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Q9LE42

- HAC5_ARATH

UniProt

Q9LE42 - HAC5_ARATH

Protein

Histone acetyltransferase HAC5

Gene

HAC5

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 99 (01 Oct 2014)
      Sequence version 1 (01 Oct 2000)
      Previous versions | rss
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    Functioni

    Acetyltransferase enzyme. Acetylates histones, giving a specific tag for transcriptional activation By similarity.By similarity

    Catalytic activityi

    Acetyl-CoA + [histone] = CoA + acetyl-[histone].

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Zinc fingeri611 – 69080TAZ-type 1PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri970 – 104677PHD-typeAdd
    BLAST
    Zinc fingeri1378 – 142548ZZ-type 1PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri1498 – 154447ZZ-type 2PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri1554 – 163481TAZ-type 2PROSITE-ProRule annotationAdd
    BLAST

    GO - Molecular functioni

    1. histone acetyltransferase activity Source: TAIR
    2. transcription cofactor activity Source: InterPro
    3. zinc ion binding Source: InterPro

    GO - Biological processi

    1. flower development Source: TAIR
    2. histone acetylation Source: GOC
    3. protein acetylation Source: TAIR
    4. regulation of transcription, DNA-templated Source: UniProtKB-KW
    5. transcription, DNA-templated Source: UniProtKB-KW

    Keywords - Molecular functioni

    Activator, Acyltransferase, Chromatin regulator, Transferase

    Keywords - Biological processi

    Transcription, Transcription regulation

    Keywords - Ligandi

    Metal-binding, Zinc

    Enzyme and pathway databases

    BioCyciARA:AT3G12980-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Histone acetyltransferase HAC5 (EC:2.3.1.48)
    Gene namesi
    Name:HAC5
    Synonyms:PCAT4
    Ordered Locus Names:At3g12980
    ORF Names:MGH6.20, MGH6_9
    OrganismiArabidopsis thaliana (Mouse-ear cress)
    Taxonomic identifieri3702 [NCBI]
    Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
    ProteomesiUP000006548: Chromosome 3

    Organism-specific databases

    TAIRiAT3G12980.

    Subcellular locationi

    Nucleus Curated

    GO - Cellular componenti

    1. nucleus Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Nucleus

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 16701670Histone acetyltransferase HAC5PRO_0000269743Add
    BLAST

    Proteomic databases

    PaxDbiQ9LE42.
    PRIDEiQ9LE42.

    Expressioni

    Tissue specificityi

    Rosette leaves, stems and flowers.1 Publication

    Developmental stagei

    Expressed in young seedlings.1 Publication

    Gene expression databases

    GenevestigatoriQ9LE42.

    Interactioni

    Protein-protein interaction databases

    MINTiMINT-8069366.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9LE42.
    SMRiQ9LE42. Positions 627-697, 933-1331, 1568-1643.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi413 – 518106Gln-richAdd
    BLAST

    Sequence similaritiesi

    Contains 1 PHD-type zinc finger.Curated
    Contains 2 TAZ-type zinc fingers.PROSITE-ProRule annotation
    Contains 2 ZZ-type zinc fingers.PROSITE-ProRule annotation

    Zinc finger

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Zinc fingeri611 – 69080TAZ-type 1PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri970 – 104677PHD-typeAdd
    BLAST
    Zinc fingeri1378 – 142548ZZ-type 1PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri1498 – 154447ZZ-type 2PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri1554 – 163481TAZ-type 2PROSITE-ProRule annotationAdd
    BLAST

    Keywords - Domaini

    Repeat, Zinc-finger

    Phylogenomic databases

    eggNOGiNOG326839.
    HOGENOMiHOG000242057.
    InParanoidiQ9LE42.
    KOiK04498.
    OMAiYNEARAN.
    PhylomeDBiQ9LE42.

    Family and domain databases

    Gene3Di1.20.1020.10. 2 hits.
    3.30.40.10. 1 hit.
    InterProiIPR013178. Histone_H3-K56_AcTrfase_RTT109.
    IPR019786. Zinc_finger_PHD-type_CS.
    IPR011011. Znf_FYVE_PHD.
    IPR001965. Znf_PHD.
    IPR013083. Znf_RING/FYVE/PHD.
    IPR000197. Znf_TAZ.
    IPR000433. Znf_ZZ.
    [Graphical view]
    PfamiPF08214. KAT11. 1 hit.
    PF02135. zf-TAZ. 2 hits.
    PF00569. ZZ. 1 hit.
    [Graphical view]
    SMARTiSM00249. PHD. 1 hit.
    SM00551. ZnF_TAZ. 2 hits.
    SM00291. ZnF_ZZ. 2 hits.
    [Graphical view]
    SUPFAMiSSF57903. SSF57903. 1 hit.
    SSF57933. SSF57933. 2 hits.
    PROSITEiPS01359. ZF_PHD_1. 1 hit.
    PS50134. ZF_TAZ. 2 hits.
    PS01357. ZF_ZZ_1. 2 hits.
    PS50135. ZF_ZZ_2. 2 hits.
    PS00028. ZINC_FINGER_C2H2_1. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q9LE42-1 [UniParc]FASTAAdd to Basket

    « Hide

    MAQGQNRTVL QSGQMHNSVV ASASSVSSQP NMVNGISQDT LLLRQEMLNR     50
    TYAWLQQRQP SKTDDASKAK LSEVAKRLES AMWRTATSKE DYLDFRSFDV 100
    RVESTLKQLL SQRRANPSSS VSTMVQTPGV SHGWGQSYTA TPMVDTSKFN 150
    SSNNLSDATT ETGRLLPTNR MYRGTINNGR QELSAVGQMI PTPGFDNSAN 200
    ADVYQSHRNE EYSGDGGKLL ATGSDFGNPS QLQKQRPTGS NDLMGYNLDH 250
    QLGGGFRSNI HQNTSGMTSI PLNAGVGMSG NNVHLANVPR SSEGVLSSTH 300
    FSTFSQPSQQ PVEQLQVSHV NRYSMSNSGT FVSGNLYGVQ TSSGSIETAV 350
    DMNSMSLNSM RRVDTSFGSQ SGLQNNPLLK PHLRHQFENG NFQSSSNSKE 400
    NLAQVSHRPL ERQFNQQAHY GQYHQQELLM NNDAYRQSQP ASNLVSQVKN 450
    EPRVEYYNEA FQMQAINKVE PSKPQNQYKQ NTVKDEYVGA QSAPVSSSQL 500
    KMSPSFPPQT HQTQQVSQWK DSSSLSAGVQ PVSGLGQWHS SSQNLTPISK 550
    NSNEEREHFG VRFHKQHEGT NNSSSVREST NCLTVAPSGT LDVPHLPVGI 600
    NVLSKQLNGD CGLSYKNQRR WLLFLLHVRK CNAAEDNCES KYCFTAKTLL 650
    KHINCCKAPA CAYQYCHQTR QLIHHYKHCG DEACPVCVFV KNFKEKQKEK 700
    FTFLQRAEPS SASLNHGPKE SFESMRTSSE RDSEAPFVVD DLQPSPKRQK 750
    VEKPSQFAYP DTQGNPATIS AGVSQAHFSM GLQEKDRLPS DVCKPVRSNV 800
    PMNADSSDSS RRLVPVSREL EKPVCKDTHM GRHGVKSALD GESLRLSKQE 850
    KPKRMNEISA PKEENAEQSL GVVSASNCGK SKIKGVSLIE LFTPEQVEEH 900
    IRGLRQWVGQ SKTKAEKNKA MGLSMSENSC QLCAVERLAF EPTPIYCTPC 950
    GARVKRNAMH YTVVAGESRH YVCIPCYNEA RANTVSVDGT PVPKSRFEKK 1000
    KNDEEVEESW VQCDKCQAWQ HQICALFNGR RNHGQAEYTC PNCYIQEVEQ 1050
    GERKPVSQNV ILGAKSLPAS TLSNHLEQRL FKKLKQERQE RARLQGKSYE 1100
    EVPGADSLVI RVVASVDKIL EVKPRFLDIF REDNYSSEFP YKSKAILLFQ 1150
    KIEGVEVCLF GMYVQEFGTD SASPNQRRVY LSYLDSVKYF RPDVRTVSGE 1200
    ALRTFVYHEI LIGYLDYCKK RGFSSCYIWA CPPLKGEDYI LYCHPEIQKT 1250
    PKTDKLREWY LAMLKKASKE KVVVECTNFY DHFFVQSGEC RAKVTAARLP 1300
    YFDGDYWPGA AEDLIDQMSQ EEDGKKSNRK LMPKKVISKR ALKAVGQLDL 1350
    SVNASKDLLL MHKLGEIILP MKEDFIMVHL QHCCKHCCTL MVSGNRWVCN 1400
    QCKNFQICDK CHEVEENRVE KEKHPVNQKE KHVLYPVAID NIPTEIKDND 1450
    DILESEFFDT RQAFLSLCQG NHYQYDTLRR AKHSSMMILY HLHNPTVPAF 1500
    AMACAICQQE LETAQGWRCE VCPDYDVCNA CYSKGINHPH SIISRPSATD 1550
    SVVQNTQTNQ IQNAQLREVL LHVMTCCTAQ CQYPRCRVIK GLIRHGLVCK 1600
    TRGCIACKKM WSLFRLHSRN CRDPQCKVPK CRELRAHFSR KQQQADSRRR 1650
    AAVMEMVRQR AADTTASTPE 1670
    Length:1,670
    Mass (Da):188,188
    Last modified:October 1, 2000 - v1
    Checksum:i2120E9184B4B98BD
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB026645 Genomic DNA. Translation: BAB02507.1.
    CP002686 Genomic DNA. Translation: AEE75270.1.
    AF512557 mRNA. Translation: AAM34787.1.
    AF512558 mRNA. Translation: AAM34788.1.
    RefSeqiNP_187904.1. NM_112135.3.
    UniGeneiAt.39511.

    Genome annotation databases

    EnsemblPlantsiAT3G12980.1; AT3G12980.1; AT3G12980.
    GeneIDi820484.
    KEGGiath:AT3G12980.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB026645 Genomic DNA. Translation: BAB02507.1 .
    CP002686 Genomic DNA. Translation: AEE75270.1 .
    AF512557 mRNA. Translation: AAM34787.1 .
    AF512558 mRNA. Translation: AAM34788.1 .
    RefSeqi NP_187904.1. NM_112135.3.
    UniGenei At.39511.

    3D structure databases

    ProteinModelPortali Q9LE42.
    SMRi Q9LE42. Positions 627-697, 933-1331, 1568-1643.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    MINTi MINT-8069366.

    Proteomic databases

    PaxDbi Q9LE42.
    PRIDEi Q9LE42.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblPlantsi AT3G12980.1 ; AT3G12980.1 ; AT3G12980 .
    GeneIDi 820484.
    KEGGi ath:AT3G12980.

    Organism-specific databases

    TAIRi AT3G12980.

    Phylogenomic databases

    eggNOGi NOG326839.
    HOGENOMi HOG000242057.
    InParanoidi Q9LE42.
    KOi K04498.
    OMAi YNEARAN.
    PhylomeDBi Q9LE42.

    Enzyme and pathway databases

    BioCyci ARA:AT3G12980-MONOMER.

    Gene expression databases

    Genevestigatori Q9LE42.

    Family and domain databases

    Gene3Di 1.20.1020.10. 2 hits.
    3.30.40.10. 1 hit.
    InterProi IPR013178. Histone_H3-K56_AcTrfase_RTT109.
    IPR019786. Zinc_finger_PHD-type_CS.
    IPR011011. Znf_FYVE_PHD.
    IPR001965. Znf_PHD.
    IPR013083. Znf_RING/FYVE/PHD.
    IPR000197. Znf_TAZ.
    IPR000433. Znf_ZZ.
    [Graphical view ]
    Pfami PF08214. KAT11. 1 hit.
    PF02135. zf-TAZ. 2 hits.
    PF00569. ZZ. 1 hit.
    [Graphical view ]
    SMARTi SM00249. PHD. 1 hit.
    SM00551. ZnF_TAZ. 2 hits.
    SM00291. ZnF_ZZ. 2 hits.
    [Graphical view ]
    SUPFAMi SSF57903. SSF57903. 1 hit.
    SSF57933. SSF57933. 2 hits.
    PROSITEi PS01359. ZF_PHD_1. 1 hit.
    PS50134. ZF_TAZ. 2 hits.
    PS01357. ZF_ZZ_1. 2 hits.
    PS50135. ZF_ZZ_2. 2 hits.
    PS00028. ZINC_FINGER_C2H2_1. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Structural analysis of Arabidopsis thaliana chromosome 3. I. Sequence features of the regions of 4,504,864 bp covered by sixty P1 and TAC clones."
      Sato S., Nakamura Y., Kaneko T., Katoh T., Asamizu E., Tabata S.
      DNA Res. 7:131-135(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: cv. Columbia.
    2. The Arabidopsis Information Resource (TAIR)
      Submitted (APR-2011) to the EMBL/GenBank/DDBJ databases
      Cited for: GENOME REANNOTATION.
      Strain: cv. Columbia.
    3. "Analysis of histone acetyltransferase and histone deacetylase families of Arabidopsis thaliana suggests functional diversification of chromatin modification among multicellular eukaryotes."
      Pandey R., Mueller A., Napoli C.A., Selinger D.A., Pikaard C.S., Richards E.J., Bender J., Mount D.W., Jorgensen R.A.
      Nucleic Acids Res. 30:5036-5055(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 32-484 AND 529-1540, NOMENCLATURE.
    4. "Plant orthologs of p300/CBP: conservation of a core domain in metazoan p300/CBP acetyltransferase-related proteins."
      Bordoli L., Netsch M., Luethi U., Lutz W., Eckner R.
      Nucleic Acids Res. 29:589-597(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: DEVELOPMENTAL STAGE, TISSUE SPECIFICITY.

    Entry informationi

    Entry nameiHAC5_ARATH
    AccessioniPrimary (citable) accession number: Q9LE42
    Secondary accession number(s): Q8LRK5, Q8LRK6
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: January 9, 2007
    Last sequence update: October 1, 2000
    Last modified: October 1, 2014
    This is version 99 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programPlant Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Arabidopsis thaliana
      Arabidopsis thaliana: entries and gene names
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3