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Protein

Alanine aminotransferase 2, mitochondrial

Gene

ALAAT2

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Catalytic activityi

L-alanine + 2-oxoglutarate = pyruvate + L-glutamate.

Cofactori

Pathwayi: C4 acid pathway

This protein is involved in the pathway C4 acid pathway, which is part of Photosynthesis.
View all proteins of this organism that are known to be involved in the pathway C4 acid pathway and in Photosynthesis.

Pathwayi: L-alanine degradation via transaminase pathway

This protein is involved in step 1 of the subpathway that synthesizes pyruvate from L-alanine.
Proteins known to be involved in this subpathway in this organism are:
  1. Alanine aminotransferase 1, mitochondrial (ALAAT1), Alanine aminotransferase 2, mitochondrial (ALAAT2), Glutamate--glyoxylate aminotransferase 2 (GGAT2), Glutamate--glyoxylate aminotransferase 1 (GGAT1)
This subpathway is part of the pathway L-alanine degradation via transaminase pathway, which is itself part of Amino-acid degradation.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes pyruvate from L-alanine, the pathway L-alanine degradation via transaminase pathway and in Amino-acid degradation.

GO - Molecular functioni

GO - Biological processi

  • biosynthetic process Source: InterPro
  • L-alanine catabolic process Source: UniProtKB-UniPathway
  • response to hypoxia Source: UniProtKB

Keywordsi

Molecular functionAminotransferase, Transferase
LigandPyridoxal phosphate

Enzyme and pathway databases

UniPathwayiUPA00322
UPA00528; UER00586

Names & Taxonomyi

Protein namesi
Recommended name:
Alanine aminotransferase 2, mitochondrial (EC:2.6.1.2)
Short name:
AtAlaAT2
Short name:
AtAlaATm
Alternative name(s):
Alanine-2-oxoglutarate aminotransferase 3 (EC:2.6.1.-)
Gene namesi
Name:ALAAT2
Synonyms:AOAT3
Ordered Locus Names:At1g72330
ORF Names:T10D10.20, T9N14.10
OrganismiArabidopsis thaliana (Mouse-ear cress)
Taxonomic identifieri3702 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
Proteomesi
  • UP000006548 Componenti: Chromosome 1

Organism-specific databases

AraportiAT1G72330

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Chloroplast Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertion Graphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Mitochondrion

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transit peptidei1 – 46Mitochondrion1 PublicationAdd BLAST46
ChainiPRO_000041604347 – 540Alanine aminotransferase 2, mitochondrialAdd BLAST494

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei357N6-(pyridoxal phosphate)lysineBy similarity1

Post-translational modificationi

The N-terminus is blocked.By similarity

Proteomic databases

PaxDbiQ9LDV4
PRIDEiQ9LDV4

Expressioni

Tissue specificityi

Expressed in shoots, essentially in leaves and flowers, mostly in vascular tissues. Also detected in stems and roots.2 Publications

Inductioni

Rapidly induced upon low-oxygen stress in roots and shoots.1 Publication

Gene expression databases

ExpressionAtlasiQ9LDV4 baseline and differential
GenevisibleiQ9LDV4 AT

Interactioni

Subunit structurei

Homodimer.By similarity

Protein-protein interaction databases

STRINGi3702.AT1G72330.3

Structurei

3D structure databases

ProteinModelPortaliQ9LDV4
SMRiQ9LDV4
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transit peptide

Phylogenomic databases

eggNOGiKOG0258 Eukaryota
COG0436 LUCA
HOGENOMiHOG000215020
InParanoidiQ9LDV4
KOiK00814
PhylomeDBiQ9LDV4

Family and domain databases

Gene3Di3.40.640.10, 1 hit
3.90.1150.10, 2 hits
InterProiView protein in InterPro
IPR004839 Aminotransferase_I/II
IPR015424 PyrdxlP-dep_Trfase
IPR015422 PyrdxlP-dep_Trfase_dom1
IPR015421 PyrdxlP-dep_Trfase_major
PfamiView protein in Pfam
PF00155 Aminotran_1_2, 1 hit
SUPFAMiSSF53383 SSF53383, 2 hits

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q9LDV4-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MRRFLINQAK GLVDHSRRQH HHKSPSFLSP QPRPLASSPP ALSRFFSSTS
60 70 80 90 100
EMSASDSTSS LPVTLDSINP KVLKCEYAVR GEIVNIAQKL QEDLKTNKDA
110 120 130 140 150
YPFDEIIYCN IGNPQSLGQL PIKFFREVLA LCDHASLLDE SETHGLFSTD
160 170 180 190 200
SIDRAWRILD HIPGRATGAY SHSQGIKGLR DVIAAGIEAR DGFPADPNDI
210 220 230 240 250
FLTDGASPAV HMMMQLLLSS EKDGILSPIP QYPLYSASIA LHGGSLVPYY
260 270 280 290 300
LDEATGWGLE ISDLKKQLEE ARSKGISVRA LVVINPGNPT GQVLAEENQR
310 320 330 340 350
DIVNFCKQEG LVLLADEVYQ ENVYVPDKKF HSFKKVARSL GYGEKDISLV
360 370 380 390 400
SFQSVSKGYY GECGKRGGYM EVTGFTSDVR EQIYKMASVN LCSNISGQIL
410 420 430 440 450
ASLVMSPPKP GDDSYDSYMA ERDGILSSMA KRAKTLEDAL NSLEGVTCNR
460 470 480 490 500
AEGAMYLFPR INLPQKAIEA AEAEKTAPDA FYCKRLLNAT GVVVVPGSGF
510 520 530 540
GQVPGTWHFR CTILPQEDKI PAIVNRLTEF HKSFMDEFRN
Length:540
Mass (Da):59,511
Last modified:October 1, 2000 - v1
Checksum:i4D1D4D4102CBD661
GO
Isoform 2 (identifier: Q9LDV4-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     410-540: PGDDSYDSYM...HKSFMDEFRN → KEMEFSHPWLNVQRLWKTLSTV

Note: Derived from EST data. No experimental confirmation available.
Show »
Length:431
Mass (Da):47,710
Checksum:i62385DCABF0834D1
GO

Sequence cautioni

The sequence AAG51787 differs from that shown. Reason: Erroneous gene model prediction.Curated
The sequence AEE35307 differs from that shown. Reason: Erroneous gene model prediction.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti265K → E in AAK59591 (PubMed:14593172).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_042467410 – 540PGDDS…DEFRN → KEMEFSHPWLNVQRLWKTLS TV in isoform 2. CuratedAdd BLAST131

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF275371 mRNA Translation: AAF82781.1
AC016529 Genomic DNA Translation: AAG52580.1
AC067754 Genomic DNA Translation: AAG51787.1 Sequence problems.
CP002684 Genomic DNA Translation: AEE35305.1
CP002684 Genomic DNA Translation: AEE35306.1
CP002684 Genomic DNA Translation: AEE35307.1 Sequence problems.
AY035086 mRNA Translation: AAK59591.2
PIRiB96747
RefSeqiNP_001077811.1, NM_001084342.1 [Q9LDV4-2]
NP_001185380.1, NM_001198451.1
NP_565040.2, NM_105892.5 [Q9LDV4-1]
UniGeneiAt.15579

Genome annotation databases

EnsemblPlantsiAT1G72330.1; AT1G72330.1; AT1G72330 [Q9LDV4-1]
AT1G72330.2; AT1G72330.2; AT1G72330 [Q9LDV4-2]
GeneIDi843565
GrameneiAT1G72330.1; AT1G72330.1; AT1G72330 [Q9LDV4-1]
AT1G72330.2; AT1G72330.2; AT1G72330 [Q9LDV4-2]
KEGGiath:AT1G72330

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Entry informationi

Entry nameiALAT2_ARATH
AccessioniPrimary (citable) accession number: Q9LDV4
Secondary accession number(s): F4IDA2
, F4IDA4, Q94C83, Q9C7S4
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 21, 2012
Last sequence update: October 1, 2000
Last modified: May 23, 2018
This is version 110 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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