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Protein

Peptidyl-prolyl cis-trans isomerase FKBP42

Gene

FKBP42

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides (By similarity). Modulates the uptake of MRP substrates into the vacuole; reduces metolachlor-GS (MOC-GS) and enhances 17-beta-estradiol 17-(beta-D-glucuronide) (E217betaG) uptake. Regulates cell elongation and orientation. Functions as a positive regulator of PGP1-mediated auxin transport. Confers drug modulation of PGP1 efflux activity as interaction with NPA or flavonol quercetin prevents its physical and functional interaction with PGP1. Required for the proper localization of auxin-related ABCB transporters. Plays a role in brassinosteroid (BR) signaling pathway.By similarity6 Publications

Catalytic activityi

Peptidylproline (omega=180) = peptidylproline (omega=0).

GO - Molecular functioni

  • calmodulin binding Source: TAIR
  • peptidyl-prolyl cis-trans isomerase activity Source: TAIR

GO - Biological processi

  • auxin-activated signaling pathway Source: UniProtKB-KW
  • leaf development Source: TAIR

Keywordsi

Molecular functionCalmodulin-binding, Isomerase, Rotamase
Biological processAuxin signaling pathway

Protein family/group databases

TCDBi8.A.11.1.1 the immunophilin-like prolyl:peptidyl isomerase regulator (i-ppi) family

Names & Taxonomyi

Protein namesi
Recommended name:
Peptidyl-prolyl cis-trans isomerase FKBP42 (EC:5.2.1.8)
Short name:
PPIase FKBP42
Alternative name(s):
42 kDa peptidyl-prolyl isomerase
FK506-binding protein 42
Short name:
AtFKBP42
Immunophilin FKBP42
Protein TWISTED DWARF 1
Protein ULTRACURVATA 2
Rotamase
Gene namesi
Name:FKBP42
Synonyms:TWD1, UCU2
Ordered Locus Names:At3g21640
ORF Names:MIL23.21
OrganismiArabidopsis thaliana (Mouse-ear cress)
Taxonomic identifieri3702 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
Proteomesi
  • UP000006548 Componenti: Chromosome 3

Organism-specific databases

AraportiAT3G21640
TAIRilocus:2089890 AT3G21640

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Chloroplast Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertion Graphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei339 – 357Helical; Anchor for type IV membrane proteinAdd BLAST19

Keywords - Cellular componenti

Cell membrane, Endoplasmic reticulum, Membrane, Vacuole

Pathology & Biotechi

Disruption phenotypei

Plants display helical rotation of several organs.1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002260871 – 365Peptidyl-prolyl cis-trans isomerase FKBP42Add BLAST365

Proteomic databases

PaxDbiQ9LDC0

Expressioni

Gene expression databases

ExpressionAtlasiQ9LDC0 baseline and differential
GenevisibleiQ9LDC0 AT

Interactioni

Subunit structurei

Interacts with calmodulin (CaM), MRP1, MRP2, MDR1/PGP1, MDR11/PGP19 and SHD/HSP90. Interacts with 1-naphthylphthalamic acid (NPA).4 Publications

Binary interactionsi

Show more details

GO - Molecular functioni

  • calmodulin binding Source: TAIR

Protein-protein interaction databases

BioGridi7050, 31 interactors
IntActiQ9LDC0, 5 interactors
STRINGi3702.AT3G21640.1

Structurei

Secondary structure

1365
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi45 – 48Combined sources4
Beta strandi51 – 57Combined sources7
Beta strandi69 – 78Combined sources10
Turni79 – 81Combined sources3
Beta strandi84 – 87Combined sources4
Turni88 – 92Combined sources5
Beta strandi95 – 98Combined sources4
Helixi104 – 106Combined sources3
Helixi107 – 113Combined sources7
Beta strandi121 – 126Combined sources6
Helixi128 – 130Combined sources3
Turni131 – 135Combined sources5
Beta strandi137 – 141Combined sources5
Beta strandi149 – 159Combined sources11
Turni166 – 168Combined sources3
Helixi172 – 188Combined sources17
Beta strandi191 – 193Combined sources3
Helixi196 – 208Combined sources13
Helixi211 – 215Combined sources5
Helixi219 – 229Combined sources11
Helixi231 – 241Combined sources11
Turni242 – 244Combined sources3
Helixi247 – 259Combined sources13
Helixi264 – 275Combined sources12
Turni276 – 278Combined sources3
Helixi280 – 289Combined sources10

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2F4EX-ray2.32A/B1-180[»]
2IF4X-ray2.85A1-338[»]
ProteinModelPortaliQ9LDC0
SMRiQ9LDC0
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ9LDC0

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini67 – 159PPIase FKBP-typePROSITE-ProRule annotationAdd BLAST93
Repeati179 – 212TPR 1Add BLAST34
Repeati230 – 263TPR 2Add BLAST34
Repeati264 – 297TPR 3Add BLAST34

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni1 – 163Interaction with MDR1/PGP1Add BLAST163
Regioni163 – 337Interaction with MRP11 PublicationAdd BLAST175
Regioni310 – 326Calmodulin-bindingSequence analysisAdd BLAST17

Sequence similaritiesi

Belongs to the FKBP-type PPIase family.Curated

Keywords - Domaini

Repeat, TPR repeat, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG0543 Eukaryota
COG0545 LUCA
HOGENOMiHOG000006189
InParanoidiQ9LDC0
OMAiAIYRYKY
OrthoDBiEOG09360ESR
PhylomeDBiQ9LDC0

Family and domain databases

Gene3Di1.25.40.10, 1 hit
InterProiView protein in InterPro
IPR023566 PPIase_FKBP
IPR001179 PPIase_FKBP_dom
IPR013026 TPR-contain_dom
IPR011990 TPR-like_helical_dom_sf
IPR019734 TPR_repeat
PANTHERiPTHR43811 PTHR43811, 1 hit
PfamiView protein in Pfam
PF00254 FKBP_C, 1 hit
PF13181 TPR_8, 1 hit
SMARTiView protein in SMART
SM00028 TPR, 3 hits
SUPFAMiSSF48452 SSF48452, 1 hit
PROSITEiView protein in PROSITE
PS50059 FKBP_PPIASE, 1 hit
PS50005 TPR, 2 hits
PS50293 TPR_REGION, 2 hits

Sequencei

Sequence statusi: Complete.

Q9LDC0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDESLEHQTQ THDQESEIVT EGSAVVHSEP SQEGNVPPKV DSEAEVLDEK
60 70 80 90 100
VSKQIIKEGH GSKPSKYSTC FLHYRAWTKN SQHKFEDTWH EQQPIELVLG
110 120 130 140 150
KEKKELAGLA IGVASMKSGE RALVHVGWEL AYGKEGNFSF PNVPPMADLL
160 170 180 190 200
YEVEVIGFDE TKEGKARSDM TVEERIGAAD RRKMDGNSLF KEEKLEEAMQ
210 220 230 240 250
QYEMAIAYMG DDFMFQLYGK YQDMALAVKN PCHLNIAACL IKLKRYDEAI
260 270 280 290 300
GHCNIVLTEE EKNPKALFRR GKAKAELGQM DSARDDFRKA QKYAPDDKAI
310 320 330 340 350
RRELRALAEQ EKALYQKQKE MYKGIFKGKD EGGAKSKSLF WLIVLWQWFV
360
SLFSRIFRRH RVKAD
Length:365
Mass (Da):41,806
Last modified:October 1, 2000 - v1
Checksum:iC939B75EEC79EA87
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti107A → P in AAM13008 (PubMed:14593172).Curated1
Sequence conflicti107A → P in AAN65079 (PubMed:14593172).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ224640 mRNA Translation: CAC00654.1
AB019232 Genomic DNA Translation: BAB02359.1
CP002686 Genomic DNA Translation: AEE76533.1
AY093009 mRNA Translation: AAM13008.1
BT001192 mRNA Translation: AAN65079.1
RefSeqiNP_188801.2, NM_113059.3
UniGeneiAt.5664

Genome annotation databases

EnsemblPlantsiAT3G21640.1; AT3G21640.1; AT3G21640
GeneIDi821718
GrameneiAT3G21640.1; AT3G21640.1; AT3G21640
KEGGiath:AT3G21640

Similar proteinsi

Entry informationi

Entry nameiFKB42_ARATH
AccessioniPrimary (citable) accession number: Q9LDC0
Secondary accession number(s): Q8RWM0
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 7, 2006
Last sequence update: October 1, 2000
Last modified: May 23, 2018
This is version 132 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Arabidopsis thaliana
    Arabidopsis thaliana: entries and gene names
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

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