Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Histone acetyltransferase HAC5

Gene

HAC5

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Acetyltransferase enzyme. Acetylates histones, giving a specific tag for transcriptional activation.By similarity

Catalytic activityi

Acetyl-CoA + [histone] = CoA + acetyl-[histone].By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei1259Acetyl-CoABy similarity1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri611 – 690TAZ-type 1PROSITE-ProRule annotationAdd BLAST80
Zinc fingeri970 – 1046PHD-typeAdd BLAST77
Zinc fingeri1378 – 1425ZZ-type 1PROSITE-ProRule annotationAdd BLAST48
Zinc fingeri1498 – 1544ZZ-type 2PROSITE-ProRule annotationAdd BLAST47
Zinc fingeri1554 – 1634TAZ-type 2PROSITE-ProRule annotationAdd BLAST81

GO - Molecular functioni

GO - Biological processi

  • flower development Source: TAIR
  • protein acetylation Source: TAIR
  • regulation of transcription, DNA-templated Source: UniProtKB-KW
  • transcription, DNA-templated Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Activator, Acyltransferase, Chromatin regulator, Transferase

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

Metal-binding, Zinc

Enzyme and pathway databases

ReactomeiR-ATH-3371568. Attenuation phase.
R-ATH-6781823. Formation of TC-NER Pre-Incision Complex.
R-ATH-6782135. Dual incision in TC-NER.
R-ATH-6782210. Gap-filling DNA repair synthesis and ligation in TC-NER.

Names & Taxonomyi

Protein namesi
Recommended name:
Histone acetyltransferase HAC5 (EC:2.3.1.48By similarity)
Gene namesi
Name:HAC5
Synonyms:PCAT4
Ordered Locus Names:At3g12980
ORF Names:MGH6.20, MGH6_9
OrganismiArabidopsis thaliana (Mouse-ear cress)
Taxonomic identifieri3702 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
Proteomesi
  • UP000006548 Componenti: Chromosome 3

Organism-specific databases

TAIRiAT3G12980.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002697431 – 1670Histone acetyltransferase HAC5Add BLAST1670

Proteomic databases

PaxDbiQ9LE42.
PRIDEiQ9LE42.

PTM databases

iPTMnetiQ9LE42.

Expressioni

Tissue specificityi

Rosette leaves, stems and flowers.1 Publication

Developmental stagei

Expressed in young seedlings.1 Publication

Gene expression databases

GenevisibleiQ9LE42. AT.

Interactioni

Protein-protein interaction databases

BioGridi5818. 1 interactor.
MINTiMINT-8069366.
STRINGi3702.AT3G12980.1.

Structurei

3D structure databases

ProteinModelPortaliQ9LE42.
SMRiQ9LE42.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini1061 – 1497CBP/p300-type HATPROSITE-ProRule annotationAdd BLAST437

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni1184 – 1186Acetyl-CoA bindingBy similarity3
Regioni1203 – 1204Acetyl-CoA bindingBy similarity2

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi413 – 518Gln-richAdd BLAST106

Sequence similaritiesi

Contains 1 CBP/p300-type HAT (histone acetyltransferase) domain.PROSITE-ProRule annotation
Contains 1 PHD-type zinc finger.Curated
Contains 2 TAZ-type zinc fingers.PROSITE-ProRule annotation
Contains 2 ZZ-type zinc fingers.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri611 – 690TAZ-type 1PROSITE-ProRule annotationAdd BLAST80
Zinc fingeri970 – 1046PHD-typeAdd BLAST77
Zinc fingeri1378 – 1425ZZ-type 1PROSITE-ProRule annotationAdd BLAST48
Zinc fingeri1498 – 1544ZZ-type 2PROSITE-ProRule annotationAdd BLAST47
Zinc fingeri1554 – 1634TAZ-type 2PROSITE-ProRule annotationAdd BLAST81

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiENOG410IRV8. Eukaryota.
ENOG4111K0H. LUCA.
HOGENOMiHOG000242057.
InParanoidiQ9LE42.
KOiK04498.
OMAiEDNCESK.
OrthoDBiEOG093600A5.
PhylomeDBiQ9LE42.

Family and domain databases

Gene3Di1.20.1020.10. 2 hits.
3.30.40.10. 2 hits.
InterProiIPR031162. CBP_P300_HAT.
IPR013178. Histone_AcTrfase_Rtt109/CBP.
IPR019786. Zinc_finger_PHD-type_CS.
IPR011011. Znf_FYVE_PHD.
IPR013083. Znf_RING/FYVE/PHD.
IPR000197. Znf_TAZ.
IPR000433. Znf_ZZ.
[Graphical view]
PfamiPF08214. HAT_KAT11. 1 hit.
PF02135. zf-TAZ. 2 hits.
PF00569. ZZ. 1 hit.
[Graphical view]
SMARTiSM01250. KAT11. 1 hit.
SM00551. ZnF_TAZ. 2 hits.
SM00291. ZnF_ZZ. 2 hits.
[Graphical view]
SUPFAMiSSF57903. SSF57903. 1 hit.
SSF57933. SSF57933. 2 hits.
PROSITEiPS51727. CBP_P300_HAT. 1 hit.
PS01359. ZF_PHD_1. 1 hit.
PS50134. ZF_TAZ. 2 hits.
PS01357. ZF_ZZ_1. 2 hits.
PS50135. ZF_ZZ_2. 2 hits.
PS00028. ZINC_FINGER_C2H2_1. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9LE42-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAQGQNRTVL QSGQMHNSVV ASASSVSSQP NMVNGISQDT LLLRQEMLNR
60 70 80 90 100
TYAWLQQRQP SKTDDASKAK LSEVAKRLES AMWRTATSKE DYLDFRSFDV
110 120 130 140 150
RVESTLKQLL SQRRANPSSS VSTMVQTPGV SHGWGQSYTA TPMVDTSKFN
160 170 180 190 200
SSNNLSDATT ETGRLLPTNR MYRGTINNGR QELSAVGQMI PTPGFDNSAN
210 220 230 240 250
ADVYQSHRNE EYSGDGGKLL ATGSDFGNPS QLQKQRPTGS NDLMGYNLDH
260 270 280 290 300
QLGGGFRSNI HQNTSGMTSI PLNAGVGMSG NNVHLANVPR SSEGVLSSTH
310 320 330 340 350
FSTFSQPSQQ PVEQLQVSHV NRYSMSNSGT FVSGNLYGVQ TSSGSIETAV
360 370 380 390 400
DMNSMSLNSM RRVDTSFGSQ SGLQNNPLLK PHLRHQFENG NFQSSSNSKE
410 420 430 440 450
NLAQVSHRPL ERQFNQQAHY GQYHQQELLM NNDAYRQSQP ASNLVSQVKN
460 470 480 490 500
EPRVEYYNEA FQMQAINKVE PSKPQNQYKQ NTVKDEYVGA QSAPVSSSQL
510 520 530 540 550
KMSPSFPPQT HQTQQVSQWK DSSSLSAGVQ PVSGLGQWHS SSQNLTPISK
560 570 580 590 600
NSNEEREHFG VRFHKQHEGT NNSSSVREST NCLTVAPSGT LDVPHLPVGI
610 620 630 640 650
NVLSKQLNGD CGLSYKNQRR WLLFLLHVRK CNAAEDNCES KYCFTAKTLL
660 670 680 690 700
KHINCCKAPA CAYQYCHQTR QLIHHYKHCG DEACPVCVFV KNFKEKQKEK
710 720 730 740 750
FTFLQRAEPS SASLNHGPKE SFESMRTSSE RDSEAPFVVD DLQPSPKRQK
760 770 780 790 800
VEKPSQFAYP DTQGNPATIS AGVSQAHFSM GLQEKDRLPS DVCKPVRSNV
810 820 830 840 850
PMNADSSDSS RRLVPVSREL EKPVCKDTHM GRHGVKSALD GESLRLSKQE
860 870 880 890 900
KPKRMNEISA PKEENAEQSL GVVSASNCGK SKIKGVSLIE LFTPEQVEEH
910 920 930 940 950
IRGLRQWVGQ SKTKAEKNKA MGLSMSENSC QLCAVERLAF EPTPIYCTPC
960 970 980 990 1000
GARVKRNAMH YTVVAGESRH YVCIPCYNEA RANTVSVDGT PVPKSRFEKK
1010 1020 1030 1040 1050
KNDEEVEESW VQCDKCQAWQ HQICALFNGR RNHGQAEYTC PNCYIQEVEQ
1060 1070 1080 1090 1100
GERKPVSQNV ILGAKSLPAS TLSNHLEQRL FKKLKQERQE RARLQGKSYE
1110 1120 1130 1140 1150
EVPGADSLVI RVVASVDKIL EVKPRFLDIF REDNYSSEFP YKSKAILLFQ
1160 1170 1180 1190 1200
KIEGVEVCLF GMYVQEFGTD SASPNQRRVY LSYLDSVKYF RPDVRTVSGE
1210 1220 1230 1240 1250
ALRTFVYHEI LIGYLDYCKK RGFSSCYIWA CPPLKGEDYI LYCHPEIQKT
1260 1270 1280 1290 1300
PKTDKLREWY LAMLKKASKE KVVVECTNFY DHFFVQSGEC RAKVTAARLP
1310 1320 1330 1340 1350
YFDGDYWPGA AEDLIDQMSQ EEDGKKSNRK LMPKKVISKR ALKAVGQLDL
1360 1370 1380 1390 1400
SVNASKDLLL MHKLGEIILP MKEDFIMVHL QHCCKHCCTL MVSGNRWVCN
1410 1420 1430 1440 1450
QCKNFQICDK CHEVEENRVE KEKHPVNQKE KHVLYPVAID NIPTEIKDND
1460 1470 1480 1490 1500
DILESEFFDT RQAFLSLCQG NHYQYDTLRR AKHSSMMILY HLHNPTVPAF
1510 1520 1530 1540 1550
AMACAICQQE LETAQGWRCE VCPDYDVCNA CYSKGINHPH SIISRPSATD
1560 1570 1580 1590 1600
SVVQNTQTNQ IQNAQLREVL LHVMTCCTAQ CQYPRCRVIK GLIRHGLVCK
1610 1620 1630 1640 1650
TRGCIACKKM WSLFRLHSRN CRDPQCKVPK CRELRAHFSR KQQQADSRRR
1660 1670
AAVMEMVRQR AADTTASTPE
Length:1,670
Mass (Da):188,188
Last modified:October 1, 2000 - v1
Checksum:i2120E9184B4B98BD
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB026645 Genomic DNA. Translation: BAB02507.1.
CP002686 Genomic DNA. Translation: AEE75270.1.
AF512557 mRNA. Translation: AAM34787.1.
AF512558 mRNA. Translation: AAM34788.1.
RefSeqiNP_187904.1. NM_112135.4.
UniGeneiAt.39511.

Genome annotation databases

EnsemblPlantsiAT3G12980.1; AT3G12980.1; AT3G12980.
GeneIDi820484.
GrameneiAT3G12980.1; AT3G12980.1; AT3G12980.
KEGGiath:AT3G12980.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB026645 Genomic DNA. Translation: BAB02507.1.
CP002686 Genomic DNA. Translation: AEE75270.1.
AF512557 mRNA. Translation: AAM34787.1.
AF512558 mRNA. Translation: AAM34788.1.
RefSeqiNP_187904.1. NM_112135.4.
UniGeneiAt.39511.

3D structure databases

ProteinModelPortaliQ9LE42.
SMRiQ9LE42.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi5818. 1 interactor.
MINTiMINT-8069366.
STRINGi3702.AT3G12980.1.

PTM databases

iPTMnetiQ9LE42.

Proteomic databases

PaxDbiQ9LE42.
PRIDEiQ9LE42.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblPlantsiAT3G12980.1; AT3G12980.1; AT3G12980.
GeneIDi820484.
GrameneiAT3G12980.1; AT3G12980.1; AT3G12980.
KEGGiath:AT3G12980.

Organism-specific databases

TAIRiAT3G12980.

Phylogenomic databases

eggNOGiENOG410IRV8. Eukaryota.
ENOG4111K0H. LUCA.
HOGENOMiHOG000242057.
InParanoidiQ9LE42.
KOiK04498.
OMAiEDNCESK.
OrthoDBiEOG093600A5.
PhylomeDBiQ9LE42.

Enzyme and pathway databases

ReactomeiR-ATH-3371568. Attenuation phase.
R-ATH-6781823. Formation of TC-NER Pre-Incision Complex.
R-ATH-6782135. Dual incision in TC-NER.
R-ATH-6782210. Gap-filling DNA repair synthesis and ligation in TC-NER.

Miscellaneous databases

PROiQ9LE42.

Gene expression databases

GenevisibleiQ9LE42. AT.

Family and domain databases

Gene3Di1.20.1020.10. 2 hits.
3.30.40.10. 2 hits.
InterProiIPR031162. CBP_P300_HAT.
IPR013178. Histone_AcTrfase_Rtt109/CBP.
IPR019786. Zinc_finger_PHD-type_CS.
IPR011011. Znf_FYVE_PHD.
IPR013083. Znf_RING/FYVE/PHD.
IPR000197. Znf_TAZ.
IPR000433. Znf_ZZ.
[Graphical view]
PfamiPF08214. HAT_KAT11. 1 hit.
PF02135. zf-TAZ. 2 hits.
PF00569. ZZ. 1 hit.
[Graphical view]
SMARTiSM01250. KAT11. 1 hit.
SM00551. ZnF_TAZ. 2 hits.
SM00291. ZnF_ZZ. 2 hits.
[Graphical view]
SUPFAMiSSF57903. SSF57903. 1 hit.
SSF57933. SSF57933. 2 hits.
PROSITEiPS51727. CBP_P300_HAT. 1 hit.
PS01359. ZF_PHD_1. 1 hit.
PS50134. ZF_TAZ. 2 hits.
PS01357. ZF_ZZ_1. 2 hits.
PS50135. ZF_ZZ_2. 2 hits.
PS00028. ZINC_FINGER_C2H2_1. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiHAC5_ARATH
AccessioniPrimary (citable) accession number: Q9LE42
Secondary accession number(s): Q8LRK5, Q8LRK6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 9, 2007
Last sequence update: October 1, 2000
Last modified: November 30, 2016
This is version 117 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Arabidopsis thaliana
    Arabidopsis thaliana: entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.