Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Argininosuccinate lyase, chloroplastic

Gene

At5g10920

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Catalytic activityi

2-(N(omega)-L-arginino)succinate = fumarate + L-arginine.

Pathwayi: L-arginine biosynthesis

This protein is involved in step 3 of the subpathway that synthesizes L-arginine from L-ornithine and carbamoyl phosphate.
Proteins known to be involved in the 3 steps of the subpathway in this organism are:
  1. no protein annotated in this organism
  2. Argininosuccinate synthase, chloroplastic (At4g24830)
  3. Argininosuccinate lyase, chloroplastic (At5g10920)
This subpathway is part of the pathway L-arginine biosynthesis, which is itself part of Amino-acid biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes L-arginine from L-ornithine and carbamoyl phosphate, the pathway L-arginine biosynthesis and in Amino-acid biosynthesis.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionLyase
Biological processAmino-acid biosynthesis, Arginine biosynthesis

Enzyme and pathway databases

BioCyciARA:AT5G10920-MONOMER
ReactomeiR-ATH-70635 Urea cycle
UniPathwayiUPA00068; UER00114

Names & Taxonomyi

Protein namesi
Recommended name:
Argininosuccinate lyase, chloroplastic (EC:4.3.2.1)
Alternative name(s):
Arginosuccinase
Gene namesi
Ordered Locus Names:At5g10920
ORF Names:T30N20.190
OrganismiArabidopsis thaliana (Mouse-ear cress)
Taxonomic identifieri3702 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
Proteomesi
  • UP000006548 Componenti: Chromosome 5

Organism-specific databases

AraportiAT5G10920
TAIRilocus:2183825 AT5G10920

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Chloroplast Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertion Graphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Chloroplast, Plastid

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transit peptidei1 – 45ChloroplastSequence analysisAdd BLAST45
ChainiPRO_000042342146 – 517Argininosuccinate lyase, chloroplasticAdd BLAST472

Proteomic databases

PaxDbiQ9LEU8
PRIDEiQ9LEU8
ProMEXiQ9LEU8

Expressioni

Gene expression databases

ExpressionAtlasiQ9LEU8 baseline and differential
GenevisibleiQ9LEU8 AT

Interactioni

Protein-protein interaction databases

BioGridi16237, 2 interactors
IntActiQ9LEU8, 1 interactor
STRINGi3702.AT5G10920.1

Structurei

3D structure databases

ProteinModelPortaliQ9LEU8
SMRiQ9LEU8
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transit peptide

Phylogenomic databases

eggNOGiKOG1316 Eukaryota
COG0165 LUCA
HOGENOMiHOG000242744
InParanoidiQ9LEU8
KOiK01755
OMAiSIMPHKK
OrthoDBiEOG093607FL
PhylomeDBiQ9LEU8

Family and domain databases

CDDicd01359 Argininosuccinate_lyase, 1 hit
Gene3Di1.10.275.10, 2 hits
HAMAPiMF_00006 Arg_succ_lyase, 1 hit
InterProiView protein in InterPro
IPR029419 Arg_succ_lyase_C
IPR009049 Argininosuccinate_lyase
IPR024083 Fumarase/histidase_N
IPR020557 Fumarate_lyase_CS
IPR000362 Fumarate_lyase_fam
IPR022761 Fumarate_lyase_N
IPR008948 L-Aspartase-like
PANTHERiPTHR43814 PTHR43814, 1 hit
PfamiView protein in Pfam
PF14698 ASL_C2, 1 hit
PF00206 Lyase_1, 1 hit
PRINTSiPR00149 FUMRATELYASE
SUPFAMiSSF48557 SSF48557, 1 hit
TIGRFAMsiTIGR00838 argH, 1 hit
PROSITEiView protein in PROSITE
PS00163 FUMARATE_LYASES, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9LEU8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGAIDLSFSQ SLLFSSSRSN LSSSTHRSVS FLPPGSKSRC LPPLRSMSHD
60 70 80 90 100
DDTASKEVKL WGGRFEESVT EKVEKFTESI SFDKVLYKQD IMGSKAHASM
110 120 130 140 150
LAHQGLITDS DKDSILRGLD DIERQIEANK FEWRTDREDV HMNIEAALTD
160 170 180 190 200
LIGEPAKKLH TARSRNDQVA TDFRLWCRDA IDTIIVKIRN LQRALVELAL
210 220 230 240 250
KNEALIVPGY THLQRAQPVL LPHVLLTFVE QLERDAGRYV DCRARLNFSP
260 270 280 290 300
LGACALAGTG LPIDRFMTAN ALGFTEPMRN SIDAVSDRDF VLEFLYTNAN
310 320 330 340 350
TGIHLSRLGE EWVLWASEEF GFMTPSDSVS TGSSIMPQKK NPDPMELVRG
360 370 380 390 400
KSARVIGDLV TVLTLCKGLP LAYNRDFQED KEPMFDSTKT IMGMIDVSAE
410 420 430 440 450
FAQNVTFNED RIKKSLPAGH LDATTLADYL VKKGMPFRSS HDIVGKLVGV
460 470 480 490 500
CVSKGCELQN LSLEEMKKLS PVFEEDVFGF LGVENSVNKF SSYGSTGSNC
510
VAEQLGYWVN KLNITST
Length:517
Mass (Da):57,512
Last modified:October 1, 2000 - v1
Checksum:iBA40F4E8109984C7
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti141H → L in AAK76572 (PubMed:14593172).Curated1
Sequence conflicti516S → T in CAB10698 (Ref. 1) Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z97558 mRNA Translation: CAB10698.1
AL365234 Genomic DNA Translation: CAB96847.1
CP002688 Genomic DNA Translation: AED91609.1
AY045898 mRNA Translation: AAK76572.1
BT000891 mRNA Translation: AAN41291.1
PIRiT50801
RefSeqiNP_196653.1, NM_121130.3
UniGeneiAt.24301

Genome annotation databases

EnsemblPlantsiAT5G10920.1; AT5G10920.1; AT5G10920
GeneIDi830959
GrameneiAT5G10920.1; AT5G10920.1; AT5G10920
KEGGiath:AT5G10920

Similar proteinsi

Entry informationi

Entry nameiARLY_ARATH
AccessioniPrimary (citable) accession number: Q9LEU8
Secondary accession number(s): O23637, Q94AP1
Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 18, 2013
Last sequence update: October 1, 2000
Last modified: May 23, 2018
This is version 125 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Cookie policy

We would like to use anonymized google analytics cookies to gather statistics on how uniprot.org is used in aggregate. Learn more

UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health