Kaneko T., Katoh T., Sato S., Nakamura Y., Asamizu E., Tabata S. DNA Res. 7:217-221(2000) [PubMed: 10907853] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: cv. Columbia.
[2]	The Arabidopsis Information Resource (TAIR) Submitted (APR-2011) to the EMBL/GenBank/DDBJ databases Cited for: GENOME REANNOTATION. Strain: cv. Columbia.
[3]	"Empirical analysis of transcriptional activity in the Arabidopsis genome." Yamada K., Lim J., Dale J.M., Chen H., Shinn P., Palm C.J., Southwick A.M., Wu H.C., Kim C.J., Nguyen M., Pham P.K., Cheuk R.F., Karlin-Newmann G., Liu S.X., Lam B., Sakano H., Wu T., Yu G. Ecker J.R. Science 302:842-846(2003) [PubMed: 14593172] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Strain: cv. Columbia.
[4]	"Full-length cDNA from Arabidopsis thaliana." Brover V.V., Troukhan M.E., Alexandrov N.A., Lu Y.-P., Flavell R.B., Feldmann K.A. Submitted (MAR-2002) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
[5]	"Arabidopsis ORF clones." Cheuk R.F., Chen H., Kim C.J., Shinn P., Ecker J.R. Submitted (MAR-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Strain: cv. Columbia.
[6]	"Large-scale analysis of RIKEN Arabidopsis full-length (RAFL) cDNAs." Totoki Y., Seki M., Ishida J., Nakajima M., Enju A., Kamiya A., Narusaka M., Shin-i T., Nakagawa M., Sakamoto N., Oishi K., Kohara Y., Kobayashi M., Toyoda A., Sakaki Y., Sakurai T., Iida K., Akiyama K. Shinozaki K. Submitted (JUL-2006) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Strain: cv. Columbia.
[7]	"Arabidopsis ORF Clone." Bautista V.R., Kim C.J., Chen H., Quinitio C., Ecker J.R. Submitted (OCT-2006) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Strain: cv. Columbia.
[8]	"Quantitative phosphoproteomics of early elicitor signaling in Arabidopsis." Benschop J.J., Mohammed S., O'Flaherty M., Heck A.J.R., Slijper M., Menke F.L.H. Mol. Cell. Proteomics 6:1198-1214(2007) [PubMed: 17317660] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-393, MASS SPECTROMETRY. Strain: cv. Columbia.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AP001309 Genomic DNA. Translation: BAB02581.1. CP002686 Genomic DNA. Translation: AEE77573.1. CP002686 Genomic DNA. Translation: AEE77574.1. AF424576 mRNA. Translation: AAL11570.1. AY088902 mRNA. Translation: AAM67208.1. BT021126 mRNA. Translation: AAX22261.1. AK226539 mRNA. Translation: BAE98678.1. BT029164 mRNA. Translation: ABJ17099.1.
IPI	IPI00545262.
RefSeq	NP_001030792.1. NM_001035715.1. NP_189582.1. NM_113861.3.
UniGene	At.22975.
3D structure databases
ProteinModelPortal	Q9LIA8.
SMR	Q9LIA8. Positions 3-467.
ModBase	Search...
Protein-protein interaction databases
IntAct	Q9LIA8. 1 interaction.
STRING	Q9LIA8.
Proteomic databases
PRIDE	Q9LIA8.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblPlants	AT3G29360.1; AT3G29360.1; AT3G29360. AT3G29360.2; AT3G29360.2; AT3G29360.
GeneID	822594.
GenomeReviews	Gene locus AT3G29360 in contig BA000014_GR.
KEGG	ath:AT3G29360.
NMPDR	fig\|3702.1.peg.15250.
Organism-specific databases
TAIR	At3g29360.
Phylogenomic databases
eggNOG	KOG2666.
GeneTree	EPGT00050000015498.
HOGENOM	HBG400967.
InParanoid	Q9LIA8.
OMA	QMCPEIR.
PhylomeDB	Q9LIA8.
ProtClustDB	PLN02353.
Gene expression databases
Genevestigator	Q9LIA8.
Family and domain databases
InterPro	IPR008927. 6-PGluconate_DH_C-like. IPR021157. Cyt_c1_TM_anchor_C. IPR016040. NAD(P)-bd_dom. IPR017476. Nucleotide_sugar_DH. IPR014027. UDP-Glc/GDP-Man_DH_C. IPR014026. UDP-Glc/GDP-Man_DH_dimer. IPR001732. UDP-Glc/GDP-Man_DH_N. [Graphical view]
Gene3D	G3DSA:1.20.5.100. Cyt_c1_TM_anchor_C. 1 hit. G3DSA:3.40.50.720. NAD(P)-bd. 2 hits.
KO	K00012.
Pfam	PF00984. UDPG_MGDP_dh. 1 hit. PF03720. UDPG_MGDP_dh_C. 1 hit. PF03721. UDPG_MGDP_dh_N. 1 hit. [Graphical view]
PIRSF	PIRSF000124. UDPglc_GDPman_dh. 1 hit.
SMART	SM00984. UDPG_MGDP_dh_C. 1 hit. [Graphical view]
SUPFAM	SSF48179. 6DGDH_C_like. 1 hit. SSF52413. UDP-Glc/GDP-Man_DH_C. 1 hit.
TIGRFAMs	TIGR03026. NDP-sugDHase. 1 hit.
ProtoNet	Search...

Entry information

Entry name

UGDH1_ARATH

Accession

Primary (citable) accession number: Q9LIA8
Secondary accession number(s): Q8L8N1, Q944R8

Entry history

Integrated into UniProtKB/Swiss-Prot:	December 4, 2007
Last sequence update:	October 1, 2000
Last modified:	January 25, 2012
This is version 90 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Plant Protein Annotation Program

Relevant documents

Arabidopsis thaliana

Arabidopsis thaliana: entries and gene names

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families

Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·Documents

Preferred order of sections

Names and origin

Protein attributes

General annotation (Comments)

Ontologies

Sequence annotation (Features)

Molecule processing

Regions

Sites

Amino acid modifications

Experimental info

Sequences

References

Cross-references

Sequence databases

3D structure databases

Protein-protein interaction databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Gene expression databases

Family and domain databases

Entry information

Relevant documents