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Protein

Probable protein phosphatase 2C 38

Gene

PP2C38

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Involved in pathogen-associated molecular pattern (PAMP)-triggered immunity (PTI) signaling. Negatively regulates immune responses by controlling the phosphorylation and activation status of BIK1, a central rate-limiting kinase in PTI signaling. Impairs the phosphorylation of the NADPH oxidase RBOHD by BIK1.1 Publication

Catalytic activityi

[a protein]-serine/threonine phosphate + H2O = [a protein]-serine/threonine + phosphate.1 Publication

Cofactori

Mg2+By similarity, Mn2+By similarityNote: Binds 2 magnesium or manganese ions per subunit.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi88Manganese 1By similarity1
Metal bindingi88Manganese 2By similarity1
Metal bindingi89Manganese 1; via carbonyl oxygenBy similarity1
Metal bindingi289Manganese 2By similarity1
Metal bindingi348Manganese 2By similarity1

GO - Molecular functioni

GO - Biological processi

  • negative regulation of defense response to bacterium Source: UniProtKB

Keywordsi

Molecular functionHydrolase, Protein phosphatase
LigandMagnesium, Manganese, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Probable protein phosphatase 2C 38Curated (EC:3.1.3.161 Publication)
Short name:
AtPP2C381 Publication
Gene namesi
Name:PP2C381 Publication
Ordered Locus Names:At3g12620
ORF Names:MMF12.6, T2E22.7
OrganismiArabidopsis thaliana (Mouse-ear cress)
Taxonomic identifieri3702 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
Proteomesi
  • UP000006548 Componenti: Chromosome 3

Organism-specific databases

AraportiAT3G12620
TAIRilocus:2091265 AT3G12620

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Chloroplast Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertion Graphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi88D → N: Abolishes phosphatase activity; when associated with N-289. 1 Publication1
Mutagenesisi289D → N: Abolishes phosphatase activity; when associated with N-88. 1 Publication1

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003679631 – 385Probable protein phosphatase 2C 38Add BLAST385

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei77Phosphoserine1 Publication1

Post-translational modificationi

Phosphorylation at Ser-77 induces dissociation of PP2C38 from BIK1.1 Publication

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiQ9LHJ9

PTM databases

iPTMnetiQ9LHJ9

Expressioni

Gene expression databases

ExpressionAtlasiQ9LHJ9 baseline and differential
GenevisibleiQ9LHJ9 AT

Interactioni

Subunit structurei

Interacts with BIK1.1 Publication

Protein-protein interaction databases

BioGridi5776, 3 interactors
IntActiQ9LHJ9, 3 interactors
STRINGi3702.AT3G12620.1

Structurei

3D structure databases

ProteinModelPortaliQ9LHJ9
SMRiQ9LHJ9
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini46 – 357PPM-type phosphatasePROSITE-ProRule annotationAdd BLAST312

Sequence similaritiesi

Belongs to the PP2C family.Curated

Phylogenomic databases

eggNOGiKOG0700 Eukaryota
COG0631 LUCA
HOGENOMiHOG000238703
InParanoidiQ9LHJ9
OMAiQANNILE
OrthoDBiEOG09360D2T
PhylomeDBiQ9LHJ9

Family and domain databases

CDDicd00143 PP2Cc, 1 hit
Gene3Di3.60.40.10, 1 hit
InterProiView protein in InterPro
IPR015655 PP2C
IPR000222 PP2C_BS
IPR036457 PPM-type_dom_sf
IPR001932 PPM-type_phosphatase_dom
PANTHERiPTHR13832 PTHR13832, 1 hit
PfamiView protein in Pfam
PF00481 PP2C, 1 hit
SMARTiView protein in SMART
SM00332 PP2Cc, 1 hit
SUPFAMiSSF81606 SSF81606, 1 hit
PROSITEiView protein in PROSITE
PS01032 PPM_1, 1 hit
PS51746 PPM_2, 1 hit

Sequencei

Sequence statusi: Complete.

Q9LHJ9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVSSATILRM VAPCWRRPSV KGDHSTRDAN GRCDGLLWYK DSGNHVAGEF
60 70 80 90 100
SMSVIQANNL LEDHSKLESG PVSMFDSGPQ ATFVGVYDGH GGPEAARFVN
110 120 130 140 150
KHLFDNIRKF TSENHGMSAN VITKAFLATE EDFLSLVRRQ WQIKPQIASV
160 170 180 190 200
GACCLVGIIC SGLLYIANAG DSRVVLGRLE KAFKIVKAVQ LSSEHNASLE
210 220 230 240 250
SVREELRSLH PNDPQIVVLK HKVWRVKGII QVSRSIGDAY LKKAEFNREP
260 270 280 290 300
LLAKFRVPEV FHKPILRAEP AITVHKIHPE DQFLIFASDG LWEHLSNQEA
310 320 330 340 350
VDIVNTCPRN GIARKLIKTA LREAAKKREM RYSDLKKIDR GVRRHFHDDI
360 370 380
TVIVVFLDSH LVSRSTSRRP LLSISGGGDL AGPST
Length:385
Mass (Da):42,851
Last modified:October 1, 2000 - v1
Checksum:i72F7C983DB972D48
GO

Sequence cautioni

The sequence AAG51012 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC069474 Genomic DNA Translation: AAG51012.1 Different initiation.
AP002044 Genomic DNA Translation: BAB02253.1
CP002686 Genomic DNA Translation: AEE75224.1
CP002686 Genomic DNA Translation: AEE75225.1
BT004824 mRNA Translation: AAO44090.1
AK317334 mRNA Translation: BAH20008.1
AK317402 mRNA Translation: BAH20072.1
AK227879 mRNA Translation: BAE99854.1
RefSeqiNP_001030682.1, NM_001035605.2
NP_187868.2, NM_112097.5
UniGeneiAt.27990

Genome annotation databases

EnsemblPlantsiAT3G12620.1; AT3G12620.1; AT3G12620
AT3G12620.2; AT3G12620.2; AT3G12620
GeneIDi820442
GrameneiAT3G12620.1; AT3G12620.1; AT3G12620
AT3G12620.2; AT3G12620.2; AT3G12620
KEGGiath:AT3G12620

Similar proteinsi

Entry informationi

Entry nameiP2C38_ARATH
AccessioniPrimary (citable) accession number: Q9LHJ9
Secondary accession number(s): Q9C7B3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 14, 2009
Last sequence update: October 1, 2000
Last modified: May 23, 2018
This is version 111 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Arabidopsis thaliana
    Arabidopsis thaliana: entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

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