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Protein

E2F transcription factor-like E2FD

Gene

E2FD

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Inhibitor of E2F-dependent regulation of gene expression. Binds specifically the E2 recognition site as a monomer without interacting with DP proteins. May be up-regulating E2FA and down-regulating repressors of cell cycle progression. Promotes cell proliferation and represses cell elongation. Regulated by proteolysis via a ubiquitin-proteasome pathway.3 Publications

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
DNA bindingi13 – 78Add BLAST66
DNA bindingi138 – 217Add BLAST80

GO - Molecular functioni

  • DNA binding Source: TAIR
  • DNA binding transcription factor activity Source: TAIR

GO - Biological processi

  • cell cycle Source: UniProtKB-KW
  • positive regulation of cell proliferation Source: UniProtKB
  • response to auxin Source: UniProtKB
  • transcription, DNA-templated Source: UniProtKB-KW

Keywordsi

Molecular functionActivator, DNA-binding, Repressor
Biological processCell cycle, Transcription, Transcription regulation

Enzyme and pathway databases

ReactomeiR-ATH-6804116 TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle Arrest

Names & Taxonomyi

Protein namesi
Recommended name:
E2F transcription factor-like E2FD
Alternative name(s):
DP-E2F-like protein 2
E2F-like repressor E2L1
Gene namesi
Name:E2FD
Synonyms:DEL2, E2L1, ELP3
Ordered Locus Names:At5g14960
ORF Names:F2G14.80
OrganismiArabidopsis thaliana (Mouse-ear cress)
Taxonomic identifieri3702 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
Proteomesi
  • UP000006548 Componenti: Chromosome 5

Organism-specific databases

AraportiAT5G14960
TAIRilocus:2147865 AT5G14960

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Chloroplast Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertion Graphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Disruption phenotypei

Increased root length and smaller cotyledons. Reduced root meristematic zone but longer cells in the differentiation zone.1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00004062921 – 359E2F transcription factor-like E2FDAdd BLAST359

Proteomic databases

PaxDbiQ9LFQ9
PRIDEiQ9LFQ9

Expressioni

Tissue specificityi

Preferentially expressed in proliferating tissues. Highly expressed in young stalk and young flowers. Lower expression in young leaves and mature flowers. Detected in cotyledonary vascular tissues, the shoot apical meristem, the base of trichomes, the fully developed stomata, the central root cylinder and in the columella of lateral roots but not in the primary root tips or in the leaf epidermal cells.2 Publications

Developmental stagei

Expressed in a cell cycle-dependent manner. Not detected at the G1/S transition, but increases during the progression into S phase and peaks after the passage into G2.1 Publication

Inductioni

Down-regulated posttranscroptionally by auxin.1 Publication

Gene expression databases

ExpressionAtlasiQ9LFQ9 baseline and differential
GenevisibleiQ9LFQ9 AT

Interactioni

Subunit structurei

Monomer. No interactions with DPA or E2FA.1 Publication

Protein-protein interaction databases

BioGridi16625, 9 interactors
STRINGi3702.AT5G14960.1

Structurei

3D structure databases

ProteinModelPortaliQ9LFQ9
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domaini

The two DNA binding domains are required for binding to the E2 site.

Sequence similaritiesi

Belongs to the E2F/DP family.Curated

Phylogenomic databases

eggNOGiKOG2578 Eukaryota
ENOG4111IGY LUCA
HOGENOMiHOG000083291
InParanoidiQ9LFQ9
OMAiDCSIDRK
OrthoDBiEOG09360FBF
PhylomeDBiQ9LFQ9

Family and domain databases

Gene3Di1.10.10.10, 2 hits
InterProiView protein in InterPro
IPR015633 E2F
IPR003316 E2F_WHTH_DNA-bd_dom
IPR036388 WH-like_DNA-bd_sf
IPR036390 WH_DNA-bd_sf
PANTHERiPTHR12081 PTHR12081, 1 hit
PfamiView protein in Pfam
PF02319 E2F_TDP, 2 hits
SMARTiView protein in SMART
SM01372 E2F_TDP, 2 hits
SUPFAMiSSF46785 SSF46785, 2 hits

Sequencei

Sequence statusi: Complete.

Q9LFQ9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDSLALAPQV YSRKDKSLGV LVANFLTLYN RPDVDLFGLD DAAAKLGVER
60 70 80 90 100
RRIYDVVNIL ESIGLVARSG KNQYSWKGFG AVPRALSELK EEGMKEKFAI
110 120 130 140 150
VPFVAKSEMV VYEKEGEESF MLSPDDQEFS PSPRPDNRKE RTLWLLAQNF
160 170 180 190 200
VKLFLCSDDD LVTFDSATKA LLNESQDMNM RKKVRRLYDI ANVFSSMKLI
210 220 230 240 250
EKTHVPETKK PAYRWLGSKT IFENRFIDGS ASLCDRNVPK KRAFGTELTN
260 270 280 290 300
VNAKRNKSGC SKEDSKRNGN QNTSIVIKQE QCDDVKPDVK NFASGSSTPA
310 320 330 340 350
GTSESNDMGN NIRPRGRLGV IEALSTLYQP SYCNPELLGL FAHYNETFRS

YQEEFGREK
Length:359
Mass (Da):40,553
Last modified:October 1, 2000 - v1
Checksum:i9E14C2933E07CF3C
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ417835 mRNA Translation: CAD10632.1
AB074531 mRNA Translation: BAB91412.1
AL391146 Genomic DNA Translation: CAC01815.1
CP002688 Genomic DNA Translation: AED92096.1
AB493750 mRNA Translation: BAH30588.1
PIRiT51441
RefSeqiNP_197000.1, NM_121500.4
UniGeneiAt.31860

Genome annotation databases

EnsemblPlantsiAT5G14960.1; AT5G14960.1; AT5G14960
GeneIDi831348
GrameneiAT5G14960.1; AT5G14960.1; AT5G14960
KEGGiath:AT5G14960

Similar proteinsi

Entry informationi

Entry nameiE2FD_ARATH
AccessioniPrimary (citable) accession number: Q9LFQ9
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 5, 2011
Last sequence update: October 1, 2000
Last modified: April 25, 2018
This is version 120 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health