SubmitCancel

Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

Q9L8F6

- MDH_VIBMI

UniProt

Q9L8F6 - MDH_VIBMI

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein
Malate dehydrogenase
Gene
mdh
Organism
Vibrio mimicus
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalyzes the reversible oxidation of malate to oxaloacetate By similarity.

Catalytic activityi

(S)-malate + NAD+ = oxaloacetate + NADH.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei27 – 271NAD By similarity
Binding sitei74 – 741Substrate By similarity
Binding sitei80 – 801Substrate By similarity
Binding sitei87 – 871NAD By similarity
Binding sitei112 – 1121Substrate By similarity
Binding sitei146 – 1461Substrate By similarity
Active sitei170 – 1701Proton acceptor By similarity
Binding sitei220 – 2201NAD By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi1 – 66NAD By similarity
Nucleotide bindingi110 – 1123NAD By similarity

GO - Molecular functioni

  1. L-malate dehydrogenase activity Source: UniProtKB-EC
Complete GO annotation...

GO - Biological processi

  1. cellular carbohydrate metabolic process Source: InterPro
  2. malate metabolic process Source: InterPro
  3. tricarboxylic acid cycle Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Tricarboxylic acid cycle

Keywords - Ligandi

NAD

Names & Taxonomyi

Protein namesi
Recommended name:
Malate dehydrogenase (EC:1.1.1.37)
Gene namesi
Name:mdh
OrganismiVibrio mimicus
Taxonomic identifieri674 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaVibrionalesVibrionaceaeVibrio

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini‹1 – ›222›222Malate dehydrogenase
PRO_0000113331Add
BLAST

Proteomic databases

PRIDEiQ9L8F6.

Interactioni

Subunit structurei

Homodimer By similarity.

Structurei

3D structure databases

ProteinModelPortaliQ9L8F6.
SMRiQ9L8F6. Positions 1-222.

Family & Domainsi

Sequence similaritiesi

Family and domain databases

Gene3Di3.40.50.720. 1 hit.
3.90.110.10. 1 hit.
InterProiIPR001557. L-lactate/malate_DH.
IPR022383. Lactate/malate_DH_C.
IPR001236. Lactate/malate_DH_N.
IPR015955. Lactate_DH/Glyco_Ohase_4_C.
IPR001252. Malate_DH_AS.
IPR010097. Malate_DH_type1.
IPR016040. NAD(P)-bd_dom.
[Graphical view]
PANTHERiPTHR11540. PTHR11540. 1 hit.
PfamiPF02866. Ldh_1_C. 1 hit.
PF00056. Ldh_1_N. 1 hit.
[Graphical view]
SUPFAMiSSF56327. SSF56327. 1 hit.
TIGRFAMsiTIGR01772. MDH_euk_gproteo. 1 hit.
PROSITEiPS00068. MDH. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Fragment.

Q9L8F6-1 [UniParc]FASTAAdd to Basket

« Hide

AAGGIGQALA LLLKNRLPAG SDLALYDIAP VTPGVAADLS HIPTPVTIKG    50
YAGEDPTPAL EGADVVLVSA GVARKPGMDR ADLFNVNAGI VKALAETIAV 100
VCPKACVGII TNPVNTTVPI AAEVLKKAGV YDKRKLFGVT TLDVIRSETF 150
VAALKDKDPG QVRVPVIGGH SGVTILPLLS QVEGVTFTDE EVAALTKRIQ 200
NAGTEVVEAK AGGGSATFSM GQ 222
Length:222
Mass (Da):22,601
Last modified:October 1, 2000 - v1
Checksum:i593BDCAFBEAE464A
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti194 – 1941A → V in strain: 523-80.

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti211 – 2111A → R in AAK15060. 1 Publication
Sequence conflicti211 – 2111A → R in AAK15061. 1 Publication
Sequence conflicti211 – 2111A → R in AAK15062. 1 Publication
Sequence conflicti218 – 2181F → L in AAK15060. 1 Publication
Sequence conflicti218 – 2181F → L in AAK15061. 1 Publication
Sequence conflicti218 – 2181F → L in AAK15062. 1 Publication

Non-terminal residue

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Non-terminal residuei1 – 11
Non-terminal residuei222 – 2221

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF207856 Genomic DNA. Translation: AAF40141.1.
AF238335 Genomic DNA. Translation: AAK15060.1.
AF238336 Genomic DNA. Translation: AAK15061.1.
AF238337 Genomic DNA. Translation: AAK15062.1.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF207856 Genomic DNA. Translation: AAF40141.1 .
AF238335 Genomic DNA. Translation: AAK15060.1 .
AF238336 Genomic DNA. Translation: AAK15061.1 .
AF238337 Genomic DNA. Translation: AAK15062.1 .

3D structure databases

ProteinModelPortali Q9L8F6.
SMRi Q9L8F6. Positions 1-222.
ModBasei Search...

Proteomic databases

PRIDEi Q9L8F6.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Family and domain databases

Gene3Di 3.40.50.720. 1 hit.
3.90.110.10. 1 hit.
InterProi IPR001557. L-lactate/malate_DH.
IPR022383. Lactate/malate_DH_C.
IPR001236. Lactate/malate_DH_N.
IPR015955. Lactate_DH/Glyco_Ohase_4_C.
IPR001252. Malate_DH_AS.
IPR010097. Malate_DH_type1.
IPR016040. NAD(P)-bd_dom.
[Graphical view ]
PANTHERi PTHR11540. PTHR11540. 1 hit.
Pfami PF02866. Ldh_1_C. 1 hit.
PF00056. Ldh_1_N. 1 hit.
[Graphical view ]
SUPFAMi SSF56327. SSF56327. 1 hit.
TIGRFAMsi TIGR01772. MDH_euk_gproteo. 1 hit.
PROSITEi PS00068. MDH. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Infectious CTXPhi and the Vibrio pathogenicity island prophage in Vibrio mimicus: evidence for recent horizontal transfer between V. mimicus and V. cholerae."
    Boyd E.F., Moyer K.E., Shi L., Waldor M.K.
    Infect. Immun. 68:1507-1513(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: PT5.
  2. "Molecular analyses of a putative CTXphi precursor and evidence for independent acquisition of distinct CTXphis by toxigenic Vibrio cholerae."
    Boyd E.F., Heilpern A.J., Waldor M.K.
    J. Bacteriol. 182:5530-5538(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 19-222.
    Strain: 523-80, PT48 and PT5.

Entry informationi

Entry nameiMDH_VIBMI
AccessioniPrimary (citable) accession number: Q9L8F6
Secondary accession number(s): Q99PX6, Q9AIU1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 7, 2004
Last sequence update: October 1, 2000
Last modified: February 19, 2014
This is version 66 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi