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Protein

Protein ELC

Gene

ELC

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Component of the ESCRT-I complex (endosomal sorting complex required for transport I), a regulator of vesicular trafficking process. Required for the sorting of endocytic ubiquitinated cargos into multivesicular bodies (MVBs). May control nuclear division through the microtubule cytoskeleton.1 Publication

GO - Molecular functioni

  • ubiquitin binding Source: TAIR

GO - Biological processi

  • cell division Source: TAIR
  • cellular protein modification process Source: InterPro
  • protein transport Source: UniProtKB-KW
  • trichome branching Source: TAIR

Keywordsi

Biological processProtein transport, Transport

Names & Taxonomyi

Protein namesi
Recommended name:
Protein ELC1 Publication
Short name:
AtELC1 Publication
Alternative name(s):
ESCRT-I complex subunit VPS23 homolog 11 Publication
Protein VACUOLAR PROTEIN SORTING 23A1 Publication
Vacuolar protein-sorting-associated protein 23 homolog 11 Publication
Gene namesi
Name:ELC1 Publication
Synonyms:ELCH1 Publication, VPS23A2 Publications
Ordered Locus Names:At3g12400Imported
ORF Names:MQC3.22Imported, T2E22.28Imported
OrganismiArabidopsis thaliana (Mouse-ear cress)
Taxonomic identifieri3702 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
Proteomesi

Organism-specific databases

AraportiAT3G12400
TAIRilocus:2092477 AT3G12400

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Chloroplast Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertion Graphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Endosome

Pathology & Biotechi

Disruption phenotypei

Clustered trichomes and multinucleated cells.1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003680201 – 398Protein ELCAdd BLAST398

Proteomic databases

PaxDbiQ9LHG8

Expressioni

Tissue specificityi

Expressed in roots, stems, leaves and flowers.1 Publication

Gene expression databases

ExpressionAtlasiQ9LHG8 baseline and differential
GenevisibleiQ9LHG8 AT

Interactioni

Subunit structurei

Component of the endosomal sorting required for transport complex I (ESCRT-I), composed of ELC, VPS28 and VPS37 (PubMed:17090720). Interacts with VPS28 and VPS37 (PubMed:17090720). Binds ubiquitin in vitro (PubMed:17090720). Interacts with FREE1 (PubMed:25438943). Interacts with TOL9/TOM1D (PubMed:22639582). Interacts with BRO1/ALIX (PubMed:26902184).4 Publications

Binary interactionsi

Show more details

GO - Molecular functioni

  • ubiquitin binding Source: TAIR

Protein-protein interaction databases

BioGridi5753, 14 interactors
IntActiQ9LHG8, 7 interactors
STRINGi3702.AT3G12400.1

Structurei

3D structure databases

ProteinModelPortaliQ9LHG8
SMRiQ9LHG8
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini18 – 162UEVPROSITE-ProRule annotationAdd BLAST145
Domaini322 – 390SBPROSITE-ProRule annotationAdd BLAST69

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili247 – 291Sequence analysisAdd BLAST45

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi156 – 197Pro-richAdd BLAST42

Sequence similaritiesi

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiKOG2391 Eukaryota
ENOG410XT2Q LUCA
HOGENOMiHOG000030046
InParanoidiQ9LHG8
KOiK12183
OMAiMNTDILD
OrthoDBiEOG09360FT6
PhylomeDBiQ9LHG8

Family and domain databases

Gene3Di3.10.110.10, 1 hit
InterProiView protein in InterPro
IPR037202 ESCRT_assembly_dom
IPR017916 SB_dom
IPR016135 UBQ-conjugating_enzyme/RWD
IPR008883 UEV_N
PfamiView protein in Pfam
PF05743 UEV, 1 hit
PF09454 Vps23_core, 1 hit
SUPFAMiSSF140111 SSF140111, 1 hit
SSF54495 SSF54495, 1 hit
PROSITEiView protein in PROSITE
PS51312 SB, 1 hit
PS51322 UEV, 1 hit

Sequencei

Sequence statusi: Complete.

Q9LHG8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVPPPSNPQQ VQQFLSSALS QRGPSSVPYE ESNKWLIRQH LLNLISSYPS
60 70 80 90 100
LEPKTASFMH NDGRSVNLLQ ADGTIPMPFH GVTYNIPVII WLLESYPRHP
110 120 130 140 150
PCVYVNPTAD MIIKRPHAHV TPSGLVSLPY LQNWVYPSSN LVDLVSDLSA
160 170 180 190 200
AFARDPPLYS RRRPQPPPPS PPTVYDSSLS RPPSADQSLP RPFPPSPYGG
210 220 230 240 250
GVSRVQVQHV HHQQQSDDAA EVFKRNAINK MVEMVHSDLV SMRRAREAEA
260 270 280 290 300
EELLSLQAGL KRREDELNIG LKEMVEEKET LEQQLQIISM NTDILDSWVR
310 320 330 340 350
ENQGKTKNLV DLDVDNAFEC GDTLSKQMLE CTALDLAIED AIYSLDKSFQ
360 370 380 390
DGVVPFDQYL RNVRLLSREQ FFHRATGSKV RAAQMEVQVA AIAGRLHS
Length:398
Mass (Da):44,716
Last modified:October 1, 2000 - v1
Checksum:i659996F9784FDC20
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AP002047 Genomic DNA Translation: BAB03147.1
AC069474 Genomic DNA Translation: AAG51025.1
CP002686 Genomic DNA Translation: AEE75193.1
AY056283 mRNA Translation: AAL07132.1
AY133779 mRNA Translation: AAM91713.1
AY087782 mRNA Translation: AAM65318.1
RefSeqiNP_566423.1, NM_112075.3
UniGeneiAt.17435
At.67881

Genome annotation databases

EnsemblPlantsiAT3G12400.1; AT3G12400.1; AT3G12400
GeneIDi820419
GrameneiAT3G12400.1; AT3G12400.1; AT3G12400
KEGGiath:AT3G12400

Entry informationi

Entry nameiELC_ARATH
AccessioniPrimary (citable) accession number: Q9LHG8
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 14, 2009
Last sequence update: October 1, 2000
Last modified: April 25, 2018
This is version 117 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Arabidopsis thaliana
    Arabidopsis thaliana: entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

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