Reviewed, UniProtKB/Swiss-Prot Q9LC45 (TAGA_STAAU)

Names and origin

Protein names

Recommended name:
    Putative N-acetylmannosaminyltransferase
    EC=2.4.1.187
Alternative name(s):
    UDP-N-acetylmannosamine transferase
    N-acetylglucosaminyldiphospho-undecaprenol N-acetyl-beta-D-mannosaminyltransferase
    Major teichoic acid biosynthesis protein A

Gene names

Name:

tagA

Organism

Staphylococcus aureus

Taxonomic identifier

1280 [NCBI]

Taxonomic lineage

Bacteria › Firmicutes › Bacillales › Staphylococcus

Protein attributes

Sequence length	254 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Function	Catalyzes the conversion of GlcNAc-PP-undecaprenol into ManNAc-GlcNAc-PP-undecaprenol, a key lipid intermediate in the de novo synthesis of teichoic acid Potential.
Catalytic activity	UDP-N-acetyl-D-mannosamine + N-acetyl-D-glucosaminyldiphosphoundecaprenol = UDP + N-acetyl-beta-D-mannosaminyl-1,4-N-acetyl-D-glucosaminyldiphosphoundecaprenol.
Pathway	Cell wall biogenesis; poly(glycerol phosphate) teichoic acid biosynthesis.
Subcellular location	Secreted › cell wall By similarity.
Sequence similarities	Belongs to the glycosyltransferase 26 family.

Ontologies

Keywords
Biological process	Cell shape Cell wall biogenesis/degradation Teichoic acid biosynthesis
Cellular component	Secreted
Molecular function	Glycosyltransferase Transferase
Gene Ontology (GO)
Biological process	cell wall organization Inferred from electronic annotation. Source: UniProtKB-KW regulation of cell shape Inferred from electronic annotation. Source: UniProtKB-KW teichoic acid biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	cell wall Inferred from electronic annotation. Source: UniProtKB-SubCell extracellular region Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	N-acetylglucosaminyldiphosphoundecaprenol N-acetyl-beta-D-mannosaminyltransferase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 254	254	Putative N-acetylmannosaminyltransferase		PRO_0000208440

Sequences

	Sequence		Length	Mass (Da)
	Q9LC45-1 [UniParc]. Last modified December 6, 2005. Version 2. Checksum: 99C014388CFED0BB	FASTA	254	29,133
	10 20 30 40 50 60 MTVEERSNTA KVDILGVDFD NTTMLQMVEN IKTFFANQST NNLFIVTANP EIVNYATTHQ 70 80 90 100 110 120 AYLELINQAS YIVADGTGVV KASHRLKQPL AHRIPGIELM DECLKIAHVN HQKVFLLGAT 130 140 150 160 170 180 NEVVEAAQYA LQQRYPNISF AHHHGYIDLE DETVVKRIKL FKPDYIFVGM GFPKQEEWIM 190 200 210 220 230 240 THENQFESTV MMGVGGSLEV FAGAKKRAPY IFRKLNIEWI YRALIDWKRI GRLKSIPIFM 250 YKIAKAKRKI KKAK

References

[1]

"The staphylokinase gene is located in the structural gene encoding N-acetylmuramyl-L-alanine amidase in methicillin-resistant Staphylococcus aureus." Horii T., Yokoyama K., Barua S., Odagiri T., Futamura N., Hasegawa T., Ohta M. FEMS Microbiol. Lett. 185:221-224(2000) [PubMed: 10754251] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Strain: NU3-1.

Cross-references

Sequence databases
EMBLGenBankDDBJ	AB033232 Genomic DNA. Translation: BAA95012.1. Different initiation.
3D structure databases
ModBase	Search...
Enzyme and pathway databases
BRENDA	2.4.1.187. 95.
Family and domain databases
InterPro	IPR004629. WecB_TagA_CpsF. [Graphical view]
Pfam	PF03808. Glyco_tran_WecB. 1 hit. [Graphical view]
TIGRFAMs	TIGR00696. wecB_tagA_cpsF. 1 hit.
ProtoNet	Search...

Entry information

Entry name

TAGA_STAAU

Accession

Primary (citable) accession number: Q9LC45

Entry history

Integrated into UniProtKB/Swiss-Prot:	December 6, 2005
Last sequence update:	December 6, 2005
Last modified:	September 22, 2009
This is version 28 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)