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Protein

Protein ELC

Gene

ELC

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Component of the ESCRT-I complex (endosomal sorting complex required for transport I), a regulator of vesicular trafficking process. Required for the sorting of endocytic ubiquitinated cargos into multivesicular bodies (MVBs) Mediates the association to the ESCRT-0 complex. May control nuclear division through the microtubule cytoskeleton.1 Publication

GO - Molecular functioni

  • ubiquitin binding Source: TAIR

GO - Biological processi

  • cell division Source: TAIR
  • cellular protein modification process Source: InterPro
  • protein transport Source: UniProtKB-KW
  • trichome branching Source: TAIR
Complete GO annotation...

Keywords - Biological processi

Protein transport, Transport

Names & Taxonomyi

Protein namesi
Recommended name:
Protein ELC
Short name:
AtELC
Alternative name(s):
ESCRT-I complex subunit VPS23 homolog 1
Vacuolar protein-sorting-associated protein 23 homolog 1
Gene namesi
Name:ELC
Synonyms:ELCH
Ordered Locus Names:At3g12400
ORF Names:T2E22.28
OrganismiArabidopsis thaliana (Mouse-ear cress)
Taxonomic identifieri3702 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
ProteomesiUP000006548 Componenti: Chromosome 3

Organism-specific databases

TAIRiAT3G12400.

Subcellular locationi

GO - Cellular componenti

  • early endosome Source: TAIR
  • ESCRT I complex Source: TAIR
  • late endosome Source: TAIR
  • protein complex Source: TAIR
Complete GO annotation...

Keywords - Cellular componenti

Endosome

Pathology & Biotechi

Disruption phenotypei

Clustered trichomes and multinucleated cells.1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 398398Protein ELCPRO_0000368020Add
BLAST

Proteomic databases

PaxDbiQ9LHG8.
PRIDEiQ9LHG8.

Expressioni

Tissue specificityi

Expressed in roots, stems, leaves and flowers.1 Publication

Interactioni

Subunit structurei

Component of the endosomal sorting required for transport complex I (ESCRT-I), composed of ELC, VPS28 and VPS37. Interacts with VPS28 and VPS37. Binds ubiquitin in vitro.1 Publication

Binary interactionsi

WithEntry#Exp.IntActNotes
ELCLQ9FFY64EBI-3865248,EBI-3865255
VPS36Q9FF813EBI-3865248,EBI-3865302
VPS37-1Q9SCP94EBI-3865248,EBI-3865264

Protein-protein interaction databases

BioGridi5753. 13 interactions.
IntActiQ9LHG8. 7 interactions.
STRINGi3702.AT3G12400.1.

Structurei

3D structure databases

ProteinModelPortaliQ9LHG8.
SMRiQ9LHG8. Positions 36-160.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini18 – 162145UEVPROSITE-ProRule annotationAdd
BLAST
Domaini322 – 39069SBPROSITE-ProRule annotationAdd
BLAST

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili247 – 29145Sequence AnalysisAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi156 – 19742Pro-richAdd
BLAST

Sequence similaritiesi

Contains 1 SB (steadiness box) domain.PROSITE-ProRule annotation
Contains 1 UEV (ubiquitin E2 variant) domain.PROSITE-ProRule annotation

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiNOG317261.
HOGENOMiHOG000030046.
InParanoidiQ9LHG8.
KOiK12183.
OMAiPEPYPRS.
PhylomeDBiQ9LHG8.

Family and domain databases

Gene3Di3.10.110.10. 1 hit.
InterProiIPR017916. Steadiness_box.
IPR016135. UBQ-conjugating_enzyme/RWD.
IPR008883. UEV_N.
[Graphical view]
PfamiPF05743. UEV. 1 hit.
PF09454. Vps23_core. 1 hit.
[Graphical view]
SUPFAMiSSF54495. SSF54495. 1 hit.
PROSITEiPS51312. SB. 1 hit.
PS51322. UEV. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9LHG8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVPPPSNPQQ VQQFLSSALS QRGPSSVPYE ESNKWLIRQH LLNLISSYPS
60 70 80 90 100
LEPKTASFMH NDGRSVNLLQ ADGTIPMPFH GVTYNIPVII WLLESYPRHP
110 120 130 140 150
PCVYVNPTAD MIIKRPHAHV TPSGLVSLPY LQNWVYPSSN LVDLVSDLSA
160 170 180 190 200
AFARDPPLYS RRRPQPPPPS PPTVYDSSLS RPPSADQSLP RPFPPSPYGG
210 220 230 240 250
GVSRVQVQHV HHQQQSDDAA EVFKRNAINK MVEMVHSDLV SMRRAREAEA
260 270 280 290 300
EELLSLQAGL KRREDELNIG LKEMVEEKET LEQQLQIISM NTDILDSWVR
310 320 330 340 350
ENQGKTKNLV DLDVDNAFEC GDTLSKQMLE CTALDLAIED AIYSLDKSFQ
360 370 380 390
DGVVPFDQYL RNVRLLSREQ FFHRATGSKV RAAQMEVQVA AIAGRLHS
Length:398
Mass (Da):44,716
Last modified:October 1, 2000 - v1
Checksum:i659996F9784FDC20
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AP002047 Genomic DNA. Translation: BAB03147.1.
AC069474 Genomic DNA. Translation: AAG51025.1.
CP002686 Genomic DNA. Translation: AEE75193.1.
AY056283 mRNA. Translation: AAL07132.1.
AY133779 mRNA. Translation: AAM91713.1.
AY087782 mRNA. Translation: AAM65318.1.
RefSeqiNP_566423.1. NM_112075.2.
UniGeneiAt.17435.
At.67881.

Genome annotation databases

EnsemblPlantsiAT3G12400.1; AT3G12400.1; AT3G12400.
GeneIDi820419.
KEGGiath:AT3G12400.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AP002047 Genomic DNA. Translation: BAB03147.1.
AC069474 Genomic DNA. Translation: AAG51025.1.
CP002686 Genomic DNA. Translation: AEE75193.1.
AY056283 mRNA. Translation: AAL07132.1.
AY133779 mRNA. Translation: AAM91713.1.
AY087782 mRNA. Translation: AAM65318.1.
RefSeqiNP_566423.1. NM_112075.2.
UniGeneiAt.17435.
At.67881.

3D structure databases

ProteinModelPortaliQ9LHG8.
SMRiQ9LHG8. Positions 36-160.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi5753. 13 interactions.
IntActiQ9LHG8. 7 interactions.
STRINGi3702.AT3G12400.1.

Proteomic databases

PaxDbiQ9LHG8.
PRIDEiQ9LHG8.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblPlantsiAT3G12400.1; AT3G12400.1; AT3G12400.
GeneIDi820419.
KEGGiath:AT3G12400.

Organism-specific databases

TAIRiAT3G12400.

Phylogenomic databases

eggNOGiNOG317261.
HOGENOMiHOG000030046.
InParanoidiQ9LHG8.
KOiK12183.
OMAiPEPYPRS.
PhylomeDBiQ9LHG8.

Miscellaneous databases

PROiQ9LHG8.

Family and domain databases

Gene3Di3.10.110.10. 1 hit.
InterProiIPR017916. Steadiness_box.
IPR016135. UBQ-conjugating_enzyme/RWD.
IPR008883. UEV_N.
[Graphical view]
PfamiPF05743. UEV. 1 hit.
PF09454. Vps23_core. 1 hit.
[Graphical view]
SUPFAMiSSF54495. SSF54495. 1 hit.
PROSITEiPS51312. SB. 1 hit.
PS51322. UEV. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Structural analysis of Arabidopsis thaliana chromosome 3. II. Sequence features of the 4,251,695 bp regions covered by 90 P1, TAC and BAC clones."
    Kaneko T., Katoh T., Sato S., Nakamura Y., Asamizu E., Tabata S.
    DNA Res. 7:217-221(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: cv. Columbia.
  2. "Sequence and analysis of chromosome 3 of the plant Arabidopsis thaliana."
    Salanoubat M., Lemcke K., Rieger M., Ansorge W., Unseld M., Fartmann B., Valle G., Bloecker H., Perez-Alonso M., Obermaier B., Delseny M., Boutry M., Grivell L.A., Mache R., Puigdomenech P., De Simone V., Choisne N., Artiguenave F.
    , Robert C., Brottier P., Wincker P., Cattolico L., Weissenbach J., Saurin W., Quetier F., Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Benes V., Wurmbach E., Drzonek H., Erfle H., Jordan N., Bangert S., Wiedelmann R., Kranz H., Voss H., Holland R., Brandt P., Nyakatura G., Vezzi A., D'Angelo M., Pallavicini A., Toppo S., Simionati B., Conrad A., Hornischer K., Kauer G., Loehnert T.-H., Nordsiek G., Reichelt J., Scharfe M., Schoen O., Bargues M., Terol J., Climent J., Navarro P., Collado C., Perez-Perez A., Ottenwaelder B., Duchemin D., Cooke R., Laudie M., Berger-Llauro C., Purnelle B., Masuy D., de Haan M., Maarse A.C., Alcaraz J.-P., Cottet A., Casacuberta E., Monfort A., Argiriou A., Flores M., Liguori R., Vitale D., Mannhaupt G., Haase D., Schoof H., Rudd S., Zaccaria P., Mewes H.-W., Mayer K.F.X., Kaul S., Town C.D., Koo H.L., Tallon L.J., Jenkins J., Rooney T., Rizzo M., Walts A., Utterback T., Fujii C.Y., Shea T.P., Creasy T.H., Haas B., Maiti R., Wu D., Peterson J., Van Aken S., Pai G., Militscher J., Sellers P., Gill J.E., Feldblyum T.V., Preuss D., Lin X., Nierman W.C., Salzberg S.L., White O., Venter J.C., Fraser C.M., Kaneko T., Nakamura Y., Sato S., Kato T., Asamizu E., Sasamoto S., Kimura T., Idesawa K., Kawashima K., Kishida Y., Kiyokawa C., Kohara M., Matsumoto M., Matsuno A., Muraki A., Nakayama S., Nakazaki N., Shinpo S., Takeuchi C., Wada T., Watanabe A., Yamada M., Yasuda M., Tabata S.
    Nature 408:820-822(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: cv. Columbia.
  3. The Arabidopsis Information Resource (TAIR)
    Submitted (APR-2011) to the EMBL/GenBank/DDBJ databases
    Cited for: GENOME REANNOTATION.
    Strain: cv. Columbia.
  4. "Empirical analysis of transcriptional activity in the Arabidopsis genome."
    Yamada K., Lim J., Dale J.M., Chen H., Shinn P., Palm C.J., Southwick A.M., Wu H.C., Kim C.J., Nguyen M., Pham P.K., Cheuk R.F., Karlin-Newmann G., Liu S.X., Lam B., Sakano H., Wu T., Yu G.
    , Miranda M., Quach H.L., Tripp M., Chang C.H., Lee J.M., Toriumi M.J., Chan M.M., Tang C.C., Onodera C.S., Deng J.M., Akiyama K., Ansari Y., Arakawa T., Banh J., Banno F., Bowser L., Brooks S.Y., Carninci P., Chao Q., Choy N., Enju A., Goldsmith A.D., Gurjal M., Hansen N.F., Hayashizaki Y., Johnson-Hopson C., Hsuan V.W., Iida K., Karnes M., Khan S., Koesema E., Ishida J., Jiang P.X., Jones T., Kawai J., Kamiya A., Meyers C., Nakajima M., Narusaka M., Seki M., Sakurai T., Satou M., Tamse R., Vaysberg M., Wallender E.K., Wong C., Yamamura Y., Yuan S., Shinozaki K., Davis R.W., Theologis A., Ecker J.R.
    Science 302:842-846(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: cv. Columbia.
  5. "Full-length cDNA from Arabidopsis thaliana."
    Brover V.V., Troukhan M.E., Alexandrov N.A., Lu Y.-P., Flavell R.B., Feldmann K.A.
    Submitted (MAR-2002) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  6. Cited for: FUNCTION, TISSUE SPECIFICITY, INTERACTION WITH VPS28; VPS37 AND UBIQUITIN, DISRUPTION PHENOTYPE, NOMENCLATURE.
  7. "Exploring the ESCRTing machinery in eukaryotes."
    Winter V., Hauser M.-T.
    Trends Plant Sci. 11:115-123(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION.

Entry informationi

Entry nameiELC_ARATH
AccessioniPrimary (citable) accession number: Q9LHG8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 14, 2009
Last sequence update: October 1, 2000
Last modified: June 24, 2015
This is version 100 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Arabidopsis thaliana
    Arabidopsis thaliana: entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.