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Protein

Laccase-9

Gene

LAC9

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Lignin degradation and detoxification of lignin-derived products.By similarity

Catalytic activityi

4 benzenediol + O2 = 4 benzosemiquinone + 2 H2O.

Cofactori

Cu cationBy similarityNote: Binds 4 Cu cations per monomer.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi83Copper 1; type 2By similarity1
Metal bindingi85Copper 2; type 3By similarity1
Metal bindingi128Copper 2; type 3By similarity1
Metal bindingi130Copper 3; type 3By similarity1
Metal bindingi469Copper 4; type 1By similarity1
Metal bindingi472Copper 1; type 2By similarity1
Metal bindingi474Copper 3; type 3By similarity1
Metal bindingi531Copper 3; type 3By similarity1
Metal bindingi532Copper 4; type 1By similarity1
Metal bindingi533Copper 2; type 3By similarity1
Metal bindingi537Copper 4; type 1By similarity1

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Lignin degradation

Keywords - Ligandi

Copper, Metal-binding

Enzyme and pathway databases

BioCyciARA:AT5G01050-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Laccase-9 (EC:1.10.3.2)
Alternative name(s):
Benzenediol:oxygen oxidoreductase 9
Diphenol oxidase 9
Urishiol oxidase 9
Gene namesi
Name:LAC9
Ordered Locus Names:At5g01050
ORF Names:F7J8.30
OrganismiArabidopsis thaliana (Mouse-ear cress)
Taxonomic identifieri3702 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
Proteomesi
  • UP000006548 Componenti: Chromosome 5

Organism-specific databases

TAIRiAT5G01050.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Apoplast, Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 25Sequence analysisAdd BLAST25
ChainiPRO_000028363726 – 586Laccase-9Add BLAST561

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi52N-linked (GlcNAc...)Sequence analysis1
Glycosylationi74N-linked (GlcNAc...)Sequence analysis1
Glycosylationi79N-linked (GlcNAc...)Sequence analysis1
Glycosylationi111N-linked (GlcNAc...)Sequence analysis1
Glycosylationi236N-linked (GlcNAc...)Sequence analysis1
Glycosylationi333N-linked (GlcNAc...)Sequence analysis1
Glycosylationi385N-linked (GlcNAc...)Sequence analysis1
Glycosylationi403N-linked (GlcNAc...)Sequence analysis1
Glycosylationi451N-linked (GlcNAc...)Sequence analysis1

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiQ9LFD1.
PRIDEiQ9LFD1.

Expressioni

Tissue specificityi

Predominantly expressed in roots.2 Publications

Gene expression databases

GenevisibleiQ9LFD1. AT.

Interactioni

Protein-protein interaction databases

STRINGi3702.AT5G01050.1.

Structurei

3D structure databases

ProteinModelPortaliQ9LFD1.
SMRiQ9LFD1.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini33 – 149Plastocyanin-like 1Add BLAST117
Domaini159 – 307Plastocyanin-like 2Add BLAST149
Domaini411 – 552Plastocyanin-like 3Add BLAST142

Sequence similaritiesi

Belongs to the multicopper oxidase family.Curated
Contains 3 plastocyanin-like domains.Curated

Keywords - Domaini

Repeat, Signal

Phylogenomic databases

eggNOGiKOG1263. Eukaryota.
COG2132. LUCA.
HOGENOMiHOG000241916.
InParanoidiQ9LFD1.
KOiK05909.
OMAiMAFIVQN.
OrthoDBiEOG093605LR.
PhylomeDBiQ9LFD1.

Family and domain databases

Gene3Di2.60.40.420. 4 hits.
InterProiIPR001117. Cu-oxidase.
IPR011706. Cu-oxidase_2.
IPR011707. Cu-oxidase_3.
IPR008972. Cupredoxin.
IPR017761. Laccase.
[Graphical view]
PfamiPF00394. Cu-oxidase. 1 hit.
PF07731. Cu-oxidase_2. 1 hit.
PF07732. Cu-oxidase_3. 1 hit.
[Graphical view]
SUPFAMiSSF49503. SSF49503. 4 hits.
TIGRFAMsiTIGR03389. laccase. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9LFD1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPRVHHSLSN QAFLVLLLFS SIASAAIVEH VLHVKDVVVT PLCKEQMIPI
60 70 80 90 100
VNGSLPGPTI NVREGDTLVV HVINKSTYNV TIHWHGVFQL KSVWMDGANM
110 120 130 140 150
ITQCPIQPSN NFTYQFDITG QEGTLLWHAH VVNLRATIHG ALIIRPRSGR
160 170 180 190 200
PYPFPKPYKE VPLIFQQWWD TDVRLLELRP APVSDAYLIN GLAGDSYPCS
210 220 230 240 250
KNRMFNLKVV QGKTYLLRII NAALNTHLFF KIANHNVTVV AVDAVYTTPY
260 270 280 290 300
LTDVMILTPG QTIDAILTAD QPIGTYYMAI IPYFSAIGVP ASPDTKPTRG
310 320 330 340 350
LIVYEGATSS SSPTKPWMPP ANDIPTAHRF SSNITSLVGG PHWTPVPRHV
360 370 380 390 400
DEKMFITMGL GLDPCPSNAK CVGPLDQRLA GSLNNRTFMI PERISMQEAY
410 420 430 440 450
FYNITGVYTD DFPDQPPLKF DFTKFEQHPT NSDMEMMFPE RKTSVKTIRF
460 470 480 490 500
NSTVEIVLQN TGILTPESHP MHLHGFNFYV LGYGFGNYDP IRDARKLNLF
510 520 530 540 550
NPQMHNTVGV PPGGWVVLRF IANNPGIWLF HCHMDAHLPL GIMMAFIVQN
560 570 580
GPTRETSLPS PPSNLPQCTR DPTIYDSRTT NVDMSY
Length:586
Mass (Da):65,589
Last modified:October 1, 2000 - v1
Checksum:i84FFF22C99A35451
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL137189 Genomic DNA. Translation: CAB69833.1.
CP002688 Genomic DNA. Translation: AED90292.1.
PIRiT45945.
RefSeqiNP_195725.1. NM_120182.3.
UniGeneiAt.33978.

Genome annotation databases

EnsemblPlantsiAT5G01050.1; AT5G01050.1; AT5G01050.
GeneIDi831812.
GrameneiAT5G01050.1; AT5G01050.1; AT5G01050.
KEGGiath:AT5G01050.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL137189 Genomic DNA. Translation: CAB69833.1.
CP002688 Genomic DNA. Translation: AED90292.1.
PIRiT45945.
RefSeqiNP_195725.1. NM_120182.3.
UniGeneiAt.33978.

3D structure databases

ProteinModelPortaliQ9LFD1.
SMRiQ9LFD1.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi3702.AT5G01050.1.

Proteomic databases

PaxDbiQ9LFD1.
PRIDEiQ9LFD1.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblPlantsiAT5G01050.1; AT5G01050.1; AT5G01050.
GeneIDi831812.
GrameneiAT5G01050.1; AT5G01050.1; AT5G01050.
KEGGiath:AT5G01050.

Organism-specific databases

TAIRiAT5G01050.

Phylogenomic databases

eggNOGiKOG1263. Eukaryota.
COG2132. LUCA.
HOGENOMiHOG000241916.
InParanoidiQ9LFD1.
KOiK05909.
OMAiMAFIVQN.
OrthoDBiEOG093605LR.
PhylomeDBiQ9LFD1.

Enzyme and pathway databases

BioCyciARA:AT5G01050-MONOMER.

Miscellaneous databases

PROiQ9LFD1.

Gene expression databases

GenevisibleiQ9LFD1. AT.

Family and domain databases

Gene3Di2.60.40.420. 4 hits.
InterProiIPR001117. Cu-oxidase.
IPR011706. Cu-oxidase_2.
IPR011707. Cu-oxidase_3.
IPR008972. Cupredoxin.
IPR017761. Laccase.
[Graphical view]
PfamiPF00394. Cu-oxidase. 1 hit.
PF07731. Cu-oxidase_2. 1 hit.
PF07732. Cu-oxidase_3. 1 hit.
[Graphical view]
SUPFAMiSSF49503. SSF49503. 4 hits.
TIGRFAMsiTIGR03389. laccase. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiLAC9_ARATH
AccessioniPrimary (citable) accession number: Q9LFD1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 3, 2007
Last sequence update: October 1, 2000
Last modified: November 30, 2016
This is version 98 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Arabidopsis thaliana
    Arabidopsis thaliana: entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.