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Protein

Sulfofructosephosphate aldolase

Gene

yihT

Organism
Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

Cleaves 6-deoxy-6-sulfo-D-fructose 1-phosphate (SFP) to form dihydroxyacetone phosphate (DHAP) and 3-sulfolactaldehyde (SLA).UniRule annotation

Catalytic activityi

6-deoxy-6-sulfo-D-fructose 1-phosphate = glycerone phosphate + 2-hydroxy-3-oxopropane-1-sulfonate.UniRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Lyase

Enzyme and pathway databases

BioCyciSENT99287:GCTI-4050-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Sulfofructosephosphate aldolaseUniRule annotation (EC:4.1.2.57UniRule annotation)
Short name:
SFP aldolaseUniRule annotation
Gene namesi
Name:yihT
Ordered Locus Names:STM4022
OrganismiSalmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720)
Taxonomic identifieri99287 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeSalmonella
Proteomesi
  • UP000001014 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 292292Sulfofructosephosphate aldolasePRO_0000203972Add
BLAST

Proteomic databases

PaxDbiQ9L7R9.
PRIDEiQ9L7R9.

Interactioni

Protein-protein interaction databases

STRINGi99287.STM4022.

Structurei

Secondary structure

1
292
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Helixi6 – 94Combined sources
Beta strandi16 – 205Combined sources
Helixi25 – 339Combined sources
Helixi42 – 5615Combined sources
Helixi57 – 593Combined sources
Beta strandi61 – 655Combined sources
Turni67 – 704Combined sources
Helixi71 – 766Combined sources
Beta strandi84 – 896Combined sources
Beta strandi91 – 966Combined sources
Beta strandi99 – 1068Combined sources
Helixi112 – 1176Combined sources
Beta strandi122 – 1298Combined sources
Helixi135 – 15016Combined sources
Turni151 – 1533Combined sources
Beta strandi155 – 1628Combined sources
Helixi173 – 18412Combined sources
Beta strandi190 – 1945Combined sources
Helixi197 – 2004Combined sources
Helixi204 – 21613Combined sources
Beta strandi222 – 2243Combined sources
Turni231 – 2333Combined sources
Helixi234 – 24310Combined sources
Beta strandi248 – 2525Combined sources
Helixi253 – 2564Combined sources
Helixi257 – 2593Combined sources
Helixi265 – 2717Combined sources
Helixi273 – 28917Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1TO3X-ray2.70A2-292[»]
ProteinModelPortaliQ9L7R9.
SMRiQ9L7R9. Positions 1-291.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ9L7R9.

Family & Domainsi

Sequence similaritiesi

Belongs to the aldolase LacD family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105D2M. Bacteria.
COG3684. LUCA.
HOGENOMiHOG000244296.
KOiK01671.
OMAiGRAVWQE.
OrthoDBiEOG6SR92W.
PhylomeDBiQ9L7R9.

Family and domain databases

Gene3Di3.20.20.70. 1 hit.
HAMAPiMF_01912. SFP_aldolase.
InterProiIPR013785. Aldolase_TIM.
IPR002915. DeoC/FbaB/lacD_aldolase.
IPR017291. SFP_aldolase_YihT.
[Graphical view]
PfamiPF01791. DeoC. 1 hit.
[Graphical view]
PIRSFiPIRSF037840. Aldolase_YihT. 1 hit.
SMARTiSM01133. DeoC. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9L7R9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNNYTIKDIT RASGGFAMLA VDQREAMRLM FAAAGAKTPV ADSVLTDFKV
60 70 80 90 100
NAAKILSPYA SAVLLDQQFC YRQAVEQNAV AKSCAMIVAA DDFIPGNGIP
110 120 130 140 150
VDNVVLDKKI NAQAVKRDGA KALKLLVLWR SDEDAQQRLN MVKEFNELCH
160 170 180 190 200
SNGLLSIIEP VVRPPRCGDK FDREQAIIDA AKELGDSGAD LYKVEMPLYG
210 220 230 240 250
KGARSDLLTA SQRLNGHINM PWVILSSGVD EKLFPRAVRV AMEAGASGFL
260 270 280 290
AGRAVWSSVI GLPDTELMLR DVSAPKLQRL GEIVDEMMAK RR
Length:292
Mass (Da):31,866
Last modified:January 23, 2002 - v2
Checksum:iB4BC0AC12D7197E1
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti235 – 2351P → L in AAF27922 (Ref. 1) Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF220438 Genomic DNA. Translation: AAF27922.1.
AE006468 Genomic DNA. Translation: AAL22861.1.
RefSeqiNP_462902.1. NC_003197.1.
WP_001067421.1. NC_003197.1.

Genome annotation databases

EnsemblBacteriaiAAL22861; AAL22861; STM4022.
GeneIDi1255548.
KEGGistm:STM4022.
PATRICi32386914. VBISalEnt20916_4237.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF220438 Genomic DNA. Translation: AAF27922.1.
AE006468 Genomic DNA. Translation: AAL22861.1.
RefSeqiNP_462902.1. NC_003197.1.
WP_001067421.1. NC_003197.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1TO3X-ray2.70A2-292[»]
ProteinModelPortaliQ9L7R9.
SMRiQ9L7R9. Positions 1-291.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi99287.STM4022.

Proteomic databases

PaxDbiQ9L7R9.
PRIDEiQ9L7R9.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAL22861; AAL22861; STM4022.
GeneIDi1255548.
KEGGistm:STM4022.
PATRICi32386914. VBISalEnt20916_4237.

Phylogenomic databases

eggNOGiENOG4105D2M. Bacteria.
COG3684. LUCA.
HOGENOMiHOG000244296.
KOiK01671.
OMAiGRAVWQE.
OrthoDBiEOG6SR92W.
PhylomeDBiQ9L7R9.

Enzyme and pathway databases

BioCyciSENT99287:GCTI-4050-MONOMER.

Miscellaneous databases

EvolutionaryTraceiQ9L7R9.

Family and domain databases

Gene3Di3.20.20.70. 1 hit.
HAMAPiMF_01912. SFP_aldolase.
InterProiIPR013785. Aldolase_TIM.
IPR002915. DeoC/FbaB/lacD_aldolase.
IPR017291. SFP_aldolase_YihT.
[Graphical view]
PfamiPF01791. DeoC. 1 hit.
[Graphical view]
PIRSFiPIRSF037840. Aldolase_YihT. 1 hit.
SMARTiSM01133. DeoC. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Utilization of dihydroorotate as sole pyrimidine source by Salmonella typhimurium."
    Krogan N.J., Zhang R., Neuhard J., Kelln R.A.
    Submitted (JAN-2000) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: LT2.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: LT2 / SGSC1412 / ATCC 700720.

Entry informationi

Entry nameiSQUT_SALTY
AccessioniPrimary (citable) accession number: Q9L7R9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 26, 2001
Last sequence update: January 23, 2002
Last modified: June 8, 2016
This is version 87 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.