Q9L7L7 (DNAA_MYCPA) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Chromosomal replication initiator protein DnaA

Gene names

Name:	dnaA
Ordered Locus Names:	MAP_0001

Organism

Mycobacterium paratuberculosis [Complete proteome] [HAMAP]

Taxonomic identifier

1770 [NCBI]

Taxonomic lineage

Bacteria › Actinobacteria › Actinobacteridae › Actinomycetales › Corynebacterineae › Mycobacteriaceae › Mycobacterium › Mycobacterium avium complex (MAC)

Protein attributes

Sequence length	509 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Plays an important role in the initiation and regulation of chromosomal replication. Binds to the origin of replication; it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box): 5'-TTATC[CA]A[CA]A-3'. DnaA binds to ATP and to acidic phospholipids By similarity. HAMAP MF_00377
Subcellular location	Cytoplasm By similarity HAMAP MF_00377.
Sequence similarities	Belongs to the DnaA family.

Ontologies

Keywords
Biological process	DNA replication
Cellular component	Cytoplasm
Ligand	ATP-binding DNA-binding Nucleotide-binding
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	DNA-dependent DNA replication initiation Inferred from electronic annotation. Source: InterPro regulation of DNA replication Inferred from electronic annotation. Source: InterPro
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW DNA replication origin binding Inferred from electronic annotation. Source: InterPro nucleoside-triphosphatase activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 509	509	Chromosomal replication initiator protein DnaA HAMAP MF_00377		PRO_0000114215
Regions
	Nucleotide binding	210 – 217	8	ATP Potential

Sequences

	Sequence		Length	Mass (Da)
	Q9L7L7 [UniParc]. Last modified October 1, 2000. Version 1. Checksum: 2472F3F644D34EC9	FASTA	509	56,620
	10 20 30 40 50 60 MADDPGSSFT TVWNAVVSEL NGEPVADGGA ANRTTLVTPL TPQQRAWLNL VRPLTIVEGF 70 80 90 100 110 120 ALLSVPSSFV QNEIERHLRA PITDALSRRL GQQIQLGVRI APPPDDVEDA PIPPAEPFPD 130 140 150 160 170 180 TDAALSADDG ADGEPVENGE PVTDTQPGWP NYFTERPHAI DPAVAAGTSL NRRYTFDTFV 190 200 210 220 230 240 IGASNRFAHA AALAIAEAPA RAYNPLFIWG ESGLGKTHLL HAAGNYAQRL FPGMRVKYVS 250 260 270 280 290 300 TEEFTNDFIN SLRDDRKVAF KRSYRDVDVL LVDDIQFIEG KEGIQEEFFH TFNTLHNANK 310 320 330 340 350 360 QIVISSDRPP KQLATLEDRL RTRFEWGLIT DVQPPELETR IAILRKKAQM ERLAVPDDVL 370 380 390 400 410 420 ELIASSIERN IRELEGALIR VTAFASLNKT PIDKSLAEIV LRDLIADAST MQISAATIMA 430 440 450 460 470 480 ATAEYFDTTV EELRGPGKTR ALAQSRQIAM YLCRELTDLS LPKIGQAFGR DHTTVMYAQR 490 500 KILSEMAERR EVFDHVKELT TRIRQRSKR

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Genomic organization of the Mycobacterium avium subsp. paratuberculosis origin of replication region." Zhang Q., Kapur V. Submitted (JAN-2000) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[2]	"The complete genome sequence of Mycobacterium avium subspecies paratuberculosis." Li L., Bannantine J.P., Zhang Q., Amonsin A., May B.J., Alt D., Banerji N., Kanjilal S., Kapur V. Proc. Natl. Acad. Sci. U.S.A. 102:12344-12349(2005) [PubMed: 16116077] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC BAA-968 / K-10.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AF222789 Genomic DNA. Translation: AAF33692.1. AE016958 Genomic DNA. Translation: AAS02318.1.
RefSeq	NP_958935.1. NC_002944.2.
3D structure databases
ProteinModelPortal	Q9L7L7.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	EBMYCT00000037244; EBMYCP00000035633; EBMYCG00000037239.
GeneID	2721021.
GenomeReviews	Gene locus MAP_0001 in contig AE016958_GR.
KEGG	mpa:MAP0001.
NMPDR	fig|262316.1.peg.1.
PATRIC	17992302. VBIMycAvi108102_0002.
Organism-specific databases
CMR	Search...
Phylogenomic databases
GeneTree	EBGT00050000017320.
HOGENOM	HBG695666.
OMA	ASVHESW.
ProtClustDB	PRK00149.
Family and domain databases
HAMAP	MF_00377. DnaA_bact. [Tree]
InterPro	IPR003593. ATPase_AAA+_core. IPR001957. Chromosome_initiator_DnaA. IPR020591. Chromosome_initiator_DnaA-like. IPR018312. Chromosome_initiator_DnaA_CS. IPR013159. DnaA_C. IPR013317. DnaA_Hda. IPR010921. Trp_repressor/repl_initiator. [Graphical view]
Gene3D	G3DSA:1.10.1750.10. DnaA_C. 1 hit.
KO	K02313.
Pfam	PF00308. Bac_DnaA. 1 hit. PF08299. Bac_DnaA_C. 1 hit. [Graphical view]
PRINTS	PR00051. DNAA.
SMART	SM00382. AAA. 1 hit. SM00760. Bac_DnaA_C. 1 hit. [Graphical view]
SUPFAM	SSF48295. Trp_repress_rep. 1 hit.
TIGRFAMs	TIGR00362. DnaA. 1 hit.
PROSITE	PS01008. DNAA. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

DNAA_MYCPA

Accession

Primary (citable) accession number: Q9L7L7

Entry history

Integrated into UniProtKB/Swiss-Prot:	April 27, 2001
Last sequence update:	October 1, 2000
Last modified:	January 25, 2012
This is version 71 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program