Reviewed, UniProtKB/Swiss-Prot Q9L888 (ALR_MYCAV)

Names and origin

Protein names

Recommended name:
    Alanine racemase
    EC=5.1.1.1

Gene names

Name:

alr

Organism

Mycobacterium avium

Taxonomic identifier

1764 [NCBI]

Taxonomic lineage

Bacteria › Actinobacteria › Actinobacteridae › Actinomycetales › Corynebacterineae › Mycobacteriaceae › Mycobacterium › Mycobacterium avium complex (MAC)

Protein attributes

Sequence length	388 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Function	Provides the D-alanine required for cell wall biosynthesis. HAMAP MF_01201
Catalytic activity	L-alanine = D-alanine. HAMAP MF_01201
Cofactor	Pyridoxal phosphate By similarity.
Pathway	Amino-acid biosynthesis; D-alanine biosynthesis; D-alanine from L-alanine: step 1/1. HAMAP MF_01201 Cell wall biogenesis; peptidoglycan biosynthesis. HAMAP MF_01201
Sequence similarities	Belongs to the alanine racemase family.

Ontologies

Keywords
Biological process	Cell shape Cell wall biogenesis/degradation Peptidoglycan synthesis
Ligand	Pyridoxal phosphate
Molecular function	Isomerase
Gene Ontology (GO)
Biological process	alanine metabolic process Inferred from electronic annotation. Source: HAMAP cell wall organization Inferred from electronic annotation. Source: UniProtKB-KW peptidoglycan biosynthetic process Inferred from electronic annotation. Source: HAMAP regulation of cell shape Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	alanine racemase activity Inferred from electronic annotation. Source: HAMAP pyridoxal phosphate binding Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 388	388	Alanine racemase HAMAP MF_01201		PRO_0000114535
Sites
	Active site	44	1	Proton acceptor; specific for D-alanine By similarity
	Active site	273	1	Proton acceptor; specific for L-alanine By similarity
Amino acid modifications
	Modified residue	44	1	N6-(pyridoxal phosphate)lysine By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q9L888-1 [UniParc]. Last modified March 5, 2002. Version 2. Checksum: 1A978A3C7546CB2A	FASTA	388	41,002
	10 20 30 40 50 60 MAVTPISLTP GVLAEALVDL GAIEHNVRLL CEQARGAQVM AVVKADGYGH GAVQTARAAL 70 80 90 100 110 120 AAGAAELGVA TVDEALALRA AGISAPVLAW LHPPGIDFRP ALLAGVQIGL SSQRQLDELL 130 140 150 160 170 180 TAVRDTGRTA TVTVKVDTGL NRNGVPPAQY PSMLTALRRA VAEQAIVPRG LMSHMVYADQ 190 200 210 220 230 240 PANPVNDVQA QRFTDMLAQA REQGVRFEVA HLSNSSATMS RPDLAFDMVR PGIAVYGLSP 250 260 270 280 290 300 VPELGDMGLV PAMTVKCTVA LVKSIRAGES VSYGHTWTAQ RDTNLALLPV GYADGIFRSL 310 320 330 340 350 360 GGRLQVSING RRRPGVGRIC MDQFVVDLGP GRPDVAEGDE AILFGPGSNG EPTAQDWADL 370 380 LGTIHYEVVT SPRGRITRTY REAHTVES

References

[1]	"Characterization of the alanine racemases from two Mycobacteria." Strych U., Penland R.L., Jimenez M., Krause K.L., Benedik M.J. FEMS Microbiol. Lett. 196:93-98(2001) [PubMed: 11267762] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Strain: 2151.

Cross-references

Sequence databases
EMBLGenBankDDBJ	AF214487 Genomic DNA. Translation: AAF25943.1. Different initiation.
3D structure databases
HSSP	HSSP built from PDB template 1BD0 based on UniProtKB P10724.
SMR	Q9L888. Positions 13-383.
ModBase	Search...
Enzyme and pathway databases
BRENDA	5.1.1.1. 599.
Family and domain databases
HAMAP	MF_01201. [Tree]
InterPro	IPR011079. Ala_racemase_C. IPR001608. Ala_racemase_N. IPR000821. Ala_racemase_reg. [Graphical view]
Pfam	PF00842. Ala_racemase_C. 1 hit. PF01168. Ala_racemase_N. 1 hit. [Graphical view]
PRINTS	PR00992. ALARACEMASE.
TIGRFAMs	TIGR00492. alr. 1 hit.
PROSITE	PS00395. ALANINE_RACEMASE. 1 hit. [Graphical view]
ProtoNet	Search...
Other Resources
DrugBank	DB00260. Cycloserine.

Entry information

Entry name

ALR_MYCAV

Accession

Primary (citable) accession number: Q9L888

Entry history

Integrated into UniProtKB/Swiss-Prot:	April 27, 2001
Last sequence update:	March 5, 2002
Last modified:	May 26, 2009
This is version 57 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)