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Q9LFJ8

- U78D2_ARATH

UniProt

Q9LFJ8 - U78D2_ARATH

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Protein

UDP-glycosyltransferase 78D2

Gene
UGT78D2, AGT, At5g17050, F2K13.200
Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed - Annotation score: 4 out of 5 - Experimental evidence at transcript leveli

Functioni

Catalyzes the glycosylation of flavonoids from UDP-glucose. Catalyzes the glycosylation of anthocyanins from UDP-glucose. Possesses high quercetin 3-O-glucosyltransferase activity in vitro. Also active in vitro on benzoates and benzoate derivatives.4 Publications

Catalytic activityi

UDP-glucose + a flavonol = UDP + a flavonol 3-O-D-glucoside.

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei286 – 2861UDP-glucose By similarity

GO - Molecular functioni

  1. anthocyanidin 3-O-glucosyltransferase activity Source: TAIR
  2. flavonol 3-O-glucosyltransferase activity Source: UniProtKB-EC
  3. quercetin 3-O-glucosyltransferase activity Source: TAIR
  4. UDP-glucosyltransferase activity Source: TAIR

GO - Biological processi

  1. flavonoid biosynthetic process Source: UniProtKB-UniPathway
  2. phenylpropanoid metabolic process Source: UniProtKB-KW
  3. response to karrikin Source: TAIR
Complete GO annotation...

Keywords - Molecular functioni

Glycosyltransferase, Transferase

Keywords - Biological processi

Phenylpropanoid metabolism

Enzyme and pathway databases

BioCyciMetaCyc:AT5G17050-MONOMER.
UniPathwayiUPA00154.

Protein family/group databases

CAZyiGT1. Glycosyltransferase Family 1.

Names & Taxonomyi

Protein namesi
Recommended name:
UDP-glycosyltransferase 78D2 (EC:2.4.1.-)
Alternative name(s):
Anthocyanin 3-O-glucosyltransferase
Flavonol 3-O-glucosyltransferase. (EC:2.4.1.91)
UDP glucose:flavonoid 3-O-glucosyltransferase
Gene namesi
Name:UGT78D2
Synonyms:AGT
Ordered Locus Names:At5g17050
ORF Names:F2K13.200
OrganismiArabidopsis thaliana (Mouse-ear cress)
Taxonomic identifieri3702 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
ProteomesiUP000006548: Chromosome 5

Organism-specific databases

TAIRiAT5G17050.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 460460UDP-glycosyltransferase 78D2PRO_0000285275Add
BLAST

Proteomic databases

PaxDbiQ9LFJ8.
PRIDEiQ9LFJ8.

Expressioni

Inductioni

By PAP1.1 Publication

Gene expression databases

GenevestigatoriQ9LFJ8.

Interactioni

Protein-protein interaction databases

STRINGi3702.AT5G17050.1-P.

Structurei

3D structure databases

ProteinModelPortaliQ9LFJ8.
SMRiQ9LFJ8. Positions 10-456.

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni339 – 3413UDP-glucose binding By similarity
Regioni356 – 3649UDP-glucose binding By similarity
Regioni378 – 3814UDP-glucose binding By similarity

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG1819.
HOGENOMiHOG000237564.
InParanoidiQ9LFJ8.
KOiK10757.
OMAiQRMNARS.
PhylomeDBiQ9LFJ8.

Family and domain databases

InterProiIPR002213. UDP_glucos_trans.
[Graphical view]
PANTHERiPTHR11926. PTHR11926. 1 hit.
PfamiPF00201. UDPGT. 1 hit.
[Graphical view]
PROSITEiPS00375. UDPGT. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9LFJ8-1 [UniParc]FASTAAdd to Basket

« Hide

MTKPSDPTRD SHVAVLAFPF GTHAAPLLTV TRRLASASPS TVFSFFNTAQ    50
SNSSLFSSGD EADRPANIRV YDIADGVPEG YVFSGRPQEA IELFLQAAPE 100
NFRREIAKAE TEVGTEVKCL MTDAFFWFAA DMATEINASW IAFWTAGANS 150
LSAHLYTDLI RETIGVKEVG ERMEETIGVI SGMEKIRVKD TPEGVVFGNL 200
DSVFSKMLHQ MGLALPRATA VFINSFEDLD PTLTNNLRSR FKRYLNIGPL 250
GLLSSTLQQL VQDPHGCLAW MEKRSSGSVA YISFGTVMTP PPGELAAIAE 300
GLESSKVPFV WSLKEKSLVQ LPKGFLDRTR EQGIVVPWAP QVELLKHEAT 350
GVFVTHCGWN SVLESVSGGV PMICRPFFGD QRLNGRAVEV VWEIGMTIIN 400
GVFTKDGFEK CLDKVLVQDD GKKMKCNAKK LKELAYEAVS SKGRSSENFR 450
GLLDAVVNII 460
Length:460
Mass (Da):50,486
Last modified:October 1, 2000 - v1
Checksum:iE9DEAD19E4E05188
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AL391141 Genomic DNA. Translation: CAC01718.1.
CP002688 Genomic DNA. Translation: AED92377.1.
AY072325 mRNA. Translation: AAL61932.1.
AY128739 mRNA. Translation: AAM91139.1.
PIRiT51560.
RefSeqiNP_197207.1. NM_121711.4.
UniGeneiAt.27563.

Genome annotation databases

EnsemblPlantsiAT5G17050.1; AT5G17050.1; AT5G17050.
GeneIDi831568.
KEGGiath:AT5G17050.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AL391141 Genomic DNA. Translation: CAC01718.1 .
CP002688 Genomic DNA. Translation: AED92377.1 .
AY072325 mRNA. Translation: AAL61932.1 .
AY128739 mRNA. Translation: AAM91139.1 .
PIRi T51560.
RefSeqi NP_197207.1. NM_121711.4.
UniGenei At.27563.

3D structure databases

ProteinModelPortali Q9LFJ8.
SMRi Q9LFJ8. Positions 10-456.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 3702.AT5G17050.1-P.

Protein family/group databases

CAZyi GT1. Glycosyltransferase Family 1.

Proteomic databases

PaxDbi Q9LFJ8.
PRIDEi Q9LFJ8.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblPlantsi AT5G17050.1 ; AT5G17050.1 ; AT5G17050 .
GeneIDi 831568.
KEGGi ath:AT5G17050.

Organism-specific databases

TAIRi AT5G17050.

Phylogenomic databases

eggNOGi COG1819.
HOGENOMi HOG000237564.
InParanoidi Q9LFJ8.
KOi K10757.
OMAi QRMNARS.
PhylomeDBi Q9LFJ8.

Enzyme and pathway databases

UniPathwayi UPA00154 .
BioCyci MetaCyc:AT5G17050-MONOMER.

Gene expression databases

Genevestigatori Q9LFJ8.

Family and domain databases

InterProi IPR002213. UDP_glucos_trans.
[Graphical view ]
PANTHERi PTHR11926. PTHR11926. 1 hit.
Pfami PF00201. UDPGT. 1 hit.
[Graphical view ]
PROSITEi PS00375. UDPGT. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Sequence and analysis of chromosome 5 of the plant Arabidopsis thaliana."
    Tabata S., Kaneko T., Nakamura Y., Kotani H., Kato T., Asamizu E., Miyajima N., Sasamoto S., Kimura T., Hosouchi T., Kawashima K., Kohara M., Matsumoto M., Matsuno A., Muraki A., Nakayama S., Nakazaki N., Naruo K.
    , Okumura S., Shinpo S., Takeuchi C., Wada T., Watanabe A., Yamada M., Yasuda M., Sato S., de la Bastide M., Huang E., Spiegel L., Gnoj L., O'Shaughnessy A., Preston R., Habermann K., Murray J., Johnson D., Rohlfing T., Nelson J., Stoneking T., Pepin K., Spieth J., Sekhon M., Armstrong J., Becker M., Belter E., Cordum H., Cordes M., Courtney L., Courtney W., Dante M., Du H., Edwards J., Fryman J., Haakensen B., Lamar E., Latreille P., Leonard S., Meyer R., Mulvaney E., Ozersky P., Riley A., Strowmatt C., Wagner-McPherson C., Wollam A., Yoakum M., Bell M., Dedhia N., Parnell L., Shah R., Rodriguez M., Hoon See L., Vil D., Baker J., Kirchoff K., Toth K., King L., Bahret A., Miller B., Marra M.A., Martienssen R., McCombie W.R., Wilson R.K., Murphy G., Bancroft I., Volckaert G., Wambutt R., Duesterhoeft A., Stiekema W., Pohl T., Entian K.-D., Terryn N., Hartley N., Bent E., Johnson S., Langham S.-A., McCullagh B., Robben J., Grymonprez B., Zimmermann W., Ramsperger U., Wedler H., Balke K., Wedler E., Peters S., van Staveren M., Dirkse W., Mooijman P., Klein Lankhorst R., Weitzenegger T., Bothe G., Rose M., Hauf J., Berneiser S., Hempel S., Feldpausch M., Lamberth S., Villarroel R., Gielen J., Ardiles W., Bents O., Lemcke K., Kolesov G., Mayer K.F.X., Rudd S., Schoof H., Schueller C., Zaccaria P., Mewes H.-W., Bevan M., Fransz P.F.
    Nature 408:823-826(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: cv. Columbia.
  2. The Arabidopsis Information Resource (TAIR)
    Submitted (APR-2011) to the EMBL/GenBank/DDBJ databases
    Cited for: GENOME REANNOTATION.
    Strain: cv. Columbia.
  3. "Empirical analysis of transcriptional activity in the Arabidopsis genome."
    Yamada K., Lim J., Dale J.M., Chen H., Shinn P., Palm C.J., Southwick A.M., Wu H.C., Kim C.J., Nguyen M., Pham P.K., Cheuk R.F., Karlin-Newmann G., Liu S.X., Lam B., Sakano H., Wu T., Yu G.
    , Miranda M., Quach H.L., Tripp M., Chang C.H., Lee J.M., Toriumi M.J., Chan M.M., Tang C.C., Onodera C.S., Deng J.M., Akiyama K., Ansari Y., Arakawa T., Banh J., Banno F., Bowser L., Brooks S.Y., Carninci P., Chao Q., Choy N., Enju A., Goldsmith A.D., Gurjal M., Hansen N.F., Hayashizaki Y., Johnson-Hopson C., Hsuan V.W., Iida K., Karnes M., Khan S., Koesema E., Ishida J., Jiang P.X., Jones T., Kawai J., Kamiya A., Meyers C., Nakajima M., Narusaka M., Seki M., Sakurai T., Satou M., Tamse R., Vaysberg M., Wallender E.K., Wong C., Yamamura Y., Yuan S., Shinozaki K., Davis R.W., Theologis A., Ecker J.R.
    Science 302:842-846(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: cv. Columbia.
  4. "Phylogenetic analysis of the UDP-glycosyltransferase multigene family of Arabidopsis thaliana."
    Li Y., Baldauf S., Lim E.K., Bowles D.J.
    J. Biol. Chem. 276:4338-4343(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: GENE FAMILY.
  5. "The activity of Arabidopsis glycosyltransferases toward salicylic acid, 4-hydroxybenzoic acid, and other benzoates."
    Lim E.K., Doucet C.J., Li Y., Elias L., Worrall D., Spencer S.P., Ross J., Bowles D.J.
    J. Biol. Chem. 277:586-592(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION.
  6. "Arabidopsis glycosyltransferases as biocatalysts in fermentation for regioselective synthesis of diverse quercetin glucosides."
    Lim E.K., Ashford D.A., Hou B., Jackson R.G., Bowles D.J.
    Biotechnol. Bioeng. 87:623-631(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION.
  7. "Functional genomics by integrated analysis of metabolome and transcriptome of Arabidopsis plants over-expressing an MYB transcription factor."
    Tohge T., Nishiyama Y., Hirai M.Y., Yano M., Nakajima J., Awazuhara M., Inoue E., Takahashi H., Goodenowe D.B., Kitayama M., Noji M., Yamazaki M., Saito K.
    Plant J. 42:218-235(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, INDUCTION BY PAP1.
  8. "The formation of anthocyanic vacuolar inclusions in Arabidopsis thaliana and implications for the sequestration of anthocyanin pigments."
    Pourcel L., Irani N.G., Lu Y., Riedl K., Schwartz S., Grotewold E.
    Mol. Plant 3:78-90(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION.
  9. "The flavonoid biosynthetic pathway in Arabidopsis: Structural and genetic diversity."
    Saito K., Yonekura-Sakakibara K., Nakabayashi R., Higashi Y., Yamazaki M., Tohge T., Fernie A.R.
    Plant Physiol. Biochem. 0:0-0(2013)
    Cited for: REVIEW, NOMENCLATURE.

Entry informationi

Entry nameiU78D2_ARATH
AccessioniPrimary (citable) accession number: Q9LFJ8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 1, 2007
Last sequence update: October 1, 2000
Last modified: July 9, 2014
This is version 82 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Arabidopsis thaliana
    Arabidopsis thaliana: entries and gene names
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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