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Protein
Submitted name:

Vacuolating cytotoxin

Gene

vacA

Organism
Helicobacter pylori (Campylobacter pylori)
Status
Unreviewed-Annotation score: Annotation score: 1 out of 5-Protein predictedi

Functioni

GO - Biological processi

Complete GO annotation...

Names & Taxonomyi

Protein namesi
Submitted name:
Vacuolating cytotoxinImported
Gene namesi
Name:vacAImported
OrganismiHelicobacter pylori (Campylobacter pylori)Imported
Taxonomic identifieri210 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaEpsilonproteobacteriaCampylobacteralesHelicobacteraceaeHelicobacter

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 3333Sequence analysisAdd
BLAST
Chaini34 – 13241291Sequence analysisPRO_5004328916Add
BLAST

Structurei

3D structure databases

ProteinModelPortaliQ9LBC7.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini1051 – 1324274Autotransporter (TC 1.B.12)InterPro annotationAdd
BLAST

Keywords - Domaini

SignalSequence analysis

Family and domain databases

Gene3Di2.40.128.130. 1 hit.
InterProiIPR005546. Autotransporte_beta.
IPR006315. OM_autotransptr_brl.
IPR003842. Vacuolating_cytotoxin.
[Graphical view]
PfamiPF02691. VacA. 1 hit.
[Graphical view]
PRINTSiPR01656. VACCYTOTOXIN.
SMARTiSM00869. Autotransporter. 1 hit.
[Graphical view]
SUPFAMiSSF103515. SSF103515. 1 hit.
TIGRFAMsiTIGR01414. autotrans_barl. 1 hit.
PROSITEiPS51208. AUTOTRANSPORTER. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9LBC7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MELQQTHRKI NRPLVSLALV GALVSITPQQ SHAAFFTTVI IPAIVGGIAT
60 70 80 90 100
GAAVGTVSGL LGWGLKQAEE ANKTPDKPDK VWCIQAGRGF NEFPNKEYDL
110 120 130 140 150
YKSLLSIKID GGWDWGNAAR HYWVKGGQWN KLEVDMKDAV GTYKLSGLKN
160 170 180 190 200
FTGGDLDVNM QKATLRLGQF NGNSFTSFKD SADRTTRVDF NAKNISIDNF
210 220 230 240 250
LESNNRVGSG AGRKASSTVL TLQASEGITS GKNAEISLYD GATLNLASNS
260 270 280 290 300
VKLMGNVWMG RLQYVGAYLA PSYSTINTSK VTGEVNFNHL TVGDRNAAQA
310 320 330 340 350
GIIASKKTYI GTLDLWQSAG LNIIAPPEGG YKDKPNNTNS QSGAKNDKNE
360 370 380 390 400
SAKNDKQDSN TQVINPPNSG QKTEIQPTQV IDGPFAGAKD TVVNINRINT
410 420 430 440 450
NADGTIKVGG YTASLTTNAA NLNIGKGGIN LSNQASGRSL LVENLTGNIT
460 470 480 490 500
VDGALMVNKE AGGAALPGSS ANFEFKAGVD TKNGTATFNN DIHLGKAVNL
510 520 530 540 550
KVDAHTINFN GNMYLGRFTH LKVNGHTANF KDIDASKGRN GIDTTILDFS
560 570 580 590 600
GVTNKVNINK LTTAATNAAI KNFDIKELVV TTNVLSVGKY TDFTEDIGDQ
610 620 630 640 650
SHIGIVRLQM GYSPAYSGGV NFKSGKKLVI DEIYHAPWNY FDARNITDVE
660 670 680 690 700
INKKILFGAP GYIAGKTGLM FNNLTLNSNA SMDYGKDLDL TIQGHFTNNQ
710 720 730 740 750
GTMNLFVQDG RVATLNAGHQ ASMMFNNLVD SATGFYKPLI KINNAQNLTK
760 770 780 790 800
NKEHVLVRAR NIDYNLVGVQ GASYDNIFAS NTNLQEQFKE RLALYNNNNR
810 820 830 840 850
MDICVVRNTN DIKACGMAIG NQSMVNNPEN YKYLEGKAWK NTGINKTADN
860 870 880 890 900
TTIAVNLGNN SAPTENGGNT TNLPTNTTNN ARFARFARYA LIKNAPFAHY
910 920 930 940 950
SATPNLVAIN KHDFGTIESV FELANRSKDI DTLYAHSGAQ GRDLLQTLLI
960 970 980 990 1000
DSHNAGYART MIDATSANEI TKQLNEANSA LNNIASLEHK TSGLQTLSLS
1010 1020 1030 1040 1050
NAMILNSRLV NLSRRHTNNI DSFAQRLQAL KDQRFASLES AAQVLYQFAP
1060 1070 1080 1090 1100
KYEKPTNVWA NAIGGASLNS GGNTSLYGTS AGVDAYLNEK VEAIVGGFGS
1110 1120 1130 1140 1150
YGYSSFNNQA NSLNFGANNA NFGVYSRIFA NRHEFDFEAQ GAVGSDQSSL
1160 1170 1180 1190 1200
NFKSALLRDL NQSYNYLAYG ATTRASYGYD FAFFRNAIVL KPSVGVRYNH
1210 1220 1230 1240 1250
LGSTNFESNS THKTALKNGA SSQHLFNASA NVEARYYYGD TSYFYMNAGV
1260 1270 1280 1290 1300
LQEFANFGSS NAVSLNTFKV NAARNPLNTH ARVMMGGELQ LAKEVFLNLG
1310 1320
FIYLHNLISN AGYFASNLGM RYSF
Length:1,324
Mass (Da):143,415
Last modified:October 1, 2000 - v1
Checksum:i739AF6E00C05C1D2
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF050320 Genomic DNA. Translation: AAF26502.1.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF050320 Genomic DNA. Translation: AAF26502.1.

3D structure databases

ProteinModelPortaliQ9LBC7.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Family and domain databases

Gene3Di2.40.128.130. 1 hit.
InterProiIPR005546. Autotransporte_beta.
IPR006315. OM_autotransptr_brl.
IPR003842. Vacuolating_cytotoxin.
[Graphical view]
PfamiPF02691. VacA. 1 hit.
[Graphical view]
PRINTSiPR01656. VACCYTOTOXIN.
SMARTiSM00869. Autotransporter. 1 hit.
[Graphical view]
SUPFAMiSSF103515. SSF103515. 1 hit.
TIGRFAMsiTIGR01414. autotrans_barl. 1 hit.
PROSITEiPS51208. AUTOTRANSPORTER. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Allelic variation of vacA gene in the Chinese Helicobacter pylori."
    Ji X., Telford J.L., Burroni D., Guidotti S., Pagliaccia C., Rayrat J.M., Xu G., Rappuoli R.
    Submitted (FEB-1998) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: CHN5147cImported.

Entry informationi

Entry nameiQ9LBC7_HELPX
AccessioniPrimary (citable) accession number: Q9LBC7
Entry historyi
Integrated into UniProtKB/TrEMBL: October 1, 2000
Last sequence update: October 1, 2000
Last modified: March 16, 2016
This is version 39 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.