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Q9LHE7

- FYPP3_ARATH

UniProt

Q9LHE7 - FYPP3_ARATH

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Protein

Phytochrome-associated serine/threonine-protein phosphatase 3

Gene
FYPP3, EMB2736, STPP, At3g19980, MZE19.3
Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

Dephosphorylates phosphorylated phytochromes, with a preference toward Pfr forms. Plays a major role in the photoperiodic control of flowering time in long days by modulating phytochrome signals in flowering time control.1 Publication

Catalytic activityi

[a protein]-serine/threonine phosphate + H2O = [a protein]-serine/threonine + phosphate.

Cofactori

Binds 2 manganese ions per subunit By similarity.1 Publication

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi50 – 501Manganese 1 By similarity
Metal bindingi52 – 521Manganese 1 By similarity
Metal bindingi78 – 781Manganese 1 By similarity
Metal bindingi78 – 781Manganese 2 By similarity
Metal bindingi110 – 1101Manganese 2 By similarity
Active sitei111 – 1111Proton donor By similarity
Metal bindingi160 – 1601Manganese 2 By similarity
Metal bindingi234 – 2341Manganese 2 By similarity

GO - Molecular functioni

  1. metal ion binding Source: UniProtKB-KW
  2. phosphoprotein phosphatase activity Source: UniProtKB-KW
  3. protein serine/threonine kinase activity Source: TAIR

GO - Biological processi

  1. negative regulation of flower development Source: TAIR
  2. protein phosphorylation Source: GOC
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Protein phosphatase

Keywords - Ligandi

Manganese, Metal-binding, Zinc

Enzyme and pathway databases

BioCyciARA:AT3G19980-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Phytochrome-associated serine/threonine-protein phosphatase 3 (EC:3.1.3.16)
Short name:
AtFyPP3
Alternative name(s):
Protein EMBRYO DEFECTIVE 2736
Gene namesi
Name:FYPP3
Synonyms:EMB2736, STPP
Ordered Locus Names:At3g19980
ORF Names:MZE19.3
OrganismiArabidopsis thaliana (Mouse-ear cress)
Taxonomic identifieri3702 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
ProteomesiUP000006548: Chromosome 3

Organism-specific databases

TAIRiAT3G19980.

Subcellular locationi

Cytoplasm By similarity

GO - Cellular componenti

  1. cytoplasm Source: TAIR
  2. nucleus Source: TAIR
  3. protein phosphatase type 2A complex Source: TAIR
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 303303Phytochrome-associated serine/threonine-protein phosphatase 3PRO_0000308990Add
BLAST

Proteomic databases

PaxDbiQ9LHE7.
PRIDEiQ9LHE7.

Expressioni

Tissue specificityi

Mostly expressed in flowers. Also detected to a lower extent in stems and leaves.1 Publication

Gene expression databases

GenevestigatoriQ9LHE7.

Interactioni

Subunit structurei

Interacts with PHYA and PHYB, mostly when they are phosphorylated and in Pfr forms.1 Publication

Protein-protein interaction databases

BioGridi6868. 5 interactions.
STRINGi3702.AT3G19980.1-P.

Structurei

3D structure databases

ProteinModelPortaliQ9LHE7.
SMRiQ9LHE7. Positions 2-277.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0639.
HOGENOMiHOG000172696.
InParanoidiQ9LHE7.
KOiK15498.
OMAiVPETSYI.
PhylomeDBiQ9LHE7.

Family and domain databases

Gene3Di3.60.21.10. 1 hit.
InterProiIPR004843. Calcineurin-like_PHP_apaH.
IPR029052. Metallo-depent_PP-like.
IPR006186. Ser/Thr-sp_prot-phosphatase.
[Graphical view]
PfamiPF00149. Metallophos. 1 hit.
[Graphical view]
PRINTSiPR00114. STPHPHTASE.
SMARTiSM00156. PP2Ac. 1 hit.
[Graphical view]
SUPFAMiSSF56300. SSF56300. 1 hit.
PROSITEiPS00125. SER_THR_PHOSPHATASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9LHE7-1 [UniParc]FASTAAdd to Basket

« Hide

MDLDQWISKV KDGQHLSEDE LQLLCEYVKE ILIEESNVQP VNSPVTVCGD    50
IHGQFHDLMK LFQTGGHVPD TNYIFMGDFV DRGYNSLEVF TILLLLKARY 100
PANITLLRGN HESRQLTQVY GFYDECQRKY GNANAWRYCT DVFDYLTLSA 150
IIDGTVLCVH GGLSPDVRTI DQIRLIERNC EIPHEGPFCD LMWSDPEDIE 200
TWAVSPRGAG WLFGSRVTTE FNHINKLDLV CRAHQLVQEG LKYMFQDKGL 250
VTVWSAPNYC YRCGNVASIL SFNDNMEREV KFFTETEENN QMRGPRTGVP 300
YFL 303
Length:303
Mass (Da):34,845
Last modified:October 1, 2000 - v1
Checksum:i342FD1E21BC7D2B1
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF275664 mRNA. Translation: AAK69404.1.
AP002050 Genomic DNA. Translation: BAB03163.1.
CP002686 Genomic DNA. Translation: AEE76315.1.
AY064136 mRNA. Translation: AAL36043.1.
AY097414 mRNA. Translation: AAM19930.1.
RefSeqiNP_188632.1. NM_112888.3.
UniGeneiAt.5940.

Genome annotation databases

EnsemblPlantsiAT3G19980.1; AT3G19980.1; AT3G19980.
GeneIDi821536.
KEGGiath:AT3G19980.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF275664 mRNA. Translation: AAK69404.1 .
AP002050 Genomic DNA. Translation: BAB03163.1 .
CP002686 Genomic DNA. Translation: AEE76315.1 .
AY064136 mRNA. Translation: AAL36043.1 .
AY097414 mRNA. Translation: AAM19930.1 .
RefSeqi NP_188632.1. NM_112888.3.
UniGenei At.5940.

3D structure databases

ProteinModelPortali Q9LHE7.
SMRi Q9LHE7. Positions 2-277.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 6868. 5 interactions.
STRINGi 3702.AT3G19980.1-P.

Proteomic databases

PaxDbi Q9LHE7.
PRIDEi Q9LHE7.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblPlantsi AT3G19980.1 ; AT3G19980.1 ; AT3G19980 .
GeneIDi 821536.
KEGGi ath:AT3G19980.

Organism-specific databases

TAIRi AT3G19980.

Phylogenomic databases

eggNOGi COG0639.
HOGENOMi HOG000172696.
InParanoidi Q9LHE7.
KOi K15498.
OMAi VPETSYI.
PhylomeDBi Q9LHE7.

Enzyme and pathway databases

BioCyci ARA:AT3G19980-MONOMER.

Miscellaneous databases

PROi Q9LHE7.

Gene expression databases

Genevestigatori Q9LHE7.

Family and domain databases

Gene3Di 3.60.21.10. 1 hit.
InterProi IPR004843. Calcineurin-like_PHP_apaH.
IPR029052. Metallo-depent_PP-like.
IPR006186. Ser/Thr-sp_prot-phosphatase.
[Graphical view ]
Pfami PF00149. Metallophos. 1 hit.
[Graphical view ]
PRINTSi PR00114. STPHPHTASE.
SMARTi SM00156. PP2Ac. 1 hit.
[Graphical view ]
SUPFAMi SSF56300. SSF56300. 1 hit.
PROSITEi PS00125. SER_THR_PHOSPHATASE. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "A phytochrome-associated protein phosphatase 2A modulates light signals in flowering time control in Arabidopsis."
    Kim D.-H., Kang J.-G., Yang S.-S., Chung K.-S., Song P.-S., Park C.-M.
    Plant Cell 14:3043-3056(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, COFACTOR, TISSUE SPECIFICITY, INTERACTION WITH PHYA AND PHYB.
  2. "Structural analysis of Arabidopsis thaliana chromosome 3. II. Sequence features of the 4,251,695 bp regions covered by 90 P1, TAC and BAC clones."
    Kaneko T., Katoh T., Sato S., Nakamura Y., Asamizu E., Tabata S.
    DNA Res. 7:217-221(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: cv. Columbia.
  3. The Arabidopsis Information Resource (TAIR)
    Submitted (APR-2011) to the EMBL/GenBank/DDBJ databases
    Cited for: GENOME REANNOTATION.
    Strain: cv. Columbia.
  4. "Empirical analysis of transcriptional activity in the Arabidopsis genome."
    Yamada K., Lim J., Dale J.M., Chen H., Shinn P., Palm C.J., Southwick A.M., Wu H.C., Kim C.J., Nguyen M., Pham P.K., Cheuk R.F., Karlin-Newmann G., Liu S.X., Lam B., Sakano H., Wu T., Yu G.
    , Miranda M., Quach H.L., Tripp M., Chang C.H., Lee J.M., Toriumi M.J., Chan M.M., Tang C.C., Onodera C.S., Deng J.M., Akiyama K., Ansari Y., Arakawa T., Banh J., Banno F., Bowser L., Brooks S.Y., Carninci P., Chao Q., Choy N., Enju A., Goldsmith A.D., Gurjal M., Hansen N.F., Hayashizaki Y., Johnson-Hopson C., Hsuan V.W., Iida K., Karnes M., Khan S., Koesema E., Ishida J., Jiang P.X., Jones T., Kawai J., Kamiya A., Meyers C., Nakajima M., Narusaka M., Seki M., Sakurai T., Satou M., Tamse R., Vaysberg M., Wallender E.K., Wong C., Yamamura Y., Yuan S., Shinozaki K., Davis R.W., Theologis A., Ecker J.R.
    Science 302:842-846(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: cv. Columbia.
  5. "Arabidopsis PPP family of serine/threonine phosphatases."
    Farkas I., Dombradi V., Miskei M., Szabados L., Koncz C.
    Trends Plant Sci. 12:169-176(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: GENE FAMILY, NOMENCLATURE.

Entry informationi

Entry nameiFYPP3_ARATH
AccessioniPrimary (citable) accession number: Q9LHE7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 13, 2007
Last sequence update: October 1, 2000
Last modified: June 11, 2014
This is version 95 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Arabidopsis thaliana
    Arabidopsis thaliana: entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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