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Protein

Auxin transporter-like protein 1

Gene

LAX1

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Carrier protein involved in proton-driven auxin influx. Mediates the formation of auxin gradient from developing leaves (site of auxin biosynthesis) to tips by contributing to the loading of auxin in vascular tissues and facilitating acropetal (base to tip) auxin transport within inner tissues of the root apex, and basipetal (tip to base) auxin transport within outer tissues of the root apex (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

  • amino acid transmembrane transport Source: GO_Central
  • auxin-activated signaling pathway Source: UniProtKB-KW
  • root cap development Source: TAIR
Complete GO annotation...

Keywords - Biological processi

Amino-acid transport, Auxin signaling pathway, Symport, Transport

Names & Taxonomyi

Protein namesi
Recommended name:
Auxin transporter-like protein 1
Alternative name(s):
AUX1-like protein 1
Gene namesi
Name:LAX1
Ordered Locus Names:At5g01240
ORF Names:F7J8_220
OrganismiArabidopsis thaliana (Mouse-ear cress)
Taxonomic identifieri3702 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
Proteomesi
  • UP000006548 Componenti: Chromosome 5

Organism-specific databases

TAIRiAT5G01240.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 64CytoplasmicSequence analysisAdd BLAST64
Transmembranei65 – 82HelicalSequence analysisAdd BLAST18
Topological domaini83 – 84ExtracellularSequence analysis2
Transmembranei85 – 105HelicalSequence analysisAdd BLAST21
Topological domaini106 – 141CytoplasmicSequence analysisAdd BLAST36
Transmembranei142 – 162HelicalSequence analysisAdd BLAST21
Topological domaini163 – 178ExtracellularSequence analysisAdd BLAST16
Transmembranei179 – 199HelicalSequence analysisAdd BLAST21
Topological domaini200 – 202CytoplasmicSequence analysis3
Transmembranei203 – 223HelicalSequence analysisAdd BLAST21
Topological domaini224 – 238ExtracellularSequence analysisAdd BLAST15
Transmembranei239 – 259HelicalSequence analysisAdd BLAST21
Topological domaini260 – 273CytoplasmicSequence analysisAdd BLAST14
Transmembranei274 – 294HelicalSequence analysisAdd BLAST21
Topological domaini295 – 320ExtracellularSequence analysisAdd BLAST26
Transmembranei321 – 341HelicalSequence analysisAdd BLAST21
Topological domaini342 – 362CytoplasmicSequence analysisAdd BLAST21
Transmembranei363 – 383HelicalSequence analysisAdd BLAST21
Topological domaini384ExtracellularSequence analysis1
Transmembranei385 – 405HelicalSequence analysisAdd BLAST21
Topological domaini406 – 427CytoplasmicSequence analysisAdd BLAST22
Transmembranei428 – 448HelicalSequence analysisAdd BLAST21
Topological domaini449 – 488ExtracellularSequence analysisAdd BLAST40

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000938421 – 488Auxin transporter-like protein 1Add BLAST488

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi303N-linked (GlcNAc...)Sequence analysis1

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiQ9LFB2.
PRIDEiQ9LFB2.

PTM databases

iPTMnetiQ9LFB2.

Expressioni

Gene expression databases

ExpressionAtlasiQ9LFB2. baseline and differential.
GenevisibleiQ9LFB2. AT.

Interactioni

Protein-protein interaction databases

BioGridi17142. 1 interactor.
MINTiMINT-8066356.
STRINGi3702.AT5G01240.1.

Structurei

3D structure databases

ProteinModelPortaliQ9LFB2.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG1303. Eukaryota.
COG0814. LUCA.
HOGENOMiHOG000238482.
InParanoidiQ9LFB2.
KOiK13946.
OMAiWAGVYVI.
OrthoDBiEOG0936078P.
PhylomeDBiQ9LFB2.

Family and domain databases

InterProiIPR013057. AA_transpt_TM.
[Graphical view]
PfamiPF01490. Aa_trans. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

This entry describes 1 isoform i produced by alternative splicing. AlignAdd to basket

Note: A number of isoforms are produced. According to EST sequences.
Isoform 1 (identifier: Q9LFB2-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MSGEKQAEES IVVSGEDEVA GRKVEDSAAE EDIDGNGGNG FSMKSFLWHG
60 70 80 90 100
GSAWDAWFSC ASNQVAQVLL TLPYSFSQLG MLSGILLQIF YGLMGSWTAY
110 120 130 140 150
LISVLYVEYR ARMEKQEAKS FKNHVIQWFE VLDGLLGPYW KAAGLAFNCT
160 170 180 190 200
FLLFGSVIQL IACASNIYYI NDRLDKRTWT YIFGACCATT VFIPSFHNYR
210 220 230 240 250
IWSFLGLGMT TYTAWYLTIA SFLHGQAEGV THSGPTKLVL YFTGATNILY
260 270 280 290 300
TFGGHAVTVE IMHAMWKPRK FKSIYLMATL YVFTLTLPSA SAVYWAFGDQ
310 320 330 340 350
LLNHSNAFSL LPKTRFRDTA VILMLIHQFI TFGFACTPLY FVWEKAIGMH
360 370 380 390 400
HTKSLCLRAL VRLPVVVPIW FLAIIFPFFG PINSAVGALL VTFTVYIIPA
410 420 430 440 450
LAHMLTYRTA SARRNAAEKP PFFIPSWAGV YVINAFIVVW VLVLGFGFGG
460 470 480
WASMTNFIRQ IDTFGLFAKC YQCKPPPAPI AAGAHHRR
Length:488
Mass (Da):54,601
Last modified:October 1, 2000 - v1
Checksum:i06B0BF524EDE2BD8
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti16 – 17ED → DE in CAB55758 (Ref. 1) Curated2
Sequence conflicti293V → L in CAB55758 (Ref. 1) Curated1
Sequence conflicti365 – 366VV → C in CAB55758 (Ref. 1) Curated2
Sequence conflicti372 – 373LA → WP in CAB55758 (Ref. 1) Curated2
Sequence conflicti379 – 381FGP → SA in CAB55758 (Ref. 1) Curated3
Sequence conflicti413 – 416RRNA → AER in CAB55758 (Ref. 1) Curated4

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ249442 mRNA. Translation: CAB55758.1.
AL137189 Genomic DNA. Translation: CAB69852.1.
CP002688 Genomic DNA. Translation: AED90315.1.
PIRiT45964.
RefSeqiNP_195744.1. NM_120202.5. [Q9LFB2-1]
UniGeneiAt.67248.
At.9820.

Genome annotation databases

EnsemblPlantsiAT5G01240.1; AT5G01240.1; AT5G01240. [Q9LFB2-1]
GeneIDi831866.
GrameneiAT5G01240.1; AT5G01240.1; AT5G01240.
KEGGiath:AT5G01240.

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ249442 mRNA. Translation: CAB55758.1.
AL137189 Genomic DNA. Translation: CAB69852.1.
CP002688 Genomic DNA. Translation: AED90315.1.
PIRiT45964.
RefSeqiNP_195744.1. NM_120202.5. [Q9LFB2-1]
UniGeneiAt.67248.
At.9820.

3D structure databases

ProteinModelPortaliQ9LFB2.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi17142. 1 interactor.
MINTiMINT-8066356.
STRINGi3702.AT5G01240.1.

PTM databases

iPTMnetiQ9LFB2.

Proteomic databases

PaxDbiQ9LFB2.
PRIDEiQ9LFB2.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblPlantsiAT5G01240.1; AT5G01240.1; AT5G01240. [Q9LFB2-1]
GeneIDi831866.
GrameneiAT5G01240.1; AT5G01240.1; AT5G01240.
KEGGiath:AT5G01240.

Organism-specific databases

TAIRiAT5G01240.

Phylogenomic databases

eggNOGiKOG1303. Eukaryota.
COG0814. LUCA.
HOGENOMiHOG000238482.
InParanoidiQ9LFB2.
KOiK13946.
OMAiWAGVYVI.
OrthoDBiEOG0936078P.
PhylomeDBiQ9LFB2.

Miscellaneous databases

PROiQ9LFB2.

Gene expression databases

ExpressionAtlasiQ9LFB2. baseline and differential.
GenevisibleiQ9LFB2. AT.

Family and domain databases

InterProiIPR013057. AA_transpt_TM.
[Graphical view]
PfamiPF01490. Aa_trans. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiLAX1_ARATH
AccessioniPrimary (citable) accession number: Q9LFB2
Secondary accession number(s): Q9SMW2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 22, 2005
Last sequence update: October 1, 2000
Last modified: November 30, 2016
This is version 101 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Arabidopsis thaliana
    Arabidopsis thaliana: entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.