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Protein

Uridine 5'-monophosphate synthase

Gene

UMPS1

Organism
Oryza sativa subsp. japonica (Rice)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Catalytic activityi

Orotidine 5'-phosphate + diphosphate = orotate + 5-phospho-alpha-D-ribose 1-diphosphate.
Orotidine 5'-phosphate = UMP + CO2.

Pathwayi: UMP biosynthesis via de novo pathway

This protein is involved in step 1 and 2 of the subpathway that synthesizes UMP from orotate.
Proteins known to be involved in the 2 steps of the subpathway in this organism are:
  1. Uridine 5'-monophosphate synthase (UMPS2), Uridine 5'-monophosphate synthase (UMPS1)
  2. Orotidine 5'-phosphate decarboxylase (UMPS2), Uridine 5'-monophosphate synthase (UMPS2), Uridine 5'-monophosphate synthase (UMPS1)
This subpathway is part of the pathway UMP biosynthesis via de novo pathway, which is itself part of Pyrimidine metabolism.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes UMP from orotate, the pathway UMP biosynthesis via de novo pathway and in Pyrimidine metabolism.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei307By similarity1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDecarboxylase, Glycosyltransferase, Lyase, Multifunctional enzyme, Transferase
Biological processPyrimidine biosynthesis

Enzyme and pathway databases

ReactomeiR-OSA-500753 Pyrimidine biosynthesis
UniPathwayiUPA00070; UER00119
UPA00070; UER00120

Names & Taxonomyi

Protein namesi
Recommended name:
Uridine 5'-monophosphate synthase
Short name:
UMP synthase
Including the following 2 domains:
Orotate phosphoribosyltransferase (EC:2.4.2.10)
Short name:
OPRTase
Orotidine 5'-phosphate decarboxylase (EC:4.1.1.23)
Alternative name(s):
OMPdecase
Gene namesi
Name:UMPS1
Ordered Locus Names:Os01g0951200, LOC_Os01g72240
ORF Names:B1147A04.37, OsJ_04774
OrganismiOryza sativa subsp. japonica (Rice)
Taxonomic identifieri39947 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaLiliopsidaPoalesPoaceaeBOP cladeOryzoideaeOryzeaeOryzinaeOryzaOryza sativa
Proteomesi
  • UP000059680 Componenti: Chromosome 1

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00004230811 – 477Uridine 5'-monophosphate synthaseAdd BLAST477

Proteomic databases

PaxDbiQ9LDN2

Expressioni

Gene expression databases

ExpressionAtlasiQ9LDN2 baseline and differential
GenevisibleiQ9LDN2 OS

Interactioni

Protein-protein interaction databases

STRINGi39947.LOC_Os01g72240.1

Structurei

3D structure databases

ProteinModelPortaliQ9LDN2
SMRiQ9LDN2
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

In the N-terminal section; belongs to the purine/pyrimidine phosphoribosyltransferase family.Curated
In the C-terminal section; belongs to the OMP decarboxylase family.Curated

Phylogenomic databases

eggNOGiKOG1377 Eukaryota
COG0284 LUCA
COG0461 LUCA
InParanoidiQ9LDN2
KOiK13421
OMAiRVSMKPE
OrthoDBiEOG093602IE

Family and domain databases

CDDicd06223 PRTases_typeI, 1 hit
Gene3Di3.20.20.70, 1 hit
HAMAPiMF_01208 PyrE, 1 hit
InterProiView protein in InterPro
IPR013785 Aldolase_TIM
IPR014732 OMPdecase
IPR018089 OMPdecase_AS
IPR001754 OMPdeCOase_dom
IPR023031 OPRT
IPR004467 Or_phspho_trans_dom
IPR000836 PRibTrfase_dom
IPR029057 PRTase-like
IPR011060 RibuloseP-bd_barrel
PfamiView protein in Pfam
PF00215 OMPdecase, 1 hit
PF00156 Pribosyltran, 1 hit
SMARTiView protein in SMART
SM00934 OMPdecase, 1 hit
SUPFAMiSSF51366 SSF51366, 1 hit
SSF53271 SSF53271, 1 hit
TIGRFAMsiTIGR00336 pyrE, 1 hit
TIGR01740 pyrF, 1 hit
PROSITEiView protein in PROSITE
PS00156 OMPDECASE, 1 hit
PS00103 PUR_PYR_PR_TRANSFER, 1 hit

Sequencei

Sequence statusi: Complete.

Q9LDN2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDAAAQESLI LELHAIEAIK FGTFVLKSGI TSPIYLDLRA LVSHPGLLSS
60 70 80 90 100
IATLLHTLPA TRPYDLLCGV PYTALPIASV LSVHRSVPMV MRRKEAKAHG
110 120 130 140 150
TAKSIEGAFR AGEAVLIIED LVTSGASVLE TAAPLRDQGL VVADAVVVVD
160 170 180 190 200
REQGGRENLA ANGITLHSLM TLTEVLAVLL KHGKVTEEKA REVRQFLDAN
210 220 230 240 250
RKVTVPGAAG AVKPKAVRKG FAERAGLAKN PMGKRLFEVM EAKQSNLCVA
260 270 280 290 300
ADVGTAKELL ELAEKVGPEI CMLKTHVDIL SDFTPDFGAK LCSIAEKHNF
310 320 330 340 350
LIFEDRKFAD IGNTVTMQYE GGIFRILDWA DIVNAHIIPG PGIVDGLKLK
360 370 380 390 400
GLPKGRGLLL LAEMSSAGNL AHGEYTAAAV KIAEQHSDFV IGFISVNPAS
410 420 430 440 450
WSVAPSSPAF IHATPGVQMV SGGDALGQQY NTPHSVINDR GSDIIIVGRG
460 470
IIKASNPAET AREYRIQGWG AYQSSLP
Length:477
Mass (Da):50,804
Last modified:October 1, 2000 - v1
Checksum:i79DC3983BE8F8DC2
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB031395 mRNA Translation: BAA92171.1
AP003735 Genomic DNA Translation: BAB86207.1
AP008207 Genomic DNA Translation: BAF07326.1
AP014957 Genomic DNA Translation: BAS76243.1
CM000138 Genomic DNA Translation: EEE56010.1
AF210322 mRNA Translation: AAF61489.1
RefSeqiXP_015622485.1, XM_015766999.1
UniGeneiOs.4468

Genome annotation databases

EnsemblPlantsiOs01t0951200-01; Os01t0951200-01; Os01g0951200
GeneIDi4325739
GrameneiOs01t0951200-01; Os01t0951200-01; Os01g0951200
KEGGiosa:4325739

Similar proteinsi

Entry informationi

Entry nameiUMPS1_ORYSJ
AccessioniPrimary (citable) accession number: Q9LDN2
Secondary accession number(s): A0A0P0VCT6, Q9M666
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 24, 2013
Last sequence update: October 1, 2000
Last modified: February 28, 2018
This is version 125 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health