Reviewed,
UniProtKB/Swiss-Prot Q9LIA8 (UGDH1_ARATH)
Last modified
February 9, 2010.
Version 74.
History...
Clusters with 100%,
90%,
50% identity |
Documents (3) |
Third-party data |
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Names and origin
| Protein names | Recommended name: Probable UDP-glucose 6-dehydrogenase 1 Short name=UDP-Glc dehydrogenase 1 Short name=UDP-GlcDH 1 Short name=UDPGDH 1 EC=1.1.1.22 | ||||||
| Gene names |
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| Organism | Arabidopsis thaliana (Mouse-ear cress) [Complete proteome] | ||||||
| Taxonomic identifier | 3702 [NCBI] | ||||||
| Taxonomic lineage | Eukaryota › Viridiplantae › Streptophyta › Embryophyta › Tracheophyta › Spermatophyta › Magnoliophyta › eudicotyledons › core eudicotyledons › rosids › malvids › Brassicales › Brassicaceae › Arabidopsis |
Protein attributes
| Sequence length | 480 AA. |
| Sequence status | Complete. |
| Protein existence | Evidence at protein level. |
General annotation (Comments)
| Function | Provides UDP-glucuronic acid for hemicellulose precursors By similarity. |
| Catalytic activity | UDP-glucose + 2 NAD+ + H2O = UDP-glucuronate + 2 NADH. |
| Pathway | |
| Post-translational modification | Phosphorylation level varies significantly during early response to general elicitors. |
| Sequence similarities | Belongs to the UDP-glucose/GDP-mannose dehydrogenase family. |
Ontologies
| Keywords | |
|---|---|
| Ligand | NAD |
| Molecular function | Oxidoreductase |
| PTM | Phosphoprotein |
| Technical term | Complete proteome |
| Gene Ontology (GO) | |
| Biological process | oxidation reduction Inferred from electronic annotation. Source: UniProtKB-KW |
| Cellular component | cytosol Inferred from direct assay. Source: TAIR nucleusInferred from direct assay. Source: TAIR |
| Molecular function | NAD or NADH binding Inferred from electronic annotation. Source: InterPro UDP-glucose 6-dehydrogenase activityInferred from electronic annotation. Source: EC |
| Complete GO annotation... | |
Sequence annotation (Features)
| Feature key | Position(s) | Length | Description | Graphical view | Feature identifier | ||||
Molecule processing | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Chain | 1 – 480 | 480 | Probable UDP-glucose 6-dehydrogenase 1 | PRO_0000312027 | |||||
Regions | |||||||||
| Nucleotide binding | 8 – 13 | 6 | NAD By similarity | ||||||
| Nucleotide binding | 86 – 90 | 5 | NAD By similarity | ||||||
| Nucleotide binding | 127 – 128 | 2 | NAD By similarity | ||||||
| Nucleotide binding | 272 – 275 | 4 | NAD By similarity | ||||||
| Region | 157 – 161 | 5 | Substrate binding By similarity | ||||||
| Region | 216 – 223 | 8 | Substrate binding By similarity | ||||||
| Region | 256 – 269 | 14 | Substrate binding By similarity | ||||||
| Region | 334 – 335 | 2 | Substrate binding By similarity | ||||||
Sites | |||||||||
| Active site | 272 | 1 | Nucleophile By similarity | ||||||
| Binding site | 33 | 1 | NAD By similarity | ||||||
| Binding site | 38 | 1 | NAD By similarity | ||||||
| Binding site | 161 | 1 | NAD By similarity | ||||||
| Binding site | 342 | 1 | NAD By similarity | ||||||
| Binding site | 447 | 1 | Substrate By similarity | ||||||
Amino acid modifications | |||||||||
| Modified residue | 393 | 1 | Phosphoserine Ref.7 | ||||||
Experimental info | |||||||||
| Sequence conflict | 12 | 1 | V → I in AAL11570. Ref.2 | ||||||
| Sequence conflict | 178 | 1 | G → R in AAL11570. Ref.2 | ||||||
| Sequence conflict | 193 | 1 | N → D in AAM67208. Ref.3 | ||||||
Sequences
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References
| [1] | "Structural analysis of Arabidopsis thaliana chromosome 3. II. Sequence features of the 4,251,695 bp regions covered by 90 P1, TAC and BAC clones." Kaneko T., Katoh T., Sato S., Nakamura Y., Asamizu E., Tabata S. DNA Res. 7:217-221(2000) [PubMed: 10907853] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: cv. Columbia. |
| [2] | "Empirical analysis of transcriptional activity in the Arabidopsis genome." Yamada K., Lim J., Dale J.M., Chen H., Shinn P., Palm C.J., Southwick A.M., Wu H.C., Kim C.J., Nguyen M., Pham P.K., Cheuk R.F., Karlin-Newmann G., Liu S.X., Lam B., Sakano H., Wu T., Yu G. Ecker J.R.Science 302:842-846(2003) [PubMed: 14593172] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Strain: cv. Columbia. |
| [3] | "Full-length cDNA from Arabidopsis thaliana." Brover V.V., Troukhan M.E., Alexandrov N.A., Lu Y.-P., Flavell R.B., Feldmann K.A. Submitted (MAR-2002) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. |
| [4] | "Arabidopsis ORF clones." Cheuk R.F., Chen H., Kim C.J., Shinn P., Ecker J.R. Submitted (MAR-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Strain: cv. Columbia. |
| [5] | "Large-scale analysis of RIKEN Arabidopsis full-length (RAFL) cDNAs." Totoki Y., Seki M., Ishida J., Nakajima M., Enju A., Kamiya A., Narusaka M., Shin-i T., Nakagawa M., Sakamoto N., Oishi K., Kohara Y., Kobayashi M., Toyoda A., Sakaki Y., Sakurai T., Iida K., Akiyama K. Shinozaki K.Submitted (JUL-2006) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Strain: cv. Columbia. |
| [6] | "Arabidopsis ORF Clone." Bautista V.R., Kim C.J., Chen H., Quinitio C., Ecker J.R. Submitted (OCT-2006) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Strain: cv. Columbia. |
| [7] | "Quantitative phosphoproteomics of early elicitor signaling in Arabidopsis." Benschop J.J., Mohammed S., O'Flaherty M., Heck A.J.R., Slijper M., Menke F.L.H. Mol. Cell. Proteomics 6:1198-1214(2007) [PubMed: 17317660] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-393, MASS SPECTROMETRY. |
| + | Additional computationally mapped references. |
Cross-references
Sequence databases | |
|---|---|
| EMBL GenBank DDBJ | AP001309 Genomic DNA. Translation: BAB02581.1. AF424576 mRNA. Translation: AAL11570.1. AY088902 mRNA. Translation: AAM67208.1. BT021126 mRNA. Translation: AAX22261.1. AK226539 mRNA. Translation: BAE98678.1. BT029164 mRNA. Translation: ABJ17099.1. |
| IPI | IPI00545262. |
| RefSeq | NP_001030792.1. NP_189582.1. |
| UniGene | At.22975 |
3D structure databases | |
| SMR | Q9LIA8. Positions 3-467. |
| ModBase | Search... |
Protein-protein interaction databases | |
| STRING | Q9LIA8. |
Proteomic databases | |
| PRIDE | Q9LIA8. |
Genome annotation databases | |
| GeneID | 822594. |
| GenomeReviews | Gene locus AT3G29360 in contig BA000014_GR. |
| KEGG | ath:AT3G29360. |
| NMPDR | fig|3702.1.peg.15250. |
Organism-specific databases | |
| TAIR | At3g29360. |
Phylogenomic databases | |
| eggNOG | KOG2666. |
| HOGENOM | HBG400967. |
| InParanoid | Q9LIA8. |
| OMA | VELNTWQ. |
| PhylomeDB | Q9LIA8. |
Enzyme and pathway databases | |
| BRENDA | 1.1.1.22. 302. |
Gene expression databases | |
| Genevestigator | Q9LIA8. |
Family and domain databases | |
| InterPro | IPR008927. 6-PGluconate_DH_C-like. IPR016040. NAD(P)-bd_dom. IPR017476. Nucleotide_sugar_DH. IPR014027. UDP-Glc/GDP-Man_DH_C. IPR014026. UDP-Glc/GDP-Man_DH_dimer. IPR014028. UDP-Glc/GDP-Man_DH_dimer-bd. IPR001732. UDP-Glc/GDP-Man_DH_N. [Graphical view] |
| Gene3D | G3DSA:3.40.50.720. NAD(P)-bd. 1 hit. G3DSA:3.40.50.1870. UDP-Glc/GDP-Man_DH_C. 1 hit. |
| PANTHER | PTHR11374. UDPG_MGDP_DH_Creg. 1 hit. |
| Pfam | PF00984. UDPG_MGDP_dh. 1 hit. PF03720. UDPG_MGDP_dh_C. 1 hit. PF03721. UDPG_MGDP_dh_N. 1 hit. [Graphical view] |
| TIGRFAMs | TIGR03026. NDP-sugDHase. 1 hit. |
| ProtoNet | Search... |
Entry information
| Entry name | UGDH1_ARATH | ||||||||
| Accession | Primary (citable) accession number: Q9LIA8 Secondary accession number(s): Q8L8N1, Q944R8 | ||||||||
| Entry history |
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| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation project | PPAP (Plant Proteome Annotation Project) | ||||||||
Relevant documents
| Arabidopsis thaliana Arabidopsis thaliana: entries and gene names |
| PATHWAY comments Index of metabolic and biosynthesis pathways |
| SIMILARITY comments Index of protein domains and families |

Clusters with


