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Q9LHE7

- FYPP3_ARATH

UniProt

Q9LHE7 - FYPP3_ARATH

Protein

Phytochrome-associated serine/threonine-protein phosphatase 3

Gene

FYPP3

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 96 (01 Oct 2014)
      Sequence version 1 (01 Oct 2000)
      Previous versions | rss
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    Functioni

    Dephosphorylates phosphorylated phytochromes, with a preference toward Pfr forms. Plays a major role in the photoperiodic control of flowering time in long days by modulating phytochrome signals in flowering time control.1 Publication

    Catalytic activityi

    [a protein]-serine/threonine phosphate + H2O = [a protein]-serine/threonine + phosphate.

    Cofactori

    Binds 2 manganese ions per subunit.By similarity

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Metal bindingi50 – 501Manganese 1By similarity
    Metal bindingi52 – 521Manganese 1By similarity
    Metal bindingi78 – 781Manganese 1By similarity
    Metal bindingi78 – 781Manganese 2By similarity
    Metal bindingi110 – 1101Manganese 2By similarity
    Active sitei111 – 1111Proton donorBy similarity
    Metal bindingi160 – 1601Manganese 2By similarity
    Metal bindingi234 – 2341Manganese 2By similarity

    GO - Molecular functioni

    1. metal ion binding Source: UniProtKB-KW
    2. phosphoprotein phosphatase activity Source: UniProtKB-KW
    3. protein serine/threonine kinase activity Source: TAIR

    GO - Biological processi

    1. negative regulation of flower development Source: TAIR
    2. protein phosphorylation Source: GOC

    Keywords - Molecular functioni

    Hydrolase, Protein phosphatase

    Keywords - Ligandi

    Manganese, Metal-binding, Zinc

    Enzyme and pathway databases

    BioCyciARA:AT3G19980-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Phytochrome-associated serine/threonine-protein phosphatase 3 (EC:3.1.3.16)
    Short name:
    AtFyPP3
    Alternative name(s):
    Protein EMBRYO DEFECTIVE 2736
    Gene namesi
    Name:FYPP3
    Synonyms:EMB2736, STPP
    Ordered Locus Names:At3g19980
    ORF Names:MZE19.3
    OrganismiArabidopsis thaliana (Mouse-ear cress)
    Taxonomic identifieri3702 [NCBI]
    Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
    ProteomesiUP000006548: Chromosome 3

    Organism-specific databases

    TAIRiAT3G19980.

    Subcellular locationi

    Cytoplasm By similarity

    GO - Cellular componenti

    1. cytoplasm Source: TAIR
    2. nucleus Source: TAIR
    3. protein phosphatase type 2A complex Source: TAIR

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 303303Phytochrome-associated serine/threonine-protein phosphatase 3PRO_0000308990Add
    BLAST

    Proteomic databases

    PaxDbiQ9LHE7.
    PRIDEiQ9LHE7.

    Expressioni

    Tissue specificityi

    Mostly expressed in flowers. Also detected to a lower extent in stems and leaves.1 Publication

    Gene expression databases

    GenevestigatoriQ9LHE7.

    Interactioni

    Subunit structurei

    Interacts with PHYA and PHYB, mostly when they are phosphorylated and in Pfr forms.1 Publication

    Protein-protein interaction databases

    BioGridi6868. 5 interactions.
    STRINGi3702.AT3G19980.1-P.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9LHE7.
    SMRiQ9LHE7. Positions 2-277.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Phylogenomic databases

    eggNOGiCOG0639.
    HOGENOMiHOG000172696.
    InParanoidiQ9LHE7.
    KOiK15498.
    OMAiVPETSYI.
    PhylomeDBiQ9LHE7.

    Family and domain databases

    Gene3Di3.60.21.10. 1 hit.
    InterProiIPR004843. Calcineurin-like_PHP_apaH.
    IPR029052. Metallo-depent_PP-like.
    IPR006186. Ser/Thr-sp_prot-phosphatase.
    [Graphical view]
    PfamiPF00149. Metallophos. 1 hit.
    [Graphical view]
    PRINTSiPR00114. STPHPHTASE.
    SMARTiSM00156. PP2Ac. 1 hit.
    [Graphical view]
    SUPFAMiSSF56300. SSF56300. 1 hit.
    PROSITEiPS00125. SER_THR_PHOSPHATASE. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q9LHE7-1 [UniParc]FASTAAdd to Basket

    « Hide

    MDLDQWISKV KDGQHLSEDE LQLLCEYVKE ILIEESNVQP VNSPVTVCGD    50
    IHGQFHDLMK LFQTGGHVPD TNYIFMGDFV DRGYNSLEVF TILLLLKARY 100
    PANITLLRGN HESRQLTQVY GFYDECQRKY GNANAWRYCT DVFDYLTLSA 150
    IIDGTVLCVH GGLSPDVRTI DQIRLIERNC EIPHEGPFCD LMWSDPEDIE 200
    TWAVSPRGAG WLFGSRVTTE FNHINKLDLV CRAHQLVQEG LKYMFQDKGL 250
    VTVWSAPNYC YRCGNVASIL SFNDNMEREV KFFTETEENN QMRGPRTGVP 300
    YFL 303
    Length:303
    Mass (Da):34,845
    Last modified:October 1, 2000 - v1
    Checksum:i342FD1E21BC7D2B1
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF275664 mRNA. Translation: AAK69404.1.
    AP002050 Genomic DNA. Translation: BAB03163.1.
    CP002686 Genomic DNA. Translation: AEE76315.1.
    AY064136 mRNA. Translation: AAL36043.1.
    AY097414 mRNA. Translation: AAM19930.1.
    RefSeqiNP_188632.1. NM_112888.3.
    UniGeneiAt.5940.

    Genome annotation databases

    EnsemblPlantsiAT3G19980.1; AT3G19980.1; AT3G19980.
    GeneIDi821536.
    KEGGiath:AT3G19980.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF275664 mRNA. Translation: AAK69404.1 .
    AP002050 Genomic DNA. Translation: BAB03163.1 .
    CP002686 Genomic DNA. Translation: AEE76315.1 .
    AY064136 mRNA. Translation: AAL36043.1 .
    AY097414 mRNA. Translation: AAM19930.1 .
    RefSeqi NP_188632.1. NM_112888.3.
    UniGenei At.5940.

    3D structure databases

    ProteinModelPortali Q9LHE7.
    SMRi Q9LHE7. Positions 2-277.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 6868. 5 interactions.
    STRINGi 3702.AT3G19980.1-P.

    Proteomic databases

    PaxDbi Q9LHE7.
    PRIDEi Q9LHE7.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblPlantsi AT3G19980.1 ; AT3G19980.1 ; AT3G19980 .
    GeneIDi 821536.
    KEGGi ath:AT3G19980.

    Organism-specific databases

    TAIRi AT3G19980.

    Phylogenomic databases

    eggNOGi COG0639.
    HOGENOMi HOG000172696.
    InParanoidi Q9LHE7.
    KOi K15498.
    OMAi VPETSYI.
    PhylomeDBi Q9LHE7.

    Enzyme and pathway databases

    BioCyci ARA:AT3G19980-MONOMER.

    Miscellaneous databases

    PROi Q9LHE7.

    Gene expression databases

    Genevestigatori Q9LHE7.

    Family and domain databases

    Gene3Di 3.60.21.10. 1 hit.
    InterProi IPR004843. Calcineurin-like_PHP_apaH.
    IPR029052. Metallo-depent_PP-like.
    IPR006186. Ser/Thr-sp_prot-phosphatase.
    [Graphical view ]
    Pfami PF00149. Metallophos. 1 hit.
    [Graphical view ]
    PRINTSi PR00114. STPHPHTASE.
    SMARTi SM00156. PP2Ac. 1 hit.
    [Graphical view ]
    SUPFAMi SSF56300. SSF56300. 1 hit.
    PROSITEi PS00125. SER_THR_PHOSPHATASE. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "A phytochrome-associated protein phosphatase 2A modulates light signals in flowering time control in Arabidopsis."
      Kim D.-H., Kang J.-G., Yang S.-S., Chung K.-S., Song P.-S., Park C.-M.
      Plant Cell 14:3043-3056(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, COFACTOR, TISSUE SPECIFICITY, INTERACTION WITH PHYA AND PHYB.
    2. "Structural analysis of Arabidopsis thaliana chromosome 3. II. Sequence features of the 4,251,695 bp regions covered by 90 P1, TAC and BAC clones."
      Kaneko T., Katoh T., Sato S., Nakamura Y., Asamizu E., Tabata S.
      DNA Res. 7:217-221(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: cv. Columbia.
    3. The Arabidopsis Information Resource (TAIR)
      Submitted (APR-2011) to the EMBL/GenBank/DDBJ databases
      Cited for: GENOME REANNOTATION.
      Strain: cv. Columbia.
    4. "Empirical analysis of transcriptional activity in the Arabidopsis genome."
      Yamada K., Lim J., Dale J.M., Chen H., Shinn P., Palm C.J., Southwick A.M., Wu H.C., Kim C.J., Nguyen M., Pham P.K., Cheuk R.F., Karlin-Newmann G., Liu S.X., Lam B., Sakano H., Wu T., Yu G.
      , Miranda M., Quach H.L., Tripp M., Chang C.H., Lee J.M., Toriumi M.J., Chan M.M., Tang C.C., Onodera C.S., Deng J.M., Akiyama K., Ansari Y., Arakawa T., Banh J., Banno F., Bowser L., Brooks S.Y., Carninci P., Chao Q., Choy N., Enju A., Goldsmith A.D., Gurjal M., Hansen N.F., Hayashizaki Y., Johnson-Hopson C., Hsuan V.W., Iida K., Karnes M., Khan S., Koesema E., Ishida J., Jiang P.X., Jones T., Kawai J., Kamiya A., Meyers C., Nakajima M., Narusaka M., Seki M., Sakurai T., Satou M., Tamse R., Vaysberg M., Wallender E.K., Wong C., Yamamura Y., Yuan S., Shinozaki K., Davis R.W., Theologis A., Ecker J.R.
      Science 302:842-846(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: cv. Columbia.
    5. "Arabidopsis PPP family of serine/threonine phosphatases."
      Farkas I., Dombradi V., Miskei M., Szabados L., Koncz C.
      Trends Plant Sci. 12:169-176(2007) [PubMed] [Europe PMC] [Abstract]
      Cited for: GENE FAMILY, NOMENCLATURE.

    Entry informationi

    Entry nameiFYPP3_ARATH
    AccessioniPrimary (citable) accession number: Q9LHE7
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 13, 2007
    Last sequence update: October 1, 2000
    Last modified: October 1, 2014
    This is version 96 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programPlant Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Arabidopsis thaliana
      Arabidopsis thaliana: entries and gene names
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3