Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Protein SUPPRESSOR OF GENE SILENCING 3

Gene

SGS3

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Required for post-transcriptional gene silencing and natural virus resistance. May bind nucleic acids and is essential for the biogenesis of trans-acting siRNAs but is not required for silencing induced by IR-PTGS. Involved in the juvenile-to-adult transition regulation. In case of begomoviruses infection, it is targeted by the viral protein V2 leading to suppression of post-transcriptional gene silencing.2 Publications

GO - Biological processi

  • defense response to virus Source: TAIR
  • production of ta-siRNAs involved in RNA interference Source: TAIR
  • regulation of defense response to virus Source: UniProtKB-KW
  • vegetative phase change Source: TAIR
  • viral process Source: UniProtKB-KW
  • virus induced gene silencing Source: TAIR
  • wax biosynthetic process Source: TAIR

Keywordsi

Molecular functionAntiviral protein
Biological processHost-virus interaction, RNA-mediated gene silencing

Names & Taxonomyi

Protein namesi
Recommended name:
Protein SUPPRESSOR OF GENE SILENCING 3
Short name:
AtSGS3
Gene namesi
Name:SGS3
Ordered Locus Names:At5g23570
ORF Names:MQM1.17
OrganismiArabidopsis thaliana (Mouse-ear cress)
Taxonomic identifieri3702 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
Proteomesi
  • UP000006548 Componenti: Chromosome 5

Organism-specific databases

AraportiAT5G23570
TAIRilocus:2171716 AT5G23570

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Chloroplast Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertion Graphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi500E → K in sgs3-3; complete suppression of post-transcriptional gene silencing. 1 Publication1

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003332891 – 625Protein SUPPRESSOR OF GENE SILENCING 3Add BLAST625

Proteomic databases

PaxDbiQ9LDX1
PRIDEiQ9LDX1

Expressioni

Gene expression databases

ExpressionAtlasiQ9LDX1 baseline and differential
GenevisibleiQ9LDX1 AT

Interactioni

Subunit structurei

Interacts with begomoviruses protein V2.1 Publication

Protein-protein interaction databases

BioGridi17697, 1 interactor
DIPiDIP-29658N
IntActiQ9LDX1, 2 interactors
MINTiQ9LDX1
STRINGi3702.AT5G23570.1

Structurei

3D structure databases

ProteinModelPortaliQ9LDX1
SMRiQ9LDX1
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili452 – 533Sequence analysisAdd BLAST82
Coiled coili564 – 615Sequence analysisAdd BLAST52

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi75 – 111Gly-richAdd BLAST37
Compositional biasi156 – 189Asp-richAdd BLAST34
Compositional biasi540 – 543Poly-Gln4

Sequence similaritiesi

Belongs to the SGS3 family.Curated

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiENOG410IQ73 Eukaryota
ENOG4111E45 LUCA
HOGENOMiHOG000085166
InParanoidiQ9LDX1
OMAiNEPARQW
OrthoDBiEOG09360A3J
PhylomeDBiQ9LDX1

Family and domain databases

CDDicd12266 RRM_like_XS, 1 hit
Gene3Di3.30.70.2890, 1 hit
InterProiView protein in InterPro
IPR005380 XS_domain
IPR038588 XS_domain_sf
IPR005381 Znf-XS_domain
PfamiView protein in Pfam
PF03468 XS, 1 hit
PF03470 zf-XS, 1 hit

Sequencei

Sequence statusi: Complete.

Q9LDX1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSSRAGPMSK EKNVQGGYRP EVEQLVQGLA GTRLASSQDD GGEWEVISKK
60 70 80 90 100
NKNKPGNTSG KTWVSQNSNP PRAWGGQQQG RGSNVSGRGN NVSGRGNGNG
110 120 130 140 150
RGIQANISGR GRALSRKYDN NFVAPPPVSR PPLEGGWNWQ ARGGSAQHTA
160 170 180 190 200
VQEFPDVEDD VDNASEEEND SDALDDSDDD LASDDYDSDV SQKSHGSRKQ
210 220 230 240 250
NKWFKKFFGS LDSLSIEQIN EPQRQWHCPA CQNGPGAIDW YNLHPLLAHA
260 270 280 290 300
RTKGARRVKL HRELAEVLEK DLQMRGASVI PCGEIYGQWK GLGEDEKDYE
310 320 330 340 350
IVWPPMVIIM NTRLDKDDND KWLGMGNQEL LEYFDKYEAL RARHSYGPQG
360 370 380 390 400
HRGMSVLMFE SSATGYLEAE RLHRELAEMG LDRIAWGQKR SMFSGGVRQL
410 420 430 440 450
YGFLATKQDL DIFNQHSQGK TRLKFELKSY QEMVVKELRQ ISEDNQQLNY
460 470 480 490 500
FKNKLSKQNK HAKVLEESLE IMSEKLRRTA EDNRIVRQRT KMQHEQNREE
510 520 530 540 550
MDAHDRFFMD SIKQIHERRD AKEENFEMLQ QQERAKVVGQ QQQNINPSSN
560 570 580 590 600
DDCRKRAEEV SSFIEFQEKE MEEFVEEREM LIKDQEKKME DMKKRHHEEI
610 620
FDLEKEFDEA LEQLMYKHGL HNEDD
Length:625
Mass (Da):71,972
Last modified:October 1, 2000 - v1
Checksum:i456E2A1396706A96
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF239719 Genomic DNA Translation: AAF73960.1
AB025633 Genomic DNA Translation: BAA97244.1
CP002688 Genomic DNA Translation: AED93184.1
CP002688 Genomic DNA Translation: ANM69842.1
BT002944 mRNA Translation: AAO22757.1
BT004380 mRNA Translation: AAO42374.1
RefSeqiNP_001331491.1, NM_001343817.1
NP_197747.1, NM_122263.3
UniGeneiAt.31001

Genome annotation databases

EnsemblPlantsiAT5G23570.1; AT5G23570.1; AT5G23570
AT5G23570.3; AT5G23570.3; AT5G23570
GeneIDi832422
GrameneiAT5G23570.1; AT5G23570.1; AT5G23570
AT5G23570.3; AT5G23570.3; AT5G23570
KEGGiath:AT5G23570

Similar proteinsi

Entry informationi

Entry nameiSGS3_ARATH
AccessioniPrimary (citable) accession number: Q9LDX1
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 20, 2008
Last sequence update: October 1, 2000
Last modified: May 23, 2018
This is version 94 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Arabidopsis thaliana
    Arabidopsis thaliana: entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

Cookie policy

We would like to use anonymized google analytics cookies to gather statistics on how uniprot.org is used in aggregate. Learn more

UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health