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Q9LG11

- HAC4_ARATH

UniProt

Q9LG11 - HAC4_ARATH

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Protein

Histone acetyltransferase HAC4

Gene

HAC4

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli

Functioni

Acetyltransferase enzyme. Acetylates histones, giving a specific tag for transcriptional activation.By similarity

Catalytic activityi

Acetyl-CoA + [histone] = CoA + acetyl-[histone].By similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei1054 – 10541Acetyl-CoABy similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri416 – 49580TAZ-type 1PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri764 – 84178PHD-typeAdd
BLAST
Zinc fingeri1174 – 122148ZZ-type 1PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri1294 – 134148ZZ-type 2PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri1358 – 143679TAZ-type 2PROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

  1. histone acetyltransferase activity Source: UniProtKB-EC
  2. transcription cofactor activity Source: InterPro
  3. zinc ion binding Source: InterPro

GO - Biological processi

  1. regulation of transcription, DNA-templated Source: UniProtKB-KW
  2. transcription, DNA-templated Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Activator, Acyltransferase, Chromatin regulator, Transferase

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

Metal-binding, Zinc

Enzyme and pathway databases

BioCyciARA:AT1G55970-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Histone acetyltransferase HAC4 (EC:2.3.1.48By similarity)
Gene namesi
Name:HAC4
Synonyms:PCAT3
Ordered Locus Names:At1g55970
ORF Names:F14J16.27, T6H22.22
OrganismiArabidopsis thaliana (Mouse-ear cress)
Taxonomic identifieri3702 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
ProteomesiUP000006548: Chromosome 1

Organism-specific databases

TAIRiAT1G55970.

Subcellular locationi

Nucleus Curated

GO - Cellular componenti

  1. nucleus Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 14701470Histone acetyltransferase HAC4PRO_0000269742Add
BLAST

Expressioni

Tissue specificityi

Rosette leaves, stems and flowers.1 Publication

Developmental stagei

Expressed in young seedlings.1 Publication

Gene expression databases

GenevestigatoriQ9LG11.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini856 – 1293438CBP/p300-type HATPROSITE-ProRule annotationAdd
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni979 – 9813Acetyl-CoA bindingBy similarity
Regioni998 – 9992Acetyl-CoA bindingBy similarity

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi54 – 8734Gln-richAdd
BLAST
Compositional biasi323 – 39573Gln-richAdd
BLAST

Sequence similaritiesi

Contains 1 CBP/p300-type HAT (histone acetyltransferase) domain.PROSITE-ProRule annotation
Contains 1 PHD-type zinc finger.Curated
Contains 2 TAZ-type zinc fingers.PROSITE-ProRule annotation
Contains 2 ZZ-type zinc fingers.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri416 – 49580TAZ-type 1PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri764 – 84178PHD-typeAdd
BLAST
Zinc fingeri1174 – 122148ZZ-type 1PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri1294 – 134148ZZ-type 2PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri1358 – 143679TAZ-type 2PROSITE-ProRule annotationAdd
BLAST

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiNOG257281.
InParanoidiQ9LG11.
KOiK04498.
PhylomeDBiQ9LG11.

Family and domain databases

Gene3Di1.20.1020.10. 2 hits.
3.30.40.10. 1 hit.
InterProiIPR013178. Histone_H3-K56_AcTrfase_RTT109.
IPR019786. Zinc_finger_PHD-type_CS.
IPR011011. Znf_FYVE_PHD.
IPR001965. Znf_PHD.
IPR019787. Znf_PHD-finger.
IPR013083. Znf_RING/FYVE/PHD.
IPR000197. Znf_TAZ.
IPR000433. Znf_ZZ.
[Graphical view]
PfamiPF08214. KAT11. 1 hit.
PF00628. PHD. 1 hit.
PF02135. zf-TAZ. 2 hits.
PF00569. ZZ. 1 hit.
[Graphical view]
SMARTiSM00249. PHD. 1 hit.
SM00551. ZnF_TAZ. 2 hits.
SM00291. ZnF_ZZ. 2 hits.
[Graphical view]
SUPFAMiSSF57903. SSF57903. 1 hit.
SSF57933. SSF57933. 2 hits.
PROSITEiPS51727. CBP_P300_HAT. 1 hit.
PS01359. ZF_PHD_1. 1 hit.
PS50134. ZF_TAZ. 2 hits.
PS01357. ZF_ZZ_1. 2 hits.
PS50135. ZF_ZZ_2. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9LG11-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MNNNKEVPQN SVAVSSSSSA PITVISPQQD ANNFIKKRRT ALRNRIYAIV
60 70 80 90 100
RHKQKQHQIF LDKKNQQQQQ RVDDATQRAL LEKQDQQCIA ATRMIEEELL
110 120 130 140 150
KSSRSFEEYF DLRTFDARVR TILQQLGTML SQRRAAAAAM NNGEAQCITS
160 170 180 190 200
TRAVHTSISV SNSFQCGRSL VPINCTTATA GAFSIGPDMQ THHSTGANHQ
210 220 230 240 250
MVEVNRPNMN QITCGISSPL ITGFNGNCVP VSANIPMTSQ DLFNATHFST
260 270 280 290 300
LPQPFLQPPP DQSHMHRYSM SNVASFGQSN PYPCGVVMSS GSMAVAQNSI
310 320 330 340 350
PWNNPNPMQG LDPTVTSYHS NLQPMQQTPL PKRQLHHPLW NTNFQSAPNN
360 370 380 390 400
RDNLPQVSQQ LSNHGSRQHR GQHSQNLYPG QLQNQDRLLP NLTQQAMALA
410 420 430 440 450
APVMHVPSKQ VNEDCGQTSS NTVLRWIPFM FHARHCKAKK DKCASKFCFQ
460 470 480 490 500
ARKIVKHIDC CKVPNCKYRY CLGTRMWLDH FKQCKSISCR TCVAVREYME
510 520 530 540 550
KNKYTIVPLR RAKCSSASSK CQPKKSSKSR QAYKKGGAEA PSVDADLQRS
560 570 580 590 600
IKRPKLHRPS QNITPETKSI SVTGCGVVCK PHSLMNMQEK DGLQSLKVEA
610 620 630 640 650
MPMDIDVPGA SEIPVTRELV KHVAEDTPKG NNCGGFAMVE KTSCLLAQGK
660 670 680 690 700
SKCMNEMSAP KEENVKQSVE VVDASKMEIS SLVELFTPEQ VKEHIRSLRQ
710 720 730 740 750
WVGQSKTKAE KNKAMGCSMS VNSCQLCAVE WLVFEPVPIY CSPCGIRIKK
760 770 780 790 800
NALHYSIAVG ESRHYVCAPC YNEAREKLVF LDGTSIPKTR LQKKKNDEQV
810 820 830 840 850
PEGWVQCDKC EAWQHIICAL FNSRRNHGES TKYTCPSCYI QEVEQRERRP
860 870 880 890 900
LPLSAVPGAT SLPVTSLSKH LEERLFKKLK EERQERARLQ GKTYEEVPGA
910 920 930 940 950
ESLTVRVVAS VDKVLEVKER FLELFREENY PSEFPYKSKA IFLFQKIENV
960 970 980 990 1000
EVCLFGMFVQ EFGTDSGPPN ERRVYLSYLD SVKYFRPTFR TVSGEALRTF
1010 1020 1030 1040 1050
VYHEILIGYL DYCKKRGFTS CYIWACPPLK GDDYILYCHP EIQKTPKTDK
1060 1070 1080 1090 1100
LREWYLAMLR KASKEDVVVE CTNLYNHFFV QSGECRANVT AARLPYFDGD
1110 1120 1130 1140 1150
YWPSAAEDLL RQMNQEDDGE TKLHRKGLTK KVISKRALKA VGQLDLSLNA
1160 1170 1180 1190 1200
SKDRLMMQKL GETICPMKED FIMVHLQHCC KHCTTLMVSG NRWVCNHCKN
1210 1220 1230 1240 1250
FQICDKCYEV EQNRINIERH PINQKEKHAL FPVAIKDVPT KIEDKDNNLE
1260 1270 1280 1290 1300
SEFFHNRQAF LNLCQGNNYQ YETLRRAKHS SMMILYHLHN PTAPAFATVC
1310 1320 1330 1340 1350
TICQQEVENS QGWHCEVCPG YDVCSACYSK DSINHSHKLT SRSSSTDSTV
1360 1370 1380 1390 1400
VQQNGQASQS YQVKLEKLKK LLVHAATCRS TQCQYQGCRK SKMLFRHCID
1410 1420 1430 1440 1450
CTTGDCPICK GLWSLLKLHA RNCRDSKCTV PKCSGLRAIS RRKQQQADKR
1460 1470
RRAAVMEMMR ERAAEATRTG
Length:1,470
Mass (Da):166,802
Last modified:January 9, 2007 - v2
Checksum:iC1583E17D19C06CD
GO

Sequence cautioni

The sequence AAK73519.1 differs from that shown. Reason: Frameshift at position 988.
The sequence AAF02849.1 differs from that shown. Reason: Erroneous gene model prediction.
The sequence AAF79331.1 differs from that shown. Reason: Erroneous gene model prediction.
The sequence AEE33326.1 differs from that shown. Reason: Erroneous gene model prediction.

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AC002304 Genomic DNA. Translation: AAF79331.1. Sequence problems.
AC009894 Genomic DNA. Translation: AAF02849.1. Sequence problems.
CP002684 Genomic DNA. Translation: AEE33326.1. Sequence problems.
AF512559 mRNA. Translation: AAM34789.1.
AF512560 mRNA. Translation: AAM34790.1.
AF389513 mRNA. Translation: AAK73519.1. Frameshift.
RefSeqiNP_564706.1. NM_104475.2.
UniGeneiAt.26162.

Genome annotation databases

EnsemblPlantsiAT1G55970.1; AT1G55970.1; AT1G55970.
GeneIDi842048.
KEGGiath:AT1G55970.

Cross-referencesi

Web resourcesi

PlantsUBQ

A functional genomics database for the ubiquitin/26S proteasome proteolytic pathway in plants

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AC002304 Genomic DNA. Translation: AAF79331.1 . Sequence problems.
AC009894 Genomic DNA. Translation: AAF02849.1 . Sequence problems.
CP002684 Genomic DNA. Translation: AEE33326.1 . Sequence problems.
AF512559 mRNA. Translation: AAM34789.1 .
AF512560 mRNA. Translation: AAM34790.1 .
AF389513 mRNA. Translation: AAK73519.1 . Frameshift.
RefSeqi NP_564706.1. NM_104475.2.
UniGenei At.26162.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblPlantsi AT1G55970.1 ; AT1G55970.1 ; AT1G55970 .
GeneIDi 842048.
KEGGi ath:AT1G55970.

Organism-specific databases

TAIRi AT1G55970.

Phylogenomic databases

eggNOGi NOG257281.
InParanoidi Q9LG11.
KOi K04498.
PhylomeDBi Q9LG11.

Enzyme and pathway databases

BioCyci ARA:AT1G55970-MONOMER.

Gene expression databases

Genevestigatori Q9LG11.

Family and domain databases

Gene3Di 1.20.1020.10. 2 hits.
3.30.40.10. 1 hit.
InterProi IPR013178. Histone_H3-K56_AcTrfase_RTT109.
IPR019786. Zinc_finger_PHD-type_CS.
IPR011011. Znf_FYVE_PHD.
IPR001965. Znf_PHD.
IPR019787. Znf_PHD-finger.
IPR013083. Znf_RING/FYVE/PHD.
IPR000197. Znf_TAZ.
IPR000433. Znf_ZZ.
[Graphical view ]
Pfami PF08214. KAT11. 1 hit.
PF00628. PHD. 1 hit.
PF02135. zf-TAZ. 2 hits.
PF00569. ZZ. 1 hit.
[Graphical view ]
SMARTi SM00249. PHD. 1 hit.
SM00551. ZnF_TAZ. 2 hits.
SM00291. ZnF_ZZ. 2 hits.
[Graphical view ]
SUPFAMi SSF57903. SSF57903. 1 hit.
SSF57933. SSF57933. 2 hits.
PROSITEi PS51727. CBP_P300_HAT. 1 hit.
PS01359. ZF_PHD_1. 1 hit.
PS50134. ZF_TAZ. 2 hits.
PS01357. ZF_ZZ_1. 2 hits.
PS50135. ZF_ZZ_2. 2 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Sequence and analysis of chromosome 1 of the plant Arabidopsis thaliana."
    Theologis A., Ecker J.R., Palm C.J., Federspiel N.A., Kaul S., White O., Alonso J., Altafi H., Araujo R., Bowman C.L., Brooks S.Y., Buehler E., Chan A., Chao Q., Chen H., Cheuk R.F., Chin C.W., Chung M.K.
    , Conn L., Conway A.B., Conway A.R., Creasy T.H., Dewar K., Dunn P., Etgu P., Feldblyum T.V., Feng J.-D., Fong B., Fujii C.Y., Gill J.E., Goldsmith A.D., Haas B., Hansen N.F., Hughes B., Huizar L., Hunter J.L., Jenkins J., Johnson-Hopson C., Khan S., Khaykin E., Kim C.J., Koo H.L., Kremenetskaia I., Kurtz D.B., Kwan A., Lam B., Langin-Hooper S., Lee A., Lee J.M., Lenz C.A., Li J.H., Li Y.-P., Lin X., Liu S.X., Liu Z.A., Luros J.S., Maiti R., Marziali A., Militscher J., Miranda M., Nguyen M., Nierman W.C., Osborne B.I., Pai G., Peterson J., Pham P.K., Rizzo M., Rooney T., Rowley D., Sakano H., Salzberg S.L., Schwartz J.R., Shinn P., Southwick A.M., Sun H., Tallon L.J., Tambunga G., Toriumi M.J., Town C.D., Utterback T., Van Aken S., Vaysberg M., Vysotskaia V.S., Walker M., Wu D., Yu G., Fraser C.M., Venter J.C., Davis R.W.
    Nature 408:816-820(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: cv. Columbia.
  2. The Arabidopsis Information Resource (TAIR)
    Submitted (APR-2011) to the EMBL/GenBank/DDBJ databases
    Cited for: GENOME REANNOTATION.
    Strain: cv. Columbia.
  3. "Analysis of histone acetyltransferase and histone deacetylase families of Arabidopsis thaliana suggests functional diversification of chromatin modification among multicellular eukaryotes."
    Pandey R., Mueller A., Napoli C.A., Selinger D.A., Pikaard C.S., Richards E.J., Bender J., Mount D.W., Jorgensen R.A.
    Nucleic Acids Res. 30:5036-5055(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 10-760 AND 1086-1470, NOMENCLATURE.
  4. Richards E.J.
    Submitted (JUN-2001) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 772-1470.
  5. "Plant orthologs of p300/CBP: conservation of a core domain in metazoan p300/CBP acetyltransferase-related proteins."
    Bordoli L., Netsch M., Luethi U., Lutz W., Eckner R.
    Nucleic Acids Res. 29:589-597(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: DEVELOPMENTAL STAGE, TISSUE SPECIFICITY.

Entry informationi

Entry nameiHAC4_ARATH
AccessioniPrimary (citable) accession number: Q9LG11
Secondary accession number(s): F4I3I0
, Q8LRK3, Q8LRK4, Q94EW2, Q9SGS6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 9, 2007
Last sequence update: January 9, 2007
Last modified: October 29, 2014
This is version 88 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Arabidopsis thaliana
    Arabidopsis thaliana: entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3