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Protein

Phytochrome-associated serine/threonine-protein phosphatase 3

Gene

FYPP3

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Dephosphorylates phosphorylated phytochromes, with a preference toward Pfr forms. Plays a major role in the photoperiodic control of flowering time in long days by modulating phytochrome signals in flowering time control.1 Publication

Catalytic activityi

[a protein]-serine/threonine phosphate + H2O = [a protein]-serine/threonine + phosphate.

Cofactori

Mn2+By similarityNote: Binds 2 manganese ions per subunit.By similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi50 – 501Manganese 1By similarity
Metal bindingi52 – 521Manganese 1By similarity
Metal bindingi78 – 781Manganese 1By similarity
Metal bindingi78 – 781Manganese 2By similarity
Metal bindingi110 – 1101Manganese 2By similarity
Active sitei111 – 1111Proton donorBy similarity
Metal bindingi160 – 1601Manganese 2By similarity
Metal bindingi234 – 2341Manganese 2By similarity

GO - Molecular functioni

  1. metal ion binding Source: UniProtKB-KW
  2. phosphoprotein phosphatase activity Source: UniProtKB-KW
  3. protein serine/threonine kinase activity Source: TAIR

GO - Biological processi

  1. negative regulation of flower development Source: TAIR
  2. protein phosphorylation Source: GOC
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Protein phosphatase

Keywords - Ligandi

Manganese, Metal-binding, Zinc

Enzyme and pathway databases

BioCyciARA:AT3G19980-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Phytochrome-associated serine/threonine-protein phosphatase 3 (EC:3.1.3.16)
Short name:
AtFyPP3
Alternative name(s):
Protein EMBRYO DEFECTIVE 2736
Gene namesi
Name:FYPP3
Synonyms:EMB2736, STPP
Ordered Locus Names:At3g19980
ORF Names:MZE19.3
OrganismiArabidopsis thaliana (Mouse-ear cress)
Taxonomic identifieri3702 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
ProteomesiUP000006548: Chromosome 3

Organism-specific databases

TAIRiAT3G19980.

Subcellular locationi

Cytoplasm By similarity

GO - Cellular componenti

  1. cytoplasm Source: TAIR
  2. nucleus Source: TAIR
  3. protein phosphatase type 2A complex Source: TAIR
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 303303Phytochrome-associated serine/threonine-protein phosphatase 3PRO_0000308990Add
BLAST

Proteomic databases

PaxDbiQ9LHE7.
PRIDEiQ9LHE7.

Expressioni

Tissue specificityi

Mostly expressed in flowers. Also detected to a lower extent in stems and leaves.1 Publication

Gene expression databases

GenevestigatoriQ9LHE7.

Interactioni

Subunit structurei

Interacts with PHYA and PHYB, mostly when they are phosphorylated and in Pfr forms.1 Publication

Protein-protein interaction databases

BioGridi6868. 5 interactions.
STRINGi3702.AT3G19980.1-P.

Structurei

3D structure databases

ProteinModelPortaliQ9LHE7.
SMRiQ9LHE7. Positions 2-277.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0639.
HOGENOMiHOG000172696.
InParanoidiQ9LHE7.
KOiK15498.
OMAiENWAVSP.
PhylomeDBiQ9LHE7.

Family and domain databases

Gene3Di3.60.21.10. 1 hit.
InterProiIPR004843. Calcineurin-like_PHP_apaH.
IPR029052. Metallo-depent_PP-like.
IPR006186. Ser/Thr-sp_prot-phosphatase.
[Graphical view]
PfamiPF00149. Metallophos. 1 hit.
[Graphical view]
PRINTSiPR00114. STPHPHTASE.
SMARTiSM00156. PP2Ac. 1 hit.
[Graphical view]
SUPFAMiSSF56300. SSF56300. 1 hit.
PROSITEiPS00125. SER_THR_PHOSPHATASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9LHE7-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MDLDQWISKV KDGQHLSEDE LQLLCEYVKE ILIEESNVQP VNSPVTVCGD
60 70 80 90 100
IHGQFHDLMK LFQTGGHVPD TNYIFMGDFV DRGYNSLEVF TILLLLKARY
110 120 130 140 150
PANITLLRGN HESRQLTQVY GFYDECQRKY GNANAWRYCT DVFDYLTLSA
160 170 180 190 200
IIDGTVLCVH GGLSPDVRTI DQIRLIERNC EIPHEGPFCD LMWSDPEDIE
210 220 230 240 250
TWAVSPRGAG WLFGSRVTTE FNHINKLDLV CRAHQLVQEG LKYMFQDKGL
260 270 280 290 300
VTVWSAPNYC YRCGNVASIL SFNDNMEREV KFFTETEENN QMRGPRTGVP

YFL
Length:303
Mass (Da):34,845
Last modified:October 1, 2000 - v1
Checksum:i342FD1E21BC7D2B1
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF275664 mRNA. Translation: AAK69404.1.
AP002050 Genomic DNA. Translation: BAB03163.1.
CP002686 Genomic DNA. Translation: AEE76315.1.
AY064136 mRNA. Translation: AAL36043.1.
AY097414 mRNA. Translation: AAM19930.1.
RefSeqiNP_188632.1. NM_112888.3.
UniGeneiAt.5940.

Genome annotation databases

EnsemblPlantsiAT3G19980.1; AT3G19980.1; AT3G19980.
GeneIDi821536.
KEGGiath:AT3G19980.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF275664 mRNA. Translation: AAK69404.1.
AP002050 Genomic DNA. Translation: BAB03163.1.
CP002686 Genomic DNA. Translation: AEE76315.1.
AY064136 mRNA. Translation: AAL36043.1.
AY097414 mRNA. Translation: AAM19930.1.
RefSeqiNP_188632.1. NM_112888.3.
UniGeneiAt.5940.

3D structure databases

ProteinModelPortaliQ9LHE7.
SMRiQ9LHE7. Positions 2-277.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi6868. 5 interactions.
STRINGi3702.AT3G19980.1-P.

Proteomic databases

PaxDbiQ9LHE7.
PRIDEiQ9LHE7.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblPlantsiAT3G19980.1; AT3G19980.1; AT3G19980.
GeneIDi821536.
KEGGiath:AT3G19980.

Organism-specific databases

TAIRiAT3G19980.

Phylogenomic databases

eggNOGiCOG0639.
HOGENOMiHOG000172696.
InParanoidiQ9LHE7.
KOiK15498.
OMAiENWAVSP.
PhylomeDBiQ9LHE7.

Enzyme and pathway databases

BioCyciARA:AT3G19980-MONOMER.

Miscellaneous databases

PROiQ9LHE7.

Gene expression databases

GenevestigatoriQ9LHE7.

Family and domain databases

Gene3Di3.60.21.10. 1 hit.
InterProiIPR004843. Calcineurin-like_PHP_apaH.
IPR029052. Metallo-depent_PP-like.
IPR006186. Ser/Thr-sp_prot-phosphatase.
[Graphical view]
PfamiPF00149. Metallophos. 1 hit.
[Graphical view]
PRINTSiPR00114. STPHPHTASE.
SMARTiSM00156. PP2Ac. 1 hit.
[Graphical view]
SUPFAMiSSF56300. SSF56300. 1 hit.
PROSITEiPS00125. SER_THR_PHOSPHATASE. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "A phytochrome-associated protein phosphatase 2A modulates light signals in flowering time control in Arabidopsis."
    Kim D.-H., Kang J.-G., Yang S.-S., Chung K.-S., Song P.-S., Park C.-M.
    Plant Cell 14:3043-3056(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, COFACTOR, TISSUE SPECIFICITY, INTERACTION WITH PHYA AND PHYB.
  2. "Structural analysis of Arabidopsis thaliana chromosome 3. II. Sequence features of the 4,251,695 bp regions covered by 90 P1, TAC and BAC clones."
    Kaneko T., Katoh T., Sato S., Nakamura Y., Asamizu E., Tabata S.
    DNA Res. 7:217-221(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: cv. Columbia.
  3. The Arabidopsis Information Resource (TAIR)
    Submitted (APR-2011) to the EMBL/GenBank/DDBJ databases
    Cited for: GENOME REANNOTATION.
    Strain: cv. Columbia.
  4. "Empirical analysis of transcriptional activity in the Arabidopsis genome."
    Yamada K., Lim J., Dale J.M., Chen H., Shinn P., Palm C.J., Southwick A.M., Wu H.C., Kim C.J., Nguyen M., Pham P.K., Cheuk R.F., Karlin-Newmann G., Liu S.X., Lam B., Sakano H., Wu T., Yu G.
    , Miranda M., Quach H.L., Tripp M., Chang C.H., Lee J.M., Toriumi M.J., Chan M.M., Tang C.C., Onodera C.S., Deng J.M., Akiyama K., Ansari Y., Arakawa T., Banh J., Banno F., Bowser L., Brooks S.Y., Carninci P., Chao Q., Choy N., Enju A., Goldsmith A.D., Gurjal M., Hansen N.F., Hayashizaki Y., Johnson-Hopson C., Hsuan V.W., Iida K., Karnes M., Khan S., Koesema E., Ishida J., Jiang P.X., Jones T., Kawai J., Kamiya A., Meyers C., Nakajima M., Narusaka M., Seki M., Sakurai T., Satou M., Tamse R., Vaysberg M., Wallender E.K., Wong C., Yamamura Y., Yuan S., Shinozaki K., Davis R.W., Theologis A., Ecker J.R.
    Science 302:842-846(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: cv. Columbia.
  5. "Arabidopsis PPP family of serine/threonine phosphatases."
    Farkas I., Dombradi V., Miskei M., Szabados L., Koncz C.
    Trends Plant Sci. 12:169-176(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: GENE FAMILY, NOMENCLATURE.

Entry informationi

Entry nameiFYPP3_ARATH
AccessioniPrimary (citable) accession number: Q9LHE7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 13, 2007
Last sequence update: October 1, 2000
Last modified: January 7, 2015
This is version 98 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Arabidopsis thaliana
    Arabidopsis thaliana: entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.