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Q9LEC8

- DHEB_NICPL

UniProt

Q9LEC8 - DHEB_NICPL

Protein

Glutamate dehydrogenase B

Gene

GDHB

Organism
Nicotiana plumbaginifolia (Leadwort-leaved tobacco) (Tex-Mex tobacco)
Status
Reviewed - Annotation score: 2 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 69 (01 Oct 2014)
      Sequence version 1 (01 Oct 2000)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    L-glutamate + H2O + NAD(P)+ = 2-oxoglutarate + NH3 + NAD(P)H.PROSITE-ProRule annotation

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei102 – 1021PROSITE-ProRule annotation

    GO - Molecular functioni

    1. glutamate dehydrogenase [NAD(P)+] activity Source: UniProtKB-EC

    GO - Biological processi

    1. cellular amino acid metabolic process Source: InterPro

    Keywords - Molecular functioni

    Oxidoreductase

    Keywords - Ligandi

    NAD

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Glutamate dehydrogenase B (EC:1.4.1.3)
    Short name:
    GDH B
    Gene namesi
    Name:GDHB
    OrganismiNicotiana plumbaginifolia (Leadwort-leaved tobacco) (Tex-Mex tobacco)
    Taxonomic identifieri4092 [NCBI]
    Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaeasteridslamiidsSolanalesSolanaceaeNicotianoideaeNicotianeaeNicotiana

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 411411Glutamate dehydrogenase BPRO_0000182751Add
    BLAST

    Proteomic databases

    ProMEXiQ9LEC8.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9LEC8.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Family and domain databases

    Gene3Di3.40.50.720. 1 hit.
    InterProiIPR006095. Glu/Leu/Phe/Val_DH.
    IPR006096. Glu/Leu/Phe/Val_DH_C.
    IPR006097. Glu/Leu/Phe/Val_DH_dimer_dom.
    IPR014362. Glu_DH.
    IPR016040. NAD(P)-bd_dom.
    [Graphical view]
    PfamiPF00208. ELFV_dehydrog. 1 hit.
    PF02812. ELFV_dehydrog_N. 1 hit.
    [Graphical view]
    PIRSFiPIRSF000185. Glu_DH. 1 hit.
    PRINTSiPR00082. GLFDHDRGNASE.
    SMARTiSM00839. ELFV_dehydrog. 1 hit.
    [Graphical view]
    PROSITEiPS00074. GLFV_DEHYDROGENASE. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q9LEC8-1 [UniParc]FASTAAdd to Basket

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    MNALAATNRN FKLASRLLGL DSKLEQCLLI PFREIKVECT IPKDDGSLAT    50
    FIGFRVQHDN ARGPMKGGIR YHPEVDPDEV NALAQLMTWK TAVANIPYGG 100
    AKGGIGCSPS DLSISELERL TRVFTQKIHD LIGVHTDVPA PDMGTNPQTM 150
    AWILDEYSKF HGYSPAVVTG KPIDLGGSLG RDAATGRGVL FAAEALLRDH 200
    GKSIAGQRFV VQGFGNVGSW AAQLITEQGG KIVAVSDITG AIKNKNGIDI 250
    ASLLKHVKEN RGVKGFHGAD SIDPNSILVE DCDVLIPAAL GGVINRDNAK 300
    DIKAKFIVEA ANHPTDPEAD EILAKKGVVI LPDIYANSGG VTVSYFEWVQ 350
    NIQGFMWDEE RVNTELKAYM NRGFKDVKDM CKTHNCDLRM GAFTLGVNRV 400
    ARATTLRGWE A 411
    Length:411
    Mass (Da):44,508
    Last modified:October 1, 2000 - v1
    Checksum:i236D4915B8B670AE
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti92 – 921A → R in CAA69601. (PubMed:10353219)Curated
    Sequence conflicti368 – 3681A → D in CAA69601. (PubMed:10353219)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    Y08293 Genomic DNA. Translation: CAA69601.2.
    AJ277950 Genomic DNA. Translation: CAB94837.1.
    PIRiT16982.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    Y08293 Genomic DNA. Translation: CAA69601.2 .
    AJ277950 Genomic DNA. Translation: CAB94837.1 .
    PIRi T16982.

    3D structure databases

    ProteinModelPortali Q9LEC8.
    ModBasei Search...
    MobiDBi Search...

    Proteomic databases

    ProMEXi Q9LEC8.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Family and domain databases

    Gene3Di 3.40.50.720. 1 hit.
    InterProi IPR006095. Glu/Leu/Phe/Val_DH.
    IPR006096. Glu/Leu/Phe/Val_DH_C.
    IPR006097. Glu/Leu/Phe/Val_DH_dimer_dom.
    IPR014362. Glu_DH.
    IPR016040. NAD(P)-bd_dom.
    [Graphical view ]
    Pfami PF00208. ELFV_dehydrog. 1 hit.
    PF02812. ELFV_dehydrog_N. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF000185. Glu_DH. 1 hit.
    PRINTSi PR00082. GLFDHDRGNASE.
    SMARTi SM00839. ELFV_dehydrog. 1 hit.
    [Graphical view ]
    PROSITEi PS00074. GLFV_DEHYDROGENASE. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Isolation and characterization of two cDNA clones encoding for glutamate dehydrogenase in Nicotiana plumbaginifolia."
      Ficarelli A., Tassi F., Restivo F.M.
      Plant Cell Physiol. 40:339-342(1999) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Tissue: Leaf.
    2. "Genomic organisation of GDH genes in Nicotiana plumbaginifolia."
      Restivo F.M., Panizzi N., De Monte G., Ficarelli A.
      Submitted (MAY-2000) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
      Tissue: Leaf.

    Entry informationi

    Entry nameiDHEB_NICPL
    AccessioniPrimary (citable) accession number: Q9LEC8
    Secondary accession number(s): O24119
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: December 1, 2000
    Last sequence update: October 1, 2000
    Last modified: October 1, 2014
    This is version 69 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programPlant Protein Annotation Program

    Miscellaneousi

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3