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Protein

3-sulfolactaldehyde reductase

Gene

yihU

Organism
Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Reduces 3-sulfolactaldehyde (SLA) to 2,3-dihydroxypropane 1-sulfonate (DHPS).UniRule annotation

Catalytic activityi

2,3-dihydroxypropane-1-sulfonate + NAD+ = 2-hydroxy-3-oxopropane-1-sulfonate + NADH.UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei96NADUniRule annotation1
Active sitei171UniRule annotation1
Binding sitei240NADUniRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi5 – 19NADUniRule annotationAdd BLAST15

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Ligandi

NAD

Names & Taxonomyi

Protein namesi
Recommended name:
3-sulfolactaldehyde reductaseUniRule annotation (EC:1.1.1.373UniRule annotation)
Short name:
SLA reductaseUniRule annotation
Gene namesi
Name:yihU
Ordered Locus Names:STM4023
OrganismiSalmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720)
Taxonomic identifieri99287 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesEnterobacteriaceaeSalmonella
Proteomesi
  • UP000001014 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001730651 – 2983-sulfolactaldehyde reductaseAdd BLAST298

Proteomic databases

PaxDbiQ9L7S0.

Interactioni

Protein-protein interaction databases

STRINGi99287.STM4023.

Structurei

3D structure databases

ProteinModelPortaliQ9L7S0.
SMRiQ9L7S0.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the 3-hydroxyisobutyrate dehydrogenase family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105CF3. Bacteria.
COG2084. LUCA.
HOGENOMiHOG000219610.
KOiK08318.
OMAiPAGQHVE.
PhylomeDBiQ9L7S0.

Family and domain databases

Gene3Di1.10.1040.10. 1 hit.
3.40.50.720. 1 hit.
HAMAPiMF_01913. SLA_reductase. 1 hit.
InterProiIPR002204. 3-OH-isobutyrate_DH-rel_CS.
IPR008927. 6-PGluconate_DH_C-like.
IPR013328. 6PGD_dom_2.
IPR006115. 6PGDH_NADP-bd.
IPR015815. HIBADH-related.
IPR016040. NAD(P)-bd_dom.
IPR029154. NADP-bd.
IPR030876. SLA_reductase.
[Graphical view]
PfamiPF14833. NAD_binding_11. 1 hit.
PF03446. NAD_binding_2. 1 hit.
[Graphical view]
PIRSFiPIRSF000103. HIBADH. 1 hit.
SUPFAMiSSF48179. SSF48179. 1 hit.
SSF51735. SSF51735. 1 hit.
PROSITEiPS00895. 3_HYDROXYISOBUT_DH. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9L7S0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAVIAFIGLG QMGSPMASNL LKQGHQLSVF DVNPDAVQRL VDKGAQPASS
60 70 80 90 100
PAQATIGAEF VITMLPNGDL VRSVLFGEQG VCETLSREAL VIDMSTIHPL
110 120 130 140 150
QTDNLIADMQ SKGFSMMDVP IGRTSDNAIT GTLLLLAGGT AEQVERATPV
160 170 180 190 200
LMAMGNELVN TGGPGMGIRV KLINNYMSIA LNALSAEAAV LCEALGLSFD
210 220 230 240 250
VALKVMSGTA AGKGHFTTTW PNKVMKGDLS PAFMIDLAHK DLGIALDVAN
260 270 280 290
QLHVPMPLGA ASREVYNLAR AAGRGREDWS AILEQVRISA GLTANVKK
Length:298
Mass (Da):31,280
Last modified:October 1, 2000 - v1
Checksum:i7ED9FA174249240C
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF220438 Genomic DNA. Translation: AAF27921.1.
AE006468 Genomic DNA. Translation: AAL22862.1.
RefSeqiNP_462903.1. NC_003197.1.
WP_000268252.1. NC_003197.1.

Genome annotation databases

EnsemblBacteriaiAAL22862; AAL22862; STM4023.
GeneIDi1255549.
KEGGistm:STM4023.
PATRICi32386916. VBISalEnt20916_4238.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF220438 Genomic DNA. Translation: AAF27921.1.
AE006468 Genomic DNA. Translation: AAL22862.1.
RefSeqiNP_462903.1. NC_003197.1.
WP_000268252.1. NC_003197.1.

3D structure databases

ProteinModelPortaliQ9L7S0.
SMRiQ9L7S0.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi99287.STM4023.

Proteomic databases

PaxDbiQ9L7S0.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAL22862; AAL22862; STM4023.
GeneIDi1255549.
KEGGistm:STM4023.
PATRICi32386916. VBISalEnt20916_4238.

Phylogenomic databases

eggNOGiENOG4105CF3. Bacteria.
COG2084. LUCA.
HOGENOMiHOG000219610.
KOiK08318.
OMAiPAGQHVE.
PhylomeDBiQ9L7S0.

Family and domain databases

Gene3Di1.10.1040.10. 1 hit.
3.40.50.720. 1 hit.
HAMAPiMF_01913. SLA_reductase. 1 hit.
InterProiIPR002204. 3-OH-isobutyrate_DH-rel_CS.
IPR008927. 6-PGluconate_DH_C-like.
IPR013328. 6PGD_dom_2.
IPR006115. 6PGDH_NADP-bd.
IPR015815. HIBADH-related.
IPR016040. NAD(P)-bd_dom.
IPR029154. NADP-bd.
IPR030876. SLA_reductase.
[Graphical view]
PfamiPF14833. NAD_binding_11. 1 hit.
PF03446. NAD_binding_2. 1 hit.
[Graphical view]
PIRSFiPIRSF000103. HIBADH. 1 hit.
SUPFAMiSSF48179. SSF48179. 1 hit.
SSF51735. SSF51735. 1 hit.
PROSITEiPS00895. 3_HYDROXYISOBUT_DH. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiSQUU_SALTY
AccessioniPrimary (citable) accession number: Q9L7S0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 29, 2001
Last sequence update: October 1, 2000
Last modified: November 2, 2016
This is version 96 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.