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Q9LFJ8

- U78D2_ARATH

UniProt

Q9LFJ8 - U78D2_ARATH

Protein

UDP-glycosyltransferase 78D2

Gene

UGT78D2

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 83 (01 Oct 2014)
      Sequence version 1 (01 Oct 2000)
      Previous versions | rss
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    Functioni

    Catalyzes the glycosylation of flavonoids from UDP-glucose. Catalyzes the glycosylation of anthocyanins from UDP-glucose. Possesses high quercetin 3-O-glucosyltransferase activity in vitro. Also active in vitro on benzoates and benzoate derivatives.4 Publications

    Catalytic activityi

    UDP-glucose + a flavonol = UDP + a flavonol 3-O-D-glucoside.

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei286 – 2861UDP-glucoseBy similarity

    GO - Molecular functioni

    1. anthocyanidin 3-O-glucosyltransferase activity Source: TAIR
    2. flavonol 3-O-glucosyltransferase activity Source: UniProtKB-EC
    3. quercetin 3-O-glucosyltransferase activity Source: TAIR
    4. UDP-glucosyltransferase activity Source: TAIR

    GO - Biological processi

    1. flavonoid biosynthetic process Source: UniProtKB-UniPathway
    2. phenylpropanoid metabolic process Source: UniProtKB-KW
    3. response to karrikin Source: TAIR

    Keywords - Molecular functioni

    Glycosyltransferase, Transferase

    Keywords - Biological processi

    Phenylpropanoid metabolism

    Enzyme and pathway databases

    BioCyciMetaCyc:AT5G17050-MONOMER.
    UniPathwayiUPA00154.

    Protein family/group databases

    CAZyiGT1. Glycosyltransferase Family 1.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    UDP-glycosyltransferase 78D2 (EC:2.4.1.-)
    Alternative name(s):
    Anthocyanin 3-O-glucosyltransferase
    Flavonol 3-O-glucosyltransferase. (EC:2.4.1.91)
    UDP glucose:flavonoid 3-O-glucosyltransferase
    Gene namesi
    Name:UGT78D2
    Synonyms:AGT
    Ordered Locus Names:At5g17050
    ORF Names:F2K13.200
    OrganismiArabidopsis thaliana (Mouse-ear cress)
    Taxonomic identifieri3702 [NCBI]
    Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
    ProteomesiUP000006548: Chromosome 5

    Organism-specific databases

    TAIRiAT5G17050.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 460460UDP-glycosyltransferase 78D2PRO_0000285275Add
    BLAST

    Proteomic databases

    PaxDbiQ9LFJ8.
    PRIDEiQ9LFJ8.

    Expressioni

    Inductioni

    By PAP1.1 Publication

    Gene expression databases

    GenevestigatoriQ9LFJ8.

    Interactioni

    Protein-protein interaction databases

    STRINGi3702.AT5G17050.1-P.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9LFJ8.
    SMRiQ9LFJ8. Positions 10-456.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni339 – 3413UDP-glucose bindingBy similarity
    Regioni356 – 3649UDP-glucose bindingBy similarity
    Regioni378 – 3814UDP-glucose bindingBy similarity

    Sequence similaritiesi

    Belongs to the UDP-glycosyltransferase family.Curated

    Phylogenomic databases

    eggNOGiCOG1819.
    HOGENOMiHOG000237564.
    InParanoidiQ9LFJ8.
    KOiK10757.
    OMAiQRMNARS.
    PhylomeDBiQ9LFJ8.

    Family and domain databases

    InterProiIPR002213. UDP_glucos_trans.
    [Graphical view]
    PANTHERiPTHR11926. PTHR11926. 1 hit.
    PfamiPF00201. UDPGT. 1 hit.
    [Graphical view]
    PROSITEiPS00375. UDPGT. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q9LFJ8-1 [UniParc]FASTAAdd to Basket

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    MTKPSDPTRD SHVAVLAFPF GTHAAPLLTV TRRLASASPS TVFSFFNTAQ    50
    SNSSLFSSGD EADRPANIRV YDIADGVPEG YVFSGRPQEA IELFLQAAPE 100
    NFRREIAKAE TEVGTEVKCL MTDAFFWFAA DMATEINASW IAFWTAGANS 150
    LSAHLYTDLI RETIGVKEVG ERMEETIGVI SGMEKIRVKD TPEGVVFGNL 200
    DSVFSKMLHQ MGLALPRATA VFINSFEDLD PTLTNNLRSR FKRYLNIGPL 250
    GLLSSTLQQL VQDPHGCLAW MEKRSSGSVA YISFGTVMTP PPGELAAIAE 300
    GLESSKVPFV WSLKEKSLVQ LPKGFLDRTR EQGIVVPWAP QVELLKHEAT 350
    GVFVTHCGWN SVLESVSGGV PMICRPFFGD QRLNGRAVEV VWEIGMTIIN 400
    GVFTKDGFEK CLDKVLVQDD GKKMKCNAKK LKELAYEAVS SKGRSSENFR 450
    GLLDAVVNII 460
    Length:460
    Mass (Da):50,486
    Last modified:October 1, 2000 - v1
    Checksum:iE9DEAD19E4E05188
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AL391141 Genomic DNA. Translation: CAC01718.1.
    CP002688 Genomic DNA. Translation: AED92377.1.
    AY072325 mRNA. Translation: AAL61932.1.
    AY128739 mRNA. Translation: AAM91139.1.
    PIRiT51560.
    RefSeqiNP_197207.1. NM_121711.4.
    UniGeneiAt.27563.

    Genome annotation databases

    EnsemblPlantsiAT5G17050.1; AT5G17050.1; AT5G17050.
    GeneIDi831568.
    KEGGiath:AT5G17050.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AL391141 Genomic DNA. Translation: CAC01718.1 .
    CP002688 Genomic DNA. Translation: AED92377.1 .
    AY072325 mRNA. Translation: AAL61932.1 .
    AY128739 mRNA. Translation: AAM91139.1 .
    PIRi T51560.
    RefSeqi NP_197207.1. NM_121711.4.
    UniGenei At.27563.

    3D structure databases

    ProteinModelPortali Q9LFJ8.
    SMRi Q9LFJ8. Positions 10-456.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 3702.AT5G17050.1-P.

    Protein family/group databases

    CAZyi GT1. Glycosyltransferase Family 1.

    Proteomic databases

    PaxDbi Q9LFJ8.
    PRIDEi Q9LFJ8.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblPlantsi AT5G17050.1 ; AT5G17050.1 ; AT5G17050 .
    GeneIDi 831568.
    KEGGi ath:AT5G17050.

    Organism-specific databases

    TAIRi AT5G17050.

    Phylogenomic databases

    eggNOGi COG1819.
    HOGENOMi HOG000237564.
    InParanoidi Q9LFJ8.
    KOi K10757.
    OMAi QRMNARS.
    PhylomeDBi Q9LFJ8.

    Enzyme and pathway databases

    UniPathwayi UPA00154 .
    BioCyci MetaCyc:AT5G17050-MONOMER.

    Gene expression databases

    Genevestigatori Q9LFJ8.

    Family and domain databases

    InterProi IPR002213. UDP_glucos_trans.
    [Graphical view ]
    PANTHERi PTHR11926. PTHR11926. 1 hit.
    Pfami PF00201. UDPGT. 1 hit.
    [Graphical view ]
    PROSITEi PS00375. UDPGT. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Sequence and analysis of chromosome 5 of the plant Arabidopsis thaliana."
      Tabata S., Kaneko T., Nakamura Y., Kotani H., Kato T., Asamizu E., Miyajima N., Sasamoto S., Kimura T., Hosouchi T., Kawashima K., Kohara M., Matsumoto M., Matsuno A., Muraki A., Nakayama S., Nakazaki N., Naruo K.
      , Okumura S., Shinpo S., Takeuchi C., Wada T., Watanabe A., Yamada M., Yasuda M., Sato S., de la Bastide M., Huang E., Spiegel L., Gnoj L., O'Shaughnessy A., Preston R., Habermann K., Murray J., Johnson D., Rohlfing T., Nelson J., Stoneking T., Pepin K., Spieth J., Sekhon M., Armstrong J., Becker M., Belter E., Cordum H., Cordes M., Courtney L., Courtney W., Dante M., Du H., Edwards J., Fryman J., Haakensen B., Lamar E., Latreille P., Leonard S., Meyer R., Mulvaney E., Ozersky P., Riley A., Strowmatt C., Wagner-McPherson C., Wollam A., Yoakum M., Bell M., Dedhia N., Parnell L., Shah R., Rodriguez M., Hoon See L., Vil D., Baker J., Kirchoff K., Toth K., King L., Bahret A., Miller B., Marra M.A., Martienssen R., McCombie W.R., Wilson R.K., Murphy G., Bancroft I., Volckaert G., Wambutt R., Duesterhoeft A., Stiekema W., Pohl T., Entian K.-D., Terryn N., Hartley N., Bent E., Johnson S., Langham S.-A., McCullagh B., Robben J., Grymonprez B., Zimmermann W., Ramsperger U., Wedler H., Balke K., Wedler E., Peters S., van Staveren M., Dirkse W., Mooijman P., Klein Lankhorst R., Weitzenegger T., Bothe G., Rose M., Hauf J., Berneiser S., Hempel S., Feldpausch M., Lamberth S., Villarroel R., Gielen J., Ardiles W., Bents O., Lemcke K., Kolesov G., Mayer K.F.X., Rudd S., Schoof H., Schueller C., Zaccaria P., Mewes H.-W., Bevan M., Fransz P.F.
      Nature 408:823-826(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: cv. Columbia.
    2. The Arabidopsis Information Resource (TAIR)
      Submitted (APR-2011) to the EMBL/GenBank/DDBJ databases
      Cited for: GENOME REANNOTATION.
      Strain: cv. Columbia.
    3. "Empirical analysis of transcriptional activity in the Arabidopsis genome."
      Yamada K., Lim J., Dale J.M., Chen H., Shinn P., Palm C.J., Southwick A.M., Wu H.C., Kim C.J., Nguyen M., Pham P.K., Cheuk R.F., Karlin-Newmann G., Liu S.X., Lam B., Sakano H., Wu T., Yu G.
      , Miranda M., Quach H.L., Tripp M., Chang C.H., Lee J.M., Toriumi M.J., Chan M.M., Tang C.C., Onodera C.S., Deng J.M., Akiyama K., Ansari Y., Arakawa T., Banh J., Banno F., Bowser L., Brooks S.Y., Carninci P., Chao Q., Choy N., Enju A., Goldsmith A.D., Gurjal M., Hansen N.F., Hayashizaki Y., Johnson-Hopson C., Hsuan V.W., Iida K., Karnes M., Khan S., Koesema E., Ishida J., Jiang P.X., Jones T., Kawai J., Kamiya A., Meyers C., Nakajima M., Narusaka M., Seki M., Sakurai T., Satou M., Tamse R., Vaysberg M., Wallender E.K., Wong C., Yamamura Y., Yuan S., Shinozaki K., Davis R.W., Theologis A., Ecker J.R.
      Science 302:842-846(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: cv. Columbia.
    4. "Phylogenetic analysis of the UDP-glycosyltransferase multigene family of Arabidopsis thaliana."
      Li Y., Baldauf S., Lim E.K., Bowles D.J.
      J. Biol. Chem. 276:4338-4343(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: GENE FAMILY.
    5. "The activity of Arabidopsis glycosyltransferases toward salicylic acid, 4-hydroxybenzoic acid, and other benzoates."
      Lim E.K., Doucet C.J., Li Y., Elias L., Worrall D., Spencer S.P., Ross J., Bowles D.J.
      J. Biol. Chem. 277:586-592(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION.
    6. "Arabidopsis glycosyltransferases as biocatalysts in fermentation for regioselective synthesis of diverse quercetin glucosides."
      Lim E.K., Ashford D.A., Hou B., Jackson R.G., Bowles D.J.
      Biotechnol. Bioeng. 87:623-631(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION.
    7. "Functional genomics by integrated analysis of metabolome and transcriptome of Arabidopsis plants over-expressing an MYB transcription factor."
      Tohge T., Nishiyama Y., Hirai M.Y., Yano M., Nakajima J., Awazuhara M., Inoue E., Takahashi H., Goodenowe D.B., Kitayama M., Noji M., Yamazaki M., Saito K.
      Plant J. 42:218-235(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, INDUCTION BY PAP1.
    8. "The formation of anthocyanic vacuolar inclusions in Arabidopsis thaliana and implications for the sequestration of anthocyanin pigments."
      Pourcel L., Irani N.G., Lu Y., Riedl K., Schwartz S., Grotewold E.
      Mol. Plant 3:78-90(2010) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION.
    9. "The flavonoid biosynthetic pathway in Arabidopsis: Structural and genetic diversity."
      Saito K., Yonekura-Sakakibara K., Nakabayashi R., Higashi Y., Yamazaki M., Tohge T., Fernie A.R.
      Plant Physiol. Biochem. 0:0-0(2013)
      Cited for: REVIEW, NOMENCLATURE.

    Entry informationi

    Entry nameiU78D2_ARATH
    AccessioniPrimary (citable) accession number: Q9LFJ8
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 1, 2007
    Last sequence update: October 1, 2000
    Last modified: October 1, 2014
    This is version 83 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programPlant Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Arabidopsis thaliana
      Arabidopsis thaliana: entries and gene names
    2. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3