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Protein

Phospholipid-transporting ATPase 10

Gene

ALA10

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Involved in transport of phospholipids.1 Publication

Catalytic activityi

ATP + H2O + phospholipid(Side 1) = ADP + phosphate + phospholipid(Side 2).1 Publication

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei430 – 43014-aspartylphosphate intermediateBy similarity
Metal bindingi865 – 8651MagnesiumBy similarity
Metal bindingi869 – 8691MagnesiumBy similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Ligandi

ATP-binding, Magnesium, Metal-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciARA:AT3G25610-MONOMER.
ReactomeiR-ATH-936837. Ion transport by P-type ATPases.

Names & Taxonomyi

Protein namesi
Recommended name:
Phospholipid-transporting ATPase 101 Publication (EC:3.6.3.11 Publication)
Short name:
AtALA101 Publication
Alternative name(s):
Aminophospholipid flippase 101 Publication
Gene namesi
Name:ALA101 Publication
Ordered Locus Names:At3g25610Imported
ORF Names:T5M7.5Imported
OrganismiArabidopsis thaliana (Mouse-ear cress)
Taxonomic identifieri3702 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
Proteomesi
  • UP000006548 Componenti: Chromosome 3

Organism-specific databases

TAIRiAT3G25610.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 7373CytoplasmicSequence analysisAdd
BLAST
Transmembranei74 – 9522HelicalSequence analysisAdd
BLAST
Topological domaini96 – 994ExtracellularSequence analysis
Transmembranei100 – 12223HelicalSequence analysisAdd
BLAST
Topological domaini123 – 305183CytoplasmicSequence analysisAdd
BLAST
Transmembranei306 – 32722HelicalSequence analysisAdd
BLAST
Topological domaini328 – 36437ExtracellularSequence analysisAdd
BLAST
Transmembranei365 – 38218HelicalSequence analysisAdd
BLAST
Topological domaini383 – 920538CytoplasmicSequence analysisAdd
BLAST
Transmembranei921 – 94020HelicalSequence analysisAdd
BLAST
Topological domaini941 – 95414ExtracellularSequence analysisAdd
BLAST
Transmembranei955 – 97420HelicalSequence analysisAdd
BLAST
Topological domaini975 – 100430CytoplasmicSequence analysisAdd
BLAST
Transmembranei1005 – 102723HelicalSequence analysisAdd
BLAST
Topological domaini1028 – 104013ExtracellularSequence analysisAdd
BLAST
Transmembranei1041 – 106323HelicalSequence analysisAdd
BLAST
Topological domaini1064 – 10696CytoplasmicSequence analysis
Transmembranei1070 – 109021HelicalSequence analysisAdd
BLAST
Topological domaini1091 – 110717ExtracellularSequence analysisAdd
BLAST
Transmembranei1108 – 113225HelicalSequence analysisAdd
BLAST
Topological domaini1133 – 120270CytoplasmicSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 12021202Phospholipid-transporting ATPase 10PRO_0000046394Add
BLAST

Proteomic databases

PaxDbiQ9LI83.
PRIDEiQ9LI83.

PTM databases

iPTMnetiQ9LI83.

Expressioni

Gene expression databases

GenevisibleiQ9LI83. AT.

Interactioni

Protein-protein interaction databases

BioGridi7479. 1 interaction.
STRINGi3702.AT3G25610.1.

Structurei

3D structure databases

ProteinModelPortaliQ9LI83.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410ITKD. Eukaryota.
ENOG410XPYK. LUCA.
HOGENOMiHOG000202528.
InParanoidiQ9LI83.
KOiK01530.
OMAiRIASMIC.
PhylomeDBiQ9LI83.

Family and domain databases

Gene3Di2.70.150.10. 2 hits.
3.40.1110.10. 2 hits.
3.40.50.1000. 2 hits.
InterProiIPR023299. ATPase_P-typ_cyto_domN.
IPR018303. ATPase_P-typ_P_site.
IPR008250. ATPase_P-typ_transduc_dom_A.
IPR023214. HAD-like_dom.
IPR006539. P-type_ATPase_IV.
IPR032631. P-type_ATPase_N.
IPR001757. P_typ_ATPase.
IPR032630. P_typ_ATPase_c.
[Graphical view]
PANTHERiPTHR24092. PTHR24092. 1 hit.
PfamiPF16212. PhoLip_ATPase_C. 1 hit.
PF16209. PhoLip_ATPase_N. 1 hit.
[Graphical view]
SUPFAMiSSF56784. SSF56784. 3 hits.
SSF81660. SSF81660. 1 hit.
TIGRFAMsiTIGR01652. ATPase-Plipid. 1 hit.
TIGR01494. ATPase_P-type. 1 hit.
PROSITEiPS00154. ATPASE_E1_E2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9LI83-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAGPSRRRRR LHLSKIYSYT CGKSSFQEDH SNIGGPGFSR VVYCNEPGSP
60 70 80 90 100
AAERRNYAGN YVRSTKYTVA SFFPKSLFEQ FRRVANFYFL VTGILSLTDL
110 120 130 140 150
SPYGAVSALL PLALVISATM VKEGIEDWRR KQQDIEVNNR KVKVHDGNGI
160 170 180 190 200
FRQEEWRNLR VGDIVRVEKD EFFPADLLLL SSSYEDSVCY VETMNLDGET
210 220 230 240 250
NLKVKQGLEA TSSLLNQDSD FKDFRGVVRC EDPNVNLYVF VGTLALEEER
260 270 280 290 300
FPLSIQQILL RDSKLRNTEY VYGAVVFTGH DTKVIQNSTD PPSKRSRIER
310 320 330 340 350
TMDKIIYLMF GLVFLMSFVG SIIFGVETRE DKVKNGRTER WYLKPDDADI
360 370 380 390 400
FFDPERAPMA AIYHFFTATM LYSYFIPISL YVSIEIVKVL QSIFINRDIH
410 420 430 440 450
MYYEETDKPA QARTSNLNEE LGMVDTILSD KTGTLTCNSM EFIKCSIAGK
460 470 480 490 500
AYGRGITEVE RAMAVRSGGS PLVNEDLDVV VDQSGPKVKG FNFEDERVMN
510 520 530 540 550
GNWVRQPEAA VLQKFFRLLA VCHTAIPETD EESGNVSYEA ESPDEAAFVV
560 570 580 590 600
AAREFGFEFF NRTQNGISFR ELDLVSGEKV ERVYRLLNVL EFNSTRKRMS
610 620 630 640 650
VIVRDDDGKL LLLSKGADNV MFERLAKNGR QFEAKTQEHV NQYADAGLRT
660 670 680 690 700
LVLAYREVDE NEYIEFNKSF NEAKASVSED REALIDEITD KMERDLILLG
710 720 730 740 750
ATAVEDKLQN GVPECIDKLA QAGIKIWVLT GDKMETAINI GFASSLLRQE
760 770 780 790 800
MKQIIINLET PQIKSLEKSG GKDEIELASR ESVVMQLQEG KALLAASGAS
810 820 830 840 850
SEAFALIIDG KSLTYALEDE IKKMFLDLAT SCASVICCRS SPKQKALVTR
860 870 880 890 900
LVKSGTGKTT LAIGDGANDV GMLQEADIGV GISGVEGMQA VMSSDIAIAQ
910 920 930 940 950
FRYLERLLLV HGHWCYSRIA SMICYFFYKN ITFGVTVFLY EAYTSFSGQP
960 970 980 990 1000
AYNDWFLSLF NVFFSSLPVI ALGVFDQDVS ARFCYKFPLL YQEGVQNILF
1010 1020 1030 1040 1050
SWKRIIGWMF NGFISALAIF FLCKESLKHQ LFDPDGKTAG REILGGTMYT
1060 1070 1080 1090 1100
CVVWVVNLQM ALSISYFTWV QHIVIWGSIA FWYIFLMIYG AMTPSFSTDA
1110 1120 1130 1140 1150
YMVFLEALAP APSYWLTTLF VMIFALIPYF VYKSVQMRFF PKYHQMIQWI
1160 1170 1180 1190 1200
RYEGHSNDPE FVEMVRQRSI RPTTVGYTAR RAASVRRSAR FHDQIYKDLV

GV
Length:1,202
Mass (Da):136,279
Last modified:October 1, 2000 - v1
Checksum:i5930D14DB7942547
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AP001313 Genomic DNA. Translation: BAB03080.1.
CP002686 Genomic DNA. Translation: AEE77042.1.
RefSeqiNP_189189.1. NM_113459.1.
UniGeneiAt.49391.

Genome annotation databases

EnsemblPlantsiAT3G25610.1; AT3G25610.1; AT3G25610.
GeneIDi822148.
GrameneiAT3G25610.1; AT3G25610.1; AT3G25610.
KEGGiath:AT3G25610.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AP001313 Genomic DNA. Translation: BAB03080.1.
CP002686 Genomic DNA. Translation: AEE77042.1.
RefSeqiNP_189189.1. NM_113459.1.
UniGeneiAt.49391.

3D structure databases

ProteinModelPortaliQ9LI83.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi7479. 1 interaction.
STRINGi3702.AT3G25610.1.

PTM databases

iPTMnetiQ9LI83.

Proteomic databases

PaxDbiQ9LI83.
PRIDEiQ9LI83.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblPlantsiAT3G25610.1; AT3G25610.1; AT3G25610.
GeneIDi822148.
GrameneiAT3G25610.1; AT3G25610.1; AT3G25610.
KEGGiath:AT3G25610.

Organism-specific databases

TAIRiAT3G25610.

Phylogenomic databases

eggNOGiENOG410ITKD. Eukaryota.
ENOG410XPYK. LUCA.
HOGENOMiHOG000202528.
InParanoidiQ9LI83.
KOiK01530.
OMAiRIASMIC.
PhylomeDBiQ9LI83.

Enzyme and pathway databases

BioCyciARA:AT3G25610-MONOMER.
ReactomeiR-ATH-936837. Ion transport by P-type ATPases.

Miscellaneous databases

PROiQ9LI83.

Gene expression databases

GenevisibleiQ9LI83. AT.

Family and domain databases

Gene3Di2.70.150.10. 2 hits.
3.40.1110.10. 2 hits.
3.40.50.1000. 2 hits.
InterProiIPR023299. ATPase_P-typ_cyto_domN.
IPR018303. ATPase_P-typ_P_site.
IPR008250. ATPase_P-typ_transduc_dom_A.
IPR023214. HAD-like_dom.
IPR006539. P-type_ATPase_IV.
IPR032631. P-type_ATPase_N.
IPR001757. P_typ_ATPase.
IPR032630. P_typ_ATPase_c.
[Graphical view]
PANTHERiPTHR24092. PTHR24092. 1 hit.
PfamiPF16212. PhoLip_ATPase_C. 1 hit.
PF16209. PhoLip_ATPase_N. 1 hit.
[Graphical view]
SUPFAMiSSF56784. SSF56784. 3 hits.
SSF81660. SSF81660. 1 hit.
TIGRFAMsiTIGR01652. ATPase-Plipid. 1 hit.
TIGR01494. ATPase_P-type. 1 hit.
PROSITEiPS00154. ATPASE_E1_E2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Structural analysis of Arabidopsis thaliana chromosome 3. II. Sequence features of the 4,251,695 bp regions covered by 90 P1, TAC and BAC clones."
    Kaneko T., Katoh T., Sato S., Nakamura Y., Asamizu E., Tabata S.
    DNA Res. 7:217-221(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: cv. Columbia.
  2. The Arabidopsis Information Resource (TAIR)
    Submitted (APR-2011) to the EMBL/GenBank/DDBJ databases
    Cited for: GENOME REANNOTATION.
    Strain: cv. Columbia.
  3. "Inventory of the superfamily of P-type ion pumps in Arabidopsis."
    Axelsen K.B., Palmgren M.G.
    Plant Physiol. 126:696-706(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: GENE FAMILY, NOMENCLATURE.
  4. "Phosphoproteomics of the Arabidopsis plasma membrane and a new phosphorylation site database."
    Nuehse T.S., Stensballe A., Jensen O.N., Peck S.C.
    Plant Cell 16:2394-2405(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: SUBCELLULAR LOCATION.

Entry informationi

Entry nameiALA10_ARATH
AccessioniPrimary (citable) accession number: Q9LI83
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 11, 2001
Last sequence update: October 1, 2000
Last modified: April 13, 2016
This is version 132 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Arabidopsis thaliana
    Arabidopsis thaliana: entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.