Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Basket 0
(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Q9LG11

- HAC4_ARATH

UniProt

Q9LG11 - HAC4_ARATH

Protein

Histone acetyltransferase HAC4

Gene

HAC4

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
    • BLAST
    • Align
    • Format
    • Add to basket
    • History
      Entry version 87 (01 Oct 2014)
      Sequence version 2 (09 Jan 2007)
      Previous versions | rss
    • Help video
    • Feedback
    • Comment

    Functioni

    Acetyltransferase enzyme. Acetylates histones, giving a specific tag for transcriptional activation By similarity.By similarity

    Catalytic activityi

    Acetyl-CoA + [histone] = CoA + acetyl-[histone].

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Zinc fingeri416 – 49580TAZ-type 1PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri764 – 84178PHD-typeAdd
    BLAST
    Zinc fingeri1174 – 122148ZZ-type 1PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri1294 – 134148ZZ-type 2PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri1358 – 143679TAZ-type 2PROSITE-ProRule annotationAdd
    BLAST

    GO - Molecular functioni

    1. histone acetyltransferase activity Source: UniProtKB-EC
    2. transcription cofactor activity Source: InterPro
    3. zinc ion binding Source: InterPro

    GO - Biological processi

    1. regulation of transcription, DNA-templated Source: UniProtKB-KW
    2. transcription, DNA-templated Source: UniProtKB-KW

    Keywords - Molecular functioni

    Activator, Acyltransferase, Chromatin regulator, Transferase

    Keywords - Biological processi

    Transcription, Transcription regulation

    Keywords - Ligandi

    Metal-binding, Zinc

    Enzyme and pathway databases

    BioCyciARA:AT1G55970-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Histone acetyltransferase HAC4 (EC:2.3.1.48)
    Gene namesi
    Name:HAC4
    Synonyms:PCAT3
    Ordered Locus Names:At1g55970
    ORF Names:F14J16.27, T6H22.22
    OrganismiArabidopsis thaliana (Mouse-ear cress)
    Taxonomic identifieri3702 [NCBI]
    Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
    ProteomesiUP000006548: Chromosome 1

    Organism-specific databases

    TAIRiAT1G55970.

    Subcellular locationi

    Nucleus Curated

    GO - Cellular componenti

    1. nucleus Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Nucleus

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 14701470Histone acetyltransferase HAC4PRO_0000269742Add
    BLAST

    Expressioni

    Tissue specificityi

    Rosette leaves, stems and flowers.1 Publication

    Developmental stagei

    Expressed in young seedlings.1 Publication

    Gene expression databases

    GenevestigatoriQ9LG11.

    Family & Domainsi

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi54 – 8734Gln-richAdd
    BLAST
    Compositional biasi323 – 39573Gln-richAdd
    BLAST

    Sequence similaritiesi

    Contains 1 PHD-type zinc finger.Curated
    Contains 2 TAZ-type zinc fingers.PROSITE-ProRule annotation
    Contains 2 ZZ-type zinc fingers.PROSITE-ProRule annotation

    Zinc finger

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Zinc fingeri416 – 49580TAZ-type 1PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri764 – 84178PHD-typeAdd
    BLAST
    Zinc fingeri1174 – 122148ZZ-type 1PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri1294 – 134148ZZ-type 2PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri1358 – 143679TAZ-type 2PROSITE-ProRule annotationAdd
    BLAST

    Keywords - Domaini

    Repeat, Zinc-finger

    Phylogenomic databases

    eggNOGiNOG257281.
    InParanoidiQ9LG11.
    KOiK04498.
    PhylomeDBiQ9LG11.

    Family and domain databases

    Gene3Di1.20.1020.10. 2 hits.
    3.30.40.10. 1 hit.
    InterProiIPR013178. Histone_H3-K56_AcTrfase_RTT109.
    IPR019786. Zinc_finger_PHD-type_CS.
    IPR011011. Znf_FYVE_PHD.
    IPR001965. Znf_PHD.
    IPR019787. Znf_PHD-finger.
    IPR013083. Znf_RING/FYVE/PHD.
    IPR000197. Znf_TAZ.
    IPR000433. Znf_ZZ.
    [Graphical view]
    PfamiPF08214. KAT11. 1 hit.
    PF00628. PHD. 1 hit.
    PF02135. zf-TAZ. 2 hits.
    PF00569. ZZ. 1 hit.
    [Graphical view]
    SMARTiSM00249. PHD. 1 hit.
    SM00551. ZnF_TAZ. 2 hits.
    SM00291. ZnF_ZZ. 2 hits.
    [Graphical view]
    SUPFAMiSSF57903. SSF57903. 1 hit.
    SSF57933. SSF57933. 2 hits.
    PROSITEiPS01359. ZF_PHD_1. 1 hit.
    PS50134. ZF_TAZ. 2 hits.
    PS01357. ZF_ZZ_1. 2 hits.
    PS50135. ZF_ZZ_2. 2 hits.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q9LG11-1 [UniParc]FASTAAdd to Basket

    « Hide

    MNNNKEVPQN SVAVSSSSSA PITVISPQQD ANNFIKKRRT ALRNRIYAIV     50
    RHKQKQHQIF LDKKNQQQQQ RVDDATQRAL LEKQDQQCIA ATRMIEEELL 100
    KSSRSFEEYF DLRTFDARVR TILQQLGTML SQRRAAAAAM NNGEAQCITS 150
    TRAVHTSISV SNSFQCGRSL VPINCTTATA GAFSIGPDMQ THHSTGANHQ 200
    MVEVNRPNMN QITCGISSPL ITGFNGNCVP VSANIPMTSQ DLFNATHFST 250
    LPQPFLQPPP DQSHMHRYSM SNVASFGQSN PYPCGVVMSS GSMAVAQNSI 300
    PWNNPNPMQG LDPTVTSYHS NLQPMQQTPL PKRQLHHPLW NTNFQSAPNN 350
    RDNLPQVSQQ LSNHGSRQHR GQHSQNLYPG QLQNQDRLLP NLTQQAMALA 400
    APVMHVPSKQ VNEDCGQTSS NTVLRWIPFM FHARHCKAKK DKCASKFCFQ 450
    ARKIVKHIDC CKVPNCKYRY CLGTRMWLDH FKQCKSISCR TCVAVREYME 500
    KNKYTIVPLR RAKCSSASSK CQPKKSSKSR QAYKKGGAEA PSVDADLQRS 550
    IKRPKLHRPS QNITPETKSI SVTGCGVVCK PHSLMNMQEK DGLQSLKVEA 600
    MPMDIDVPGA SEIPVTRELV KHVAEDTPKG NNCGGFAMVE KTSCLLAQGK 650
    SKCMNEMSAP KEENVKQSVE VVDASKMEIS SLVELFTPEQ VKEHIRSLRQ 700
    WVGQSKTKAE KNKAMGCSMS VNSCQLCAVE WLVFEPVPIY CSPCGIRIKK 750
    NALHYSIAVG ESRHYVCAPC YNEAREKLVF LDGTSIPKTR LQKKKNDEQV 800
    PEGWVQCDKC EAWQHIICAL FNSRRNHGES TKYTCPSCYI QEVEQRERRP 850
    LPLSAVPGAT SLPVTSLSKH LEERLFKKLK EERQERARLQ GKTYEEVPGA 900
    ESLTVRVVAS VDKVLEVKER FLELFREENY PSEFPYKSKA IFLFQKIENV 950
    EVCLFGMFVQ EFGTDSGPPN ERRVYLSYLD SVKYFRPTFR TVSGEALRTF 1000
    VYHEILIGYL DYCKKRGFTS CYIWACPPLK GDDYILYCHP EIQKTPKTDK 1050
    LREWYLAMLR KASKEDVVVE CTNLYNHFFV QSGECRANVT AARLPYFDGD 1100
    YWPSAAEDLL RQMNQEDDGE TKLHRKGLTK KVISKRALKA VGQLDLSLNA 1150
    SKDRLMMQKL GETICPMKED FIMVHLQHCC KHCTTLMVSG NRWVCNHCKN 1200
    FQICDKCYEV EQNRINIERH PINQKEKHAL FPVAIKDVPT KIEDKDNNLE 1250
    SEFFHNRQAF LNLCQGNNYQ YETLRRAKHS SMMILYHLHN PTAPAFATVC 1300
    TICQQEVENS QGWHCEVCPG YDVCSACYSK DSINHSHKLT SRSSSTDSTV 1350
    VQQNGQASQS YQVKLEKLKK LLVHAATCRS TQCQYQGCRK SKMLFRHCID 1400
    CTTGDCPICK GLWSLLKLHA RNCRDSKCTV PKCSGLRAIS RRKQQQADKR 1450
    RRAAVMEMMR ERAAEATRTG 1470
    Length:1,470
    Mass (Da):166,802
    Last modified:January 9, 2007 - v2
    Checksum:iC1583E17D19C06CD
    GO

    Sequence cautioni

    The sequence AAK73519.1 differs from that shown. Reason: Frameshift at position 988.
    The sequence AAF02849.1 differs from that shown. Reason: Erroneous gene model prediction.
    The sequence AAF79331.1 differs from that shown. Reason: Erroneous gene model prediction.
    The sequence AEE33326.1 differs from that shown. Reason: Erroneous gene model prediction.

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AC002304 Genomic DNA. Translation: AAF79331.1. Sequence problems.
    AC009894 Genomic DNA. Translation: AAF02849.1. Sequence problems.
    CP002684 Genomic DNA. Translation: AEE33326.1. Sequence problems.
    AF512559 mRNA. Translation: AAM34789.1.
    AF512560 mRNA. Translation: AAM34790.1.
    AF389513 mRNA. Translation: AAK73519.1. Frameshift.
    RefSeqiNP_564706.1. NM_104475.2.
    UniGeneiAt.26162.

    Genome annotation databases

    EnsemblPlantsiAT1G55970.1; AT1G55970.1; AT1G55970.
    GeneIDi842048.
    KEGGiath:AT1G55970.

    Cross-referencesi

    Web resourcesi

    PlantsUBQ

    A functional genomics database for the ubiquitin/26S proteasome proteolytic pathway in plants

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AC002304 Genomic DNA. Translation: AAF79331.1 . Sequence problems.
    AC009894 Genomic DNA. Translation: AAF02849.1 . Sequence problems.
    CP002684 Genomic DNA. Translation: AEE33326.1 . Sequence problems.
    AF512559 mRNA. Translation: AAM34789.1 .
    AF512560 mRNA. Translation: AAM34790.1 .
    AF389513 mRNA. Translation: AAK73519.1 . Frameshift.
    RefSeqi NP_564706.1. NM_104475.2.
    UniGenei At.26162.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblPlantsi AT1G55970.1 ; AT1G55970.1 ; AT1G55970 .
    GeneIDi 842048.
    KEGGi ath:AT1G55970.

    Organism-specific databases

    TAIRi AT1G55970.

    Phylogenomic databases

    eggNOGi NOG257281.
    InParanoidi Q9LG11.
    KOi K04498.
    PhylomeDBi Q9LG11.

    Enzyme and pathway databases

    BioCyci ARA:AT1G55970-MONOMER.

    Gene expression databases

    Genevestigatori Q9LG11.

    Family and domain databases

    Gene3Di 1.20.1020.10. 2 hits.
    3.30.40.10. 1 hit.
    InterProi IPR013178. Histone_H3-K56_AcTrfase_RTT109.
    IPR019786. Zinc_finger_PHD-type_CS.
    IPR011011. Znf_FYVE_PHD.
    IPR001965. Znf_PHD.
    IPR019787. Znf_PHD-finger.
    IPR013083. Znf_RING/FYVE/PHD.
    IPR000197. Znf_TAZ.
    IPR000433. Znf_ZZ.
    [Graphical view ]
    Pfami PF08214. KAT11. 1 hit.
    PF00628. PHD. 1 hit.
    PF02135. zf-TAZ. 2 hits.
    PF00569. ZZ. 1 hit.
    [Graphical view ]
    SMARTi SM00249. PHD. 1 hit.
    SM00551. ZnF_TAZ. 2 hits.
    SM00291. ZnF_ZZ. 2 hits.
    [Graphical view ]
    SUPFAMi SSF57903. SSF57903. 1 hit.
    SSF57933. SSF57933. 2 hits.
    PROSITEi PS01359. ZF_PHD_1. 1 hit.
    PS50134. ZF_TAZ. 2 hits.
    PS01357. ZF_ZZ_1. 2 hits.
    PS50135. ZF_ZZ_2. 2 hits.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Sequence and analysis of chromosome 1 of the plant Arabidopsis thaliana."
      Theologis A., Ecker J.R., Palm C.J., Federspiel N.A., Kaul S., White O., Alonso J., Altafi H., Araujo R., Bowman C.L., Brooks S.Y., Buehler E., Chan A., Chao Q., Chen H., Cheuk R.F., Chin C.W., Chung M.K.
      , Conn L., Conway A.B., Conway A.R., Creasy T.H., Dewar K., Dunn P., Etgu P., Feldblyum T.V., Feng J.-D., Fong B., Fujii C.Y., Gill J.E., Goldsmith A.D., Haas B., Hansen N.F., Hughes B., Huizar L., Hunter J.L., Jenkins J., Johnson-Hopson C., Khan S., Khaykin E., Kim C.J., Koo H.L., Kremenetskaia I., Kurtz D.B., Kwan A., Lam B., Langin-Hooper S., Lee A., Lee J.M., Lenz C.A., Li J.H., Li Y.-P., Lin X., Liu S.X., Liu Z.A., Luros J.S., Maiti R., Marziali A., Militscher J., Miranda M., Nguyen M., Nierman W.C., Osborne B.I., Pai G., Peterson J., Pham P.K., Rizzo M., Rooney T., Rowley D., Sakano H., Salzberg S.L., Schwartz J.R., Shinn P., Southwick A.M., Sun H., Tallon L.J., Tambunga G., Toriumi M.J., Town C.D., Utterback T., Van Aken S., Vaysberg M., Vysotskaia V.S., Walker M., Wu D., Yu G., Fraser C.M., Venter J.C., Davis R.W.
      Nature 408:816-820(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: cv. Columbia.
    2. The Arabidopsis Information Resource (TAIR)
      Submitted (APR-2011) to the EMBL/GenBank/DDBJ databases
      Cited for: GENOME REANNOTATION.
      Strain: cv. Columbia.
    3. "Analysis of histone acetyltransferase and histone deacetylase families of Arabidopsis thaliana suggests functional diversification of chromatin modification among multicellular eukaryotes."
      Pandey R., Mueller A., Napoli C.A., Selinger D.A., Pikaard C.S., Richards E.J., Bender J., Mount D.W., Jorgensen R.A.
      Nucleic Acids Res. 30:5036-5055(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 10-760 AND 1086-1470, NOMENCLATURE.
    4. Richards E.J.
      Submitted (JUN-2001) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 772-1470.
    5. "Plant orthologs of p300/CBP: conservation of a core domain in metazoan p300/CBP acetyltransferase-related proteins."
      Bordoli L., Netsch M., Luethi U., Lutz W., Eckner R.
      Nucleic Acids Res. 29:589-597(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: DEVELOPMENTAL STAGE, TISSUE SPECIFICITY.

    Entry informationi

    Entry nameiHAC4_ARATH
    AccessioniPrimary (citable) accession number: Q9LG11
    Secondary accession number(s): F4I3I0
    , Q8LRK3, Q8LRK4, Q94EW2, Q9SGS6
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: January 9, 2007
    Last sequence update: January 9, 2007
    Last modified: October 1, 2014
    This is version 87 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programPlant Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Arabidopsis thaliana
      Arabidopsis thaliana: entries and gene names
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3