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Protein

Heat shock 70 kDa protein 10, mitochondrial

Gene

HSP70-10

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

In cooperation with other chaperones, Hsp70s stabilize preexistent proteins against aggregation and mediate the folding of newly translated polypeptides in the cytosol as well as within organelles. These chaperones participate in all these processes through their ability to recognize nonnative conformations of other proteins. They bind extended peptide segments with a net hydrophobic character exposed by polypeptides during translation and membrane translocation, or following stress-induced damage (By similarity).By similarity

GO - Molecular functioni

  • ATP binding Source: TAIR

GO - Biological processi

  • protein folding Source: InterPro
  • response to cadmium ion Source: TAIR
  • response to heat Source: TAIR
  • response to salt stress Source: TAIR
  • response to virus Source: TAIR
Complete GO annotation...

Keywords - Molecular functioni

Chaperone

Keywords - Biological processi

Stress response

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Heat shock 70 kDa protein 10, mitochondrial
Alternative name(s):
Heat shock protein 70-10
Short name:
AtHsp70-10
Mitochondrial heat shock protein 70-2
Short name:
mtHsc70-2
Gene namesi
Name:HSP70-10
Synonyms:HSC70-5, MTHSC70-2
Ordered Locus Names:At5g09590
ORF Names:F17I14_220
OrganismiArabidopsis thaliana (Mouse-ear cress)
Taxonomic identifieri3702 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
Proteomesi
  • UP000006548 Componenti: Chromosome 5

Organism-specific databases

TAIRiAT5G09590.

Subcellular locationi

GO - Cellular componenti

  • cell wall Source: TAIR
  • chloroplast Source: TAIR
  • mitochondrion Source: TAIR
  • vacuolar membrane Source: TAIR
Complete GO annotation...

Keywords - Cellular componenti

Mitochondrion

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transit peptidei1 – 5757MitochondrionSequence analysisAdd
BLAST
Chaini58 – 682625Heat shock 70 kDa protein 10, mitochondrialPRO_0000415429Add
BLAST

Proteomic databases

PaxDbiQ9LDZ0.
PRIDEiQ9LDZ0.

PTM databases

iPTMnetiQ9LDZ0.
SwissPalmiQ9LDZ0.

Expressioni

Developmental stagei

Up-regulated during seed maturation.1 Publication

Inductioni

By heat shock.1 Publication

Gene expression databases

GenevisibleiQ9LDZ0. AT.

Interactioni

Protein-protein interaction databases

BioGridi16096. 1 interaction.
IntActiQ9LDZ0. 1 interaction.
MINTiMINT-8385682.
STRINGi3702.AT5G09590.1.

Structurei

3D structure databases

ProteinModelPortaliQ9LDZ0.
SMRiQ9LDZ0. Positions 59-649.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transit peptide

Phylogenomic databases

eggNOGiKOG0102. Eukaryota.
COG0443. LUCA.
HOGENOMiHOG000228135.
InParanoidiQ9LDZ0.
KOiK03283.
OMAiIFASNTK.
PhylomeDBiQ9LDZ0.

Family and domain databases

Gene3Di1.20.1270.10. 1 hit.
2.60.34.10. 1 hit.
HAMAPiMF_00332. DnaK.
InterProiIPR012725. Chaperone_DnaK.
IPR018181. Heat_shock_70_CS.
IPR029048. HSP70_C.
IPR029047. HSP70_peptide-bd.
IPR013126. Hsp_70_fam.
[Graphical view]
PfamiPF00012. HSP70. 1 hit.
[Graphical view]
PRINTSiPR00301. HEATSHOCK70.
SUPFAMiSSF100920. SSF100920. 1 hit.
TIGRFAMsiTIGR02350. prok_dnaK. 1 hit.
PROSITEiPS00297. HSP70_1. 1 hit.
PS00329. HSP70_2. 1 hit.
PS01036. HSP70_3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9LDZ0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MATAALLRSI RRREVVSSPF SAYRCLSSSG KASLNSSYLG QNFRSFSRAF
60 70 80 90 100
SSKPAGNDVI GIDLGTTNSC VAVMEGKNPK VIENAEGART TPSVVAFNTK
110 120 130 140 150
GELLVGTPAK RQAVTNPTNT VSGTKRLIGR KFDDPQTQKE MKMVPYKIVR
160 170 180 190 200
APNGDAWVEA NGQQYSPSQI GAFILTKMKE TAEAYLGKSV TKAVVTVPAY
210 220 230 240 250
FNDAQRQATK DAGRIAGLDV ERIINEPTAA ALSYGMTNKE GLIAVFDLGG
260 270 280 290 300
GTFDVSVLEI SNGVFEVKAT NGDTFLGGED FDNALLDFLV NEFKTTEGID
310 320 330 340 350
LAKDRLALQR LREAAEKAKI ELSSTSQTEI NLPFITADAS GAKHFNITLT
360 370 380 390 400
RSRFETLVNH LIERTRDPCK NCLKDAGISA KEVDEVLLVG GMTRVPKVQS
410 420 430 440 450
IVAEIFGKSP SKGVNPDEAV AMGAALQGGI LRGDVKELLL LDVTPLSLGI
460 470 480 490 500
ETLGGVFTRL ITRNTTIPTK KSQVFSTAAD NQTQVGIRVL QGEREMATDN
510 520 530 540 550
KLLGEFDLVG IPPSPRGVPQ IEVTFDIDAN GIVTVSAKDK TTGKVQQITI
560 570 580 590 600
RSSGGLSEDD IQKMVREAEL HAQKDKERKE LIDTKNTADT TIYSIEKSLG
610 620 630 640 650
EYREKIPSEI AKEIEDAVAD LRSASSGDDL NEIKAKIEAA NKAVSKIGEH
660 670 680
MSGGSGGGSA PGGGSEGGSD QAPEAEYEEV KK
Length:682
Mass (Da):72,991
Last modified:October 1, 2000 - v1
Checksum:i3BB193B42A4A3C89
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF217458 mRNA. Translation: AAF27638.1.
AL353994 Genomic DNA. Translation: CAB89371.1.
CP002688 Genomic DNA. Translation: AED91413.1.
BT046197 mRNA. Translation: ACI49796.1.
PIRiT49939.
RefSeqiNP_196521.1. NM_120996.3.
UniGeneiAt.49002.
At.72790.
At.73206.

Genome annotation databases

EnsemblPlantsiAT5G09590.1; AT5G09590.1; AT5G09590.
GeneIDi830818.
GrameneiAT5G09590.1; AT5G09590.1; AT5G09590.
KEGGiath:AT5G09590.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF217458 mRNA. Translation: AAF27638.1.
AL353994 Genomic DNA. Translation: CAB89371.1.
CP002688 Genomic DNA. Translation: AED91413.1.
BT046197 mRNA. Translation: ACI49796.1.
PIRiT49939.
RefSeqiNP_196521.1. NM_120996.3.
UniGeneiAt.49002.
At.72790.
At.73206.

3D structure databases

ProteinModelPortaliQ9LDZ0.
SMRiQ9LDZ0. Positions 59-649.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi16096. 1 interaction.
IntActiQ9LDZ0. 1 interaction.
MINTiMINT-8385682.
STRINGi3702.AT5G09590.1.

PTM databases

iPTMnetiQ9LDZ0.
SwissPalmiQ9LDZ0.

Proteomic databases

PaxDbiQ9LDZ0.
PRIDEiQ9LDZ0.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblPlantsiAT5G09590.1; AT5G09590.1; AT5G09590.
GeneIDi830818.
GrameneiAT5G09590.1; AT5G09590.1; AT5G09590.
KEGGiath:AT5G09590.

Organism-specific databases

TAIRiAT5G09590.

Phylogenomic databases

eggNOGiKOG0102. Eukaryota.
COG0443. LUCA.
HOGENOMiHOG000228135.
InParanoidiQ9LDZ0.
KOiK03283.
OMAiIFASNTK.
PhylomeDBiQ9LDZ0.

Miscellaneous databases

PROiQ9LDZ0.

Gene expression databases

GenevisibleiQ9LDZ0. AT.

Family and domain databases

Gene3Di1.20.1270.10. 1 hit.
2.60.34.10. 1 hit.
HAMAPiMF_00332. DnaK.
InterProiIPR012725. Chaperone_DnaK.
IPR018181. Heat_shock_70_CS.
IPR029048. HSP70_C.
IPR029047. HSP70_peptide-bd.
IPR013126. Hsp_70_fam.
[Graphical view]
PfamiPF00012. HSP70. 1 hit.
[Graphical view]
PRINTSiPR00301. HEATSHOCK70.
SUPFAMiSSF100920. SSF100920. 1 hit.
TIGRFAMsiTIGR02350. prok_dnaK. 1 hit.
PROSITEiPS00297. HSP70_1. 1 hit.
PS00329. HSP70_2. 1 hit.
PS01036. HSP70_3. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Comprehensive expression profile analysis of the Arabidopsis Hsp70 gene family."
    Sung D.Y., Vierling E., Guy C.L.
    Plant Physiol. 126:789-800(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], DNAK GENE SUBFAMILY, INDUCTION, DEVELOPMENTAL STAGE.
    Strain: cv. Columbia.
  2. "Sequence and analysis of chromosome 5 of the plant Arabidopsis thaliana."
    Tabata S., Kaneko T., Nakamura Y., Kotani H., Kato T., Asamizu E., Miyajima N., Sasamoto S., Kimura T., Hosouchi T., Kawashima K., Kohara M., Matsumoto M., Matsuno A., Muraki A., Nakayama S., Nakazaki N., Naruo K.
    , Okumura S., Shinpo S., Takeuchi C., Wada T., Watanabe A., Yamada M., Yasuda M., Sato S., de la Bastide M., Huang E., Spiegel L., Gnoj L., O'Shaughnessy A., Preston R., Habermann K., Murray J., Johnson D., Rohlfing T., Nelson J., Stoneking T., Pepin K., Spieth J., Sekhon M., Armstrong J., Becker M., Belter E., Cordum H., Cordes M., Courtney L., Courtney W., Dante M., Du H., Edwards J., Fryman J., Haakensen B., Lamar E., Latreille P., Leonard S., Meyer R., Mulvaney E., Ozersky P., Riley A., Strowmatt C., Wagner-McPherson C., Wollam A., Yoakum M., Bell M., Dedhia N., Parnell L., Shah R., Rodriguez M., Hoon See L., Vil D., Baker J., Kirchoff K., Toth K., King L., Bahret A., Miller B., Marra M.A., Martienssen R., McCombie W.R., Wilson R.K., Murphy G., Bancroft I., Volckaert G., Wambutt R., Duesterhoeft A., Stiekema W., Pohl T., Entian K.-D., Terryn N., Hartley N., Bent E., Johnson S., Langham S.-A., McCullagh B., Robben J., Grymonprez B., Zimmermann W., Ramsperger U., Wedler H., Balke K., Wedler E., Peters S., van Staveren M., Dirkse W., Mooijman P., Klein Lankhorst R., Weitzenegger T., Bothe G., Rose M., Hauf J., Berneiser S., Hempel S., Feldpausch M., Lamberth S., Villarroel R., Gielen J., Ardiles W., Bents O., Lemcke K., Kolesov G., Mayer K.F.X., Rudd S., Schoof H., Schueller C., Zaccaria P., Mewes H.-W., Bevan M., Fransz P.F.
    Nature 408:823-826(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: cv. Columbia.
  3. The Arabidopsis Information Resource (TAIR)
    Submitted (APR-2011) to the EMBL/GenBank/DDBJ databases
    Cited for: GENOME REANNOTATION.
    Strain: cv. Columbia.
  4. "Arabidopsis ORF clones."
    de los Reyes C., Quan R., Chen H., Bautista V., Kim C.J., Ecker J.R.
    Submitted (OCT-2008) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: cv. Columbia.
  5. "Genomic analysis of the Hsp70 superfamily in Arabidopsis thaliana."
    Lin B.L., Wang J.S., Liu H.C., Chen R.W., Meyer Y., Barakat A., Delseny M.
    Cell Stress Chaperones 6:201-208(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: GENE FAMILY, NOMENCLATURE.

Entry informationi

Entry nameiHSP7J_ARATH
AccessioniPrimary (citable) accession number: Q9LDZ0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 22, 2012
Last sequence update: October 1, 2000
Last modified: April 13, 2016
This is version 107 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Arabidopsis thaliana
    Arabidopsis thaliana: entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.