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Q9LFB2

- LAX1_ARATH

UniProt

Q9LFB2 - LAX1_ARATH

Protein

Auxin transporter-like protein 1

Gene

LAX1

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 84 (01 Oct 2014)
      Sequence version 1 (01 Oct 2000)
      Previous versions | rss
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    Functioni

    Carrier protein involved in proton-driven auxin influx. Mediates the formation of auxin gradient from developing leaves (site of auxin biosynthesis) to tips by contributing to the loading of auxin in vascular tissues and facilitating acropetal (base to tip) auxin transport within inner tissues of the root apex, and basipetal (tip to base) auxin transport within outer tissues of the root apex By similarity.By similarity

    GO - Molecular functioni

    1. auxin influx transmembrane transporter activity Source: TAIR
    2. symporter activity Source: UniProtKB-KW

    GO - Biological processi

    1. amino acid transport Source: UniProtKB-KW
    2. auxin-activated signaling pathway Source: UniProtKB-KW
    3. auxin influx Source: GOC
    4. root cap development Source: TAIR

    Keywords - Biological processi

    Amino-acid transport, Auxin signaling pathway, Symport, Transport

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Auxin transporter-like protein 1
    Alternative name(s):
    AUX1-like protein 1
    Gene namesi
    Name:LAX1
    Ordered Locus Names:At5g01240
    ORF Names:F7J8_220
    OrganismiArabidopsis thaliana (Mouse-ear cress)
    Taxonomic identifieri3702 [NCBI]
    Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
    ProteomesiUP000006548: Chromosome 5

    Organism-specific databases

    TAIRiAT5G01240.

    Subcellular locationi

    Cell membrane By similarity; Multi-pass membrane protein By similarity

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW
    2. plasma membrane Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cell membrane, Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 488488Auxin transporter-like protein 1PRO_0000093842Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi303 – 3031N-linked (GlcNAc...)Sequence Analysis

    Keywords - PTMi

    Glycoprotein

    Proteomic databases

    PaxDbiQ9LFB2.
    PRIDEiQ9LFB2.

    Expressioni

    Gene expression databases

    GenevestigatoriQ9LFB2.

    Interactioni

    Protein-protein interaction databases

    MINTiMINT-8066356.
    STRINGi3702.AT5G01240.1-P.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9LFB2.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 6464CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini83 – 842ExtracellularSequence Analysis
    Topological domaini106 – 14136CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini163 – 17816ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini200 – 2023CytoplasmicSequence Analysis
    Topological domaini224 – 23815ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini260 – 27314CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini295 – 32026ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini342 – 36221CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini384 – 3841ExtracellularSequence Analysis
    Topological domaini406 – 42722CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini449 – 48840ExtracellularSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei65 – 8218HelicalSequence AnalysisAdd
    BLAST
    Transmembranei85 – 10521HelicalSequence AnalysisAdd
    BLAST
    Transmembranei142 – 16221HelicalSequence AnalysisAdd
    BLAST
    Transmembranei179 – 19921HelicalSequence AnalysisAdd
    BLAST
    Transmembranei203 – 22321HelicalSequence AnalysisAdd
    BLAST
    Transmembranei239 – 25921HelicalSequence AnalysisAdd
    BLAST
    Transmembranei274 – 29421HelicalSequence AnalysisAdd
    BLAST
    Transmembranei321 – 34121HelicalSequence AnalysisAdd
    BLAST
    Transmembranei363 – 38321HelicalSequence AnalysisAdd
    BLAST
    Transmembranei385 – 40521HelicalSequence AnalysisAdd
    BLAST
    Transmembranei428 – 44821HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiKOG1303.
    HOGENOMiHOG000238482.
    InParanoidiQ9LFB2.
    KOiK13946.
    OMAiYVINAFI.
    PhylomeDBiQ9LFB2.

    Family and domain databases

    InterProiIPR013057. AA_transpt_TM.
    [Graphical view]
    PfamiPF01490. Aa_trans. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    This entry describes 1 isoform i produced by alternative splicing. Align

    Note: A number of isoforms are produced. According to EST sequences.

    Isoform 1 (identifier: Q9LFB2-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MSGEKQAEES IVVSGEDEVA GRKVEDSAAE EDIDGNGGNG FSMKSFLWHG    50
    GSAWDAWFSC ASNQVAQVLL TLPYSFSQLG MLSGILLQIF YGLMGSWTAY 100
    LISVLYVEYR ARMEKQEAKS FKNHVIQWFE VLDGLLGPYW KAAGLAFNCT 150
    FLLFGSVIQL IACASNIYYI NDRLDKRTWT YIFGACCATT VFIPSFHNYR 200
    IWSFLGLGMT TYTAWYLTIA SFLHGQAEGV THSGPTKLVL YFTGATNILY 250
    TFGGHAVTVE IMHAMWKPRK FKSIYLMATL YVFTLTLPSA SAVYWAFGDQ 300
    LLNHSNAFSL LPKTRFRDTA VILMLIHQFI TFGFACTPLY FVWEKAIGMH 350
    HTKSLCLRAL VRLPVVVPIW FLAIIFPFFG PINSAVGALL VTFTVYIIPA 400
    LAHMLTYRTA SARRNAAEKP PFFIPSWAGV YVINAFIVVW VLVLGFGFGG 450
    WASMTNFIRQ IDTFGLFAKC YQCKPPPAPI AAGAHHRR 488
    Length:488
    Mass (Da):54,601
    Last modified:October 1, 2000 - v1
    Checksum:i06B0BF524EDE2BD8
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti16 – 172ED → DE in CAB55758. 1 PublicationCurated
    Sequence conflicti293 – 2931V → L in CAB55758. 1 PublicationCurated
    Sequence conflicti365 – 3662VV → C in CAB55758. 1 PublicationCurated
    Sequence conflicti372 – 3732LA → WP in CAB55758. 1 PublicationCurated
    Sequence conflicti379 – 3813FGP → SA in CAB55758. 1 PublicationCurated
    Sequence conflicti413 – 4164RRNA → AER in CAB55758. 1 PublicationCurated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AJ249442 mRNA. Translation: CAB55758.1.
    AL137189 Genomic DNA. Translation: CAB69852.1.
    CP002688 Genomic DNA. Translation: AED90315.1.
    PIRiT45964.
    RefSeqiNP_195744.1. NM_120202.4. [Q9LFB2-1]
    UniGeneiAt.67248.
    At.9820.

    Genome annotation databases

    EnsemblPlantsiAT5G01240.1; AT5G01240.1; AT5G01240. [Q9LFB2-1]
    GeneIDi831866.
    KEGGiath:AT5G01240.

    Keywords - Coding sequence diversityi

    Alternative splicing

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AJ249442 mRNA. Translation: CAB55758.1 .
    AL137189 Genomic DNA. Translation: CAB69852.1 .
    CP002688 Genomic DNA. Translation: AED90315.1 .
    PIRi T45964.
    RefSeqi NP_195744.1. NM_120202.4. [Q9LFB2-1 ]
    UniGenei At.67248.
    At.9820.

    3D structure databases

    ProteinModelPortali Q9LFB2.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    MINTi MINT-8066356.
    STRINGi 3702.AT5G01240.1-P.

    Proteomic databases

    PaxDbi Q9LFB2.
    PRIDEi Q9LFB2.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblPlantsi AT5G01240.1 ; AT5G01240.1 ; AT5G01240 . [Q9LFB2-1 ]
    GeneIDi 831866.
    KEGGi ath:AT5G01240.

    Organism-specific databases

    GeneFarmi 5109.
    TAIRi AT5G01240.

    Phylogenomic databases

    eggNOGi KOG1303.
    HOGENOMi HOG000238482.
    InParanoidi Q9LFB2.
    KOi K13946.
    OMAi YVINAFI.
    PhylomeDBi Q9LFB2.

    Gene expression databases

    Genevestigatori Q9LFB2.

    Family and domain databases

    InterProi IPR013057. AA_transpt_TM.
    [Graphical view ]
    Pfami PF01490. Aa_trans. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [MRNA], GENE FAMILY, NOMENCLATURE.
    2. "Sequence and analysis of chromosome 5 of the plant Arabidopsis thaliana."
      Tabata S., Kaneko T., Nakamura Y., Kotani H., Kato T., Asamizu E., Miyajima N., Sasamoto S., Kimura T., Hosouchi T., Kawashima K., Kohara M., Matsumoto M., Matsuno A., Muraki A., Nakayama S., Nakazaki N., Naruo K.
      , Okumura S., Shinpo S., Takeuchi C., Wada T., Watanabe A., Yamada M., Yasuda M., Sato S., de la Bastide M., Huang E., Spiegel L., Gnoj L., O'Shaughnessy A., Preston R., Habermann K., Murray J., Johnson D., Rohlfing T., Nelson J., Stoneking T., Pepin K., Spieth J., Sekhon M., Armstrong J., Becker M., Belter E., Cordum H., Cordes M., Courtney L., Courtney W., Dante M., Du H., Edwards J., Fryman J., Haakensen B., Lamar E., Latreille P., Leonard S., Meyer R., Mulvaney E., Ozersky P., Riley A., Strowmatt C., Wagner-McPherson C., Wollam A., Yoakum M., Bell M., Dedhia N., Parnell L., Shah R., Rodriguez M., Hoon See L., Vil D., Baker J., Kirchoff K., Toth K., King L., Bahret A., Miller B., Marra M.A., Martienssen R., McCombie W.R., Wilson R.K., Murphy G., Bancroft I., Volckaert G., Wambutt R., Duesterhoeft A., Stiekema W., Pohl T., Entian K.-D., Terryn N., Hartley N., Bent E., Johnson S., Langham S.-A., McCullagh B., Robben J., Grymonprez B., Zimmermann W., Ramsperger U., Wedler H., Balke K., Wedler E., Peters S., van Staveren M., Dirkse W., Mooijman P., Klein Lankhorst R., Weitzenegger T., Bothe G., Rose M., Hauf J., Berneiser S., Hempel S., Feldpausch M., Lamberth S., Villarroel R., Gielen J., Ardiles W., Bents O., Lemcke K., Kolesov G., Mayer K.F.X., Rudd S., Schoof H., Schueller C., Zaccaria P., Mewes H.-W., Bevan M., Fransz P.F.
      Nature 408:823-826(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: cv. Columbia.
    3. The Arabidopsis Information Resource (TAIR)
      Submitted (APR-2011) to the EMBL/GenBank/DDBJ databases
      Cited for: GENOME REANNOTATION.
      Strain: cv. Columbia.

    Entry informationi

    Entry nameiLAX1_ARATH
    AccessioniPrimary (citable) accession number: Q9LFB2
    Secondary accession number(s): Q9SMW2
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 22, 2005
    Last sequence update: October 1, 2000
    Last modified: October 1, 2014
    This is version 84 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programPlant Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Arabidopsis thaliana
      Arabidopsis thaliana: entries and gene names
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3