Q9LGB4 (SPCS3_ORYSJ) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Probable signal peptidase complex subunit 3
EC=3.4.-.-

Alternative name(s):
Microsomal signal peptidase 22 kDa subunit
Short name=SPC22
Short name=SPase 22 kDa subunit

Gene names

Ordered Locus Names:	Os01g0131800, LOC_Os01g04030
ORF Names:	P0504H10.30

Organism

Oryza sativa subsp. japonica (Rice)

Taxonomic identifier

39947 [NCBI]

Taxonomic lineage

Eukaryota › Viridiplantae › Streptophyta › Embryophyta › Tracheophyta › Spermatophyta › Magnoliophyta › Liliopsida › Poales › Poaceae › BEP clade › Ehrhartoideae › Oryzeae › Oryza

Protein attributes

Sequence length	147 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Microsomal signal peptidase is a membrane-bound endoproteinase that removes signal peptides from nascent proteins as they are translocated into the lumen of the endoplasmic reticulum By similarity.
Subunit structure	Complex of five different proteins: SEC11L1, SEC11L3, SPCS1, SPCS2 and SPCS3 By similarity.
Subcellular location	Microsome membrane; Single-pass type II membrane protein Potential. Endoplasmic reticulum membrane; Single-pass type II membrane protein Potential.
Sequence similarities	Belongs to the SPCS3 family.

Ontologies

Keywords
Cellular component	Endoplasmic reticulum Membrane Microsome
Domain	Signal-anchor Transmembrane Transmembrane helix
Molecular function	Hydrolase Protease
Gene Ontology (GO)
Biological process	proteolysis Inferred from electronic annotation. Source: UniProtKB-KW signal peptide processing Inferred from electronic annotation. Source: InterPro
Cellular component	integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW microsome Inferred from electronic annotation. Source: UniProtKB-SubCell signal peptidase complex Inferred from electronic annotation. Source: InterPro
Molecular function	peptidase activity Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 147	147	Probable signal peptidase complex subunit 3		PRO_0000218946
Regions
	Topological domain	1 – 6	6	Cytoplasmic Potential
	Transmembrane	7 – 29	23	Helical; Signal-anchor for type II membrane protein; Potential
	Topological domain	30 – 147	118	Lumenal Potential

Sequences

	Sequence		Length	Mass (Da)
	Q9LGB4 [UniParc]. Last modified May 2, 2006. Version 2. Checksum: 2A5E760527F9663B	FASTA	147	16,483
	10 20 30 40 50 60 MHSWVQRLLT TATTAALLLL AACCAASALD AFHVPSVQAQ AHVTKINRFH KQLNGNDKVF 70 80 90 100 110 120 VFLTAEYENS KNSLNQVSLW DHIIPDKDKA NLQVEVKSKY PLIDQGSSLR GKKVQLVLHW 130 140 HVMPKAGVMI RDRMALSEFN LPDSYTS

References

[1]

"The genome sequence and structure of rice chromosome 1." Sasaki T., Matsumoto T., Yamamoto K., Sakata K., Baba T., Katayose Y., Wu J., Niimura Y., Cheng Z., Nagamura Y., Antonio B.A., Kanamori H., Hosokawa S., Masukawa M., Arikawa K., Chiden Y., Hayashi M., Okamoto M. , Ando T., Aoki H., Arita K., Hamada M., Harada C., Hijishita S., Honda M., Ichikawa Y., Idonuma A., Iijima M., Ikeda M., Ikeno M., Ito S., Ito T., Ito Y., Ito Y., Iwabuchi A., Kamiya K., Karasawa W., Katagiri S., Kikuta A., Kobayashi N., Kono I., Machita K., Maehara T., Mizuno H., Mizubayashi T., Mukai Y., Nagasaki H., Nakashima M., Nakama Y., Nakamichi Y., Nakamura M., Namiki N., Negishi M., Ohta I., Ono N., Saji S., Sakai K., Shibata M., Shimokawa T., Shomura A., Song J., Takazaki Y., Terasawa K., Tsuji K., Waki K., Yamagata H., Yamane H., Yoshiki S., Yoshihara R., Yukawa K., Zhong H., Iwama H., Endo T., Ito H., Hahn J.H., Kim H.-I., Eun M.-Y., Yano M., Jiang J., Gojobori T. Nature 420:312-316(2002) [PubMed: 12447438] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: cv. Nipponbare.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AP002526 Genomic DNA. Translation: BAD52472.1.
3D structure databases
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Organism-specific databases
Gramene	Q9LGB4.
Family and domain databases
InterPro	IPR007653. SPC22. [Graphical view]
PANTHER	PTHR12804. SPC22. 1 hit.
Pfam	PF04573. SPC22. 1 hit. [Graphical view]
PIRSF	PIRSF016089. SPC22. 1 hit.
ProtoNet	Search...

Entry information

Entry name

SPCS3_ORYSJ

Accession

Primary (citable) accession number: Q9LGB4
Secondary accession number(s): Q5ZEG5

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 2, 2001
Last sequence update:	May 2, 2006
Last modified:	November 16, 2011
This is version 48 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Plant Protein Annotation Program