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Q9LHG8

- ELC_ARATH

UniProt

Q9LHG8 - ELC_ARATH

Protein

Protein ELC

Gene

ELC

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 96 (01 Oct 2014)
      Sequence version 1 (01 Oct 2000)
      Previous versions | rss
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    Functioni

    Component of the ESCRT-I complex (endosomal sorting complex required for transport I), a regulator of vesicular trafficking process. Required for the sorting of endocytic ubiquitinated cargos into multivesicular bodies (MVBs) Mediates the association to the ESCRT-0 complex. May control nuclear division through the microtubule cytoskeleton.1 Publication

    GO - Molecular functioni

    1. protein binding Source: IntAct
    2. ubiquitin binding Source: TAIR

    GO - Biological processi

    1. cell division Source: TAIR
    2. cellular protein modification process Source: InterPro
    3. protein transport Source: UniProtKB-KW
    4. trichome branching Source: TAIR

    Keywords - Biological processi

    Protein transport, Transport

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Protein ELC
    Short name:
    AtELC
    Alternative name(s):
    ESCRT-I complex subunit VPS23 homolog 1
    Vacuolar protein-sorting-associated protein 23 homolog 1
    Gene namesi
    Name:ELC
    Synonyms:ELCH
    Ordered Locus Names:At3g12400
    ORF Names:T2E22.28
    OrganismiArabidopsis thaliana (Mouse-ear cress)
    Taxonomic identifieri3702 [NCBI]
    Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
    ProteomesiUP000006548: Chromosome 3

    Organism-specific databases

    TAIRiAT3G12400.

    Subcellular locationi

    GO - Cellular componenti

    1. early endosome Source: TAIR
    2. ESCRT I complex Source: TAIR
    3. late endosome Source: TAIR
    4. protein complex Source: TAIR

    Keywords - Cellular componenti

    Endosome

    Pathology & Biotechi

    Disruption phenotypei

    Clustered trichomes and multinucleated cells.1 Publication

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 398398Protein ELCPRO_0000368020Add
    BLAST

    Proteomic databases

    PaxDbiQ9LHG8.
    PRIDEiQ9LHG8.

    Expressioni

    Tissue specificityi

    Expressed in roots, stems, leaves and flowers.1 Publication

    Gene expression databases

    GenevestigatoriQ9LHG8.

    Interactioni

    Subunit structurei

    Component of the endosomal sorting required for transport complex I (ESCRT-I), composed of ELC, VPS28 and VPS37. Interacts with VPS28 and VPS37. Binds ubiquitin in vitro.1 Publication

    Binary interactionsi

    WithEntry#Exp.IntActNotes
    ELCLQ9FFY64EBI-3865248,EBI-3865255
    VPS36Q9FF813EBI-3865248,EBI-3865302
    VPS37-1Q9SCP94EBI-3865248,EBI-3865264

    Protein-protein interaction databases

    BioGridi5753. 13 interactions.
    IntActiQ9LHG8. 7 interactions.
    STRINGi3702.AT3G12400.1-P.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9LHG8.
    SMRiQ9LHG8. Positions 36-160.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini18 – 162145UEVPROSITE-ProRule annotationAdd
    BLAST
    Domaini322 – 39069SBPROSITE-ProRule annotationAdd
    BLAST

    Coiled coil

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Coiled coili247 – 29145Sequence AnalysisAdd
    BLAST

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi156 – 19742Pro-richAdd
    BLAST

    Sequence similaritiesi

    Contains 1 SB (steadiness box) domain.PROSITE-ProRule annotation
    Contains 1 UEV (ubiquitin E2 variant) domain.PROSITE-ProRule annotation

    Keywords - Domaini

    Coiled coil

    Phylogenomic databases

    eggNOGiNOG317261.
    HOGENOMiHOG000030046.
    InParanoidiQ9LHG8.
    KOiK12183.
    OMAiASYMPGM.
    PhylomeDBiQ9LHG8.

    Family and domain databases

    Gene3Di3.10.110.10. 1 hit.
    InterProiIPR017916. Steadiness_box.
    IPR016135. UBQ-conjugating_enzyme/RWD.
    IPR008883. UEV_N.
    [Graphical view]
    PfamiPF05743. UEV. 1 hit.
    PF09454. Vps23_core. 1 hit.
    [Graphical view]
    SUPFAMiSSF54495. SSF54495. 1 hit.
    PROSITEiPS51312. SB. 1 hit.
    PS51322. UEV. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q9LHG8-1 [UniParc]FASTAAdd to Basket

    « Hide

    MVPPPSNPQQ VQQFLSSALS QRGPSSVPYE ESNKWLIRQH LLNLISSYPS    50
    LEPKTASFMH NDGRSVNLLQ ADGTIPMPFH GVTYNIPVII WLLESYPRHP 100
    PCVYVNPTAD MIIKRPHAHV TPSGLVSLPY LQNWVYPSSN LVDLVSDLSA 150
    AFARDPPLYS RRRPQPPPPS PPTVYDSSLS RPPSADQSLP RPFPPSPYGG 200
    GVSRVQVQHV HHQQQSDDAA EVFKRNAINK MVEMVHSDLV SMRRAREAEA 250
    EELLSLQAGL KRREDELNIG LKEMVEEKET LEQQLQIISM NTDILDSWVR 300
    ENQGKTKNLV DLDVDNAFEC GDTLSKQMLE CTALDLAIED AIYSLDKSFQ 350
    DGVVPFDQYL RNVRLLSREQ FFHRATGSKV RAAQMEVQVA AIAGRLHS 398
    Length:398
    Mass (Da):44,716
    Last modified:October 1, 2000 - v1
    Checksum:i659996F9784FDC20
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AP002047 Genomic DNA. Translation: BAB03147.1.
    AC069474 Genomic DNA. Translation: AAG51025.1.
    CP002686 Genomic DNA. Translation: AEE75193.1.
    AY056283 mRNA. Translation: AAL07132.1.
    AY133779 mRNA. Translation: AAM91713.1.
    AY087782 mRNA. Translation: AAM65318.1.
    RefSeqiNP_566423.1. NM_112075.2.
    UniGeneiAt.17435.
    At.67881.

    Genome annotation databases

    EnsemblPlantsiAT3G12400.1; AT3G12400.1; AT3G12400.
    GeneIDi820419.
    KEGGiath:AT3G12400.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AP002047 Genomic DNA. Translation: BAB03147.1 .
    AC069474 Genomic DNA. Translation: AAG51025.1 .
    CP002686 Genomic DNA. Translation: AEE75193.1 .
    AY056283 mRNA. Translation: AAL07132.1 .
    AY133779 mRNA. Translation: AAM91713.1 .
    AY087782 mRNA. Translation: AAM65318.1 .
    RefSeqi NP_566423.1. NM_112075.2.
    UniGenei At.17435.
    At.67881.

    3D structure databases

    ProteinModelPortali Q9LHG8.
    SMRi Q9LHG8. Positions 36-160.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 5753. 13 interactions.
    IntActi Q9LHG8. 7 interactions.
    STRINGi 3702.AT3G12400.1-P.

    Proteomic databases

    PaxDbi Q9LHG8.
    PRIDEi Q9LHG8.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblPlantsi AT3G12400.1 ; AT3G12400.1 ; AT3G12400 .
    GeneIDi 820419.
    KEGGi ath:AT3G12400.

    Organism-specific databases

    TAIRi AT3G12400.

    Phylogenomic databases

    eggNOGi NOG317261.
    HOGENOMi HOG000030046.
    InParanoidi Q9LHG8.
    KOi K12183.
    OMAi ASYMPGM.
    PhylomeDBi Q9LHG8.

    Gene expression databases

    Genevestigatori Q9LHG8.

    Family and domain databases

    Gene3Di 3.10.110.10. 1 hit.
    InterProi IPR017916. Steadiness_box.
    IPR016135. UBQ-conjugating_enzyme/RWD.
    IPR008883. UEV_N.
    [Graphical view ]
    Pfami PF05743. UEV. 1 hit.
    PF09454. Vps23_core. 1 hit.
    [Graphical view ]
    SUPFAMi SSF54495. SSF54495. 1 hit.
    PROSITEi PS51312. SB. 1 hit.
    PS51322. UEV. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Structural analysis of Arabidopsis thaliana chromosome 3. II. Sequence features of the 4,251,695 bp regions covered by 90 P1, TAC and BAC clones."
      Kaneko T., Katoh T., Sato S., Nakamura Y., Asamizu E., Tabata S.
      DNA Res. 7:217-221(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: cv. Columbia.
    2. "Sequence and analysis of chromosome 3 of the plant Arabidopsis thaliana."
      Salanoubat M., Lemcke K., Rieger M., Ansorge W., Unseld M., Fartmann B., Valle G., Bloecker H., Perez-Alonso M., Obermaier B., Delseny M., Boutry M., Grivell L.A., Mache R., Puigdomenech P., De Simone V., Choisne N., Artiguenave F.
      , Robert C., Brottier P., Wincker P., Cattolico L., Weissenbach J., Saurin W., Quetier F., Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Benes V., Wurmbach E., Drzonek H., Erfle H., Jordan N., Bangert S., Wiedelmann R., Kranz H., Voss H., Holland R., Brandt P., Nyakatura G., Vezzi A., D'Angelo M., Pallavicini A., Toppo S., Simionati B., Conrad A., Hornischer K., Kauer G., Loehnert T.-H., Nordsiek G., Reichelt J., Scharfe M., Schoen O., Bargues M., Terol J., Climent J., Navarro P., Collado C., Perez-Perez A., Ottenwaelder B., Duchemin D., Cooke R., Laudie M., Berger-Llauro C., Purnelle B., Masuy D., de Haan M., Maarse A.C., Alcaraz J.-P., Cottet A., Casacuberta E., Monfort A., Argiriou A., Flores M., Liguori R., Vitale D., Mannhaupt G., Haase D., Schoof H., Rudd S., Zaccaria P., Mewes H.-W., Mayer K.F.X., Kaul S., Town C.D., Koo H.L., Tallon L.J., Jenkins J., Rooney T., Rizzo M., Walts A., Utterback T., Fujii C.Y., Shea T.P., Creasy T.H., Haas B., Maiti R., Wu D., Peterson J., Van Aken S., Pai G., Militscher J., Sellers P., Gill J.E., Feldblyum T.V., Preuss D., Lin X., Nierman W.C., Salzberg S.L., White O., Venter J.C., Fraser C.M., Kaneko T., Nakamura Y., Sato S., Kato T., Asamizu E., Sasamoto S., Kimura T., Idesawa K., Kawashima K., Kishida Y., Kiyokawa C., Kohara M., Matsumoto M., Matsuno A., Muraki A., Nakayama S., Nakazaki N., Shinpo S., Takeuchi C., Wada T., Watanabe A., Yamada M., Yasuda M., Tabata S.
      Nature 408:820-822(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: cv. Columbia.
    3. The Arabidopsis Information Resource (TAIR)
      Submitted (APR-2011) to the EMBL/GenBank/DDBJ databases
      Cited for: GENOME REANNOTATION.
      Strain: cv. Columbia.
    4. "Empirical analysis of transcriptional activity in the Arabidopsis genome."
      Yamada K., Lim J., Dale J.M., Chen H., Shinn P., Palm C.J., Southwick A.M., Wu H.C., Kim C.J., Nguyen M., Pham P.K., Cheuk R.F., Karlin-Newmann G., Liu S.X., Lam B., Sakano H., Wu T., Yu G.
      , Miranda M., Quach H.L., Tripp M., Chang C.H., Lee J.M., Toriumi M.J., Chan M.M., Tang C.C., Onodera C.S., Deng J.M., Akiyama K., Ansari Y., Arakawa T., Banh J., Banno F., Bowser L., Brooks S.Y., Carninci P., Chao Q., Choy N., Enju A., Goldsmith A.D., Gurjal M., Hansen N.F., Hayashizaki Y., Johnson-Hopson C., Hsuan V.W., Iida K., Karnes M., Khan S., Koesema E., Ishida J., Jiang P.X., Jones T., Kawai J., Kamiya A., Meyers C., Nakajima M., Narusaka M., Seki M., Sakurai T., Satou M., Tamse R., Vaysberg M., Wallender E.K., Wong C., Yamamura Y., Yuan S., Shinozaki K., Davis R.W., Theologis A., Ecker J.R.
      Science 302:842-846(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: cv. Columbia.
    5. "Full-length cDNA from Arabidopsis thaliana."
      Brover V.V., Troukhan M.E., Alexandrov N.A., Lu Y.-P., Flavell R.B., Feldmann K.A.
      Submitted (MAR-2002) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    6. Cited for: FUNCTION, TISSUE SPECIFICITY, INTERACTION WITH VPS28; VPS37 AND UBIQUITIN, DISRUPTION PHENOTYPE, NOMENCLATURE.
    7. "Exploring the ESCRTing machinery in eukaryotes."
      Winter V., Hauser M.-T.
      Trends Plant Sci. 11:115-123(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: IDENTIFICATION.

    Entry informationi

    Entry nameiELC_ARATH
    AccessioniPrimary (citable) accession number: Q9LHG8
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: April 14, 2009
    Last sequence update: October 1, 2000
    Last modified: October 1, 2014
    This is version 96 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programPlant Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Arabidopsis thaliana
      Arabidopsis thaliana: entries and gene names
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3