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Q9LE42 (HAC5_ARATH) Reviewed, UniProtKB/Swiss-Prot

Last modified January 25, 2012. Version 76. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
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to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Histone acetyltransferase HAC5
EC=2.3.1.48
Gene names
Name:HAC5
Synonyms:PCAT4
Ordered Locus Names:At3g12980
ORF Names:MGH6_9, MGH6.20
OrganismArabidopsis thaliana (Mouse-ear cress)
Taxonomic identifier3702 [NCBI]
Taxonomic lineageEukaryota › Viridiplantae › Streptophyta › Embryophyta › Tracheophyta › Spermatophyta › Magnoliophyta › eudicotyledons › core eudicotyledons › rosids › malvids › Brassicales › Brassicaceae › Camelineae › Arabidopsis

Protein attributes

Sequence length1670 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Acetyltransferase enzyme. Acetylates histones, giving a specific tag for transcriptional activation By similarity.

Catalytic activity

Acetyl-CoA + [histone] = CoA + acetyl-[histone].

Subcellular location

Nucleus Probable.

Tissue specificity

Rosette leaves, stems and flowers. Ref.4

Developmental stage

Expressed in young seedlings. Ref.4

Sequence similarities

Contains 1 PHD-type zinc finger.

Contains 2 TAZ-type zinc fingers.

Contains 2 ZZ-type zinc fingers.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 16701670Histone acetyltransferase HAC5
PRO_0000269743

Regions

Zinc finger611 – 69080TAZ-type 1
Zinc finger970 – 104677PHD-type
Zinc finger1378 – 142548ZZ-type 1
Zinc finger1498 – 154447ZZ-type 2
Zinc finger1554 – 163481TAZ-type 2
Compositional bias413 – 518106Gln-rich

Sequences

Sequence LengthMass (Da)Tools
Q9LE42 [UniParc].

Last modified October 1, 2000. Version 1.
Checksum: 2120E9184B4B98BD

FASTA1,670188,188
        10         20         30         40         50         60 
MAQGQNRTVL QSGQMHNSVV ASASSVSSQP NMVNGISQDT LLLRQEMLNR TYAWLQQRQP 

        70         80         90        100        110        120 
SKTDDASKAK LSEVAKRLES AMWRTATSKE DYLDFRSFDV RVESTLKQLL SQRRANPSSS 

       130        140        150        160        170        180 
VSTMVQTPGV SHGWGQSYTA TPMVDTSKFN SSNNLSDATT ETGRLLPTNR MYRGTINNGR 

       190        200        210        220        230        240 
QELSAVGQMI PTPGFDNSAN ADVYQSHRNE EYSGDGGKLL ATGSDFGNPS QLQKQRPTGS 

       250        260        270        280        290        300 
NDLMGYNLDH QLGGGFRSNI HQNTSGMTSI PLNAGVGMSG NNVHLANVPR SSEGVLSSTH 

       310        320        330        340        350        360 
FSTFSQPSQQ PVEQLQVSHV NRYSMSNSGT FVSGNLYGVQ TSSGSIETAV DMNSMSLNSM 

       370        380        390        400        410        420 
RRVDTSFGSQ SGLQNNPLLK PHLRHQFENG NFQSSSNSKE NLAQVSHRPL ERQFNQQAHY 

       430        440        450        460        470        480 
GQYHQQELLM NNDAYRQSQP ASNLVSQVKN EPRVEYYNEA FQMQAINKVE PSKPQNQYKQ 

       490        500        510        520        530        540 
NTVKDEYVGA QSAPVSSSQL KMSPSFPPQT HQTQQVSQWK DSSSLSAGVQ PVSGLGQWHS 

       550        560        570        580        590        600 
SSQNLTPISK NSNEEREHFG VRFHKQHEGT NNSSSVREST NCLTVAPSGT LDVPHLPVGI 

       610        620        630        640        650        660 
NVLSKQLNGD CGLSYKNQRR WLLFLLHVRK CNAAEDNCES KYCFTAKTLL KHINCCKAPA 

       670        680        690        700        710        720 
CAYQYCHQTR QLIHHYKHCG DEACPVCVFV KNFKEKQKEK FTFLQRAEPS SASLNHGPKE 

       730        740        750        760        770        780 
SFESMRTSSE RDSEAPFVVD DLQPSPKRQK VEKPSQFAYP DTQGNPATIS AGVSQAHFSM 

       790        800        810        820        830        840 
GLQEKDRLPS DVCKPVRSNV PMNADSSDSS RRLVPVSREL EKPVCKDTHM GRHGVKSALD 

       850        860        870        880        890        900 
GESLRLSKQE KPKRMNEISA PKEENAEQSL GVVSASNCGK SKIKGVSLIE LFTPEQVEEH 

       910        920        930        940        950        960 
IRGLRQWVGQ SKTKAEKNKA MGLSMSENSC QLCAVERLAF EPTPIYCTPC GARVKRNAMH 

       970        980        990       1000       1010       1020 
YTVVAGESRH YVCIPCYNEA RANTVSVDGT PVPKSRFEKK KNDEEVEESW VQCDKCQAWQ 

      1030       1040       1050       1060       1070       1080 
HQICALFNGR RNHGQAEYTC PNCYIQEVEQ GERKPVSQNV ILGAKSLPAS TLSNHLEQRL 

      1090       1100       1110       1120       1130       1140 
FKKLKQERQE RARLQGKSYE EVPGADSLVI RVVASVDKIL EVKPRFLDIF REDNYSSEFP 

      1150       1160       1170       1180       1190       1200 
YKSKAILLFQ KIEGVEVCLF GMYVQEFGTD SASPNQRRVY LSYLDSVKYF RPDVRTVSGE 

      1210       1220       1230       1240       1250       1260 
ALRTFVYHEI LIGYLDYCKK RGFSSCYIWA CPPLKGEDYI LYCHPEIQKT PKTDKLREWY 

      1270       1280       1290       1300       1310       1320 
LAMLKKASKE KVVVECTNFY DHFFVQSGEC RAKVTAARLP YFDGDYWPGA AEDLIDQMSQ 

      1330       1340       1350       1360       1370       1380 
EEDGKKSNRK LMPKKVISKR ALKAVGQLDL SVNASKDLLL MHKLGEIILP MKEDFIMVHL 

      1390       1400       1410       1420       1430       1440 
QHCCKHCCTL MVSGNRWVCN QCKNFQICDK CHEVEENRVE KEKHPVNQKE KHVLYPVAID 

      1450       1460       1470       1480       1490       1500 
NIPTEIKDND DILESEFFDT RQAFLSLCQG NHYQYDTLRR AKHSSMMILY HLHNPTVPAF 

      1510       1520       1530       1540       1550       1560 
AMACAICQQE LETAQGWRCE VCPDYDVCNA CYSKGINHPH SIISRPSATD SVVQNTQTNQ 

      1570       1580       1590       1600       1610       1620 
IQNAQLREVL LHVMTCCTAQ CQYPRCRVIK GLIRHGLVCK TRGCIACKKM WSLFRLHSRN 

      1630       1640       1650       1660       1670 
CRDPQCKVPK CRELRAHFSR KQQQADSRRR AAVMEMVRQR AADTTASTPE

« Hide

References

« Hide 'large scale' references
[1]"Structural analysis of Arabidopsis thaliana chromosome 3. I. Sequence features of the regions of 4,504,864 bp covered by sixty P1 and TAC clones."
Sato S., Nakamura Y., Kaneko T., Katoh T., Asamizu E., Tabata S.
DNA Res. 7:131-135(2000) [PubMed: 10819329] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: cv. Columbia.
[2]The Arabidopsis Information Resource (TAIR)
Submitted (APR-2011) to the EMBL/GenBank/DDBJ databases
Cited for: GENOME REANNOTATION.
Strain: cv. Columbia.
[3]"Analysis of histone acetyltransferase and histone deacetylase families of Arabidopsis thaliana suggests functional diversification of chromatin modification among multicellular eukaryotes."
Pandey R., Mueller A., Napoli C.A., Selinger D.A., Pikaard C.S., Richards E.J., Bender J., Mount D.W., Jorgensen R.A.
Nucleic Acids Res. 30:5036-5055(2002) [PubMed: 12466527] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 32-484 AND 529-1540, NOMENCLATURE.
[4]"Plant orthologs of p300/CBP: conservation of a core domain in metazoan p300/CBP acetyltransferase-related proteins."
Bordoli L., Netsch M., Luethi U., Lutz W., Eckner R.
Nucleic Acids Res. 29:589-597(2001) [PubMed: 11160878] [Abstract]
Cited for: DEVELOPMENTAL STAGE, TISSUE SPECIFICITY.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		AB026645 Genomic DNA. Translation: BAB02507.1.
CP002686 Genomic DNA. Translation: AEE75270.1.
AF512557 mRNA. Translation: AAM34787.1.
AF512558 mRNA. Translation: AAM34788.1.
IPIIPI00533541.
RefSeqNP_187904.1. NM_112135.3.
UniGeneAt.39511.

3D structure databases

HSSPHSSP built from PDB template 1L8C based on UniProtKB P45481.
ProteinModelPortalQ9LE42.
SMRQ9LE42. Positions 615-695, 1006-1046, 1061-1550, 1554-1663.
ModBaseSearch...

Protein-protein interaction databases

STRINGQ9LE42.

Proteomic databases

PRIDEQ9LE42.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblPlantsAT3G12980.1; AT3G12980.1; AT3G12980.
GeneID820484.
GenomeReviewsGene locus AT3G12980 in contig BA000014_GR.
KEGGath:AT3G12980.
NMPDRfig|3702.1.peg.13379.

Organism-specific databases

TAIRAt3g12980.

Phylogenomic databases

eggNOGKOG1778.
GeneTreeEPGT00050000000620.
HOGENOMHBG633230.
InParanoidQ9LE42.
OMAYNEARAN.
PhylomeDBQ9LE42.
ProtClustDBCLSN2915408.

Gene expression databases

GenevestigatorQ9LE42.

Family and domain databases

InterProIPR013178. Histone_H3-K56_AcTrfase_RTT109.
IPR019786. Zinc_finger_PHD-type_CS.
IPR011011. Znf_FYVE_PHD.
IPR001965. Znf_PHD.
IPR013083. Znf_RING/FYVE/PHD.
IPR000197. Znf_TAZ.
IPR000433. Znf_ZZ.
[Graphical view]
Gene3DG3DSA:3.30.40.10. Znf_RING/FYVE/PHD. 1 hit.
G3DSA:1.20.1020.10. Znf_TAZ. 2 hits.
KOK04498.
PfamPF08214. KAT11. 1 hit.
PF02135. zf-TAZ. 2 hits.
PF00569. ZZ. 1 hit.
[Graphical view]
SMARTSM00249. PHD. 1 hit.
SM00551. ZnF_TAZ. 2 hits.
SM00291. ZnF_ZZ. 2 hits.
[Graphical view]
SUPFAMSSF57903. FYVE_PHD_ZnF. 1 hit.
SSF57933. TAZ_finger. 2 hits.
PROSITEPS01359. ZF_PHD_1. 1 hit.
PS50016. ZF_PHD_2. False negative.
PS50134. ZF_TAZ. 2 hits.
PS01357. ZF_ZZ_1. 2 hits.
PS50135. ZF_ZZ_2. 2 hits.
PS00028. ZINC_FINGER_C2H2_1. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameHAC5_ARATH
AccessionPrimary (citable) accession number: Q9LE42
Secondary accession number(s): Q8LRK5, Q8LRK6
Entry history
Integrated into UniProtKB/Swiss-Prot: January 9, 2007
Last sequence update: October 1, 2000
Last modified: January 25, 2012
This is version 76 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Relevant documents

Arabidopsis thaliana

Arabidopsis thaliana: entries and gene names

SIMILARITY comments

Index of protein domains and families

to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·Documents