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Protein

Peroxidase 37

Gene

PER37

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Removal of H2O2, oxidation of toxic reductants, biosynthesis and degradation of lignin, suberization, auxin catabolism, response to environmental stresses such as wounding, pathogen attack and oxidative stress. These functions might be dependent on each isozyme/isoform in each plant tissue.

Miscellaneous

There are 73 peroxidase genes in A.thaliana.

Catalytic activityi

2 phenolic donor + H2O2 = 2 phenoxyl radical of the donor + 2 H2O.

Cofactori

Protein has several cofactor binding sites:
  • heme bPROSITE-ProRule annotationNote: Binds 1 heme b (iron(II)-protoporphyrin IX) group per subunit.PROSITE-ProRule annotation
  • Ca2+PROSITE-ProRule annotationNote: Binds 2 calcium ions per subunit.PROSITE-ProRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sitei60Transition state stabilizerPROSITE-ProRule annotation1
Active sitei64Proton acceptorPROSITE-ProRule annotation1
Metal bindingi65Calcium 1PROSITE-ProRule annotation1
Metal bindingi68Calcium 1; via carbonyl oxygenPROSITE-ProRule annotation1
Metal bindingi70Calcium 1; via carbonyl oxygenPROSITE-ProRule annotation1
Metal bindingi72Calcium 1PROSITE-ProRule annotation1
Metal bindingi74Calcium 1PROSITE-ProRule annotation1
Binding sitei161Substrate; via carbonyl oxygenPROSITE-ProRule annotation1
Metal bindingi192Iron (heme axial ligand)PROSITE-ProRule annotation1
Metal bindingi193Calcium 2PROSITE-ProRule annotation1
Metal bindingi244Calcium 2PROSITE-ProRule annotation1
Metal bindingi247Calcium 2PROSITE-ProRule annotation1
Metal bindingi252Calcium 2PROSITE-ProRule annotation1

GO - Molecular functioni

GO - Biological processi

  • hydrogen peroxide catabolic process Source: UniProtKB-KW
  • negative regulation of growth Source: TAIR
  • response to oxidative stress Source: InterPro

Keywordsi

Molecular functionOxidoreductase, Peroxidase
Biological processHydrogen peroxide
LigandCalcium, Heme, Iron, Metal-binding

Enzyme and pathway databases

BioCyciARA:AT4G08770-MONOMER

Protein family/group databases

PeroxiBasei203 AtPrx37

Names & Taxonomyi

Protein namesi
Recommended name:
Peroxidase 37 (EC:1.11.1.7)
Short name:
Atperox P37
Alternative name(s):
ATP38
Gene namesi
Name:PER37
Synonyms:P37
Ordered Locus Names:At4g08770
ORF Names:T32A17.80
OrganismiArabidopsis thaliana (Mouse-ear cress)
Taxonomic identifieri3702 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
Proteomesi
  • UP000006548 Componenti: Chromosome 4

Organism-specific databases

AraportiAT4G08770
TAIRilocus:2138273 AT4G08770

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Chloroplast Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertion Graphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted, Vacuole

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 22Sequence analysisAdd BLAST22
ChainiPRO_000002370323 – 346Peroxidase 37Add BLAST324

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei23Pyrrolidone carboxylic acidPROSITE-ProRule annotationBy similarity1
Disulfide bondi33 ↔ 113PROSITE-ProRule annotation
Disulfide bondi66 ↔ 71PROSITE-ProRule annotation
Glycosylationi79N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi119 ↔ 323PROSITE-ProRule annotation
Disulfide bondi199 ↔ 231PROSITE-ProRule annotation
Glycosylationi208N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi236N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Disulfide bond, Glycoprotein, Pyrrolidone carboxylic acid

Proteomic databases

PaxDbiQ9LDN9
PRIDEiQ9LDN9

Expressioni

Gene expression databases

ExpressionAtlasiQ9LDN9 baseline and differential
GenevisibleiQ9LDN9 AT

Interactioni

Protein-protein interaction databases

BioGridi11746, 2 interactors
STRINGi3702.AT4G08770.1

Structurei

3D structure databases

ProteinModelPortaliQ9LDN9
SMRiQ9LDN9
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the peroxidase family. Classical plant (class III) peroxidase subfamily.PROSITE-ProRule annotation

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410JAWC Eukaryota
ENOG41119N5 LUCA
HOGENOMiHOG000237557
InParanoidiQ9LDN9
KOiK00430
OMAiDDSCPHV
OrthoDBiEOG09360FST
PhylomeDBiQ9LDN9

Family and domain databases

CDDicd00693 secretory_peroxidase, 1 hit
InterProiView protein in InterPro
IPR010255 Haem_peroxidase
IPR002016 Haem_peroxidase_pln/fun/bac
IPR000823 Peroxidase_pln
IPR019794 Peroxidases_AS
IPR019793 Peroxidases_heam-ligand_BS
IPR033905 Secretory_peroxidase
PfamiView protein in Pfam
PF00141 peroxidase, 1 hit
PRINTSiPR00458 PEROXIDASE
PR00461 PLPEROXIDASE
SUPFAMiSSF48113 SSF48113, 1 hit
PROSITEiView protein in PROSITE
PS00435 PEROXIDASE_1, 1 hit
PS00436 PEROXIDASE_2, 1 hit
PS50873 PEROXIDASE_4, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9LDN9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MHSSLIKLGF LLLLIQVSLS HAQLSPSFYD KTCPQVFDIA TTTIVNALRS
60 70 80 90 100
DPRIAASILR LHFHDCFVNG CDASILLDNT TSFRTEKDAF GNANSARGFD
110 120 130 140 150
VIDKMKAAVE KACPKTVSCA DLLAIAAQES VVLAGGPSWR VPNGRRDSLR
160 170 180 190 200
GFMDLANDNL PAPFFTLNQL KDRFKNVGLD RASDLVALSG GHTFGKNQCQ
210 220 230 240 250
FIMDRLYNFS NTGLPDPTLD KSYLSTLRKQ CPRNGNQSVL VDFDLRTPTL
260 270 280 290 300
FDNKYYVNLK ENKGLIQSDQ ELFSSPDASD TLPLVREYAD GQGKFFDAFA
310 320 330 340
KAMIRMSSLS PLTGKQGEIR LNCRVVNSKS KIMDVVEDAL EFASSM
Length:346
Mass (Da):38,203
Last modified:October 1, 2000 - v1
Checksum:i744A4B8B618E15EE
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti28F → L in AAM97030 (PubMed:14593172).Curated1
Sequence conflicti28F → L in AAN15499 (PubMed:14593172).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF452387 mRNA Translation: AAL40851.1
AL161512 Genomic DNA Translation: CAB78002.1
AL161813 Genomic DNA Translation: CAB82113.1
CP002687 Genomic DNA Translation: AEE82676.1
AY136364 mRNA Translation: AAM97030.1
BT000180 mRNA Translation: AAN15499.1
PIRiB85088
RefSeqiNP_192617.1, NM_116947.3
UniGeneiAt.4181
At.54214

Genome annotation databases

EnsemblPlantsiAT4G08770.1; AT4G08770.1; AT4G08770
GeneIDi826447
GrameneiAT4G08770.1; AT4G08770.1; AT4G08770
KEGGiath:AT4G08770

Similar proteinsi

Entry informationi

Entry nameiPER37_ARATH
AccessioniPrimary (citable) accession number: Q9LDN9
Secondary accession number(s): Q8L7B3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 6, 2002
Last sequence update: October 1, 2000
Last modified: April 25, 2018
This is version 133 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health