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Q9LE42

- HAC5_ARATH

UniProt

Q9LE42 - HAC5_ARATH

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Protein

Histone acetyltransferase HAC5

Gene
HAC5, PCAT4, At3g12980, MGH6.20, MGH6_9
Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed - Annotation score: 4 out of 5 - Experimental evidence at transcript leveli

Functioni

Acetyltransferase enzyme. Acetylates histones, giving a specific tag for transcriptional activation By similarity.

Catalytic activityi

Acetyl-CoA + [histone] = CoA + acetyl-[histone].

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri611 – 69080TAZ-type 1Add
BLAST
Zinc fingeri970 – 104677PHD-typeAdd
BLAST
Zinc fingeri1378 – 142548ZZ-type 1Add
BLAST
Zinc fingeri1498 – 154447ZZ-type 2Add
BLAST
Zinc fingeri1554 – 163481TAZ-type 2Add
BLAST

GO - Molecular functioni

  1. histone acetyltransferase activity Source: TAIR
  2. transcription cofactor activity Source: InterPro
  3. zinc ion binding Source: InterPro

GO - Biological processi

  1. flower development Source: TAIR
  2. histone acetylation Source: GOC
  3. protein acetylation Source: TAIR
  4. regulation of transcription, DNA-templated Source: UniProtKB-KW
  5. transcription, DNA-templated Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Activator, Acyltransferase, Chromatin regulator, Transferase

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

Metal-binding, Zinc

Enzyme and pathway databases

BioCyciARA:AT3G12980-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Histone acetyltransferase HAC5 (EC:2.3.1.48)
Gene namesi
Name:HAC5
Synonyms:PCAT4
Ordered Locus Names:At3g12980
ORF Names:MGH6.20, MGH6_9
OrganismiArabidopsis thaliana (Mouse-ear cress)
Taxonomic identifieri3702 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
ProteomesiUP000006548: Chromosome 3

Organism-specific databases

TAIRiAT3G12980.

Subcellular locationi

Nucleus Inferred

GO - Cellular componenti

  1. nucleus Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 16701670Histone acetyltransferase HAC5PRO_0000269743Add
BLAST

Proteomic databases

PaxDbiQ9LE42.
PRIDEiQ9LE42.

Expressioni

Tissue specificityi

Rosette leaves, stems and flowers.1 Publication

Developmental stagei

Expressed in young seedlings.1 Publication

Gene expression databases

GenevestigatoriQ9LE42.

Interactioni

Protein-protein interaction databases

MINTiMINT-8069366.

Structurei

3D structure databases

ProteinModelPortaliQ9LE42.
SMRiQ9LE42. Positions 627-697, 933-1331, 1568-1643.

Family & Domainsi

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi413 – 518106Gln-richAdd
BLAST

Sequence similaritiesi

Contains 2 ZZ-type zinc fingers.

Zinc finger

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri611 – 69080TAZ-type 1Add
BLAST
Zinc fingeri970 – 104677PHD-typeAdd
BLAST
Zinc fingeri1378 – 142548ZZ-type 1Add
BLAST
Zinc fingeri1498 – 154447ZZ-type 2Add
BLAST
Zinc fingeri1554 – 163481TAZ-type 2Add
BLAST

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiNOG326839.
HOGENOMiHOG000242057.
InParanoidiQ9LE42.
KOiK04498.
OMAiYNEARAN.
PhylomeDBiQ9LE42.

Family and domain databases

Gene3Di1.20.1020.10. 2 hits.
3.30.40.10. 1 hit.
InterProiIPR013178. Histone_H3-K56_AcTrfase_RTT109.
IPR019786. Zinc_finger_PHD-type_CS.
IPR011011. Znf_FYVE_PHD.
IPR001965. Znf_PHD.
IPR013083. Znf_RING/FYVE/PHD.
IPR000197. Znf_TAZ.
IPR000433. Znf_ZZ.
[Graphical view]
PfamiPF08214. KAT11. 1 hit.
PF02135. zf-TAZ. 2 hits.
PF00569. ZZ. 1 hit.
[Graphical view]
SMARTiSM00249. PHD. 1 hit.
SM00551. ZnF_TAZ. 2 hits.
SM00291. ZnF_ZZ. 2 hits.
[Graphical view]
SUPFAMiSSF57903. SSF57903. 1 hit.
SSF57933. SSF57933. 2 hits.
PROSITEiPS01359. ZF_PHD_1. 1 hit.
PS50134. ZF_TAZ. 2 hits.
PS01357. ZF_ZZ_1. 2 hits.
PS50135. ZF_ZZ_2. 2 hits.
PS00028. ZINC_FINGER_C2H2_1. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9LE42-1 [UniParc]FASTAAdd to Basket

« Hide

MAQGQNRTVL QSGQMHNSVV ASASSVSSQP NMVNGISQDT LLLRQEMLNR     50
TYAWLQQRQP SKTDDASKAK LSEVAKRLES AMWRTATSKE DYLDFRSFDV 100
RVESTLKQLL SQRRANPSSS VSTMVQTPGV SHGWGQSYTA TPMVDTSKFN 150
SSNNLSDATT ETGRLLPTNR MYRGTINNGR QELSAVGQMI PTPGFDNSAN 200
ADVYQSHRNE EYSGDGGKLL ATGSDFGNPS QLQKQRPTGS NDLMGYNLDH 250
QLGGGFRSNI HQNTSGMTSI PLNAGVGMSG NNVHLANVPR SSEGVLSSTH 300
FSTFSQPSQQ PVEQLQVSHV NRYSMSNSGT FVSGNLYGVQ TSSGSIETAV 350
DMNSMSLNSM RRVDTSFGSQ SGLQNNPLLK PHLRHQFENG NFQSSSNSKE 400
NLAQVSHRPL ERQFNQQAHY GQYHQQELLM NNDAYRQSQP ASNLVSQVKN 450
EPRVEYYNEA FQMQAINKVE PSKPQNQYKQ NTVKDEYVGA QSAPVSSSQL 500
KMSPSFPPQT HQTQQVSQWK DSSSLSAGVQ PVSGLGQWHS SSQNLTPISK 550
NSNEEREHFG VRFHKQHEGT NNSSSVREST NCLTVAPSGT LDVPHLPVGI 600
NVLSKQLNGD CGLSYKNQRR WLLFLLHVRK CNAAEDNCES KYCFTAKTLL 650
KHINCCKAPA CAYQYCHQTR QLIHHYKHCG DEACPVCVFV KNFKEKQKEK 700
FTFLQRAEPS SASLNHGPKE SFESMRTSSE RDSEAPFVVD DLQPSPKRQK 750
VEKPSQFAYP DTQGNPATIS AGVSQAHFSM GLQEKDRLPS DVCKPVRSNV 800
PMNADSSDSS RRLVPVSREL EKPVCKDTHM GRHGVKSALD GESLRLSKQE 850
KPKRMNEISA PKEENAEQSL GVVSASNCGK SKIKGVSLIE LFTPEQVEEH 900
IRGLRQWVGQ SKTKAEKNKA MGLSMSENSC QLCAVERLAF EPTPIYCTPC 950
GARVKRNAMH YTVVAGESRH YVCIPCYNEA RANTVSVDGT PVPKSRFEKK 1000
KNDEEVEESW VQCDKCQAWQ HQICALFNGR RNHGQAEYTC PNCYIQEVEQ 1050
GERKPVSQNV ILGAKSLPAS TLSNHLEQRL FKKLKQERQE RARLQGKSYE 1100
EVPGADSLVI RVVASVDKIL EVKPRFLDIF REDNYSSEFP YKSKAILLFQ 1150
KIEGVEVCLF GMYVQEFGTD SASPNQRRVY LSYLDSVKYF RPDVRTVSGE 1200
ALRTFVYHEI LIGYLDYCKK RGFSSCYIWA CPPLKGEDYI LYCHPEIQKT 1250
PKTDKLREWY LAMLKKASKE KVVVECTNFY DHFFVQSGEC RAKVTAARLP 1300
YFDGDYWPGA AEDLIDQMSQ EEDGKKSNRK LMPKKVISKR ALKAVGQLDL 1350
SVNASKDLLL MHKLGEIILP MKEDFIMVHL QHCCKHCCTL MVSGNRWVCN 1400
QCKNFQICDK CHEVEENRVE KEKHPVNQKE KHVLYPVAID NIPTEIKDND 1450
DILESEFFDT RQAFLSLCQG NHYQYDTLRR AKHSSMMILY HLHNPTVPAF 1500
AMACAICQQE LETAQGWRCE VCPDYDVCNA CYSKGINHPH SIISRPSATD 1550
SVVQNTQTNQ IQNAQLREVL LHVMTCCTAQ CQYPRCRVIK GLIRHGLVCK 1600
TRGCIACKKM WSLFRLHSRN CRDPQCKVPK CRELRAHFSR KQQQADSRRR 1650
AAVMEMVRQR AADTTASTPE 1670
Length:1,670
Mass (Da):188,188
Last modified:October 1, 2000 - v1
Checksum:i2120E9184B4B98BD
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AB026645 Genomic DNA. Translation: BAB02507.1.
CP002686 Genomic DNA. Translation: AEE75270.1.
AF512557 mRNA. Translation: AAM34787.1.
AF512558 mRNA. Translation: AAM34788.1.
RefSeqiNP_187904.1. NM_112135.3.
UniGeneiAt.39511.

Genome annotation databases

EnsemblPlantsiAT3G12980.1; AT3G12980.1; AT3G12980.
GeneIDi820484.
KEGGiath:AT3G12980.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AB026645 Genomic DNA. Translation: BAB02507.1 .
CP002686 Genomic DNA. Translation: AEE75270.1 .
AF512557 mRNA. Translation: AAM34787.1 .
AF512558 mRNA. Translation: AAM34788.1 .
RefSeqi NP_187904.1. NM_112135.3.
UniGenei At.39511.

3D structure databases

ProteinModelPortali Q9LE42.
SMRi Q9LE42. Positions 627-697, 933-1331, 1568-1643.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

MINTi MINT-8069366.

Proteomic databases

PaxDbi Q9LE42.
PRIDEi Q9LE42.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblPlantsi AT3G12980.1 ; AT3G12980.1 ; AT3G12980 .
GeneIDi 820484.
KEGGi ath:AT3G12980.

Organism-specific databases

TAIRi AT3G12980.

Phylogenomic databases

eggNOGi NOG326839.
HOGENOMi HOG000242057.
InParanoidi Q9LE42.
KOi K04498.
OMAi YNEARAN.
PhylomeDBi Q9LE42.

Enzyme and pathway databases

BioCyci ARA:AT3G12980-MONOMER.

Gene expression databases

Genevestigatori Q9LE42.

Family and domain databases

Gene3Di 1.20.1020.10. 2 hits.
3.30.40.10. 1 hit.
InterProi IPR013178. Histone_H3-K56_AcTrfase_RTT109.
IPR019786. Zinc_finger_PHD-type_CS.
IPR011011. Znf_FYVE_PHD.
IPR001965. Znf_PHD.
IPR013083. Znf_RING/FYVE/PHD.
IPR000197. Znf_TAZ.
IPR000433. Znf_ZZ.
[Graphical view ]
Pfami PF08214. KAT11. 1 hit.
PF02135. zf-TAZ. 2 hits.
PF00569. ZZ. 1 hit.
[Graphical view ]
SMARTi SM00249. PHD. 1 hit.
SM00551. ZnF_TAZ. 2 hits.
SM00291. ZnF_ZZ. 2 hits.
[Graphical view ]
SUPFAMi SSF57903. SSF57903. 1 hit.
SSF57933. SSF57933. 2 hits.
PROSITEi PS01359. ZF_PHD_1. 1 hit.
PS50134. ZF_TAZ. 2 hits.
PS01357. ZF_ZZ_1. 2 hits.
PS50135. ZF_ZZ_2. 2 hits.
PS00028. ZINC_FINGER_C2H2_1. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Structural analysis of Arabidopsis thaliana chromosome 3. I. Sequence features of the regions of 4,504,864 bp covered by sixty P1 and TAC clones."
    Sato S., Nakamura Y., Kaneko T., Katoh T., Asamizu E., Tabata S.
    DNA Res. 7:131-135(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: cv. Columbia.
  2. The Arabidopsis Information Resource (TAIR)
    Submitted (APR-2011) to the EMBL/GenBank/DDBJ databases
    Cited for: GENOME REANNOTATION.
    Strain: cv. Columbia.
  3. "Analysis of histone acetyltransferase and histone deacetylase families of Arabidopsis thaliana suggests functional diversification of chromatin modification among multicellular eukaryotes."
    Pandey R., Mueller A., Napoli C.A., Selinger D.A., Pikaard C.S., Richards E.J., Bender J., Mount D.W., Jorgensen R.A.
    Nucleic Acids Res. 30:5036-5055(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 32-484 AND 529-1540, NOMENCLATURE.
  4. "Plant orthologs of p300/CBP: conservation of a core domain in metazoan p300/CBP acetyltransferase-related proteins."
    Bordoli L., Netsch M., Luethi U., Lutz W., Eckner R.
    Nucleic Acids Res. 29:589-597(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: DEVELOPMENTAL STAGE, TISSUE SPECIFICITY.

Entry informationi

Entry nameiHAC5_ARATH
AccessioniPrimary (citable) accession number: Q9LE42
Secondary accession number(s): Q8LRK5, Q8LRK6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 9, 2007
Last sequence update: October 1, 2000
Last modified: June 11, 2014
This is version 98 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Arabidopsis thaliana
    Arabidopsis thaliana: entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi