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Protein

6-phosphogluconate dehydrogenase, decarboxylating 1

Gene

G6PGH1

Organism
Oryza sativa subsp. japonica (Rice)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Catalyzes the oxidative decarboxylation of 6-phosphogluconate to ribulose 5-phosphate and CO2, with concomitant reduction of NADP to NADPH.By similarity

Catalytic activityi

6-phospho-D-gluconate + NADP+ = D-ribulose 5-phosphate + CO2 + NADPH.

Pathwayi: pentose phosphate pathway

This protein is involved in step 3 of the subpathway that synthesizes D-ribulose 5-phosphate from D-glucose 6-phosphate (oxidative stage).
Proteins known to be involved in the 3 steps of the subpathway in this organism are:
  1. Glucose-6-phosphate 1-dehydrogenase (Os03g0412800), Glucose-6-phosphate 1-dehydrogenase (OsJ_23916), Glucose-6-phosphate 1-dehydrogenase (P0613B07.138), Glucose-6-phosphate 1-dehydrogenase (Os02g0600400), Glucose-6-phosphate 1-dehydrogenase (pG6PDH), Glucose-6-phosphate 1-dehydrogenase (Os04g0485300), Glucose-6-phosphate 1-dehydrogenase (Os03g0318500), Glucose-6-phosphate 1-dehydrogenase (LOC_Os03g29950), Glucose-6-phosphate 1-dehydrogenase (g6pdh)
  2. Probable 6-phosphogluconolactonase 1 (Os03g0416500), Probable 6-phosphogluconolactonase 4, chloroplastic (Os09g0529100), Probable 6-phosphogluconolactonase 3, chloroplastic (Os08g0547100), Probable 6-phosphogluconolactonase 2 (Os07g0604000)
  3. 6-phosphogluconate dehydrogenase, decarboxylating 2, chloroplastic (G6PGH2), 6-phosphogluconate dehydrogenase, decarboxylating (P0029D06.14-2), 6-phosphogluconate dehydrogenase, decarboxylating (Os06g0111500), 6-phosphogluconate dehydrogenase, decarboxylating (OsJ_33909), 6-phosphogluconate dehydrogenase, decarboxylating 1 (G6PGH1)
This subpathway is part of the pathway pentose phosphate pathway, which is itself part of Carbohydrate degradation.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes D-ribulose 5-phosphate from D-glucose 6-phosphate (oxidative stage), the pathway pentose phosphate pathway and in Carbohydrate degradation.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei105NADPBy similarity1
Binding sitei105SubstrateBy similarity1
Active sitei186Proton acceptorBy similarity1
Active sitei193Proton donorBy similarity1
Binding sitei194SubstrateBy similarity1
Binding sitei264Substrate; via amide nitrogenBy similarity1
Binding sitei291SubstrateBy similarity1
Binding sitei450Substrate; shared with dimeric partnerBy similarity1
Binding sitei456Substrate; shared with dimeric partnerBy similarity1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi10 – 15NADPBy similarity6
Nucleotide bindingi33 – 35NADPBy similarity3
Nucleotide bindingi77 – 79NADPBy similarity3

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionOxidoreductase
Biological processGluconate utilization, Pentose shunt
LigandNADP

Enzyme and pathway databases

BRENDAi1.1.1.44. 4460.
ReactomeiR-OSA-71336. Pentose phosphate pathway (hexose monophosphate shunt).
UniPathwayiUPA00115; UER00410.

Names & Taxonomyi

Protein namesi
Recommended name:
6-phosphogluconate dehydrogenase, decarboxylating 1 (EC:1.1.1.44)
Short name:
OsG6PGH1
Gene namesi
Name:G6PGH1
Ordered Locus Names:Os06g0111500, LOC_Os06g02144
ORF Names:OsJ_19864, P0029D06.14-1
OrganismiOryza sativa subsp. japonica (Rice)
Taxonomic identifieri39947 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaLiliopsidaPoalesPoaceaeBOP cladeOryzoideaeOryzeaeOryzinaeOryzaOryza sativa
Proteomesi
  • UP000059680 Componenti: Chromosome 6

Subcellular locationi

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00004211011 – 4806-phosphogluconate dehydrogenase, decarboxylating 1Add BLAST480

Proteomic databases

PaxDbiQ9LI00.
PRIDEiQ9LI00.

Expressioni

Tissue specificityi

Highly expressed in inflorescence, lowly expressed in root and embryos and almost absent in leaves.1 Publication

Inductioni

By drought, cold, high salinity and abscisic acid (ABA) treatments.2 Publications

Gene expression databases

ExpressionAtlasiQ9LI00. baseline and differential.
GenevisibleiQ9LI00. OS.

Interactioni

Subunit structurei

Homodimer.By similarity

Protein-protein interaction databases

STRINGi39947.LOC_Os06g02144.1.

Structurei

3D structure databases

ProteinModelPortaliQ9LI00.
SMRiQ9LI00.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni131 – 133Substrate bindingBy similarity3
Regioni189 – 190Substrate bindingBy similarity2

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG2653. Eukaryota.
COG0362. LUCA.
HOGENOMiHOG000255147.
InParanoidiQ9LI00.
KOiK00033.
OMAiNSHYPDS.
OrthoDBiEOG09360AB8.

Family and domain databases

Gene3Di1.10.1040.10. 1 hit.
InterProiView protein in InterPro
IPR008927. 6-PGluconate_DH_C-like.
IPR013328. 6PGD_dom_2.
IPR006114. 6PGDH_C.
IPR006113. 6PGDH_Gnd/GntZ.
IPR006115. 6PGDH_NADP-bd.
IPR016040. NAD(P)-bd_dom.
IPR006183. Pgluconate_DH.
PfamiView protein in Pfam
PF00393. 6PGD. 1 hit.
PF03446. NAD_binding_2. 1 hit.
PIRSFiPIRSF000109. 6PGD. 1 hit.
PRINTSiPR00076. 6PGDHDRGNASE.
SMARTiView protein in SMART
SM01350. 6PGD. 1 hit.
SUPFAMiSSF48179. SSF48179. 1 hit.
SSF51735. SSF51735. 1 hit.
TIGRFAMsiTIGR00873. gnd. 1 hit.

Sequencei

Sequence statusi: Complete.

Q9LI00-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAVTRIGLAG LAVMGQNLAL NIAEKGFPIS VYNRTTSKVD ETVQRAKVEG
60 70 80 90 100
NLPVYGFHDP ASFVNSIQKP RVVIMLVKAG APVDQTIATL AAHLEQGDCI
110 120 130 140 150
IDGGNEWYEN TERREKAMEE RGLLYLGMGV SGGEEGARNG PSLMPGGSFE
160 170 180 190 200
AYKYIEDILL KVAAQVPDSG PCVTYIGKGG SGNFVKMVHN GIEYGDMQLI
210 220 230 240 250
SEAYDVLKSV GKLTNSELQQ VFSEWNKGEL LSFLIEITAD IFSIKDDQGS
260 270 280 290 300
GHLVDKVLDK TGMKGTGKWT VQQAAELSVA APTIEASLDS RFLSGLKDER
310 320 330 340 350
VEAAKVFQGD FSSNLPVDKA QLIEDVRQAL YASKICSYAQ GMNIIKAKSM
360 370 380 390 400
EKGWSLNLGE LARIWKGGCI IRAIFLDRIK KAYDRNSDLA NLLVDPEFAQ
410 420 430 440 450
EIMDRQAAWR RVVCLAINNG VSTPGMSASL AYFDSYRRDR LPANLVQAQR
460 470 480
DYFGAHTYER VDMPGSFHTE WFKIARAAKM
Length:480
Mass (Da):52,721
Last modified:October 1, 2000 - v1
Checksum:iA39AC9C0D9625355
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF486280 mRNA. Translation: AAL92029.1.
AP001552 Genomic DNA. Translation: BAA93024.1.
AP008212 Genomic DNA. Translation: BAF18500.1.
AP014962 Genomic DNA. Translation: BAS95792.1.
CM000143 Genomic DNA. Translation: EAZ35578.1.
AK065920 mRNA. Translation: BAG89736.1.
RefSeqiXP_015642949.1. XM_015787463.1.
XP_015642950.1. XM_015787464.1.
UniGeneiOs.7894.

Genome annotation databases

EnsemblPlantsiOS06T0111500-01; OS06T0111500-01; OS06G0111500.
GeneIDi4339892.
GrameneiOS06T0111500-01; OS06T0111500-01; OS06G0111500.
KEGGiosa:4339892.

Similar proteinsi

Entry informationi

Entry namei6PGD1_ORYSJ
AccessioniPrimary (citable) accession number: Q9LI00
Secondary accession number(s): A0A0P0WRR6, Q7FRX8
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 6, 2013
Last sequence update: October 1, 2000
Last modified: August 30, 2017
This is version 116 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. Oryza sativa (rice)
    Index of Oryza sativa entries and their corresponding gene designations
  3. SIMILARITY comments
    Index of protein domains and families