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Protein

Phytochrome-associated serine/threonine-protein phosphatase 3

Gene

FYPP3

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Dephosphorylates phosphorylated phytochromes, with a preference toward Pfr forms. Plays a major role in the photoperiodic control of flowering time in long days by modulating phytochrome signals in flowering time control.1 Publication

Catalytic activityi

[a protein]-serine/threonine phosphate + H2O = [a protein]-serine/threonine + phosphate.

Cofactori

Mn2+By similarityNote: Binds 2 manganese ions per subunit.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi50Manganese 1By similarity1
Metal bindingi52Manganese 1By similarity1
Metal bindingi78Manganese 1By similarity1
Metal bindingi78Manganese 2By similarity1
Metal bindingi110Manganese 2By similarity1
Active sitei111Proton donorBy similarity1
Metal bindingi160Manganese 2By similarity1
Metal bindingi234Manganese 2By similarity1

GO - Molecular functioni

  • metal ion binding Source: UniProtKB-KW
  • phosphoprotein phosphatase activity Source: UniProtKB-KW
  • protein serine/threonine kinase activity Source: TAIR

GO - Biological processi

  • negative regulation of flower development Source: TAIR
  • protein dephosphorylation Source: TAIR

Keywordsi

Molecular functionHydrolase, Protein phosphatase
LigandManganese, Metal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Phytochrome-associated serine/threonine-protein phosphatase 3 (EC:3.1.3.16)
Short name:
AtFyPP3
Alternative name(s):
Protein EMBRYO DEFECTIVE 2736
Gene namesi
Name:FYPP3
Synonyms:EMB2736, STPP
Ordered Locus Names:At3g19980
ORF Names:MZE19.3
OrganismiArabidopsis thaliana (Mouse-ear cress)
Taxonomic identifieri3702 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
Proteomesi
  • UP000006548 Componenti: Chromosome 3

Organism-specific databases

AraportiAT3G19980
TAIRilocus:2095380 AT3G19980

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Chloroplast Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertion Graphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003089901 – 303Phytochrome-associated serine/threonine-protein phosphatase 3Add BLAST303

Proteomic databases

PaxDbiQ9LHE7
PRIDEiQ9LHE7

Expressioni

Tissue specificityi

Mostly expressed in flowers. Also detected to a lower extent in stems and leaves.1 Publication

Gene expression databases

ExpressionAtlasiQ9LHE7 baseline and differential
GenevisibleiQ9LHE7 AT

Interactioni

Subunit structurei

Interacts with PHYA and PHYB, mostly when they are phosphorylated and in Pfr forms (PubMed:12468726). Interacts with TAP46 (PubMed:24357600).2 Publications

Protein-protein interaction databases

BioGridi6868, 5 interactors
STRINGi3702.AT3G19980.1

Structurei

3D structure databases

ProteinModelPortaliQ9LHE7
SMRiQ9LHE7
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG0373 Eukaryota
ENOG410XNR9 LUCA
HOGENOMiHOG000172696
InParanoidiQ9LHE7
KOiK15498
OMAiNRRQEIP
OrthoDBiEOG09360F5Z
PhylomeDBiQ9LHE7

Family and domain databases

Gene3Di3.60.21.10, 1 hit
InterProiView protein in InterPro
IPR004843 Calcineurin-like_PHP_ApaH
IPR029052 Metallo-depent_PP-like
IPR006186 Ser/Thr-sp_prot-phosphatase
PfamiView protein in Pfam
PF00149 Metallophos, 1 hit
PRINTSiPR00114 STPHPHTASE
SMARTiView protein in SMART
SM00156 PP2Ac, 1 hit
PROSITEiView protein in PROSITE
PS00125 SER_THR_PHOSPHATASE, 1 hit

Sequencei

Sequence statusi: Complete.

Q9LHE7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDLDQWISKV KDGQHLSEDE LQLLCEYVKE ILIEESNVQP VNSPVTVCGD
60 70 80 90 100
IHGQFHDLMK LFQTGGHVPD TNYIFMGDFV DRGYNSLEVF TILLLLKARY
110 120 130 140 150
PANITLLRGN HESRQLTQVY GFYDECQRKY GNANAWRYCT DVFDYLTLSA
160 170 180 190 200
IIDGTVLCVH GGLSPDVRTI DQIRLIERNC EIPHEGPFCD LMWSDPEDIE
210 220 230 240 250
TWAVSPRGAG WLFGSRVTTE FNHINKLDLV CRAHQLVQEG LKYMFQDKGL
260 270 280 290 300
VTVWSAPNYC YRCGNVASIL SFNDNMEREV KFFTETEENN QMRGPRTGVP

YFL
Length:303
Mass (Da):34,845
Last modified:October 1, 2000 - v1
Checksum:i342FD1E21BC7D2B1
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF275664 mRNA Translation: AAK69404.1
AP002050 Genomic DNA Translation: BAB03163.1
CP002686 Genomic DNA Translation: AEE76315.1
AY064136 mRNA Translation: AAL36043.1
AY097414 mRNA Translation: AAM19930.1
RefSeqiNP_188632.1, NM_112888.4
UniGeneiAt.5940

Genome annotation databases

EnsemblPlantsiAT3G19980.1; AT3G19980.1; AT3G19980
GeneIDi821536
GrameneiAT3G19980.1; AT3G19980.1; AT3G19980
KEGGiath:AT3G19980

Similar proteinsi

Entry informationi

Entry nameiFYPP3_ARATH
AccessioniPrimary (citable) accession number: Q9LHE7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 13, 2007
Last sequence update: October 1, 2000
Last modified: April 25, 2018
This is version 113 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health