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Protein

Probable protein phosphatase 2C 38

Gene

PP2C38

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Involved in pathogen-associated molecular pattern (PAMP)-triggered immunity (PTI) signaling. Negatively regulates immune responses by controlling the phosphorylation and activation status of BIK1, a central rate-limiting kinase in PTI signaling. Impairs the phosphorylation of the NADPH oxidase RBOHD by BIK1.1 Publication

Catalytic activityi

[a protein]-serine/threonine phosphate + H2O = [a protein]-serine/threonine + phosphate.1 Publication

Cofactori

Mg2+By similarity, Mn2+By similarityNote: Binds 2 magnesium or manganese ions per subunit.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi88Manganese 1By similarity1
Metal bindingi88Manganese 2By similarity1
Metal bindingi89Manganese 1; via carbonyl oxygenBy similarity1
Metal bindingi289Manganese 2By similarity1
Metal bindingi348Manganese 2By similarity1

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Protein phosphatase

Keywords - Ligandi

Magnesium, Manganese, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Probable protein phosphatase 2C 38Curated (EC:3.1.3.161 Publication)
Short name:
AtPP2C381 Publication
Gene namesi
Name:PP2C381 Publication
Ordered Locus Names:At3g12620
ORF Names:MMF12.6, T2E22.7
OrganismiArabidopsis thaliana (Mouse-ear cress)
Taxonomic identifieri3702 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
Proteomesi
  • UP000006548 Componenti: Chromosome 3

Organism-specific databases

TAIRiAT3G12620.

Subcellular locationi

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi88D → N: Abolishes phosphatase activity; when associated with N-289. 1 Publication1
Mutagenesisi289D → N: Abolishes phosphatase activity; when associated with N-88. 1 Publication1

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003679631 – 385Probable protein phosphatase 2C 38Add BLAST385

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei77Phosphoserine1 Publication1

Post-translational modificationi

Phosphorylation at Ser-77 induces dissociation of PP2C38 from BIK1.1 Publication

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiQ9LHJ9.

Expressioni

Gene expression databases

GenevisibleiQ9LHJ9. AT.

Interactioni

Subunit structurei

Interacts with BIK1.1 Publication

Protein-protein interaction databases

BioGridi5776. 3 interactors.
IntActiQ9LHJ9. 3 interactors.
STRINGi3702.AT3G12620.1.

Structurei

3D structure databases

ProteinModelPortaliQ9LHJ9.
SMRiQ9LHJ9.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini46 – 357PPM-type phosphatasePROSITE-ProRule annotationAdd BLAST312

Sequence similaritiesi

Belongs to the PP2C family.Curated
Contains 1 PPM-type phosphatase domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiKOG0700. Eukaryota.
COG0631. LUCA.
HOGENOMiHOG000238703.
InParanoidiQ9LHJ9.
OMAiDANGRCD.
OrthoDBiEOG09360D2T.
PhylomeDBiQ9LHJ9.

Family and domain databases

Gene3Di3.60.40.10. 1 hit.
InterProiIPR015655. PP2C.
IPR000222. PP2C_BS.
IPR001932. PPM-type_phosphatase_dom.
[Graphical view]
PANTHERiPTHR13832. PTHR13832. 1 hit.
PfamiPF00481. PP2C. 1 hit.
[Graphical view]
SMARTiSM00332. PP2Cc. 1 hit.
[Graphical view]
SUPFAMiSSF81606. SSF81606. 1 hit.
PROSITEiPS01032. PPM_1. 1 hit.
PS51746. PPM_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9LHJ9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVSSATILRM VAPCWRRPSV KGDHSTRDAN GRCDGLLWYK DSGNHVAGEF
60 70 80 90 100
SMSVIQANNL LEDHSKLESG PVSMFDSGPQ ATFVGVYDGH GGPEAARFVN
110 120 130 140 150
KHLFDNIRKF TSENHGMSAN VITKAFLATE EDFLSLVRRQ WQIKPQIASV
160 170 180 190 200
GACCLVGIIC SGLLYIANAG DSRVVLGRLE KAFKIVKAVQ LSSEHNASLE
210 220 230 240 250
SVREELRSLH PNDPQIVVLK HKVWRVKGII QVSRSIGDAY LKKAEFNREP
260 270 280 290 300
LLAKFRVPEV FHKPILRAEP AITVHKIHPE DQFLIFASDG LWEHLSNQEA
310 320 330 340 350
VDIVNTCPRN GIARKLIKTA LREAAKKREM RYSDLKKIDR GVRRHFHDDI
360 370 380
TVIVVFLDSH LVSRSTSRRP LLSISGGGDL AGPST
Length:385
Mass (Da):42,851
Last modified:October 1, 2000 - v1
Checksum:i72F7C983DB972D48
GO

Sequence cautioni

The sequence AAG51012 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC069474 Genomic DNA. Translation: AAG51012.1. Different initiation.
AP002044 Genomic DNA. Translation: BAB02253.1.
CP002686 Genomic DNA. Translation: AEE75224.1.
CP002686 Genomic DNA. Translation: AEE75225.1.
BT004824 mRNA. Translation: AAO44090.1.
AK317334 mRNA. Translation: BAH20008.1.
AK317402 mRNA. Translation: BAH20072.1.
AK227879 mRNA. Translation: BAE99854.1.
RefSeqiNP_001030682.1. NM_001035605.2.
NP_187868.2. NM_112097.5.
UniGeneiAt.27990.

Genome annotation databases

EnsemblPlantsiAT3G12620.1; AT3G12620.1; AT3G12620.
AT3G12620.2; AT3G12620.2; AT3G12620.
GeneIDi820442.
GrameneiAT3G12620.1; AT3G12620.1; AT3G12620.
AT3G12620.2; AT3G12620.2; AT3G12620.
KEGGiath:AT3G12620.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC069474 Genomic DNA. Translation: AAG51012.1. Different initiation.
AP002044 Genomic DNA. Translation: BAB02253.1.
CP002686 Genomic DNA. Translation: AEE75224.1.
CP002686 Genomic DNA. Translation: AEE75225.1.
BT004824 mRNA. Translation: AAO44090.1.
AK317334 mRNA. Translation: BAH20008.1.
AK317402 mRNA. Translation: BAH20072.1.
AK227879 mRNA. Translation: BAE99854.1.
RefSeqiNP_001030682.1. NM_001035605.2.
NP_187868.2. NM_112097.5.
UniGeneiAt.27990.

3D structure databases

ProteinModelPortaliQ9LHJ9.
SMRiQ9LHJ9.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi5776. 3 interactors.
IntActiQ9LHJ9. 3 interactors.
STRINGi3702.AT3G12620.1.

Proteomic databases

PaxDbiQ9LHJ9.

Protocols and materials databases

DNASUi820442.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblPlantsiAT3G12620.1; AT3G12620.1; AT3G12620.
AT3G12620.2; AT3G12620.2; AT3G12620.
GeneIDi820442.
GrameneiAT3G12620.1; AT3G12620.1; AT3G12620.
AT3G12620.2; AT3G12620.2; AT3G12620.
KEGGiath:AT3G12620.

Organism-specific databases

TAIRiAT3G12620.

Phylogenomic databases

eggNOGiKOG0700. Eukaryota.
COG0631. LUCA.
HOGENOMiHOG000238703.
InParanoidiQ9LHJ9.
OMAiDANGRCD.
OrthoDBiEOG09360D2T.
PhylomeDBiQ9LHJ9.

Miscellaneous databases

PROiQ9LHJ9.

Gene expression databases

GenevisibleiQ9LHJ9. AT.

Family and domain databases

Gene3Di3.60.40.10. 1 hit.
InterProiIPR015655. PP2C.
IPR000222. PP2C_BS.
IPR001932. PPM-type_phosphatase_dom.
[Graphical view]
PANTHERiPTHR13832. PTHR13832. 1 hit.
PfamiPF00481. PP2C. 1 hit.
[Graphical view]
SMARTiSM00332. PP2Cc. 1 hit.
[Graphical view]
SUPFAMiSSF81606. SSF81606. 1 hit.
PROSITEiPS01032. PPM_1. 1 hit.
PS51746. PPM_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiP2C38_ARATH
AccessioniPrimary (citable) accession number: Q9LHJ9
Secondary accession number(s): Q9C7B3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 14, 2009
Last sequence update: October 1, 2000
Last modified: November 30, 2016
This is version 104 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Arabidopsis thaliana
    Arabidopsis thaliana: entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.