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Q9LEC8

- DHEB_NICPL

UniProt

Q9LEC8 - DHEB_NICPL

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Protein
Glutamate dehydrogenase B
Gene
GDHB
Organism
Nicotiana plumbaginifolia (Leadwort-leaved tobacco) (Tex-Mex tobacco)
Status
Reviewed - Annotation score: 2 out of 5 - Experimental evidence at protein leveli

Functioni

Catalytic activityi

L-glutamate + H2O + NAD(P)+ = 2-oxoglutarate + NH3 + NAD(P)H.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei102 – 1021 By similarity

GO - Molecular functioni

  1. glutamate dehydrogenase [NAD(P)+] activity Source: UniProtKB-EC
Complete GO annotation...

GO - Biological processi

  1. cellular amino acid metabolic process Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Ligandi

NAD

Names & Taxonomyi

Protein namesi
Recommended name:
Glutamate dehydrogenase B (EC:1.4.1.3)
Short name:
GDH B
Gene namesi
Name:GDHB
OrganismiNicotiana plumbaginifolia (Leadwort-leaved tobacco) (Tex-Mex tobacco)
Taxonomic identifieri4092 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaeasteridslamiidsSolanalesSolanaceaeNicotianoideaeNicotianeaeNicotiana

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 411411Glutamate dehydrogenase B
PRO_0000182751Add
BLAST

Proteomic databases

ProMEXiQ9LEC8.

Structurei

3D structure databases

ProteinModelPortaliQ9LEC8.

Family & Domainsi

Sequence similaritiesi

Family and domain databases

Gene3Di3.40.50.720. 1 hit.
InterProiIPR006095. Glu/Leu/Phe/Val_DH.
IPR006096. Glu/Leu/Phe/Val_DH_C.
IPR006097. Glu/Leu/Phe/Val_DH_dimer_dom.
IPR014362. Glu_DH.
IPR016040. NAD(P)-bd_dom.
[Graphical view]
PfamiPF00208. ELFV_dehydrog. 1 hit.
PF02812. ELFV_dehydrog_N. 1 hit.
[Graphical view]
PIRSFiPIRSF000185. Glu_DH. 1 hit.
PRINTSiPR00082. GLFDHDRGNASE.
SMARTiSM00839. ELFV_dehydrog. 1 hit.
[Graphical view]
PROSITEiPS00074. GLFV_DEHYDROGENASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9LEC8-1 [UniParc]FASTAAdd to Basket

« Hide

MNALAATNRN FKLASRLLGL DSKLEQCLLI PFREIKVECT IPKDDGSLAT    50
FIGFRVQHDN ARGPMKGGIR YHPEVDPDEV NALAQLMTWK TAVANIPYGG 100
AKGGIGCSPS DLSISELERL TRVFTQKIHD LIGVHTDVPA PDMGTNPQTM 150
AWILDEYSKF HGYSPAVVTG KPIDLGGSLG RDAATGRGVL FAAEALLRDH 200
GKSIAGQRFV VQGFGNVGSW AAQLITEQGG KIVAVSDITG AIKNKNGIDI 250
ASLLKHVKEN RGVKGFHGAD SIDPNSILVE DCDVLIPAAL GGVINRDNAK 300
DIKAKFIVEA ANHPTDPEAD EILAKKGVVI LPDIYANSGG VTVSYFEWVQ 350
NIQGFMWDEE RVNTELKAYM NRGFKDVKDM CKTHNCDLRM GAFTLGVNRV 400
ARATTLRGWE A 411
Length:411
Mass (Da):44,508
Last modified:October 1, 2000 - v1
Checksum:i236D4915B8B670AE
GO

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti92 – 921A → R in CAA69601. 1 Publication
Sequence conflicti368 – 3681A → D in CAA69601. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
Y08293 Genomic DNA. Translation: CAA69601.2.
AJ277950 Genomic DNA. Translation: CAB94837.1.
PIRiT16982.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
Y08293 Genomic DNA. Translation: CAA69601.2 .
AJ277950 Genomic DNA. Translation: CAB94837.1 .
PIRi T16982.

3D structure databases

ProteinModelPortali Q9LEC8.
ModBasei Search...

Proteomic databases

ProMEXi Q9LEC8.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Family and domain databases

Gene3Di 3.40.50.720. 1 hit.
InterProi IPR006095. Glu/Leu/Phe/Val_DH.
IPR006096. Glu/Leu/Phe/Val_DH_C.
IPR006097. Glu/Leu/Phe/Val_DH_dimer_dom.
IPR014362. Glu_DH.
IPR016040. NAD(P)-bd_dom.
[Graphical view ]
Pfami PF00208. ELFV_dehydrog. 1 hit.
PF02812. ELFV_dehydrog_N. 1 hit.
[Graphical view ]
PIRSFi PIRSF000185. Glu_DH. 1 hit.
PRINTSi PR00082. GLFDHDRGNASE.
SMARTi SM00839. ELFV_dehydrog. 1 hit.
[Graphical view ]
PROSITEi PS00074. GLFV_DEHYDROGENASE. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Isolation and characterization of two cDNA clones encoding for glutamate dehydrogenase in Nicotiana plumbaginifolia."
    Ficarelli A., Tassi F., Restivo F.M.
    Plant Cell Physiol. 40:339-342(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Leaf.
  2. "Genomic organisation of GDH genes in Nicotiana plumbaginifolia."
    Restivo F.M., Panizzi N., De Monte G., Ficarelli A.
    Submitted (MAY-2000) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Tissue: Leaf.

Entry informationi

Entry nameiDHEB_NICPL
AccessioniPrimary (citable) accession number: Q9LEC8
Secondary accession number(s): O24119
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 1, 2000
Last sequence update: October 1, 2000
Last modified: July 9, 2014
This is version 68 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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