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Q9LFB2

- LAX1_ARATH

UniProt

Q9LFB2 - LAX1_ARATH

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Protein
Auxin transporter-like protein 1
Gene
LAX1, At5g01240, F7J8_220
Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at transcript leveli

Functioni

Carrier protein involved in proton-driven auxin influx. Mediates the formation of auxin gradient from developing leaves (site of auxin biosynthesis) to tips by contributing to the loading of auxin in vascular tissues and facilitating acropetal (base to tip) auxin transport within inner tissues of the root apex, and basipetal (tip to base) auxin transport within outer tissues of the root apex By similarity.

GO - Molecular functioni

  1. auxin influx transmembrane transporter activity Source: TAIR
  2. symporter activity Source: UniProtKB-KW

GO - Biological processi

  1. amino acid transport Source: UniProtKB-KW
  2. auxin influx Source: GOC
  3. auxin-activated signaling pathway Source: UniProtKB-KW
  4. root cap development Source: TAIR
Complete GO annotation...

Keywords - Biological processi

Amino-acid transport, Auxin signaling pathway, Symport, Transport

Names & Taxonomyi

Protein namesi
Recommended name:
Auxin transporter-like protein 1
Alternative name(s):
AUX1-like protein 1
Gene namesi
Name:LAX1
Ordered Locus Names:At5g01240
ORF Names:F7J8_220
OrganismiArabidopsis thaliana (Mouse-ear cress)
Taxonomic identifieri3702 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
ProteomesiUP000006548: Chromosome 5

Organism-specific databases

TAIRiAT5G01240.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 6464Cytoplasmic Reviewed prediction
Add
BLAST
Transmembranei65 – 8218Helical; Reviewed prediction
Add
BLAST
Topological domaini83 – 842Extracellular Reviewed prediction
Transmembranei85 – 10521Helical; Reviewed prediction
Add
BLAST
Topological domaini106 – 14136Cytoplasmic Reviewed prediction
Add
BLAST
Transmembranei142 – 16221Helical; Reviewed prediction
Add
BLAST
Topological domaini163 – 17816Extracellular Reviewed prediction
Add
BLAST
Transmembranei179 – 19921Helical; Reviewed prediction
Add
BLAST
Topological domaini200 – 2023Cytoplasmic Reviewed prediction
Transmembranei203 – 22321Helical; Reviewed prediction
Add
BLAST
Topological domaini224 – 23815Extracellular Reviewed prediction
Add
BLAST
Transmembranei239 – 25921Helical; Reviewed prediction
Add
BLAST
Topological domaini260 – 27314Cytoplasmic Reviewed prediction
Add
BLAST
Transmembranei274 – 29421Helical; Reviewed prediction
Add
BLAST
Topological domaini295 – 32026Extracellular Reviewed prediction
Add
BLAST
Transmembranei321 – 34121Helical; Reviewed prediction
Add
BLAST
Topological domaini342 – 36221Cytoplasmic Reviewed prediction
Add
BLAST
Transmembranei363 – 38321Helical; Reviewed prediction
Add
BLAST
Topological domaini384 – 3841Extracellular Reviewed prediction
Transmembranei385 – 40521Helical; Reviewed prediction
Add
BLAST
Topological domaini406 – 42722Cytoplasmic Reviewed prediction
Add
BLAST
Transmembranei428 – 44821Helical; Reviewed prediction
Add
BLAST
Topological domaini449 – 48840Extracellular Reviewed prediction
Add
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. plasma membrane Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 488488Auxin transporter-like protein 1
PRO_0000093842Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi303 – 3031N-linked (GlcNAc...) Reviewed prediction

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiQ9LFB2.
PRIDEiQ9LFB2.

Expressioni

Gene expression databases

GenevestigatoriQ9LFB2.

Interactioni

Protein-protein interaction databases

MINTiMINT-8066356.
STRINGi3702.AT5G01240.1-P.

Structurei

3D structure databases

ProteinModelPortaliQ9LFB2.

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG1303.
HOGENOMiHOG000238482.
InParanoidiQ9LFB2.
KOiK13946.
OMAiYVINAFI.
PhylomeDBiQ9LFB2.

Family and domain databases

InterProiIPR013057. AA_transpt_TM.
[Graphical view]
PfamiPF01490. Aa_trans. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

This entry describes 1 isoform i produced by alternative splicing. Align

Note: A number of isoforms are produced. According to EST sequences.

Isoform 1 (identifier: Q9LFB2-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

MSGEKQAEES IVVSGEDEVA GRKVEDSAAE EDIDGNGGNG FSMKSFLWHG    50
GSAWDAWFSC ASNQVAQVLL TLPYSFSQLG MLSGILLQIF YGLMGSWTAY 100
LISVLYVEYR ARMEKQEAKS FKNHVIQWFE VLDGLLGPYW KAAGLAFNCT 150
FLLFGSVIQL IACASNIYYI NDRLDKRTWT YIFGACCATT VFIPSFHNYR 200
IWSFLGLGMT TYTAWYLTIA SFLHGQAEGV THSGPTKLVL YFTGATNILY 250
TFGGHAVTVE IMHAMWKPRK FKSIYLMATL YVFTLTLPSA SAVYWAFGDQ 300
LLNHSNAFSL LPKTRFRDTA VILMLIHQFI TFGFACTPLY FVWEKAIGMH 350
HTKSLCLRAL VRLPVVVPIW FLAIIFPFFG PINSAVGALL VTFTVYIIPA 400
LAHMLTYRTA SARRNAAEKP PFFIPSWAGV YVINAFIVVW VLVLGFGFGG 450
WASMTNFIRQ IDTFGLFAKC YQCKPPPAPI AAGAHHRR 488
Length:488
Mass (Da):54,601
Last modified:October 1, 2000 - v1
Checksum:i06B0BF524EDE2BD8
GO

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti16 – 172ED → DE in CAB55758. 1 Publication
Sequence conflicti293 – 2931V → L in CAB55758. 1 Publication
Sequence conflicti365 – 3662VV → C in CAB55758. 1 Publication
Sequence conflicti372 – 3732LA → WP in CAB55758. 1 Publication
Sequence conflicti379 – 3813FGP → SA in CAB55758. 1 Publication
Sequence conflicti413 – 4164RRNA → AER in CAB55758. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AJ249442 mRNA. Translation: CAB55758.1.
AL137189 Genomic DNA. Translation: CAB69852.1.
CP002688 Genomic DNA. Translation: AED90315.1.
PIRiT45964.
RefSeqiNP_195744.1. NM_120202.4. [Q9LFB2-1]
UniGeneiAt.67248.
At.9820.

Genome annotation databases

EnsemblPlantsiAT5G01240.1; AT5G01240.1; AT5G01240. [Q9LFB2-1]
GeneIDi831866.
KEGGiath:AT5G01240.

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AJ249442 mRNA. Translation: CAB55758.1 .
AL137189 Genomic DNA. Translation: CAB69852.1 .
CP002688 Genomic DNA. Translation: AED90315.1 .
PIRi T45964.
RefSeqi NP_195744.1. NM_120202.4. [Q9LFB2-1 ]
UniGenei At.67248.
At.9820.

3D structure databases

ProteinModelPortali Q9LFB2.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

MINTi MINT-8066356.
STRINGi 3702.AT5G01240.1-P.

Proteomic databases

PaxDbi Q9LFB2.
PRIDEi Q9LFB2.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblPlantsi AT5G01240.1 ; AT5G01240.1 ; AT5G01240 . [Q9LFB2-1 ]
GeneIDi 831866.
KEGGi ath:AT5G01240.

Organism-specific databases

GeneFarmi 5109.
TAIRi AT5G01240.

Phylogenomic databases

eggNOGi KOG1303.
HOGENOMi HOG000238482.
InParanoidi Q9LFB2.
KOi K13946.
OMAi YVINAFI.
PhylomeDBi Q9LFB2.

Gene expression databases

Genevestigatori Q9LFB2.

Family and domain databases

InterProi IPR013057. AA_transpt_TM.
[Graphical view ]
Pfami PF01490. Aa_trans. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [MRNA], GENE FAMILY, NOMENCLATURE.
  2. "Sequence and analysis of chromosome 5 of the plant Arabidopsis thaliana."
    Tabata S., Kaneko T., Nakamura Y., Kotani H., Kato T., Asamizu E., Miyajima N., Sasamoto S., Kimura T., Hosouchi T., Kawashima K., Kohara M., Matsumoto M., Matsuno A., Muraki A., Nakayama S., Nakazaki N., Naruo K.
    , Okumura S., Shinpo S., Takeuchi C., Wada T., Watanabe A., Yamada M., Yasuda M., Sato S., de la Bastide M., Huang E., Spiegel L., Gnoj L., O'Shaughnessy A., Preston R., Habermann K., Murray J., Johnson D., Rohlfing T., Nelson J., Stoneking T., Pepin K., Spieth J., Sekhon M., Armstrong J., Becker M., Belter E., Cordum H., Cordes M., Courtney L., Courtney W., Dante M., Du H., Edwards J., Fryman J., Haakensen B., Lamar E., Latreille P., Leonard S., Meyer R., Mulvaney E., Ozersky P., Riley A., Strowmatt C., Wagner-McPherson C., Wollam A., Yoakum M., Bell M., Dedhia N., Parnell L., Shah R., Rodriguez M., Hoon See L., Vil D., Baker J., Kirchoff K., Toth K., King L., Bahret A., Miller B., Marra M.A., Martienssen R., McCombie W.R., Wilson R.K., Murphy G., Bancroft I., Volckaert G., Wambutt R., Duesterhoeft A., Stiekema W., Pohl T., Entian K.-D., Terryn N., Hartley N., Bent E., Johnson S., Langham S.-A., McCullagh B., Robben J., Grymonprez B., Zimmermann W., Ramsperger U., Wedler H., Balke K., Wedler E., Peters S., van Staveren M., Dirkse W., Mooijman P., Klein Lankhorst R., Weitzenegger T., Bothe G., Rose M., Hauf J., Berneiser S., Hempel S., Feldpausch M., Lamberth S., Villarroel R., Gielen J., Ardiles W., Bents O., Lemcke K., Kolesov G., Mayer K.F.X., Rudd S., Schoof H., Schueller C., Zaccaria P., Mewes H.-W., Bevan M., Fransz P.F.
    Nature 408:823-826(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: cv. Columbia.
  3. The Arabidopsis Information Resource (TAIR)
    Submitted (APR-2011) to the EMBL/GenBank/DDBJ databases
    Cited for: GENOME REANNOTATION.
    Strain: cv. Columbia.

Entry informationi

Entry nameiLAX1_ARATH
AccessioniPrimary (citable) accession number: Q9LFB2
Secondary accession number(s): Q9SMW2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 22, 2005
Last sequence update: October 1, 2000
Last modified: May 14, 2014
This is version 83 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Arabidopsis thaliana
    Arabidopsis thaliana: entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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