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Q9LG11

- HAC4_ARATH

UniProt

Q9LG11 - HAC4_ARATH

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Protein
Histone acetyltransferase HAC4
Gene
HAC4, PCAT3, At1g55970, F14J16.27, T6H22.22
Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at transcript leveli

Functioni

Acetyltransferase enzyme. Acetylates histones, giving a specific tag for transcriptional activation By similarity.

Catalytic activityi

Acetyl-CoA + [histone] = CoA + acetyl-[histone].

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri416 – 49580TAZ-type 1
Add
BLAST
Zinc fingeri764 – 84178PHD-type
Add
BLAST
Zinc fingeri1174 – 122148ZZ-type 1
Add
BLAST
Zinc fingeri1294 – 134148ZZ-type 2
Add
BLAST
Zinc fingeri1358 – 143679TAZ-type 2
Add
BLAST

GO - Molecular functioni

  1. histone acetyltransferase activity Source: UniProtKB-EC
  2. transcription cofactor activity Source: InterPro
  3. zinc ion binding Source: InterPro

GO - Biological processi

  1. regulation of transcription, DNA-templated Source: UniProtKB-KW
  2. transcription, DNA-templated Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Activator, Acyltransferase, Chromatin regulator, Transferase

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

Metal-binding, Zinc

Enzyme and pathway databases

BioCyciARA:AT1G55970-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Histone acetyltransferase HAC4 (EC:2.3.1.48)
Gene namesi
Name:HAC4
Synonyms:PCAT3
Ordered Locus Names:At1g55970
ORF Names:F14J16.27, T6H22.22
OrganismiArabidopsis thaliana (Mouse-ear cress)
Taxonomic identifieri3702 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
ProteomesiUP000006548: Chromosome 1

Organism-specific databases

TAIRiAT1G55970.

Subcellular locationi

Nucleus Inferred

GO - Cellular componenti

  1. nucleus Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 14701470Histone acetyltransferase HAC4
PRO_0000269742Add
BLAST

Expressioni

Tissue specificityi

Rosette leaves, stems and flowers.1 Publication

Developmental stagei

Expressed in young seedlings.1 Publication

Gene expression databases

GenevestigatoriQ9LG11.

Family & Domainsi

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi54 – 8734Gln-rich
Add
BLAST
Compositional biasi323 – 39573Gln-rich
Add
BLAST

Sequence similaritiesi

Contains 2 ZZ-type zinc fingers.

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiNOG257281.
InParanoidiQ9LG11.
KOiK04498.
PhylomeDBiQ9LG11.

Family and domain databases

Gene3Di1.20.1020.10. 2 hits.
3.30.40.10. 1 hit.
InterProiIPR013178. Histone_H3-K56_AcTrfase_RTT109.
IPR019786. Zinc_finger_PHD-type_CS.
IPR011011. Znf_FYVE_PHD.
IPR001965. Znf_PHD.
IPR019787. Znf_PHD-finger.
IPR013083. Znf_RING/FYVE/PHD.
IPR000197. Znf_TAZ.
IPR000433. Znf_ZZ.
[Graphical view]
PfamiPF08214. KAT11. 1 hit.
PF00628. PHD. 1 hit.
PF02135. zf-TAZ. 2 hits.
PF00569. ZZ. 1 hit.
[Graphical view]
SMARTiSM00249. PHD. 1 hit.
SM00551. ZnF_TAZ. 2 hits.
SM00291. ZnF_ZZ. 2 hits.
[Graphical view]
SUPFAMiSSF57903. SSF57903. 1 hit.
SSF57933. SSF57933. 2 hits.
PROSITEiPS01359. ZF_PHD_1. 1 hit.
PS50134. ZF_TAZ. 2 hits.
PS01357. ZF_ZZ_1. 2 hits.
PS50135. ZF_ZZ_2. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9LG11-1 [UniParc]FASTAAdd to Basket

« Hide

MNNNKEVPQN SVAVSSSSSA PITVISPQQD ANNFIKKRRT ALRNRIYAIV     50
RHKQKQHQIF LDKKNQQQQQ RVDDATQRAL LEKQDQQCIA ATRMIEEELL 100
KSSRSFEEYF DLRTFDARVR TILQQLGTML SQRRAAAAAM NNGEAQCITS 150
TRAVHTSISV SNSFQCGRSL VPINCTTATA GAFSIGPDMQ THHSTGANHQ 200
MVEVNRPNMN QITCGISSPL ITGFNGNCVP VSANIPMTSQ DLFNATHFST 250
LPQPFLQPPP DQSHMHRYSM SNVASFGQSN PYPCGVVMSS GSMAVAQNSI 300
PWNNPNPMQG LDPTVTSYHS NLQPMQQTPL PKRQLHHPLW NTNFQSAPNN 350
RDNLPQVSQQ LSNHGSRQHR GQHSQNLYPG QLQNQDRLLP NLTQQAMALA 400
APVMHVPSKQ VNEDCGQTSS NTVLRWIPFM FHARHCKAKK DKCASKFCFQ 450
ARKIVKHIDC CKVPNCKYRY CLGTRMWLDH FKQCKSISCR TCVAVREYME 500
KNKYTIVPLR RAKCSSASSK CQPKKSSKSR QAYKKGGAEA PSVDADLQRS 550
IKRPKLHRPS QNITPETKSI SVTGCGVVCK PHSLMNMQEK DGLQSLKVEA 600
MPMDIDVPGA SEIPVTRELV KHVAEDTPKG NNCGGFAMVE KTSCLLAQGK 650
SKCMNEMSAP KEENVKQSVE VVDASKMEIS SLVELFTPEQ VKEHIRSLRQ 700
WVGQSKTKAE KNKAMGCSMS VNSCQLCAVE WLVFEPVPIY CSPCGIRIKK 750
NALHYSIAVG ESRHYVCAPC YNEAREKLVF LDGTSIPKTR LQKKKNDEQV 800
PEGWVQCDKC EAWQHIICAL FNSRRNHGES TKYTCPSCYI QEVEQRERRP 850
LPLSAVPGAT SLPVTSLSKH LEERLFKKLK EERQERARLQ GKTYEEVPGA 900
ESLTVRVVAS VDKVLEVKER FLELFREENY PSEFPYKSKA IFLFQKIENV 950
EVCLFGMFVQ EFGTDSGPPN ERRVYLSYLD SVKYFRPTFR TVSGEALRTF 1000
VYHEILIGYL DYCKKRGFTS CYIWACPPLK GDDYILYCHP EIQKTPKTDK 1050
LREWYLAMLR KASKEDVVVE CTNLYNHFFV QSGECRANVT AARLPYFDGD 1100
YWPSAAEDLL RQMNQEDDGE TKLHRKGLTK KVISKRALKA VGQLDLSLNA 1150
SKDRLMMQKL GETICPMKED FIMVHLQHCC KHCTTLMVSG NRWVCNHCKN 1200
FQICDKCYEV EQNRINIERH PINQKEKHAL FPVAIKDVPT KIEDKDNNLE 1250
SEFFHNRQAF LNLCQGNNYQ YETLRRAKHS SMMILYHLHN PTAPAFATVC 1300
TICQQEVENS QGWHCEVCPG YDVCSACYSK DSINHSHKLT SRSSSTDSTV 1350
VQQNGQASQS YQVKLEKLKK LLVHAATCRS TQCQYQGCRK SKMLFRHCID 1400
CTTGDCPICK GLWSLLKLHA RNCRDSKCTV PKCSGLRAIS RRKQQQADKR 1450
RRAAVMEMMR ERAAEATRTG 1470
Length:1,470
Mass (Da):166,802
Last modified:January 9, 2007 - v2
Checksum:iC1583E17D19C06CD
GO

Sequence cautioni

The sequence AAK73519.1 differs from that shown. Reason: Frameshift at position 988.
The sequence AAF02849.1 differs from that shown. Reason: Erroneous gene model prediction.
The sequence AAF79331.1 differs from that shown. Reason: Erroneous gene model prediction.
The sequence AEE33326.1 differs from that shown. Reason: Erroneous gene model prediction.

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AC002304 Genomic DNA. Translation: AAF79331.1. Sequence problems.
AC009894 Genomic DNA. Translation: AAF02849.1. Sequence problems.
CP002684 Genomic DNA. Translation: AEE33326.1. Sequence problems.
AF512559 mRNA. Translation: AAM34789.1.
AF512560 mRNA. Translation: AAM34790.1.
AF389513 mRNA. Translation: AAK73519.1. Frameshift.
RefSeqiNP_564706.1. NM_104475.2.
UniGeneiAt.26162.

Genome annotation databases

EnsemblPlantsiAT1G55970.1; AT1G55970.1; AT1G55970.
GeneIDi842048.
KEGGiath:AT1G55970.

Cross-referencesi

Web resourcesi

PlantsUBQ

A functional genomics database for the ubiquitin/26S proteasome proteolytic pathway in plants

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AC002304 Genomic DNA. Translation: AAF79331.1 . Sequence problems.
AC009894 Genomic DNA. Translation: AAF02849.1 . Sequence problems.
CP002684 Genomic DNA. Translation: AEE33326.1 . Sequence problems.
AF512559 mRNA. Translation: AAM34789.1 .
AF512560 mRNA. Translation: AAM34790.1 .
AF389513 mRNA. Translation: AAK73519.1 . Frameshift.
RefSeqi NP_564706.1. NM_104475.2.
UniGenei At.26162.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblPlantsi AT1G55970.1 ; AT1G55970.1 ; AT1G55970 .
GeneIDi 842048.
KEGGi ath:AT1G55970.

Organism-specific databases

TAIRi AT1G55970.

Phylogenomic databases

eggNOGi NOG257281.
InParanoidi Q9LG11.
KOi K04498.
PhylomeDBi Q9LG11.

Enzyme and pathway databases

BioCyci ARA:AT1G55970-MONOMER.

Gene expression databases

Genevestigatori Q9LG11.

Family and domain databases

Gene3Di 1.20.1020.10. 2 hits.
3.30.40.10. 1 hit.
InterProi IPR013178. Histone_H3-K56_AcTrfase_RTT109.
IPR019786. Zinc_finger_PHD-type_CS.
IPR011011. Znf_FYVE_PHD.
IPR001965. Znf_PHD.
IPR019787. Znf_PHD-finger.
IPR013083. Znf_RING/FYVE/PHD.
IPR000197. Znf_TAZ.
IPR000433. Znf_ZZ.
[Graphical view ]
Pfami PF08214. KAT11. 1 hit.
PF00628. PHD. 1 hit.
PF02135. zf-TAZ. 2 hits.
PF00569. ZZ. 1 hit.
[Graphical view ]
SMARTi SM00249. PHD. 1 hit.
SM00551. ZnF_TAZ. 2 hits.
SM00291. ZnF_ZZ. 2 hits.
[Graphical view ]
SUPFAMi SSF57903. SSF57903. 1 hit.
SSF57933. SSF57933. 2 hits.
PROSITEi PS01359. ZF_PHD_1. 1 hit.
PS50134. ZF_TAZ. 2 hits.
PS01357. ZF_ZZ_1. 2 hits.
PS50135. ZF_ZZ_2. 2 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Sequence and analysis of chromosome 1 of the plant Arabidopsis thaliana."
    Theologis A., Ecker J.R., Palm C.J., Federspiel N.A., Kaul S., White O., Alonso J., Altafi H., Araujo R., Bowman C.L., Brooks S.Y., Buehler E., Chan A., Chao Q., Chen H., Cheuk R.F., Chin C.W., Chung M.K.
    , Conn L., Conway A.B., Conway A.R., Creasy T.H., Dewar K., Dunn P., Etgu P., Feldblyum T.V., Feng J.-D., Fong B., Fujii C.Y., Gill J.E., Goldsmith A.D., Haas B., Hansen N.F., Hughes B., Huizar L., Hunter J.L., Jenkins J., Johnson-Hopson C., Khan S., Khaykin E., Kim C.J., Koo H.L., Kremenetskaia I., Kurtz D.B., Kwan A., Lam B., Langin-Hooper S., Lee A., Lee J.M., Lenz C.A., Li J.H., Li Y.-P., Lin X., Liu S.X., Liu Z.A., Luros J.S., Maiti R., Marziali A., Militscher J., Miranda M., Nguyen M., Nierman W.C., Osborne B.I., Pai G., Peterson J., Pham P.K., Rizzo M., Rooney T., Rowley D., Sakano H., Salzberg S.L., Schwartz J.R., Shinn P., Southwick A.M., Sun H., Tallon L.J., Tambunga G., Toriumi M.J., Town C.D., Utterback T., Van Aken S., Vaysberg M., Vysotskaia V.S., Walker M., Wu D., Yu G., Fraser C.M., Venter J.C., Davis R.W.
    Nature 408:816-820(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: cv. Columbia.
  2. The Arabidopsis Information Resource (TAIR)
    Submitted (APR-2011) to the EMBL/GenBank/DDBJ databases
    Cited for: GENOME REANNOTATION.
    Strain: cv. Columbia.
  3. "Analysis of histone acetyltransferase and histone deacetylase families of Arabidopsis thaliana suggests functional diversification of chromatin modification among multicellular eukaryotes."
    Pandey R., Mueller A., Napoli C.A., Selinger D.A., Pikaard C.S., Richards E.J., Bender J., Mount D.W., Jorgensen R.A.
    Nucleic Acids Res. 30:5036-5055(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 10-760 AND 1086-1470, NOMENCLATURE.
  4. Richards E.J.
    Submitted (JUN-2001) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 772-1470.
  5. "Plant orthologs of p300/CBP: conservation of a core domain in metazoan p300/CBP acetyltransferase-related proteins."
    Bordoli L., Netsch M., Luethi U., Lutz W., Eckner R.
    Nucleic Acids Res. 29:589-597(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: DEVELOPMENTAL STAGE, TISSUE SPECIFICITY.

Entry informationi

Entry nameiHAC4_ARATH
AccessioniPrimary (citable) accession number: Q9LG11
Secondary accession number(s): F4I3I0
, Q8LRK3, Q8LRK4, Q94EW2, Q9SGS6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 9, 2007
Last sequence update: January 9, 2007
Last modified: June 11, 2014
This is version 86 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Arabidopsis thaliana
    Arabidopsis thaliana: entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi