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Protein

Probable carboxylesterase 17

Gene

CXE17

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

Carboxylesterase acting on esters with varying acyl chain length.By similarity

Catalytic activityi

A carboxylic ester + H2O = an alcohol + a carboxylate.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei184 – 1841PROSITE-ProRule annotation
Active sitei285 – 2851PROSITE-ProRule annotation
Active sitei315 – 3151PROSITE-ProRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Serine esterase

Enzyme and pathway databases

BioCyciARA:AT5G16080-MONOMER.

Protein family/group databases

ESTHERiarath-F1N13.220. Plant_carboxylesterase.
MEROPSiS09.A12.

Names & Taxonomyi

Protein namesi
Recommended name:
Probable carboxylesterase 17
Alternative name(s):
AtCXE17 (EC:3.1.1.1)
Gene namesi
Name:CXE17
Ordered Locus Names:At5g16080
ORF Names:F1N13.220
OrganismiArabidopsis thaliana (Mouse-ear cress)
Taxonomic identifieri3702 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
Proteomesi
  • UP000006548 Componenti: Chromosome 5

Organism-specific databases

TAIRiAT5G16080.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 344344Probable carboxylesterase 17PRO_0000402561Add
BLAST

Proteomic databases

PaxDbiQ9LFR7.
PRIDEiQ9LFR7.

Expressioni

Tissue specificityi

Expressed in leaves, stems and flowers.1 Publication

Gene expression databases

GenevisibleiQ9LFR7. AT.

Interactioni

Protein-protein interaction databases

BioGridi16741. 6 interactions.
IntActiQ9LFR7. 6 interactions.
STRINGi3702.AT5G16080.1.

Structurei

3D structure databases

ProteinModelPortaliQ9LFR7.
SMRiQ9LFR7. Positions 41-321.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi99 – 1013Involved in the stabilization of the negatively charged intermediate by the formation of the oxyanion holeBy similarity

Sequence similaritiesi

Belongs to the 'GDXG' lipolytic enzyme family.Curated

Phylogenomic databases

eggNOGiKOG1515. Eukaryota.
COG0657. LUCA.
HOGENOMiHOG000152323.
InParanoidiQ9LFR7.
OMAiSASDAYW.
PhylomeDBiQ9LFR7.

Family and domain databases

Gene3Di3.40.50.1820. 1 hit.
InterProiIPR029058. AB_hydrolase.
IPR013094. AB_hydrolase_3.
IPR033140. Lipase_GDXG_put_SER_AS.
[Graphical view]
PfamiPF07859. Abhydrolase_3. 1 hit.
[Graphical view]
SUPFAMiSSF53474. SSF53474. 1 hit.
PROSITEiPS01174. LIPASE_GDXG_SER. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9LFR7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MATISFSHNH QSSDNRRGGS HHHRHGPVVE EIEGLIKVFN DGCVERPPIV
60 70 80 90 100
PIVSPTIHPS SKATAFDIKL SNDTWTRVYI PDAAAASPSV TLPLLVYFHG
110 120 130 140 150
GGFCVGSAAW SCYHDFLTSL AVKARCVIVS VNYRLAPEHR LPAAYDDGVN
160 170 180 190 200
VVSWLVKQQI STGGGYPSWL SKCNLSNVFL AGDSAGANIA YQVAVRIMAS
210 220 230 240 250
GKYANTLHLK GIILIHPFFG GESRTSSEKQ QHHTKSSALT LSASDAYWRL
260 270 280 290 300
ALPRGASRDH PWCNPLMSSA GAKLPTTMVF MAEFDILKER NLEMCKVMRS
310 320 330 340
HGKRVEGIVH GGVGHAFHIL DNSSVSRDRI HDMMCRLHNF IHPS
Length:344
Mass (Da):37,698
Last modified:October 1, 2000 - v1
Checksum:iE24D0838E4DED93B
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti156 – 1594VKQQ → IKQH in AAM65164 (Ref. 4) Curated
Sequence conflicti170 – 1701L → V in AAM65164 (Ref. 4) Curated
Sequence conflicti343 – 3431P → L in AAM65164 (Ref. 4) Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL391145 Genomic DNA. Translation: CAC01807.1.
CP002688 Genomic DNA. Translation: AED92244.1.
AF370327 mRNA. Translation: AAK44142.1.
AY113907 mRNA. Translation: AAM44955.1.
AY087623 mRNA. Translation: AAM65164.1.
PIRiT51391.
RefSeqiNP_197112.1. NM_121613.2.
UniGeneiAt.20852.

Genome annotation databases

EnsemblPlantsiAT5G16080.1; AT5G16080.1; AT5G16080.
GeneIDi831465.
GrameneiAT5G16080.1; AT5G16080.1; AT5G16080.
KEGGiath:AT5G16080.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL391145 Genomic DNA. Translation: CAC01807.1.
CP002688 Genomic DNA. Translation: AED92244.1.
AF370327 mRNA. Translation: AAK44142.1.
AY113907 mRNA. Translation: AAM44955.1.
AY087623 mRNA. Translation: AAM65164.1.
PIRiT51391.
RefSeqiNP_197112.1. NM_121613.2.
UniGeneiAt.20852.

3D structure databases

ProteinModelPortaliQ9LFR7.
SMRiQ9LFR7. Positions 41-321.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi16741. 6 interactions.
IntActiQ9LFR7. 6 interactions.
STRINGi3702.AT5G16080.1.

Protein family/group databases

ESTHERiarath-F1N13.220. Plant_carboxylesterase.
MEROPSiS09.A12.

Proteomic databases

PaxDbiQ9LFR7.
PRIDEiQ9LFR7.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblPlantsiAT5G16080.1; AT5G16080.1; AT5G16080.
GeneIDi831465.
GrameneiAT5G16080.1; AT5G16080.1; AT5G16080.
KEGGiath:AT5G16080.

Organism-specific databases

TAIRiAT5G16080.

Phylogenomic databases

eggNOGiKOG1515. Eukaryota.
COG0657. LUCA.
HOGENOMiHOG000152323.
InParanoidiQ9LFR7.
OMAiSASDAYW.
PhylomeDBiQ9LFR7.

Enzyme and pathway databases

BioCyciARA:AT5G16080-MONOMER.

Miscellaneous databases

PROiQ9LFR7.

Gene expression databases

GenevisibleiQ9LFR7. AT.

Family and domain databases

Gene3Di3.40.50.1820. 1 hit.
InterProiIPR029058. AB_hydrolase.
IPR013094. AB_hydrolase_3.
IPR033140. Lipase_GDXG_put_SER_AS.
[Graphical view]
PfamiPF07859. Abhydrolase_3. 1 hit.
[Graphical view]
SUPFAMiSSF53474. SSF53474. 1 hit.
PROSITEiPS01174. LIPASE_GDXG_SER. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Sequence and analysis of chromosome 5 of the plant Arabidopsis thaliana."
    Tabata S., Kaneko T., Nakamura Y., Kotani H., Kato T., Asamizu E., Miyajima N., Sasamoto S., Kimura T., Hosouchi T., Kawashima K., Kohara M., Matsumoto M., Matsuno A., Muraki A., Nakayama S., Nakazaki N., Naruo K.
    , Okumura S., Shinpo S., Takeuchi C., Wada T., Watanabe A., Yamada M., Yasuda M., Sato S., de la Bastide M., Huang E., Spiegel L., Gnoj L., O'Shaughnessy A., Preston R., Habermann K., Murray J., Johnson D., Rohlfing T., Nelson J., Stoneking T., Pepin K., Spieth J., Sekhon M., Armstrong J., Becker M., Belter E., Cordum H., Cordes M., Courtney L., Courtney W., Dante M., Du H., Edwards J., Fryman J., Haakensen B., Lamar E., Latreille P., Leonard S., Meyer R., Mulvaney E., Ozersky P., Riley A., Strowmatt C., Wagner-McPherson C., Wollam A., Yoakum M., Bell M., Dedhia N., Parnell L., Shah R., Rodriguez M., Hoon See L., Vil D., Baker J., Kirchoff K., Toth K., King L., Bahret A., Miller B., Marra M.A., Martienssen R., McCombie W.R., Wilson R.K., Murphy G., Bancroft I., Volckaert G., Wambutt R., Duesterhoeft A., Stiekema W., Pohl T., Entian K.-D., Terryn N., Hartley N., Bent E., Johnson S., Langham S.-A., McCullagh B., Robben J., Grymonprez B., Zimmermann W., Ramsperger U., Wedler H., Balke K., Wedler E., Peters S., van Staveren M., Dirkse W., Mooijman P., Klein Lankhorst R., Weitzenegger T., Bothe G., Rose M., Hauf J., Berneiser S., Hempel S., Feldpausch M., Lamberth S., Villarroel R., Gielen J., Ardiles W., Bents O., Lemcke K., Kolesov G., Mayer K.F.X., Rudd S., Schoof H., Schueller C., Zaccaria P., Mewes H.-W., Bevan M., Fransz P.F.
    Nature 408:823-826(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: cv. Columbia.
  2. The Arabidopsis Information Resource (TAIR)
    Submitted (APR-2011) to the EMBL/GenBank/DDBJ databases
    Cited for: GENOME REANNOTATION.
    Strain: cv. Columbia.
  3. "Empirical analysis of transcriptional activity in the Arabidopsis genome."
    Yamada K., Lim J., Dale J.M., Chen H., Shinn P., Palm C.J., Southwick A.M., Wu H.C., Kim C.J., Nguyen M., Pham P.K., Cheuk R.F., Karlin-Newmann G., Liu S.X., Lam B., Sakano H., Wu T., Yu G.
    , Miranda M., Quach H.L., Tripp M., Chang C.H., Lee J.M., Toriumi M.J., Chan M.M., Tang C.C., Onodera C.S., Deng J.M., Akiyama K., Ansari Y., Arakawa T., Banh J., Banno F., Bowser L., Brooks S.Y., Carninci P., Chao Q., Choy N., Enju A., Goldsmith A.D., Gurjal M., Hansen N.F., Hayashizaki Y., Johnson-Hopson C., Hsuan V.W., Iida K., Karnes M., Khan S., Koesema E., Ishida J., Jiang P.X., Jones T., Kawai J., Kamiya A., Meyers C., Nakajima M., Narusaka M., Seki M., Sakurai T., Satou M., Tamse R., Vaysberg M., Wallender E.K., Wong C., Yamamura Y., Yuan S., Shinozaki K., Davis R.W., Theologis A., Ecker J.R.
    Science 302:842-846(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: cv. Columbia.
  4. "Full-length cDNA from Arabidopsis thaliana."
    Brover V.V., Troukhan M.E., Alexandrov N.A., Lu Y.-P., Flavell R.B., Feldmann K.A.
    Submitted (MAR-2002) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  5. "The carboxylesterase gene family from Arabidopsis thaliana."
    Marshall S.D., Putterill J.J., Plummer K.M., Newcomb R.D.
    J. Mol. Evol. 57:487-500(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: TISSUE SPECIFICITY, GENE FAMILY, NOMENCLATURE.

Entry informationi

Entry nameiCXE17_ARATH
AccessioniPrimary (citable) accession number: Q9LFR7
Secondary accession number(s): Q8LAT4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 11, 2011
Last sequence update: October 1, 2000
Last modified: July 6, 2016
This is version 97 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Arabidopsis thaliana
    Arabidopsis thaliana: entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.