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Q9L7X5

- CLPX_BRUAB

UniProt

Q9L7X5 - CLPX_BRUAB

Protein

ATP-dependent Clp protease ATP-binding subunit ClpX

Gene

clpX

Organism
Brucella abortus biovar 1 (strain 9-941)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 83 (01 Oct 2014)
      Sequence version 2 (21 Jun 2005)
      Previous versions | rss
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    Functioni

    ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP.UniRule annotation

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Zinc fingeri17 – 4226C4-typeUniRule annotationAdd
    BLAST
    Nucleotide bindingi121 – 1288ATPUniRule annotation

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-HAMAP
    2. nucleoside-triphosphatase activity Source: InterPro
    3. zinc ion binding Source: InterPro

    GO - Biological processi

    1. protein folding Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Chaperone

    Keywords - Ligandi

    ATP-binding, Metal-binding, Nucleotide-binding, Zinc

    Enzyme and pathway databases

    BioCyciBABO262698:GJC2-1136-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    ATP-dependent Clp protease ATP-binding subunit ClpXUniRule annotation
    Gene namesi
    Name:clpXUniRule annotation
    Ordered Locus Names:BruAb1_1114
    OrganismiBrucella abortus biovar 1 (strain 9-941)
    Taxonomic identifieri262698 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhizobialesBrucellaceaeBrucella
    ProteomesiUP000000540: Chromosome I

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 424424ATP-dependent Clp protease ATP-binding subunit ClpXPRO_0000160325Add
    BLAST

    Proteomic databases

    PRIDEiQ9L7X5.

    Interactioni

    Subunit structurei

    Component of the ClpX-ClpP complex. Forms a hexameric ring that, in the presence of ATP, binds to fourteen ClpP subunits assembled into a disk-like structure with a central cavity, resembling the structure of eukaryotic proteasomes.UniRule annotation

    Protein-protein interaction databases

    STRINGi262698.BruAb1_1114.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9L7X5.
    SMRiQ9L7X5. Positions 11-53.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the ClpX chaperone family.UniRule annotation

    Zinc finger

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Zinc fingeri17 – 4226C4-typeUniRule annotationAdd
    BLAST

    Keywords - Domaini

    Zinc-finger

    Phylogenomic databases

    eggNOGiCOG1219.
    HOGENOMiHOG000010093.
    KOiK03544.
    OMAiKLFSMEG.
    OrthoDBiEOG625JZK.

    Family and domain databases

    Gene3Di3.40.50.300. 2 hits.
    HAMAPiMF_00175. ClpX.
    InterProiIPR003593. AAA+_ATPase.
    IPR003959. ATPase_AAA_core.
    IPR019489. Clp_ATPase_C.
    IPR004487. Clp_protease_ATP-bd_su_ClpX.
    IPR027417. P-loop_NTPase.
    IPR010603. Znf_CppX_C4.
    [Graphical view]
    PfamiPF07724. AAA_2. 1 hit.
    PF10431. ClpB_D2-small. 1 hit.
    PF06689. zf-C4_ClpX. 1 hit.
    [Graphical view]
    SMARTiSM00382. AAA. 1 hit.
    SM01086. ClpB_D2-small. 1 hit.
    SM00994. zf-C4_ClpX. 1 hit.
    [Graphical view]
    SUPFAMiSSF52540. SSF52540. 1 hit.
    TIGRFAMsiTIGR00382. clpX. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Q9L7X5-1 [UniParc]FASTAAdd to Basket

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    MSKVSNGGGD SKNTLYCSFC GKSQHEVRKL IAGPTVFICD ECVELCMDII    50
    REENKSSMVK SREGVPTPQE IMAVLDDYVI GQKDAKRVLS VAVHNHYKRL 100
    AHQSKNSDIE LAKSNILLVG PTGCGKTYLA QTLARIIDVP FIMADATTLT 150
    EAGYVGEDVE NIILKLLQAA DYNVERAQRG IVYIDEVDKI SRKSDNPSIT 200
    RDVSGEGVQQ ALLKIMEGTV ASVPPQGGRK HPQQEFLQVD TTNILFICGG 250
    AFAGLDRIIS ARGEKTSIGF GATVKSVDER RIGEVFKELE PEDLLKFGLI 300
    PEFVGRLPVI ATLEDLDVDA LVQILTEPKN ALVKQYQRLF DMENVELVFH 350
    DDALRAIANK AVERKTGARG LRSIMEKILL DTMFELPTLE GVREVVISGD 400
    VVDGSARPLY IYAERQDEKG NVSA 424
    Length:424
    Mass (Da):46,656
    Last modified:June 21, 2005 - v2
    Checksum:i6A68089A37209608
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti68 – 703PQE → RRQ in AAF32319. 1 PublicationCurated
    Sequence conflicti178 – 1781Missing1 PublicationCurated
    Sequence conflicti180 – 1801G → S1 PublicationCurated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF218420 Genomic DNA. Translation: AAF32319.1.
    AE017223 Genomic DNA. Translation: AAX74455.1.
    RefSeqiYP_221816.1. NC_006932.1.

    Genome annotation databases

    EnsemblBacteriaiAAX74455; AAX74455; BruAb1_1114.
    GeneIDi3340036.
    KEGGibmb:BruAb1_1114.
    PATRICi17823917. VBIBruAbo15061_1181.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF218420 Genomic DNA. Translation: AAF32319.1 .
    AE017223 Genomic DNA. Translation: AAX74455.1 .
    RefSeqi YP_221816.1. NC_006932.1.

    3D structure databases

    ProteinModelPortali Q9L7X5.
    SMRi Q9L7X5. Positions 11-53.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 262698.BruAb1_1114.

    Proteomic databases

    PRIDEi Q9L7X5.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AAX74455 ; AAX74455 ; BruAb1_1114 .
    GeneIDi 3340036.
    KEGGi bmb:BruAb1_1114.
    PATRICi 17823917. VBIBruAbo15061_1181.

    Phylogenomic databases

    eggNOGi COG1219.
    HOGENOMi HOG000010093.
    KOi K03544.
    OMAi KLFSMEG.
    OrthoDBi EOG625JZK.

    Enzyme and pathway databases

    BioCyci BABO262698:GJC2-1136-MONOMER.

    Family and domain databases

    Gene3Di 3.40.50.300. 2 hits.
    HAMAPi MF_00175. ClpX.
    InterProi IPR003593. AAA+_ATPase.
    IPR003959. ATPase_AAA_core.
    IPR019489. Clp_ATPase_C.
    IPR004487. Clp_protease_ATP-bd_su_ClpX.
    IPR027417. P-loop_NTPase.
    IPR010603. Znf_CppX_C4.
    [Graphical view ]
    Pfami PF07724. AAA_2. 1 hit.
    PF10431. ClpB_D2-small. 1 hit.
    PF06689. zf-C4_ClpX. 1 hit.
    [Graphical view ]
    SMARTi SM00382. AAA. 1 hit.
    SM01086. ClpB_D2-small. 1 hit.
    SM00994. zf-C4_ClpX. 1 hit.
    [Graphical view ]
    SUPFAMi SSF52540. SSF52540. 1 hit.
    TIGRFAMsi TIGR00382. clpX. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "The Brucella abortus clpP and clpX are not subject to classical heat shock regulation and are critical for cell viability."
      Robertson G.T., Roop R.M. II
      Submitted (DEC-1999) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    2. "Completion of the genome sequence of Brucella abortus and comparison to the highly similar genomes of Brucella melitensis and Brucella suis."
      Halling S.M., Peterson-Burch B.D., Bricker B.J., Zuerner R.L., Qing Z., Li L.-L., Kapur V., Alt D.P., Olsen S.C.
      J. Bacteriol. 187:2715-2726(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: 9-941.

    Entry informationi

    Entry nameiCLPX_BRUAB
    AccessioniPrimary (citable) accession number: Q9L7X5
    Secondary accession number(s): Q57D29
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 31, 2003
    Last sequence update: June 21, 2005
    Last modified: October 1, 2014
    This is version 83 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome

    Documents

    1. Brucella abortus strain 9-941
      Brucella abortus (strain 9-941): entries and gene names
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3