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Q9LFD1

- LAC9_ARATH

UniProt

Q9LFD1 - LAC9_ARATH

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Protein

Laccase-9

Gene

LAC9

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli

Functioni

Lignin degradation and detoxification of lignin-derived products.By similarity

Catalytic activityi

4 benzenediol + O2 = 4 benzosemiquinone + 2 H2O.

Cofactori

Binds 4 copper ions per monomer.By similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi83 – 831Copper 1; type 2By similarity
Metal bindingi85 – 851Copper 2; type 3By similarity
Metal bindingi128 – 1281Copper 2; type 3By similarity
Metal bindingi130 – 1301Copper 3; type 3By similarity
Metal bindingi469 – 4691Copper 4; type 1By similarity
Metal bindingi472 – 4721Copper 1; type 2By similarity
Metal bindingi474 – 4741Copper 3; type 3By similarity
Metal bindingi531 – 5311Copper 3; type 3By similarity
Metal bindingi532 – 5321Copper 4; type 1By similarity
Metal bindingi533 – 5331Copper 2; type 3By similarity
Metal bindingi537 – 5371Copper 4; type 1By similarity

GO - Molecular functioni

  1. copper ion binding Source: InterPro
  2. hydroquinone:oxygen oxidoreductase activity Source: UniProtKB-EC

GO - Biological processi

  1. lignin catabolic process Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Lignin degradation

Keywords - Ligandi

Copper, Metal-binding

Enzyme and pathway databases

BioCyciARA:AT5G01050-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Laccase-9 (EC:1.10.3.2)
Alternative name(s):
Benzenediol:oxygen oxidoreductase 9
Diphenol oxidase 9
Urishiol oxidase 9
Gene namesi
Name:LAC9
Ordered Locus Names:At5g01050
ORF Names:F7J8.30
OrganismiArabidopsis thaliana (Mouse-ear cress)
Taxonomic identifieri3702 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
ProteomesiUP000006548: Chromosome 5

Organism-specific databases

TAIRiAT5G01050.

Subcellular locationi

GO - Cellular componenti

  1. apoplast Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Apoplast, Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2525Sequence AnalysisAdd
BLAST
Chaini26 – 586561Laccase-9PRO_0000283637Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi52 – 521N-linked (GlcNAc...)Sequence Analysis
Glycosylationi74 – 741N-linked (GlcNAc...)Sequence Analysis
Glycosylationi79 – 791N-linked (GlcNAc...)Sequence Analysis
Glycosylationi111 – 1111N-linked (GlcNAc...)Sequence Analysis
Glycosylationi236 – 2361N-linked (GlcNAc...)Sequence Analysis
Glycosylationi333 – 3331N-linked (GlcNAc...)Sequence Analysis
Glycosylationi385 – 3851N-linked (GlcNAc...)Sequence Analysis
Glycosylationi403 – 4031N-linked (GlcNAc...)Sequence Analysis
Glycosylationi451 – 4511N-linked (GlcNAc...)Sequence Analysis

Keywords - PTMi

Glycoprotein

Proteomic databases

PRIDEiQ9LFD1.

Expressioni

Tissue specificityi

Predominantly expressed in roots.2 Publications

Gene expression databases

GenevestigatoriQ9LFD1.

Interactioni

Protein-protein interaction databases

STRINGi3702.AT5G01050.1-P.

Structurei

3D structure databases

ProteinModelPortaliQ9LFD1.
SMRiQ9LFD1. Positions 29-555.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini33 – 149117Plastocyanin-like 1Add
BLAST
Domaini159 – 307149Plastocyanin-like 2Add
BLAST
Domaini411 – 552142Plastocyanin-like 3Add
BLAST

Sequence similaritiesi

Belongs to the multicopper oxidase family.Curated
Contains 3 plastocyanin-like domains.Curated

Keywords - Domaini

Repeat, Signal

Phylogenomic databases

eggNOGiCOG2132.
HOGENOMiHOG000241916.
InParanoidiQ9LFD1.
OMAiNDIPTAH.
PhylomeDBiQ9LFD1.

Family and domain databases

Gene3Di2.60.40.420. 4 hits.
InterProiIPR001117. Cu-oxidase.
IPR011706. Cu-oxidase_2.
IPR011707. Cu-oxidase_3.
IPR008972. Cupredoxin.
IPR017761. Laccase.
[Graphical view]
PfamiPF00394. Cu-oxidase. 1 hit.
PF07731. Cu-oxidase_2. 1 hit.
PF07732. Cu-oxidase_3. 1 hit.
[Graphical view]
SUPFAMiSSF49503. SSF49503. 4 hits.
TIGRFAMsiTIGR03389. laccase. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9LFD1-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MPRVHHSLSN QAFLVLLLFS SIASAAIVEH VLHVKDVVVT PLCKEQMIPI
60 70 80 90 100
VNGSLPGPTI NVREGDTLVV HVINKSTYNV TIHWHGVFQL KSVWMDGANM
110 120 130 140 150
ITQCPIQPSN NFTYQFDITG QEGTLLWHAH VVNLRATIHG ALIIRPRSGR
160 170 180 190 200
PYPFPKPYKE VPLIFQQWWD TDVRLLELRP APVSDAYLIN GLAGDSYPCS
210 220 230 240 250
KNRMFNLKVV QGKTYLLRII NAALNTHLFF KIANHNVTVV AVDAVYTTPY
260 270 280 290 300
LTDVMILTPG QTIDAILTAD QPIGTYYMAI IPYFSAIGVP ASPDTKPTRG
310 320 330 340 350
LIVYEGATSS SSPTKPWMPP ANDIPTAHRF SSNITSLVGG PHWTPVPRHV
360 370 380 390 400
DEKMFITMGL GLDPCPSNAK CVGPLDQRLA GSLNNRTFMI PERISMQEAY
410 420 430 440 450
FYNITGVYTD DFPDQPPLKF DFTKFEQHPT NSDMEMMFPE RKTSVKTIRF
460 470 480 490 500
NSTVEIVLQN TGILTPESHP MHLHGFNFYV LGYGFGNYDP IRDARKLNLF
510 520 530 540 550
NPQMHNTVGV PPGGWVVLRF IANNPGIWLF HCHMDAHLPL GIMMAFIVQN
560 570 580
GPTRETSLPS PPSNLPQCTR DPTIYDSRTT NVDMSY
Length:586
Mass (Da):65,589
Last modified:October 1, 2000 - v1
Checksum:i84FFF22C99A35451
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AL137189 Genomic DNA. Translation: CAB69833.1.
CP002688 Genomic DNA. Translation: AED90292.1.
PIRiT45945.
RefSeqiNP_195725.1. NM_120182.2.
UniGeneiAt.33978.

Genome annotation databases

EnsemblPlantsiAT5G01050.1; AT5G01050.1; AT5G01050.
GeneIDi831812.
KEGGiath:AT5G01050.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AL137189 Genomic DNA. Translation: CAB69833.1 .
CP002688 Genomic DNA. Translation: AED90292.1 .
PIRi T45945.
RefSeqi NP_195725.1. NM_120182.2.
UniGenei At.33978.

3D structure databases

ProteinModelPortali Q9LFD1.
SMRi Q9LFD1. Positions 29-555.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 3702.AT5G01050.1-P.

Proteomic databases

PRIDEi Q9LFD1.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblPlantsi AT5G01050.1 ; AT5G01050.1 ; AT5G01050 .
GeneIDi 831812.
KEGGi ath:AT5G01050.

Organism-specific databases

TAIRi AT5G01050.

Phylogenomic databases

eggNOGi COG2132.
HOGENOMi HOG000241916.
InParanoidi Q9LFD1.
OMAi NDIPTAH.
PhylomeDBi Q9LFD1.

Enzyme and pathway databases

BioCyci ARA:AT5G01050-MONOMER.

Gene expression databases

Genevestigatori Q9LFD1.

Family and domain databases

Gene3Di 2.60.40.420. 4 hits.
InterProi IPR001117. Cu-oxidase.
IPR011706. Cu-oxidase_2.
IPR011707. Cu-oxidase_3.
IPR008972. Cupredoxin.
IPR017761. Laccase.
[Graphical view ]
Pfami PF00394. Cu-oxidase. 1 hit.
PF07731. Cu-oxidase_2. 1 hit.
PF07732. Cu-oxidase_3. 1 hit.
[Graphical view ]
SUPFAMi SSF49503. SSF49503. 4 hits.
TIGRFAMsi TIGR03389. laccase. 1 hit.
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Sequence and analysis of chromosome 5 of the plant Arabidopsis thaliana."
    Tabata S., Kaneko T., Nakamura Y., Kotani H., Kato T., Asamizu E., Miyajima N., Sasamoto S., Kimura T., Hosouchi T., Kawashima K., Kohara M., Matsumoto M., Matsuno A., Muraki A., Nakayama S., Nakazaki N., Naruo K.
    , Okumura S., Shinpo S., Takeuchi C., Wada T., Watanabe A., Yamada M., Yasuda M., Sato S., de la Bastide M., Huang E., Spiegel L., Gnoj L., O'Shaughnessy A., Preston R., Habermann K., Murray J., Johnson D., Rohlfing T., Nelson J., Stoneking T., Pepin K., Spieth J., Sekhon M., Armstrong J., Becker M., Belter E., Cordum H., Cordes M., Courtney L., Courtney W., Dante M., Du H., Edwards J., Fryman J., Haakensen B., Lamar E., Latreille P., Leonard S., Meyer R., Mulvaney E., Ozersky P., Riley A., Strowmatt C., Wagner-McPherson C., Wollam A., Yoakum M., Bell M., Dedhia N., Parnell L., Shah R., Rodriguez M., Hoon See L., Vil D., Baker J., Kirchoff K., Toth K., King L., Bahret A., Miller B., Marra M.A., Martienssen R., McCombie W.R., Wilson R.K., Murphy G., Bancroft I., Volckaert G., Wambutt R., Duesterhoeft A., Stiekema W., Pohl T., Entian K.-D., Terryn N., Hartley N., Bent E., Johnson S., Langham S.-A., McCullagh B., Robben J., Grymonprez B., Zimmermann W., Ramsperger U., Wedler H., Balke K., Wedler E., Peters S., van Staveren M., Dirkse W., Mooijman P., Klein Lankhorst R., Weitzenegger T., Bothe G., Rose M., Hauf J., Berneiser S., Hempel S., Feldpausch M., Lamberth S., Villarroel R., Gielen J., Ardiles W., Bents O., Lemcke K., Kolesov G., Mayer K.F.X., Rudd S., Schoof H., Schueller C., Zaccaria P., Mewes H.-W., Bevan M., Fransz P.F.
    Nature 408:823-826(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: cv. Columbia.
  2. The Arabidopsis Information Resource (TAIR)
    Submitted (APR-2011) to the EMBL/GenBank/DDBJ databases
    Cited for: GENOME REANNOTATION.
    Strain: cv. Columbia.
  3. "Gene structure and molecular analysis of the laccase-like multicopper oxidase (LMCO) gene family in Arabidopsis thaliana."
    McCaig B.C., Meagher R.B., Dean J.F.D.
    Planta 221:619-636(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: TISSUE SPECIFICITY.
  4. "Mutant identification and characterization of the laccase gene family in Arabidopsis."
    Cai X., Davis E.J., Ballif J., Liang M., Bushman E., Haroldsen V., Torabinejad J., Wu Y.
    J. Exp. Bot. 57:2563-2569(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: TISSUE SPECIFICITY.

Entry informationi

Entry nameiLAC9_ARATH
AccessioniPrimary (citable) accession number: Q9LFD1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 3, 2007
Last sequence update: October 1, 2000
Last modified: October 29, 2014
This is version 85 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Arabidopsis thaliana
    Arabidopsis thaliana: entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3