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Q9LFB2

- LAX1_ARATH

UniProt

Q9LFB2 - LAX1_ARATH

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Protein

Auxin transporter-like protein 1

Gene

LAX1

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli

Functioni

Carrier protein involved in proton-driven auxin influx. Mediates the formation of auxin gradient from developing leaves (site of auxin biosynthesis) to tips by contributing to the loading of auxin in vascular tissues and facilitating acropetal (base to tip) auxin transport within inner tissues of the root apex, and basipetal (tip to base) auxin transport within outer tissues of the root apex (By similarity).By similarity

GO - Molecular functioni

  1. auxin influx transmembrane transporter activity Source: TAIR
  2. symporter activity Source: UniProtKB-KW

GO - Biological processi

  1. amino acid transport Source: UniProtKB-KW
  2. auxin-activated signaling pathway Source: UniProtKB-KW
  3. auxin influx Source: GOC
  4. root cap development Source: TAIR
Complete GO annotation...

Keywords - Biological processi

Amino-acid transport, Auxin signaling pathway, Symport, Transport

Names & Taxonomyi

Protein namesi
Recommended name:
Auxin transporter-like protein 1
Alternative name(s):
AUX1-like protein 1
Gene namesi
Name:LAX1
Ordered Locus Names:At5g01240
ORF Names:F7J8_220
OrganismiArabidopsis thaliana (Mouse-ear cress)
Taxonomic identifieri3702 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
ProteomesiUP000006548: Chromosome 5

Organism-specific databases

TAIRiAT5G01240.

Subcellular locationi

Cell membrane By similarity; Multi-pass membrane protein By similarity

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. plasma membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 488488Auxin transporter-like protein 1PRO_0000093842Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi303 – 3031N-linked (GlcNAc...)Sequence Analysis

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiQ9LFB2.
PRIDEiQ9LFB2.

Expressioni

Gene expression databases

GenevestigatoriQ9LFB2.

Interactioni

Protein-protein interaction databases

MINTiMINT-8066356.
STRINGi3702.AT5G01240.1-P.

Structurei

3D structure databases

ProteinModelPortaliQ9LFB2.
ModBaseiSearch...
MobiDBiSearch...

Topological domain

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 6464CytoplasmicSequence AnalysisAdd
BLAST
Topological domaini83 – 842ExtracellularSequence Analysis
Topological domaini106 – 14136CytoplasmicSequence AnalysisAdd
BLAST
Topological domaini163 – 17816ExtracellularSequence AnalysisAdd
BLAST
Topological domaini200 – 2023CytoplasmicSequence Analysis
Topological domaini224 – 23815ExtracellularSequence AnalysisAdd
BLAST
Topological domaini260 – 27314CytoplasmicSequence AnalysisAdd
BLAST
Topological domaini295 – 32026ExtracellularSequence AnalysisAdd
BLAST
Topological domaini342 – 36221CytoplasmicSequence AnalysisAdd
BLAST
Topological domaini384 – 3841ExtracellularSequence Analysis
Topological domaini406 – 42722CytoplasmicSequence AnalysisAdd
BLAST
Topological domaini449 – 48840ExtracellularSequence AnalysisAdd
BLAST

Transmembrane

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei65 – 8218HelicalSequence AnalysisAdd
BLAST
Transmembranei85 – 10521HelicalSequence AnalysisAdd
BLAST
Transmembranei142 – 16221HelicalSequence AnalysisAdd
BLAST
Transmembranei179 – 19921HelicalSequence AnalysisAdd
BLAST
Transmembranei203 – 22321HelicalSequence AnalysisAdd
BLAST
Transmembranei239 – 25921HelicalSequence AnalysisAdd
BLAST
Transmembranei274 – 29421HelicalSequence AnalysisAdd
BLAST
Transmembranei321 – 34121HelicalSequence AnalysisAdd
BLAST
Transmembranei363 – 38321HelicalSequence AnalysisAdd
BLAST
Transmembranei385 – 40521HelicalSequence AnalysisAdd
BLAST
Transmembranei428 – 44821HelicalSequence AnalysisAdd
BLAST

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG1303.
HOGENOMiHOG000238482.
InParanoidiQ9LFB2.
KOiK13946.
OMAiYVINAFI.
PhylomeDBiQ9LFB2.

Family and domain databases

InterProiIPR013057. AA_transpt_TM.
[Graphical view]
PfamiPF01490. Aa_trans. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

This entry describes 1 isoform i produced by alternative splicing. Align

Note: A number of isoforms are produced. According to EST sequences.

Isoform 1 (identifier: Q9LFB2-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MSGEKQAEES IVVSGEDEVA GRKVEDSAAE EDIDGNGGNG FSMKSFLWHG
60 70 80 90 100
GSAWDAWFSC ASNQVAQVLL TLPYSFSQLG MLSGILLQIF YGLMGSWTAY
110 120 130 140 150
LISVLYVEYR ARMEKQEAKS FKNHVIQWFE VLDGLLGPYW KAAGLAFNCT
160 170 180 190 200
FLLFGSVIQL IACASNIYYI NDRLDKRTWT YIFGACCATT VFIPSFHNYR
210 220 230 240 250
IWSFLGLGMT TYTAWYLTIA SFLHGQAEGV THSGPTKLVL YFTGATNILY
260 270 280 290 300
TFGGHAVTVE IMHAMWKPRK FKSIYLMATL YVFTLTLPSA SAVYWAFGDQ
310 320 330 340 350
LLNHSNAFSL LPKTRFRDTA VILMLIHQFI TFGFACTPLY FVWEKAIGMH
360 370 380 390 400
HTKSLCLRAL VRLPVVVPIW FLAIIFPFFG PINSAVGALL VTFTVYIIPA
410 420 430 440 450
LAHMLTYRTA SARRNAAEKP PFFIPSWAGV YVINAFIVVW VLVLGFGFGG
460 470 480
WASMTNFIRQ IDTFGLFAKC YQCKPPPAPI AAGAHHRR
Length:488
Mass (Da):54,601
Last modified:October 1, 2000 - v1
Checksum:i06B0BF524EDE2BD8
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti16 – 172ED → DE in CAB55758. 1 PublicationCurated
Sequence conflicti293 – 2931V → L in CAB55758. 1 PublicationCurated
Sequence conflicti365 – 3662VV → C in CAB55758. 1 PublicationCurated
Sequence conflicti372 – 3732LA → WP in CAB55758. 1 PublicationCurated
Sequence conflicti379 – 3813FGP → SA in CAB55758. 1 PublicationCurated
Sequence conflicti413 – 4164RRNA → AER in CAB55758. 1 PublicationCurated

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AJ249442 mRNA. Translation: CAB55758.1.
AL137189 Genomic DNA. Translation: CAB69852.1.
CP002688 Genomic DNA. Translation: AED90315.1.
PIRiT45964.
RefSeqiNP_195744.1. NM_120202.4. [Q9LFB2-1]
UniGeneiAt.67248.
At.9820.

Genome annotation databases

EnsemblPlantsiAT5G01240.1; AT5G01240.1; AT5G01240. [Q9LFB2-1]
GeneIDi831866.
KEGGiath:AT5G01240.

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AJ249442 mRNA. Translation: CAB55758.1 .
AL137189 Genomic DNA. Translation: CAB69852.1 .
CP002688 Genomic DNA. Translation: AED90315.1 .
PIRi T45964.
RefSeqi NP_195744.1. NM_120202.4. [Q9LFB2-1 ]
UniGenei At.67248.
At.9820.

3D structure databases

ProteinModelPortali Q9LFB2.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

MINTi MINT-8066356.
STRINGi 3702.AT5G01240.1-P.

Proteomic databases

PaxDbi Q9LFB2.
PRIDEi Q9LFB2.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblPlantsi AT5G01240.1 ; AT5G01240.1 ; AT5G01240 . [Q9LFB2-1 ]
GeneIDi 831866.
KEGGi ath:AT5G01240.

Organism-specific databases

GeneFarmi 5109.
TAIRi AT5G01240.

Phylogenomic databases

eggNOGi KOG1303.
HOGENOMi HOG000238482.
InParanoidi Q9LFB2.
KOi K13946.
OMAi YVINAFI.
PhylomeDBi Q9LFB2.

Gene expression databases

Genevestigatori Q9LFB2.

Family and domain databases

InterProi IPR013057. AA_transpt_TM.
[Graphical view ]
Pfami PF01490. Aa_trans. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [MRNA], GENE FAMILY, NOMENCLATURE.
  2. "Sequence and analysis of chromosome 5 of the plant Arabidopsis thaliana."
    Tabata S., Kaneko T., Nakamura Y., Kotani H., Kato T., Asamizu E., Miyajima N., Sasamoto S., Kimura T., Hosouchi T., Kawashima K., Kohara M., Matsumoto M., Matsuno A., Muraki A., Nakayama S., Nakazaki N., Naruo K.
    , Okumura S., Shinpo S., Takeuchi C., Wada T., Watanabe A., Yamada M., Yasuda M., Sato S., de la Bastide M., Huang E., Spiegel L., Gnoj L., O'Shaughnessy A., Preston R., Habermann K., Murray J., Johnson D., Rohlfing T., Nelson J., Stoneking T., Pepin K., Spieth J., Sekhon M., Armstrong J., Becker M., Belter E., Cordum H., Cordes M., Courtney L., Courtney W., Dante M., Du H., Edwards J., Fryman J., Haakensen B., Lamar E., Latreille P., Leonard S., Meyer R., Mulvaney E., Ozersky P., Riley A., Strowmatt C., Wagner-McPherson C., Wollam A., Yoakum M., Bell M., Dedhia N., Parnell L., Shah R., Rodriguez M., Hoon See L., Vil D., Baker J., Kirchoff K., Toth K., King L., Bahret A., Miller B., Marra M.A., Martienssen R., McCombie W.R., Wilson R.K., Murphy G., Bancroft I., Volckaert G., Wambutt R., Duesterhoeft A., Stiekema W., Pohl T., Entian K.-D., Terryn N., Hartley N., Bent E., Johnson S., Langham S.-A., McCullagh B., Robben J., Grymonprez B., Zimmermann W., Ramsperger U., Wedler H., Balke K., Wedler E., Peters S., van Staveren M., Dirkse W., Mooijman P., Klein Lankhorst R., Weitzenegger T., Bothe G., Rose M., Hauf J., Berneiser S., Hempel S., Feldpausch M., Lamberth S., Villarroel R., Gielen J., Ardiles W., Bents O., Lemcke K., Kolesov G., Mayer K.F.X., Rudd S., Schoof H., Schueller C., Zaccaria P., Mewes H.-W., Bevan M., Fransz P.F.
    Nature 408:823-826(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: cv. Columbia.
  3. The Arabidopsis Information Resource (TAIR)
    Submitted (APR-2011) to the EMBL/GenBank/DDBJ databases
    Cited for: GENOME REANNOTATION.
    Strain: cv. Columbia.

Entry informationi

Entry nameiLAX1_ARATH
AccessioniPrimary (citable) accession number: Q9LFB2
Secondary accession number(s): Q9SMW2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 22, 2005
Last sequence update: October 1, 2000
Last modified: October 29, 2014
This is version 85 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Arabidopsis thaliana
    Arabidopsis thaliana: entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3