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Protein

Cyclin-dependent kinase C-1

Gene

CDKC-1

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Catalytic activityi

ATP + a protein = ADP + a phosphoprotein.
ATP + [DNA-directed RNA polymerase] = ADP + [DNA-directed RNA polymerase] phosphate.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei55ATPPROSITE-ProRule annotation1
Active sitei164Proton acceptorPROSITE-ProRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi32 – 40ATPPROSITE-ProRule annotation9

GO - Molecular functioni

GO - Biological processi

  • leaf development Source: TAIR
  • protein phosphorylation Source: GO_Central
  • response to virus Source: TAIR

Keywordsi

Molecular functionKinase, Serine/threonine-protein kinase, Transferase
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

ReactomeiR-ATH-674695. RNA Polymerase II Pre-transcription Events.
R-ATH-6796648. TP53 Regulates Transcription of DNA Repair Genes.

Names & Taxonomyi

Protein namesi
Recommended name:
Cyclin-dependent kinase C-1 (EC:2.7.11.22, EC:2.7.11.23)
Short name:
CDKC;1
Gene namesi
Name:CDKC-1
Ordered Locus Names:At5g10270
ORF Names:F18D22.40
OrganismiArabidopsis thaliana (Mouse-ear cress)
Taxonomic identifieri3702 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
Proteomesi
  • UP000006548 Componenti: Chromosome 5

Organism-specific databases

AraportiAT5G10270.
TAIRilocus:2145397. AT5G10270.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Chloroplast Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertion Graphics by Christian Stolte; Source: COMPARTMENTS

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002931171 – 505Cyclin-dependent kinase C-1Add BLAST505

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei37PhosphotyrosineBy similarity1
Modified residuei198PhosphothreonineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiQ9LFT8.
PRIDEiQ9LFT8.

PTM databases

iPTMnetiQ9LFT8.

Expressioni

Tissue specificityi

Highly expressed in flowers. Expressed in seedlings, roots, rosettes and stems.1 Publication

Gene expression databases

ExpressionAtlasiQ9LFT8. baseline and differential.
GenevisibleiQ9LFT8. AT.

Interactioni

Subunit structurei

Interacts with CYCT1-3.1 Publication

Binary interactionsi

Show more details

Protein-protein interaction databases

BioGridi16169. 10 interactors.
IntActiQ9LFT8. 12 interactors.
STRINGi3702.AT5G10270.1.

Structurei

3D structure databases

ProteinModelPortaliQ9LFT8.
SMRiQ9LFT8.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini26 – 325Protein kinasePROSITE-ProRule annotationAdd BLAST300

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi417 – 493Gly-richAdd BLAST77

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG0600. Eukaryota.
ENOG410XPIR. LUCA.
HOGENOMiHOG000233024.
InParanoidiQ9LFT8.
KOiK08819.
OMAiKDPTGCD.
OrthoDBiEOG093607V4.
PhylomeDBiQ9LFT8.

Family and domain databases

InterProiView protein in InterPro
IPR011009. Kinase-like_dom_sf.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR008271. Ser/Thr_kinase_AS.
PfamiView protein in Pfam
PF00069. Pkinase. 1 hit.
SMARTiView protein in SMART
SM00220. S_TKc. 1 hit.
SUPFAMiSSF56112. SSF56112. 1 hit.
PROSITEiView protein in PROSITE
PS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.

Sequencei

Sequence statusi: Complete.

Q9LFT8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAMASFGQLN LEEPPPIWGS RSVDCFEKLE QIGEGTYGQV YMAKEIKTGE
60 70 80 90 100
IVALKKIRMD NEREGFPITA IREIKILKKL HHENVIQLKE IVTSPGRDRD
110 120 130 140 150
DQGKPDNNKY KGGIYMVFEY MDHDLTGLAD RPGLRFTVPQ IKCYMKQLLT
160 170 180 190 200
GLHYCHVNQV LHRDIKGSNL LIDNEGNLKL ADFGLARSYS HDHTGNLTNR
210 220 230 240 250
VITLWYRPPE LLLGATKYGP AIDMWSVGCI FAELLHAKPI LPGKNEQEQL
260 270 280 290 300
NKIFELCGSP DEKLWPGVSK MPWFNNFKPA RPLKRRVREF FRHFDRHALE
310 320 330 340 350
LLEKMLVLDP AQRISAKDAL DAEYFWTDPL PCDPKSLPTY ESSHEFQTKK
360 370 380 390 400
KRQQQRQNEE AAKRQKLQHP PLQHSRLPPL QHGGQSHAAP HWPAGPNHPT
410 420 430 440 450
NNAPPQVPAG PSHNFYGKPR GPPGPNRYPP SGNQSGGYNQ SRGGYSSGSY
460 470 480 490 500
PPQGRGAPYV AGPRGPSGGP YGVGPPNYTQ GGQYGGSGSS GRGQNQRNQQ

YGWQQ
Length:505
Mass (Da):56,729
Last modified:October 1, 2000 - v1
Checksum:i9159218AEB976361
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL360334 Genomic DNA. Translation: CAB96683.1.
CP002688 Genomic DNA. Translation: AED91515.1.
AF375437 mRNA. Translation: AAK53021.1.
AY120690 mRNA. Translation: AAM52233.1.
PIRiT50815.
RefSeqiNP_196589.1. NM_121065.3.
UniGeneiAt.19998.

Genome annotation databases

EnsemblPlantsiAT5G10270.1; AT5G10270.1; AT5G10270.
GeneIDi830891.
GrameneiAT5G10270.1; AT5G10270.1; AT5G10270.
KEGGiath:AT5G10270.

Similar proteinsi

Entry informationi

Entry nameiCDKC1_ARATH
AccessioniPrimary (citable) accession number: Q9LFT8
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 10, 2007
Last sequence update: October 1, 2000
Last modified: November 22, 2017
This is version 125 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Arabidopsis thaliana
    Arabidopsis thaliana: entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families